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Perifosine (KRX-0401)

Name: Perifosine (KRX-0401)
Brand: Selleck Chemicals
SKU: S1037
Rating: 5 (158 reviews)

Catalog No.S1037 Synonyms: NSC639966, D21266

For research use only.

Perifosine (KRX-0401, NSC639966, D21266) is a novel Akt inhibitor with IC50 of 4.7 μM in MM.1S cells, targets pleckstrin homology domain of Akt. Phase 3.

Perifosine (KRX-0401) Chemical Structure

CAS No. 157716-52-4

Selleck's Perifosine (KRX-0401) has been cited by 158 publications

Purity & Quality Control

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Akt Signaling Pathway Map

Biological Activity

Description

Perifosine (KRX-0401, NSC639966, D21266) is a novel Akt inhibitor with IC50 of 4.7 μM in MM.1S cells, targets pleckstrin homology domain of Akt. Phase 3.

Targets

Akt ^[1]
(MM.1S cells)

4.7 μM

In vitro

Perifosine develops anti-proliferative properties with IC50 of 0.6-8.9 μM in immortalized keratinocytes (HaCaT), and head and neck squamous carcinoma cells. ^[1] Perifosine strongly reduces phosphorylation levels of Akt and extracellular signal-regulated kinase (Erk) 1/2, induces cell cycle arrest in G1 and G2, and causes dose-dependent growth inhibition of mouse glial progenitors. ^[2] Perifosine (10 μM) completely inhibits the phosphorylation of Akt in MM.1S cells. ^[3] A recent study demonstrates Perifosine induces cell cycle arrest and apoptosis in human hepatocellular carcinoma cell lines by blockade of Akt phosphorylation. ^[4]

