IWR-1-endo

Catalog No.S7086

IWR-1-endo Chemical Structure

Molecular Weight(MW): 409.44

IWR-1-endo is a Wnt pathway inhibitor with IC50 of 180 nM in L-cells expressing Wnt3A, induces Axin2 protein levels and promotes β-catenin phosphorylation by stabilizing Axin-scaffolded destruction complexes.

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USD 250 In stock
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3 Customer Reviews

  • Effect of IWR-1 treatment on total β-catenin levels and adipogenesis in high-passage shSCR and shTCF7L2 cells. Cells were treated with IWR-1 (10 μmol/L) every other day for 6 days during differentiation. Western blot demonstrates the effect of IWR-1 on total β-catenin protein levels at the end of adipogenesis (each lane represents a single independent adipogenesis experiment, n = 4 for each treatment).

    Diabetes, 2018, 67(4):554-568. IWR-1-endo purchased from Selleck.

    Dose effect of IWR-1-endo, PRI-724, and ICG-001 on FAS and CD36 protein levels measured by immunoblots.

    Biochim Biophys Acta Mol Cell Biol Lipids, 2018, 1863(8):834-843. IWR-1-endo purchased from Selleck.

  • (F) UNC119 influences the activity of Wnt/β-catenin signaling. β-catenin inhibitor IWR-1-endo significantly inhibits SKHep1 proliferation.

    Am J Cancer Res, 2015, 5(10):3123-3134.. IWR-1-endo purchased from Selleck.

Purity & Quality Control

Choose Selective Wnt/beta-catenin Inhibitors

Biological Activity

Description IWR-1-endo is a Wnt pathway inhibitor with IC50 of 180 nM in L-cells expressing Wnt3A, induces Axin2 protein levels and promotes β-catenin phosphorylation by stabilizing Axin-scaffolded destruction complexes.
Targets
Wnt [1]
(L-cells expressing Wnt3A)
180 nM
In vitro

