Vinorelbine ditartrate

Catalog No.S4269 Batch:S426901

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Technical Data

Formula

C45H54N4O8.2C4H6O6
Molecular Weight 1079.11 CAS No. 125317-39-7
Solubility (25°C)* In vitro DMSO 100 mg/mL (92.66 mM)
Water 100 mg/mL (92.66 mM)
Ethanol 100 mg/mL (92.66 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

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Biological Activity

Description Vinorelbine ditartrate is a semi-synthetic vinca alkaloid, and inhibits mitosis through interaction with tubulin. Vinorelbine Tartrate exhibits anti-tumor activities via inducing the mitotic apoptosis, autophagy and inflammation.
Targets
Tubulin [1]
(Cell-free assay)
In vitro

Vinorelbine inhibits microtubule assembly by inducing tubulin aggregation into spirals and paracrystals. [1]

Vinorelbine shows potent antiproliferative activity against a series of tumor cells, including human melanoma, non-small-cell lung cancer, breast cancer, etc. [2][3][4]
In vivo

In vivo, Vinorelbine also shows antitumour activity against a series of subcutaneously-implanted human tumour xenografts. [5]
Features A semi-synthetic vinca alkaloid as an anti-mitotic chemotherapy drug.

Protocol (from reference)

Animal Study:

[5]
  • Animal Models

    Bladder (BXF1299), pancreas (PAXF546), kidney (RXF944LX), colon (DLD-1, HT-29, TC37), central nervous system (SF-295), small cell lung (NCI-H69) and prostate (PC-3) xenografts.

  • Dosages

    ~10 mg/kg

  • Administration

    i.p.

Customer Product Validation

, , Cynthia Bernia from McGill University

Data from [Data independently produced by , , Mol Cancer Ther, 2016, 15(8):1823-33.]

Data from [Data independently produced by , , J Biol Chem, 2017, 292(19):7806-7816]

Data from [Data independently produced by , , Breast Cancer Res Treat, 2018, 172(1):23-32]

Selleck's Vinorelbine ditartrate has been cited by 39 publications

Targeting MCL-1 triggers DNA damage and an anti-proliferative response independent from apoptosis induction [ Cell Rep, 2023, 42(10):113176] PubMed: 37773750
Comprehensive molecular characterization of adenoid cystic carcinoma reveals tumor suppressors as novel drivers and prognostic biomarkers [ J Pathol, 2023, 261(3):256-268] PubMed: 37565350
Small extracellular vesicles promote invadopodia activity in glioblastoma cells in a therapy-dependent manner [ Cell Oncol (Dordr), 2023, 10.1007/s13402-023-00786-w] PubMed: 37014551
Immunofluorescence-Based Assay for High-Throughput Analysis of Multidrug Resistance Markers in Non-Small Cell Lung Carcinoma Patient-Derived Cells [ Diagnostics (Basel), 2023, 13(24)3617] PubMed: 38132201
Immune checkpoint inhibitors modulate the cytotoxic effect of chemotherapy in lung adenocarcinoma cells [ Oncol Lett, 2023, 25(4):152] PubMed: 36936028
Immune checkpoint inhibitors modulate the cytotoxic effect of chemotherapy in lung adenocarcinoma cells [ Oncology Letters, 2023, 152] PubMed: None
Effect of Chemotherapeutics on In Vitro Immune Checkpoint Expression in Non-Small Cell Lung Cancer [ Technol Cancer Res Treat, 2023, 22:15330338231202307] PubMed: 37728201
Effect of Chemotherapeutics on In Vitro Immune Checkpoint Expression in Non-Small Cell Lung Cancer [ Technol Cancer Res Treat, 2023, 22:15330338231202307] PubMed: 37728201
MET-induced CD73 restrains STING-mediated immunogenicity of EGFR-mutant lung cancer [ Cancer Res, 2022, CAN-22-0770] PubMed: 36066413
Comprehensive drug response profiling and pan-omic analysis identified therapeutic candidates and prognostic biomarkers for Asian cholangiocarcinoma [ iScience, 2022, 25(10):105182] PubMed: 36248745

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.