Cell Data

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID

HL-60	NUL0S2VQSXCxcITvd4l{KEG\|c4PhfS=>	NG\1eYwyOMLizszN	NXXI[Hd[OjRxNEigbC=>	MojkbY5lfWOnczDhdI9xfG:\|aYOgeIlu\S2mZYDlcoRmdnSueR?=	Mn63QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjBzM{C5OlAoRjJyMUOwPVYxRC:jPh?=
MOLM	NUnnelRWSXCxcITvd4l{KEG\|c4PhfS=>	MVKxNOKh\|ryP	MoK2NlQwPDhiaB?=	MYnpcoR2[2W\|IHHwc5B1d3OrczD0bY1mNWSncHXu[IVvfGy7	MlXnQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjBzM{C5OlAoRjJyMUOwPVYxRC:jPh?=
OCI	MmLyRZBweHSxc3nzJGF{e3OjeR?=	MVqxNOKh\|ryP	NGfaVWEzPC92ODDo	M2XhU4lv\HWlZYOgZZBweHSxc3nzJJRqdWVvZHXw[Y5l\W62bIm=	MXG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODF\|MEm2NEc,OjBzM{C5OlA9N2F-
BJAB	MnHHRZBweHSxc3nzJGF{e3OjeR?=	MWexNOKh\|ryP	NX\iRVNMOjRxNEigbC=>	NInTUFhqdmS3Y3XzJIFxd3C2b4Ppd{B1cW2nLXTldIVv\GWwdHz5	M3jPXlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyMUOwPVYxLz5{MEGzNFk3ODxxYU6=
MAVER	Mof4RZBweHSxc3nzJGF{e3OjeR?=	Mn3uNVDDqM7:TR?=	M{SwRVI1NzR6IHi=	NUnHdXY{cW6mdXPld{BieG:ydH;zbZMhfGmvZT3k[ZBmdmSnboTsfS=>	MV:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODF\|MEm2NEc,OjBzM{C5OlA9N2F-
SKW6.4	NEe1SohCeG:ydH;zbZMhSXO\|c3H5	Ml\ONVDDqM7:TR?=	NIjoe\|UzPC92ODDo	MonrbY5lfWOnczDhdI9xfG:\|aYOgeIlu\S2mZYDlcoRmdnSueR?=	NWrL[pAyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCxN\|A6PjBpPkKwNVMxQTZyPD;hQi=>
HL-60	MlPRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NH7ROmIzNTFywrFOwG0>	M{nEWVQ5yqCq	M2D0cIlvcGmkaYTzJINmdGxiZ4Lve5RpKGmwIHGg[I9{\SCmZYDlcoRmdnRibXHucoVz	NVXje2I{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCxN\|A6PjBpPkKwNVMxQTZyPD;hQi=>
MOLM	NWPpS2FsT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NUKw[3JJOi1zMNMg{txO	NITYcYc1QMLiaB?=	NH;0T3FqdmirYnn0d{Bk\WyuIHfyc5d1cCCrbjDhJIRwe2ViZHXw[Y5l\W62IH3hco5meg>?	MmjaQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjBzM{C5OlAoRjJyMUOwPVYxRC:jPh?=
OCI	MljRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NHHsd5gzNTFywrFOwG0>	NVKwOYhWPDkEoHi=	NYfFW3JlcW6qaXLpeJMh[2WubDDndo94fGhiaX6gZUBld3OnIHTldIVv\GWwdDDtZY5v\XJ?	MlPFQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjBzM{C5OlAoRjJyMUOwPVYxRC:jPh?=
BJAB	NH:3[pZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MV:yMVExyqEQvF2=	M4XhTlQ5yqCq	M{\GUIlvcGmkaYTzJINmdGxiZ4Lve5RpKGmwIHGg[I9{\SCmZYDlcoRmdnRibXHucoVz	MnWzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjBzM{C5OlAoRjJyMUOwPVYxRC:jPh?=
MAVER	M3fmd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	Mn;UNk0yOMLizszN	NFnIOGI1QMLiaB?=	NIPWOXFqdmirYnn0d{Bk\WyuIHfyc5d1cCCrbjDhJIRwe2ViZHXw[Y5l\W62IH3hco5meg>?	NIXDWIE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEGzNFk3OCd-MkCxN\|A6PjB:L3G+