Although both IWR-1 and XAV939 act as reversible Wnt pathway inhibitors and exhibit similar pharmacological effects both in vitro and in vivo, IWR-1 exerts its effect via interaction with Axin, while XAV939 binds TNKS directly. [1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
human HEK293T cells  MVXGeY5kfGmxbjDhd5NigQ>? NIiwO|BKdmirYnn0bY9vKG:oIHLleIEu[2G|ZXnuMYRmeGWwZHXueEBk[W6xbnnjZYwhX262MzDwZZRpf2G7IHnuJIh2dWGwIFjFT|I6O1RiY3XscJMh[nlibIXjbYZmemG|ZTDy[ZBwenSncjDn[Y5mKGG|c3H5MEBKSzVyPUCuNFI3KM7:TR?= NXTjVYExOjJzOUG1OVc>
mouse L-Wnt-STF cells Mn\6SpVv[3Srb36gZZN{[Xl? MXjJcohq[mm2aX;uJI9nKFSQS2OtNkBqdiCvb4Xz[UBNNVewdD3TWGYh[2WubIOgZZN{\XO|ZXSgZZMh\Gm|coXweIlwdiCxZjDXcpQhe2mpbnHsbY5oKGGodHXyJFI1KGi{czDifUBtfWOrZnXyZZNmKHKncH;yeIVzKGenbnWgZZN{[XluIFnDOVA:OC5yNU[g{txO NXvJeI1LOjR3Mke3PVI>
mouse L-Wnt-STF cells MmD4SpVv[3Srb36gZZN{[Xl? MmX5TY5pcWKrdHnvckBw\iCWTlvTMVEhcW5ibX;1d4UhVC2ZboStV3RHKGOnbHzzJIF{e2W|c3XkJIF{KGSrc4L1dJRqd25ib3[gW451KHOrZ37hcIlv\yCjZoTldkAzPCCqcoOgZpkhdHWlaX\ldoF{\SC{ZYDvdpRmeiCpZX7lJIF{e2G7LDDJR|UxRTBwMUOxJO69VQ>? NWHZeGcyOjR3Mke3PVI>
Escherichia coli BL21 (DE3) cells NU\1Rm83TnWwY4Tpc44h[XO|YYm= M3HidlkxKG2rboO= MVnBZ5Rqfmm2eTDv[kBPNXSncn3pcpV{KGineHHIbZMufGGpZ3XkJIh2dWGwIGTOV2szKGW6cILld5Nm\CCrbjDFd4Np\XKrY3jpZUBkd2yrIFLMNlEhMESHMzmgZ4VtdHNidYPpcoch[mmxdHnufYxifGWmIF7BSEsh[XNic4Xid5Rz[XSnIHHmeIVzKDlyIH3pcpMh[nliV3XzeIVzdiCkbH;0JIFv[Wy7c3nzMEBGSzVyPUCuNkDPxE1? NWjKc5JsOjJ{M{OzNlA>
human SW480 cells MYnGeY5kfGmxbjDhd5NigQ>? Mnf6OFAhfG9iNEigbC=> MV3Jcohq[mm2aX;uJI9nKHSjbnv5doF{\SCrbjDoeY1idiCVV{S4NEBk\WyuczDhd5Nme3OnZDDhd{Bl\We{YXTheIlwdiCxZjDi[ZRiKGOjdHXubY4h[W[2ZYKgOFAhfG9iNEigbJJ{NCCLQ{WwQVAvOjVizszN M3nvVVI{PzBzNUG3
human SW480 cells NFLQfldHfW6ldHnvckBie3OjeR?= NWXiZm1zOjRiaB?= NGrm[JJKdmirYnn0bY9vKG:oIIThcot6emG|ZTDpckBpfW2jbjDTW|Q5OCClZXzsd{Bie3Onc4Pl[EBieyCjY3P1cZVt[XSrb36gc4Yh[XirbkKgZYZ1\XJiMkSgbJJ{KGK7IFjv[YNpe3RiZInlMYJie2WmIH3leIhw\A>? NHHuV4UzOzdyMUWxOy=>
human HT29 cells MUXGeY5kfGmxbjDhd5NigQ>? NHeyeGozPCCq MoXaTY5pcWKrdHnvckBw\iCZboSgd4lodmGuaX7nJIlvKGi3bXHuJGhVOjliY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBj\XSjLXPheIVvcW5vbXXkbYF1\WRiVHPmM2xm\iC2cnHud4NzcXC2aX;uZYwh[WO2aY\peJkh[W[2ZYKgNlQhcHK|IHL5JIR2[WxibIXjbYZmemG|ZTDy[ZBwenSncjDn[Y5mKGG|c3H5JJJmdGG2aY\lJJRwKGOxboTyc4wtKEmFNUC9NlQvPCEQvF2= NXvp[FBXOjR7NUC0PFk>
human HT29 cells Moj5SpVv[3Srb36gZZN{[Xl? NEHVXYozPSEQvF2= Mmn0NlQhcA>? NXnjeFI5UW6qaXLpeIlwdiCxZjDXcpQhe2mpbnHsbY5oKGmwIHj1cYFvKEiWMkmgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iCkZYThMYNifGWwaX6tcYVlcWG2ZXSgWINnN0ynZjD0doFve2O{aYD0bY9v[WxiYXP0bZZqfHliYYSgNlUhfU1iYX\0[ZIhOjRiaILzJIJ6KGS3YXygcJVkcW[ncnHz[UBz\XCxcoTldkBo\W6nIHHzd4F6KHKnbHH0bZZmKHSxIHPvcpRzd2xiaX6gdJJme2WwY3Wgc4YhT1ONLUPi[ZRiKGmwaHnibZRweiCOaVPs M2fQclI1QTVyNEi5
human DLD1 cells NIK1[lNHfW6ldHnvckBie3OjeR?= M3X0O|IhcA>? NWHle3BFUW6mdXP0bY9vKG:oIFH4bY4zKHO2YXLpcIl7[XSrb36gbY4hcHWvYX6gSGxFOSClZXzsd{Bie3Onc4Pl[EBieyCmZXPy[YF{\WRidILhcpNkemmydHnvckBw\iCDeHnuNkBi\nSncjCyJIhzeyCkeTDSWE1RS1JibXX0bI9lNg>? NGnqfHQyQTF{NUG1Oi=>
HEK293 cells M17OZWZ2dmO2aX;uJIF{e2G7 MXXEbZNxdGGlZX3lcpQhd2ZiSWfSMXBDKG[{b32gRZhqdjJiaX6gTGVMOjl|IHPlcIx{KGK7IGfld5Rmem5iYnzveEBu\XSqb3S= MmLJNVkyOjVzNU[=

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Protocol

Solubility (25°C)

In vitro DMSO 21 mg/mL (51.28 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 409.44
Formula

C25H19N3O3

CAS No. 1127442-82-3
Storage powder
in solvent
Synonyms N/A

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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Wnt/beta-catenin Signaling Pathway Map

Related Wnt/beta-catenin Products0

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID