Home GPCR & G Protein cAMP EPAC2 Selective Inhibitors | Antagonists

EPAC2 Selective Inhibitors | Antagonists

  • AC
  • EPAC1
  • EPAC2
  • PACAP receptor
Catalog No. Product Name Information Selective / Pan IC50 / Ki
S7500 HJC0350 HJC0350 is a potent and selective EPAC2 inhibitor with IC50 of 0.3 μM, exhibiting no inhibition on Epac1. Selective EPAC2, IC50: 0.3 μM
S3382 ESI-05 ESI-05 (NSC 116966) is a specific EPAC2 (exchange protein directly activated by cAMP 2) antagonist with IC50 of 0.4 µM. ESI-05 (NSC 116966) inhibits cAMP-mediated activation of EPAC2 and EAPC2 mediated Rap1 activation. Selective EPAC2, IC50: 0.43 μM
S7499 ESI-09 ESI-09 is a specific exchange protein directly activated by cAMP (EPAC) inhibitor with IC50 of 3.2 μM and 1.4 μM for EPAC1 and EPAC2, respectively, >100-fold selectivity over PKA. Pan EPAC2, IC50: 1.4 μM
S0837 HJC0197 HJC0197 is a selective Epac 1/2 dual antagonists with an IC50 of 5.9 μM for Epac2. Pan