SKW6.4	NXPvOVF4T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	MmTBNk0yOMLizszN	NInoWXc1QMLiaB?=	NVTRXlBRcW6qaXLpeJMh[2WubDDndo94fGhiaX6gZUBld3OnIHTldIVv\GWwdDDtZY5v\XJ?	NU\LVZE4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCxN\|A6PjBpPkKwNVMxQTZyPD;hQi=>
A2780cis	Ml3OS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	NXTKfmhJOC1{MDFOwG0>	Mo\rOFgwPzJiaB?=	NYX4cYpMUUN3MNMgQeKhPsLizszt	NV[0RXFzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC0NFUzQTZpPkKwOFA2Ojl4PD;hQi=>
A2780	MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MnHwNE0zOCEQvF2=	MkLIOFgwPzJiaB?=	NW\TRlZvUUN3MNMgQeKhO8Lizszt	MoTEQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB2MEWyPVYoRjJyNEC1Nlk3RC:jPh?=
SKOV3	NXnMXlNGT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NEK4fWwxNTRyIN88US=>	MnnGO\|LDqGh?	M1S4OGlEPTC-M{Cg{txONCCrbnjpZol1eyClZXzsJIdzd3e2aDDpckBiKGSxc3Wg[IVx\W6mZX70JI1idm6nch?=	NXKye3NkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC0NFUzQTZpPkKwOFA2Ojl4PD;hQi=>
PA-1	MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MVKwMVQxKM7:TR?=	MXW3NuKhcA>?	NUTPe5cyUUN3MI6yOUDPxE1uIHnubIljcXS\|IHPlcIwh\3Kxd4ToJIlvKGFiZH;z[UBl\XCnbnTlcpQhdWGwbnXy	M2e4T\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyNEC1Nlk3Lz5{MESwOVI6PjxxYU6=
OAW-42	NFfxZXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MX6wMVQxKM7:TR?=	M4jZ[FczyqCq	MWnJR\|UxhjFyIN88UUwhcW6qaXLpeJMh[2WubDDndo94fGhiaX6gZUBld3OnIHTldIVv\GWwdDDtZY5v\XJ?	NVm4fXZ4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC0NFUzQTZpPkKwOFA2Ojl4PD;hQi=>
Bel-7402	MnruRZBweHSxc3nzJGF{e3OjeR?=	NHe4XG42NzFyL{KwJO69VQ>?	M4PJTVI1NzR6IHi=	NUDLbGo4cW6mdXPld{BieG:ydH;zbZMh[XRidHjlJIxwdmdvdHnt[UBmgHCxc4Xy[S=>	MUm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODh2MkSyOUc,OjB6NEK0NlU9N2F-
HepG2	NUDVOYVbSXCxcITvd4l{KEG\|c4PhfS=>	M3myXlUwOTBxMkCg{txO	Ml3INlQwPDhiaB?=	NELBeldqdmS3Y3XzJIFxd3C2b4Ppd{BifCC2aHWgcI9v\y22aX3lJIV5eG:\|dYLl	M1\OWFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyOESyOFI2Lz5{MEi0NlQzPTxxYU6=
Bel-7402	M{LYVWZ2dmO2aX;uJGF{e2G7	M2n3WlUwOTBxMkCg{txO	MYqyOEBp	NEC0UZBz\XO3bITzJIlvKHSqZTDhZ4N2dXWuYYTpc44hd2ZiY3XscEBvfW2kZYKgbY4hfGinIFeyM20heGijc3W=	M{mxWlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyOESyOFI2Lz5{MEi0NlQzPTxxYU6=
HepG2	NULnZog1TnWwY4Tpc44hSXO\|YYm=	M{G0dFUwOTBxMkCg{txO	MWGyOEBp	MWny[ZN2dHS\|IHnuJJRp\SCjY3P1cZVt[XSrb36gc4Yh[2WubDDueY1j\XJiaX6geIhmKEd{L12gdIhie2V?	NV\6VJNqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC4OFI1OjVpPkKwPFQzPDJ3PD;hQi=>
