Oridonin (NSC-250682)

Catalog No.S2335 Synonyms: Isodonol, Rubescenin

For research use only.

Oridonin (Isodonol, Rubescenin, NSC-250682), a diterpenoid purified from Rabdosia rubescens, is a traditional agent with antitumor, anti-bacterial and anti-inflammatory effects. Oridonin inhibits AKT1 and AKT2 kinase activity with IC50 of 8.4 μM and 8.9 μM, respectively.

Oridonin (NSC-250682) Chemical Structure

CAS No. 28957-04-2

Selleck's Oridonin (NSC-250682) has been cited by 17 publications

Purity & Quality Control

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Biological Activity

Description Oridonin (Isodonol, Rubescenin, NSC-250682), a diterpenoid purified from Rabdosia rubescens, is a traditional agent with antitumor, anti-bacterial and anti-inflammatory effects. Oridonin inhibits AKT1 and AKT2 kinase activity with IC50 of 8.4 μM and 8.9 μM, respectively.
Targets
Akt1 [5]
(Cell-free assay)
Akt2 [5]
(Cell-free assay)
8.4 μM 8.9 μM
In vitro

Oridonin effectively inhibites the proliferation of a wide variety of cancer cells including those from prostate (LNCaP, DU145, PC3), breast (MCF-7, MDA-MB231), non-small cell lung (NSCL) (NCI-H520, NCI-H460, NCI-H1299) cancers, acute promyelocytic leukemia (NB4), and glioblastoma multiforme (U118, U138) with ED50s ranging from 1.8 to 7.5 μg/ml. [1] The antitumor activities of Oridonin may due to its inhibitory effects on NF-kappaB and MAPKs signal pathways. [2] [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HL60 MnPUR5l1d3SxeHnjbZR6KGG|c3H5 NHP5XIg1QCCqcoO= NWfEb4JnS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hUEx4MDDj[YxteyCjZoTldkA1QCCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwQVIvPc7:TR?= NHPUPY09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{ixPVg4OSd-MkO4NVk5PzF:L3G+
RAW264.7 NYjmN2RpSW62aXnu[oxidW2jdH;yfUBie3OjeR?= NGjVPW8yQCCqcoO= Mnm3RY51cWmwZnzhcY1ifG:{eTDhZ5Rqfmm2eTDpckBud3W|ZTDSRXczPjRwNzDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKEySUz3pcoR2[2WmIH7peJJq[yCxeHnk[UBxem:mdXP0bY9vKGGodHXyJFE5KGi{czDifUBIemmnc4OgcYV1cG:mLDDJR|UxRTVwMt88US=> M3i1RVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|OEG5PFcyLz5{M{ixPVg4OTxxYU6=
K562 NYPRNZJMSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= M1\wOVczKGi{cx?= NH;BVZVCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFu1OlIh[2WubIOgZYZ1\XJiN{KgbJJ{KGK7IF3UWEBie3OjeTygTWM2OD12LkOz{txO NGL2fmc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEG2OVc{QCd-MkixOlU4Ozh:L3G+
Bel7402 NWnaTHhkSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MoLmO|IhcHK| M4HEXWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iQnXsO|QxOiClZXzsd{Bi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBKSzVyPUWuOFHPxE1? MlfxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhzNkW3N|goRjJ6MU[1O|M5RC:jPh?=
MGC803 MXXBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NVLzRppjPzJiaILz MXXBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2JQ{iwN{Bk\WyuczDh[pRmeiB5MjDodpMh[nliTWTUJIF{e2G7LDDJR|UxRTlwMEdOwG0> NHnsbJI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEG2OVc{QCd-MkixOlU4Ozh:L3G+
KB/CP4 MmfPRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NYHnbm15PDhiaILz MmHKRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCNQj;DVFQh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OD1zMD64{txO M176N|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MU[1O|M5Lz5{OEG2OVc{QDxxYU6=
KB-3-1 NHLXWYZCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NEHafIU1QCCqcoO= M1TMN2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iS1KtN{0yKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTB;MUOuNlTPxE1? MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDF4NUezPEc,OjhzNkW3N|g9N2F-
