5-HT4 Selective Inhibitors | Agonists
|Catalog No.||Product Name||Information||Selective / Pan||IC50 / Ki|
Prucalopride is a selective, high affinity 5-HT receptor agonist for 5-HT4A and 5-HT4B receptor with Ki of 2.5 nM and 8 nM, respectively, exhibits >290-fold selectivity against other 5-HT receptor subtypes.
|Selective||5-HT4A, Ki: 2.5 nM; 5-HT4B, Ki: 8 nM|
Prucalopride is a selective, high affinity 5-HT4 receptor agonist, inhibiting human 5-HT(4a) and 5-HT(4b) receptor with Ki value of 2.5 nM and 8 nM, respectively.
|Selective||5-HT4B, Ki: 8 nM; 5-HT4A, Ki: 2.5 nM|
Amitriptyline inhibits serotonin receptor, norepinephrine receptor, 5-HT4, 5-HT2 and sigma 1 receptor with IC50 of 3.45 nM, 13.3 nM, 7.31 nM, 235 nM and 287 nM, respectively.
|Selective||5-HT4, IC50: 7.31 nM|
Mosapride Citrate is a gastroprokinetic agent that acts as a selective 5HT4 agonist.
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