Bel-7402	MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NXXIcmxGPS9zMD:yNE81OCEQvF2=	Ml3ONlQwPDhxN{KgbC=>	MmSzbY5pcWKrdIOgZ4VtdCCpcn;3eIghcW5iYn;0bEB1cW2nIHHu[EBld3OnIHTldIVv\GWwdDDtZY5v\XJ?	MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODh2MkSyOUc,OjB6NEK0NlU9N2F-
HepG2	MlnzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl?	M17lU\|UwOTBxMkCvOFAh\|ryP	MnT4NlQwPDhxN{KgbC=>	MoTybY5pcWKrdIOgZ4VtdCCpcn;3eIghcW5iYn;0bEB1cW2nIHHu[EBld3OnIHTldIVv\GWwdDDtZY5v\XJ?	NEjNd\|I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEi0NlQzPSd-MkC4OFI1OjV:L3G+
CWR22RV1	M1HPT2Z2dmO2aX;uJGF{e2G7	MV[1JO69VQ>?	MX[yOEBp	Mn3PdoVlfWOnZDDwbI9{eGixconsZZRqd25ib3[gRYt1KHOrZ37p[olk[W62bIm=	NF7nNmU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUS5OlI4Oyd-MkG0PVYzPzN:L3G+
CWR22RV1	MkfpRZBweHSxc3nzJGF{e3OjeR?=	NFWxR5YyOCEQvF2=	MXSyOEBp	NGPOOXlmdmijbnPld{Bz[WSrYYTpc44hcW6mdXPl[EBieG:ydH;zbZM>	NXz6dXQ{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG0PVYzPzNpPkKxOFk3Ojd\|PD;hQi=>
CWR22RV1	MoPLR4VtdCCYaXHibYxqfHliQYPzZZk>	M135S\|ExKM7:TR?=	MYKyOEBp	Mn;nbY5kemWjc3XzJJNmdnOrdHn2bZR6KG:oIHj1cYFvKEOZUkKyVnYyKGOnbHzzJJRwKHKjZHnheIlwdg>?	NYPLdW9ERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG0PVYzPzNpPkKxOFk3Ojd\|PD;hQi=>
A498	NVnTdnh1T3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	NVrZVVJqOC1{MDFOwG0>	MmLxO\|IhcA>?	NWO3cpFZcW6qaXLpeJMh[2WubDDndo94fGhiaX6gZUBld3OnIHTldIVv\GWwdDDtZY5v\XJ?	M1H1dVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzNkS0NFUxLz5{MU[0OFA2ODxxYU6=
769-P	M1jOe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7	NIDXcXkxNTJyIN88US=>	NH7Eb2Y4OiCq	M{Die4lvcGmkaYTzJINmdGxiZ4Lve5RpKGmwIHGg[I9{\SCmZYDlcoRmdnRibXHucoVz	M3zhUlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzNkS0NFUxLz5{MU[0OFA2ODxxYU6=
CAKI-1	NUfvXmxsT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M2XCelAuOjBizszN	M4jD[VczKGh?	NF[wbpNqdmirYnn0d{Bk\WyuIHfyc5d1cCCrbjDhJIRwe2ViZHXw[Y5l\W62IH3hco5meg>?	MWC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTZ2NEC1NEc,OjF4NESwOVA9N2F-
786-O	M4HFZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MXuwMVIxKM7:TR?=	M2T1U\|czKGh?	MmHFbY5pcWKrdIOgZ4VtdCCpcn;3eIghcW5iYTDkc5NmKGSncHXu[IVvfCCvYX7u[ZI>	MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTZ2NEC1NEc,OjF4NESwOVA9N2F-
786-0	NWCwZZdiT3Kxd4ToJGlvcGmkaYTpc44hSXO\|YYm=	M{LSRVAuPDBizszN	NEXGZpE4OiCq	NXHjbYhpUUN3MI61JO69VQ>?	NYfzemVrRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG2OFQxPTBpPkKxOlQ1ODVyPD;hQi=>
769-P	NIrvc3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	MmLQNE01OCEQvF2=	Mlr2O\|IhcA>?	M1zlTGlEPTC-NT2xNEDPxE1?	MmnZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF4NESwOVAoRjJzNkS0NFUxRC:jPh?=