BEL7404/CP20 NYnN[lQ2SW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= M33FSFQ5KGi{cx?= NUXG[ldmSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDCSWw4PDB2L1PQNlAh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OD1zNz6xO:69VQ>? NVq0W|JsRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkixOlU4OzhpPkK4NVY2PzN6PD;hQi=>
MCF7 MnjXRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? Mo\sO|IhcHK| MYLBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2FRkegZ4VtdHNiYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NF0yPy56Od88US=> M{PYb|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MU[1O|M5Lz5{OEG2OVc{QDxxYU6=
Bel7404 NGfBRmlCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MmnZOFghcHK| M1Pk[WFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iQnXsO|QxPCClZXzsd{Bi\nSncjC0PEBpenNiYomgUXRVKGG|c3H5MEBKSzVyPUG3Mlkz|ryP NHvjZpk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEG2OVc{QCd-MkixOlU4Ozh:L3G+
NCI-H460 MXnBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NFf3e5Q1QCCqcoO= MV7BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE6FST3IOFYxKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDNWHQh[XO|YYmsJGlEPTB;MkCuOVHPxE1? NWr4dHlORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkixOlU4OzhpPkK4NVY2PzN6PD;hQi=>
NCI-H460/MX20 NY\zToM1SW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MknVOFghcHK| NGLuUmxCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF7DTU1JPDZyL13YNlAh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IF3UWEBie3OjeTygTWM2OD1{NT64Ou69VQ>? MkjNQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjhzNkW3N|goRjJ6MU[1O|M5RC:jPh?=
K562 M3znfmFvfGmycn;sbYZmemG2aY\lJIF{e2G7 NX\hWmx6PzJiaILz NHPSXpJCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFu1OlIh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwIHPlcIwhfmmjYnnsbZR6KGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUC9OE43PM7:TR?= M3T4NlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyOUKxO|U4Lz5|MEmyNVc2PzxxYU6=
SGC7901 Mm\WRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NUC4cmV2PzJiaILz MX\BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKFOJQ{e5NFEh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwIHPlcIwhfmmjYnnsbZR6KGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUC9O{4yO87:TR?= MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODl{MUe1O{c,OzB7MkG3OVc9N2F-
Bel7402 MmfXRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NXX6c4x3PzJiaILz M1rTZmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iQnXsO|QxOiClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gZ4VtdCC4aXHibYxqfHliYX\0[ZIhPzJiaILzJIJ6KE2WVDDhd5NigSxiSVO1NF04Njh3zszN M3ztVlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyOUKxO|U4Lz5|MEmyNVc2PzxxYU6=
HL60 MYTBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NWfCToRjPzJiaILz NUnmXJNFSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDIUFYxKGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCrbjDj[YxtKH[rYXLpcIl1gSCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwQVkvPDcQvF2= Mnn5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB7MkG3OVcoRjNyOUKxO|U4RC:jPh?=
PC3 MYTBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? M{TyPVczKGi{cx?= M1T1WGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iUFOzJINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiClZXzsJJZq[WKrbHn0fUBi\nSncjC3NkBpenNiYomgUXRVKGG|c3H5MEBKSzVyPUGwMlA4|ryP MoriQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB7MkG3OVcoRjNyOUKxO|U4RC:jPh?=
A549 M1LBdWFvfGmycn;sbYZmemG2aY\lJIF{e2G7 M3TOc|czKGi{cx?= NGG0fFNCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFG1OFkh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwIHPlcIwhfmmjYnnsbZR6KGGodHXyJFczKGi{czDifUBOXFRiYYPzZZktKEmFNUC9NVgvOTYQvF2= NHPISHY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEmyNVc2Pyd-M{C5NlE4PTd:L3G+
