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IWP-2
Catalog No.S7085
For research use only.
IWP-2 is an inhibitor of Wnt processing and secretion with IC50 of 27 nM in a cell-free assay, selective blockage of Porcn-mediated Wnt palmitoylation, does not affect Wnt/β-catenin in general and displays no effect against Wnt-stimulated cellular responses. IWP-2 specifically inhibits CK1δ.
CAS No. 686770-61-6
Selleck's IWP-2 has been cited by 55 publications
Purity & Quality Control
Choose Selective Wnt/beta-catenin Inhibitors
Related Compound Libraries
Other Wnt/beta-catenin Products
Biological Activity
| Description | IWP-2 is an inhibitor of Wnt processing and secretion with IC50 of 27 nM in a cell-free assay, selective blockage of Porcn-mediated Wnt palmitoylation, does not affect Wnt/β-catenin in general and displays no effect against Wnt-stimulated cellular responses. IWP-2 specifically inhibits CK1δ. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Features | Selective inhibitor of Porcn-mediated Wnt secretion. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Targets |
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| In vitro |
IWP-2 is useful in both regenerative medicine and anticancer efforts. IWP-2 inactivates Porcn, a membrane-bound O-acyltransferase (MBOAT), and selectively inhibits palmitoylation of Wnt. IWP-2 blocks Wnt-dependent phosphorylation of Lrp6 receptor and Dvl2, and β-catenin accumulation. [1] |
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| Cell Data |
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| Assay |
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Protocol (from reference)
| Cell Research: |
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| Animal Research: |
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| References |
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Solubility (25°C)
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In vitro |
DMF |
22 mg/mL
warmed (47.14 mM) |
| DMSO |
4 mg/mL
warmed (8.57 mM) |
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| Water |
Insoluble
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Chemical Information
| Molecular Weight | 466.6 | ||
|---|---|---|---|
| Formula | C22H18N4O2S3 |
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| CAS No. | 686770-61-6 | ||
| Storage | 3 years | -20°C | powder |
| 2 years | -80°C | in solvent | |
| Smiles | CC1=CC2=C(C=C1)N=C(S2)NC(=O)CSC3=NC4=C(C(=O)N3C5=CC=CC=C5)SCC4 | ||
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Tech Support
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
Tel: +1-832-582-8158 Ext:3
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Products are for research use only. Not for human use. We do not sell to patients.
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