CAKI-1	MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	MknDNE01OCEQvF2=	MmnMO\|IhcA>?	MXrJR\|UxhjFyIN88US=>	MkXvQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF4NESwOVAoRjJzNkS0NFUxRC:jPh?=
A498	MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NEXHRXIxNTRyIN88US=>	M37mZlczKGh?	MVPpcohq[mm2czDj[YxtKGe{b4f0bEBqdiCjIHTvd4Uh\GWyZX7k[Y51KG2jbn7ldi=>	NV7Lb4NtRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG2OFQxPTBpPkKxOlQ1ODVyPD;hQi=>
HT-29	M2jVN2N6fG:2b4jpZ4l1gSCDc4PhfS=>	M{fjPVUh\|ryP	NVLkWFBOPDhiaB?=	NH3ndIRmdmijbnPld{Bx[WOuaYThfIVtKGmwZIXj[YQhd3[jcnnhckBk[W6lZYKgZ4VtdCCmZXH0bOKh	Mnf2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF5N{WwOVQoRjJzN{e1NFU1RC:jPh?=
A2780	MkfoR5l1d3SxeHnjbZR6KEG\|c3H5	MXq1JO69VQ>?	MXy0PEBp	MkXl[Y5p[W6lZYOgdIFkdGm2YYjlcEBqdmS3Y3XkJI93[XKrYX6gZ4Fv[2W{IHPlcIwh\GWjdHlCpC=>	MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTd5NUC1OEc,OjF5N{WwOVQ9N2F-
SKOV3	MkTlR5l1d3SxeHnjbZR6KEG\|c3H5	M1vOb\|Uh\|ryP	M13EOFQ5KGh?	M1W0bIVvcGGwY3XzJJBi[2yrdHH4[YwhcW6mdXPl[EBwfmG{aXHuJINidmOncjDj[YxtKGSnYYToxsA>	MXu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTd5NUC1OEc,OjF5N{WwOVQ9N2F-
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RMG2	NXTROXVFSXCxcITvd4l{KEG\|c4PhfS=>	MW[zNEDPxE1?	M4rob\|I1KGh?	NHLHNpFqdmS3Y3XzJIFxd3C2b4Ppdy=>	NFLaTmw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUWxPVE1QCd-MkW1NVkyPDh:L3G+
RMG1	M1nOcGFxd3C2b4Ppd{BCe3O\|YYm=	MlWzN\|Ah\|ryP	NGfYTJQzPCCq	MWrpcoR2[2W\|IHHwc5B1d3Orcx?=	MmW0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV3MUmxOFgoRjJ3NUG5NVQ5RC:jPh?=
A2780	M2jQWGNmdGxiVnnhZoltcXS7IFHzd4F6	Ml;tNU0{OCEQvF2=	NXvaeVY5PDhiaB?=	NVywT\|dF\GWlcnXhd4V{KGOnbHygeoli[mmuaYT5JIlvKGFiZH;z[UBl\XCnbnTlcpQhdWGwbnXy	M2rqPVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3NUG5NVQ5Lz5{NUWxPVE1QDxxYU6=
SKOV3	M2\OUGNmdGxiVnnhZoltcXS7IFHzd4F6	NIK5UJcyNTNyIN88US=>	NVnMcJJDPDhiaB?=	NULoXlhl\GWlcnXhd4V{KGOnbHygeoli[mmuaYT5JIlvKGFiZH;z[UBl\XCnbnTlcpQhdWGwbnXy	MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTVzOUG0PEc,OjV3MUmxOFg9N2F-
OVISE	MV\D[YxtKF[rYXLpcIl1gSCDc4PhfS=>	NGn4OGUyNTNyIN88US=>	M{DxU\|Q5KGh?	MUDk[YNz\WG\|ZYOgZ4VtdCC4aXHibYxqfHliaX6gZUBld3OnIHTldIVv\GWwdDDtZY5v\XJ?	MlXsQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV3MUmxOFgoRjJ3NUG5NVQ5RC:jPh?=
RMG2	MVfD[YxtKF[rYXLpcIl1gSCDc4PhfS=>	NV7vfZNNOS1\|MDFOwG0>	MUi0PEBp	NHe2VIVl\WO{ZXHz[ZMh[2WubDD2bYFjcWyrdImgbY4h[SCmb4PlJIRmeGWwZHXueEBu[W6wZYK=	NGL3N\|U9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUWxPVE1QCd-MkW1NVkyPDh:L3G+
HAC2	M3zNW2NmdGxiVnnhZoltcXS7IFHzd4F6	MUixMVMxKM7:TR?=	NUPvTHpPPzJiaB?=	M3zhdoRm[3KnYYPld{Bk\WyuII\pZYJqdGm2eTDpckBiKGSxc3Wg[IVx\W6mZX70JI1idm6nch?=	MoniQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV3MUmxOFgoRjJ3NUG5NVQ5RC:jPh?=