L02 NFfhZYtEgXSxdH;4bYNqfHliYYPzZZk> MVS3NkBpenN? MoL6R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUFAzKGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCrbjDj[YxtKH[rYXLpcIl1gSCjZoTldkA4OiCqcoOgZpkhVVSWIHHzd4F6NCCLQ{WwQVE6NjV|zszN MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODl{MUe1O{c,OzB7MkG3OVc9N2F-
HCT116 MXzBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MknuOFghcHK| MkXERY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCKQ2SxNVYh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwIHPlcIwhfmmjYnnsbZR6KGmwY4XiZZRm\CCob4KgOFghcHK|IHL5JG1VXCCjc4PhfUwhUUN3ME22Mlg1|ryP MlTmQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB7OEGxNVMoRjNyOUixNVE{RC:jPh?=
L02 M1vJWWN6fG:2b4jpZ4l1gSCjc4PhfS=> M3rNNFQ5KGi{cx?= MWXDfZRwfG:6aXPpeJkhcW5iaIXtZY4hVDB{IHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDpckBk\WyuII\pZYJqdGm2eTDpcoN2[mG2ZXSg[o9zKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVA:Pi57N988US=> M3fvW|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyOUixNVE{Lz5|MEm4NVEyOzxxYU6=
Bel7402 M4O0emFvfGmycn;sbYZmemG2aY\lJIF{e2G7 NHHHPXk1QCCqcoO= NX3PXVdLSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDC[Yw4PDB{IHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDpckBk\WyuII\pZYJqdGm2eTDpcoN2[mG2ZXSg[o9zKDR6IHjyd{BjgSCPVGSgZZN{[XluIFnDOVA:QS53Od88US=> MlT5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB7OEGxNVMoRjNyOUixNVE{RC:jPh?=
MCF7 NILoRmhCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= M1\ibVQ5KGi{cx?= NGS4O4JCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3DSlch[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwIHPlcIwhfmmjYnnsbZR6KGmwY4XiZZRm\CCob4KgOFghcHK|IHL5JG1VXCCjc4PhfUwhUUN3ME2xO{42Ps7:TR?= MnfGQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB7OEGxNVMoRjNyOUixNVE{RC:jPh?=
MDA-MB-231 NFTqSnNCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MYm0PEBpenN? MoO5RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPRFGtUWIuOjNzIHPlcIx{KGmwY4XiZZRm\CCob4KgOFghcHK|IHL5JG1VXCCjc4PhfUwhTUN3ME2yPU41|ryP NWLvZXNHRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{C5PFEyOTNpPkOwPVgyOTF|PD;hQi=>
HCT116 Mnm1R4VtdCCleXPs[UBienKnc4SgZZN{[Xl? NWjoWGNlOyC3TR?= MmjFNlQhcHK| MYDJcoR2[3Srb36gbY4h[2WubDDjfYNt\SCjcoLld5QhcW5iaIXtZY4hUEOWMUG2JINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hcW5iY4njcIlvKEFicILveIVqdiCneIDy[ZN{cW:wIHzleoVtKGG2IEOgeW0hcW6ldXLheIVlKG[xcjCyOEBpenNiYomgW4V{fGW{bjDicI91KGGwYXz5d4l{ M37sUFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyOUixNVE{Lz5|MEm4NVEyOzxxYU6=
HCT116 M4rTOGNmdGxiY4njcIUh[XK{ZYP0JIF{e2G7 MVmzJJVO NVXQ[3VGOjRiaILz NWSzb4VKUW6mdXP0bY9vKGmwIHPlcIwh[3mlbHWgZZJz\XO2IHnuJIh2dWGwIFjDWFEyPiClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIHnuJIN6[2yrbjDCNUBxem:2ZXnuJIV5eHKnc4Ppc44hdGW4ZXygZZQhOyC3TTDpcoN2[mG2ZXSg[o9zKDJ2IHjyd{BjgSCZZYP0[ZJvKGKub4SgZY5idHm|aYO= M3fIZ|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyOUixNVE{Lz5|MEm4NVEyOzxxYU6=
HCT116 NFTDcW1CeG:ydH;0bYMh[XO|YYm= Moi4NUB2VQ>? NXrFbVFEOjRiaILz NXj5cXZYUW6mdXP0bY9vKG:oIHHwc5B1d3SrYzDtc5JxcG:ub3fpZ4FtKGOqYX7n[UBqdiCqdX3hckBJS1RzMU[gZ4VtdHNiYYPz[ZN{\WRiYYOgcI9{eyCxZjDvdolocW6jbDDtc5JxcG:ub3f5JIF1KDFidV2gbY5kfWKjdHXkJIZweiB{NDDodpMh[nliaHHlcYF1d3i7bHnuMYVwe2mwIIP0ZYlvcW6pIHLhd4VlKG2rY4Lvd4NweGmlIH3leIhw\A>? NVfacJljRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{C5PFEyOTNpPkOwPVgyOTF|PD;hQi=>
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HCT116 M4rRXGFxd3C2b4TpZ{Bie3OjeR?= MmqzNUB2VQ>? NVrSb|VWOjRiaILz M2n6NGlv\HWldHnvckBw\iCjcH;weI91cWNibX;ydIhwdG:paXPhcEBkcGGwZ3WgbY4hcHWvYX6gTGNVOTF4IHPlcIx{KGG|c3Xzd4VlKGG|IH\vdo1ifGmxbjDv[kB3d2y3bXWgd5dmdGyrbnegZZQhOSC3TTDpcoN2[mG2ZXSg[o9zKDJ2IHjyd{BjgSCqYXXtZZRwgHmuaX6t[Y9{cW5ic4ThbY5qdmdiYnHz[YQhdWmlcn;zZ49xcWNibXX0bI9l NFe1RZk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEm4NVEyOyd-M{C5PFEyOTN:L3G+
