Signaling Pathway Map

Research Area

  • Inhibitory Selectivity
  • Solubility
Catalog No. Product Name Solubility(25°C)
Water DMSO Alcohol
S8414 PACAP 1-27 100 mg/mL -1 mg/mL -1 mg/mL
S7499 ESI-09 <1 mg/mL 66 mg/mL 20 mg/mL
S8416 PACAP 6-38 100 mg/mL -1 mg/mL -1 mg/mL
S7500 HJC0350 <1 mg/mL 52 mg/mL <1 mg/mL
S8283 SQ22536 41 mg/mL 41 mg/mL 41 mg/mL
S4552 Bithionol <1 mg/mL 71 mg/mL 22 mg/mL
S2449 Forskolin <1 mg/mL 82 mg/mL 37 mg/mL
S8415 PACAP 1-38 100 mg/mL -1 mg/mL -1 mg/mL

Isoform-specific Inhibitors

Catalog No. Information Product Use Citations Product Validations

PACAP 1-27

Pituitary adenylate cyclase activating polypeptide (PACAP 1-27) is a potent PACAP receptor antagonist.



ESI-09 is a specific exchange protein directly activated by cAMP (EPAC) inhibitor with IC50 of 3.2 μM and 1.4 μM for EPAC1 and EPAC2, respectively, >100-fold selectivity over PKA.


PACAP 6-38

PACAP 6-38 is a PACAP (pituitary adenylate cyclase-activating polypeptide) non-stimulating competitive antagonist with an IC50 value of 2 nM. It also acts as a functional CARTp antagonist in vivo.



HJC0350 is a potent and selective EPAC2 inhibitor with IC50 of 0.3 μM, exhibiting no inhibition on Epac1.



SQ22536 is an inhibitor of adenylyl cyclase with an IC50 of 1.4 μM. It can inhibit PGE1-stimulated increases in cAMP levels in intact human platelets.



Bithionol is a potent inhibitor of soluble adenylyl cyclase(sAC) with an IC50 of 4 μM and has antibacterial and anthelmintic properties along with algaecide activity.



Forskolin is a ubiquitous activator of eukaryotic adenylyl cyclase (AC) in a wide variety of cell types, commonly used to raise levels of cAMP in the study and research of cell physiology.


PACAP 1-38

PACAP 1-38 is a highly potent PACAP receptor agonist (Kd = 100 pM). It stimulates adenylate cyclase and phagocytosis.