KOC7C	NIO1bmZE\WyuIG\pZYJqdGm2eTDBd5NigQ>?	NYrUSGtnOS1\|MDFOwG0>	NFrENmY4OiCq	M1rFfIRm[3KnYYPld{Bk\WyuII\pZYJqdGm2eTDpckBiKGSxc3Wg[IVx\W6mZX70JI1idm6nch?=	M1f4TlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3NUG5NVQ5Lz5{NUWxPVE1QDxxYU6=
RMG2	NFXZTFdE\WyuIG\pZYJqdGm2eTDBd5NigQ>?	MkG0NU0{OCEQvF2=	M1;ibVczKGh?	NEjFNJNl\WO{ZXHz[ZMh[2WubDD2bYFjcWyrdImgbY4h[SCmb4PlJIRmeGWwZHXueEBu[W6wZYK=	MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTVzOUG0PEc,OjV3MUmxOFg9N2F-
RMG1	NUC1b2dqS2WubDDWbYFjcWyrdImgRZN{[Xl?	NFfocYIyNTNyIN88US=>	M2DU[VczKGh?	NG\qepNl\WO{ZXHz[ZMh[2WubDD2bYFjcWyrdImgbY4h[SCmb4PlJIRmeGWwZHXueEBu[W6wZYK=	MnPaQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV3MUmxOFgoRjJ3NUG5NVQ5RC:jPh?=
H460	MVLGeY5kfGmxbjDBd5NigQ>?	MYOzJO69VQ>?	MX[4JIg>	MUHicI9kc3NibWTPVmMyNCCjbnSgSXJMNU2DUFugZYN1cX[jdHnvckBkd22kaX7l[EB4cXSqIF3FT{0yPjJ?	NX3UN5d6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW2PVc5QTlpPkK1Olk4QDl7PD;hQi=>
A549	NWfTZo9{TnWwY4Tpc44hSXO\|YYm=	M163UFMh\|ryP	NYrBTWMyQCCq	M1nQNoJtd2OtczDtWG9TSzFuIHHu[EBGWktvTVHQT{Bi[3SrdnH0bY9vKGOxbXLpcoVlKHerdHigUWVMNTF4Mh?=	MnG3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV4OUe4PVkoRjJ3Nkm3PFk6RC:jPh?=
H460	M1jFbGZ2dmO2aX;uJGF{e2G7	M3HzbFMh\|ryP	NXLZXopmQCCq	NW\sOpFQ[myxY3vzJGFMXCCjY4TpeoF1cW:w	NHL2W3c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NU[5O\|g6QSd-MkW2PVc5QTl:L3G+
A549	NWDOcJI2TnWwY4Tpc44hSXO\|YYm=	MWezJO69VQ>?	MYi4JIg>	NEfBdnBjdG:la4OgRWtVKGGldHn2ZZRqd25?	M1TnOVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3Nkm3PFk6Lz5{NU[5O\|g6QTxxYU6=
H460	M4PyW2Fxd3C2b4Ppd{BCe3O\|YYm=	M3rrNlEwOyEQvF2=	MWm0PEBp	NHHrZ4VqdmS3Y3XzJIFxd3C2b4Ppdy=>	M3XjU\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3Nkm3PFk6Lz5{NU[5O\|g6QTxxYU6=
A549	NXTtR3ZsSXCxcITvd4l{KEG\|c4PhfS=>	MXixM\|Mh\|ryP	MorxOFghcA>?	M{Hicolv\HWlZYOgZZBweHSxc3nz	Ml;wQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV4OUe4PVkoRjJ3Nkm3PFk6RC:jPh?=
H460	MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>?	NWj4W\|llOC5\|LUGwJO69VQ>?	MnzINlQwPzJiaB?=	MYjpcohq[mm2czDj[YxtKGe{b4f0bEBqdiCkb4ToJJRqdWViYX7kJIRwe2ViZHXw[Y5l\W62IH3hco5meg>?	MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTZ7N{i5PUc,OjV4OUe4PVk9N2F-
A549	NHfCVGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?=	NHPLcYkxNjNvMUCg{txO	NULXdJdCOjRxN{KgbC=>	MVXpcohq[mm2czDj[YxtKGe{b4f0bEBqdiCkb4ToJJRqdWViYX7kJIRwe2ViZHXw[Y5l\W62IH3hco5meg>?	NIPaVJg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NU[5O\|g6QSd-MkW2PVc5QTl:L3G+