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PLC/PRF/5 MVXBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MmXyO|IhcHK| M1;MR2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iUFzDM3BTTi93IHPlcIx{KGmwY4XiZZRm\CCob4KgO|IhcHK|IHL5JGNEUzhiY3XscJMtKEmFNUC9O{41Oc7:TR?= MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{OTJyMEKzPEc,OzF{MECyN|g9N2F-
HepG2 MWPBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MW[3NkBpenN? MV\BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKEincFeyJINmdGy|IHnuZ5Vj[XSnZDDmc5IhPzJiaILzJIJ6KEOFS{igZ4VtdHNuIFnDOVA:QC5zMt88US=> M17aUFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNzMkCwNlM5Lz5|MUKwNFI{QDxxYU6=
RPMI8226 NHzJc2VCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MmXTO|IhcHK| NV3MXWpjSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDSVG1KQDJ{NjDj[YxteyCrbnP1ZoF1\WRiZn;yJFczKGi{czDifUBES0t6IHPlcIx{NCCLQ{WwQVkvOjYQvF2= NYPlT|h5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{GyNFAzOzhpPkOxNlAxOjN6PD;hQi=>
LO2 NVfTUnpuS3m2b4TvfIlkcXS7IHHzd4F6 NXXwcIVWPzJiaILz MY\DfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDMU|Ih[2WubIOgbY5kfWKjdHXkJIZweiB5MjDodpMh[nliQ1PLPEBk\WyuczygTWM2OD1zNz60O:69VQ>? NWTlTWc6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{GyNFAzOzhpPkOxNlAxOjN6PD;hQi=>
A549 M{jtPGFvfGmycn;sbYZmemG2aY\lJIF{e2G7 MkHvO|IhcHK| M1Pjb2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iQUW0PUBk\WyuczDpcoN2[mG2ZXSg[o9zKDd{IHjyd{BjgSCFQ1u4JINmdGy|LDDJR|UxRTNyLkVOwG0> MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{OTJyMEKzPEc,OzF{MECyN|g9N2F-
HepG2 M3W5[2Z2dmO2aX;uJIF{e2G7 M3vqU|AvOSC2bzCxJJVO MXixNEBl[Xm| MnHTTY5pcWKrdHnvckBw\iClb3zvcpkh\m:{bXH0bY9vKGmwIHj1cYFvKEincFeyJINmdGy|IHH0JFAvOSC2bzCxJJVOKGmwY4XiZZRm\CCob4KgNVAh\GG7czDifUBkenm|dHHsJJZqd2yndDDzeIFqdmmwZzDiZZNm\CCvaXPyc5Nkd3CrYzDt[ZRpd2R? M3zJ[|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNzMkCwNlM5Lz5|MUKwNFI{QDxxYU6=
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MGC803 NYfVeHdsSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NUHj[4ppPzJiaILz MWPBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE2JQ{iwN{Bk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5iY3XscEB3cWGkaXzpeJkhcW6ldXLheIVlKG[xcjC3NkBpenNiYomgV3JDKGG|c3H5MEBKSzVyPUG0MlE{|ryP NXnOSnhURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{G0PVQ1PzJpPkOxOFk1PDd{PD;hQi=>
MCF7 NGiw[4dCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NEe1NVI4OiCqcoO= NFL2PG9CdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3DSlch[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwIHPlcIwhfmmjYnnsbZR6KGmwY4XiZZRm\CCob4KgO|IhcHK|IHL5JHNTSiCjc4PhfUwhUUN3ME2yNU46P87:TR?= MorCQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzF2OUS0O|IoRjNzNEm0OFczRC:jPh?=
Assay
Methods Test Index PMID
Western blot BCR-ABL / Myc ; p-AMPK / AMPK / Glut1 / LC3 28128329 28230866
Immunofluorescence HSF1 ; p65 28128329 25886043
Growth inhibition assay Cell viability 26496199
In vivo

LD50: Mice 35-40mg/kg. [4]

Protocol (from reference)

Solubility (25°C)

In vitro

In vivo

Add solvents to the product individually and in order
(Data is from Selleck tests instead of citations):
5% DMSO+20%PEG 300+ddH2O
For best results, use promptly after mixing.

12.5mg/ml

Chemical Information

Molecular Weight 364.43
Formula

C20H28O6

CAS No. 28957-04-2
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC1(CCC(C23C1C(C(C45C2CCC(C4O)C(=C)C5=O)(OC3)O)O)O)C

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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