U-87 MG	M3WzSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	MXGyNE81OCEQvF2=	M1vuV\|I1NzR6IHi=	NEPKfXVqdmirYnn0d{Bk\WyuIHfyc5d1cCCrbjDic5RpKHSrbXWgZY5lKGSxc3Wg[IVx\W6mZX70JI1idm6nch?=	NWq1XZRJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW5N\|QzOzJpPkK1PVM1OjN{PD;hQi=>
HepG2	M33sXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7	M2TnPVIxNzRyIN88US=>	NVKxUnpiOjRxNEigbC=>	NFTRVHFqdmirYnn0d{Bk\WyuIHfyc5d1cCCrbjDic5RpKHSrbXWgZY5lKGSxc3Wg[IVx\W6mZX70JI1idm6nch?=	NYfNSnhNRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW5N\|QzOzJpPkK1PVM1OjN{PD;hQi=>
U-87 MG	M4mxRmZ2dmO2aX;uJGF{e2G7	MXSyNOKh\|ryP	MXu2M\|I1KGh?	MmrDbY5kemWjc3XzJJRp\SCjdYTvdIhi\2mlIH\seZghKGG2IE[gbEB4cGmuZTDpcohq[mm2czD0bIl{KG[udYigZZQhOjSq	M3f1OVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3OUO0NlMzLz5{NUmzOFI{OjxxYU6=
HepG2	Mn3aSpVv[3Srb36gRZN{[Xl?	M4e4RlIxyqEQvF2=	MWO2M\|I1KGh?	NHfse3pl\WO{ZXHz[ZMhVEN\|LVnJJIRm\3KjZHH0bY9vyqCocn;tJFYhcA>?	MoPyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV7M{SyN\|IoRjJ3OUO0NlMzRC:jPh?=
U-87 MG	MUXGeY5kfGmxbjDBd5NigQ>?	MlPhNlDDqM7:TR?=	NFTCS5k3NzJ2IHi=	MnzQbY5kemWjc3XzJJRp\SCuZY\lcJMhd2ZiTFOzMWlKKGOxdILlZZRm\CC5aYToJGNS	NXLWUWNpRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW5N\|QzOzJpPkK1PVM1OjN{PD;hQi=>
HepG2	MmizSpVv[3Srb36gRZN{[Xl?	MXSyNOKh\|ryP	MkHYOk8zPCCq	NHGyNWhqdmO{ZXHz[ZMhfGinIHzleoVteyCxZjDMR\|MuUUliY3;0doVifGWmIIfpeIghS1F?	NX;4eIFpRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW5N\|QzOzJpPkK1PVM1OjN{PD;hQi=>
U-87 MG	M1HBbGZ2dmO2aX;uJGF{e2G7	MX2yNOKh\|ryP	M4jIS\|I1yqCq	M{fYUolv[3KnYYPld{Bld3WkbHWtcYVu[nKjbnWgZo92dmRic4TyeYN1fXKncx?=	NE\Sd\|Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUmzOFI{Oid-MkW5N\|QzOzJ:L3G+
HepG2	NHv5N5pHfW6ldHnvckBCe3OjeR?=	MmLlNlDDqM7:TR?=	NF;W[VIzPMLiaB?=	MXvwdo9lfWOnczDhckBqdnSnboPlJIN6fG:ybHHzcYlkKH[jY4XvcIl7[XSrb36gZ49zemW\|cH;u[Ilv\yC2bzDhJI5wfGGkbHWg[Ilt[XSjdHnvckBw\iC2aHWgSXIh[2m\|dHXycpM>	NUXzN\|VDRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW5N\|QzOzJpPkK1PVM1OjN{PD;hQi=>
T24 BC	M2K5cmFxd3C2b4Ppd{BCe3O\|YYm=	MWiyMlUh\|ryP	NX\jdItKOjRiaB?=	NWLDWItye2Wwc3n0bZpmeyCEQzDj[YxteyC2bzDzc5Ji\mWwaXKtbY5lfWOnZDDhdI9xfG:2aXRCpC=>	M37nOVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4MEm3PFc{Lz5{NkC5O\|g4OzxxYU6=
T24 BC	MU\D[YxtKF[rYXLpcIl1gSCDc4PhfS=>	NVzD[plKOC53L{GvNk42KM7:TR?=	M2HKNVI1KGh?	MoXr[Y5p[W6lZYOgd49z[W[nbnniMYlv\HWlZXSgZ4VtdCC4aXHibYxqfHliZHXjdoVie2V?	MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjB7N{i3N{c,OjZyOUe4O\|M9N2F-
T24 BC	NF3ydVZHfW6ldHnvckBCe3OjeR?=	NV;HRpRSOC53L{GvNk42KM7:TR?=	M1rhXVMhcA>?	MmLWdoVlfWOnczD0bIUh[mG\|YXygR2IhfHm{b4PpcoUheGixc4Doc5J6dGG2aX;uJIxmfmWuczDpckBiKGSxc3Wt[IVx\W6mZX70JI1idm6nch?=	M2\T[\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4MEm3PFc{Lz5{NkC5O\|g4OzxxYU6=
RBL2H3	Mn\MSpVv[3Srb36gZZN{[Xl?			MnXiWI95cWOrdImgbY4hemG2IGLCUFJJOyClZXzsd{whVVSGPUK1{txO	NUnZOpE{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCxOVM2PjVpPkKwNVU{PTZ3PD;hQi=>
PC3	MVnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?			NFfGbnFIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBRSzNiY3XscJMh[nlic4Xs[o9zcG:mYX3pcoUhSiCjc4PhfUwhT0l3ME2wMlQ1\|ryP	MkDzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF3NEOxOFEoRjJzNUSzNVQyRC:jPh?=
NUGC3	NXXTbFI4T3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=			MU\Hdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDOWWdEOyClZXzsd{BjgSC\|dXzmc5Jpd2SjbXnu[UBDKGG\|c3H5MEBIUTVyPUCuOVTPxE1?	M1jq[\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzNUSzNVQyLz5{MUW0N\|E1OTxxYU6=
HCT15	MoH1S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?			NXLzXJc4T3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hUEOWMUWgZ4VtdHNiYomgd5Vt\m:{aH;kZY1qdmViQjDhd5NigSxiR1m1NF0yNjJ3zszN	MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTV2M{G0NUc,OjF3NEOxOFE9N2F-
MDA-MB-231	MXXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?			MkflS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gUWRCNU2ELUKzNUBk\WyuczDifUB{fWyob4Loc4RidWmwZTDCJIF{e2G7LDDHTVUxRTJwOEdOwG0>	NEXwcmM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUW0N\|E1OSd-MkG1OFMyPDF:L3G+
NCI-H23	Mn7JS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?			NFj2eoxIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEKzJINmdGy\|IHL5JJN2dG[xcnjv[IFucW6nIFKgZZN{[XluIFfJOVA:PC5{Md88US=>	M3nUflxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzNUSzNVQyLz5{MUW0N\|E1OTxxYU6=
ACHN	MVjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?			NFO5e2hIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBCS0iQIHPlcIx{KGK7IIP1cIZwemixZHHtbY5mKEJiYYPzZZktKEeLNUC9OE42Ps7:TR?=	MmrWQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF3NEOxOFEoRjJzNUSzNVQyRC:jPh?=
A549	Ml:2SpVv[3Srb36gZZN{[Xl?		NI\nTHo{OCCvaX7z	MmPpTY5pcWKrdHnvckBw\iCDa4SgdIhwe3Cqb4L5cIF1cW:wIHnuJIlve3WuaX6td5RqdXWuYYTl[EBpfW2jbjDBOVQ6KGOnbHzzJJRz\WG2ZXSgNkBpenNiYnXmc5JmKGmwc4XsbY4he3SrbYXsZZRqd25ibXXhd5Vz\WRiYX\0[ZIhOzBibXnud{BjgSCHTFnTRUwhUUN3ME21MlPPxE1?	M3LFXFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{MUO4N\|A6Lz5{MkGzPFMxQTxxYU6=
A549	NHjoXHNEgXSxdH;4bYNqfHliYYPzZZk>		NUTrenpQOjRiaILz	M{jMU2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGE2PDliY3XscJMh[W[2ZYKgNlQhcHK\|IHL5JGZCS1NiYX7hcJl{cXNuIFnDOVA:P87:TR?=	NWPr[4J1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKxN\|g{ODlpPkKyNVM5OzB7PD;hQi=>
KATO III	NGHieGdEgXSxdH;4bYNqfHliYYPzZZk>		M2P3clI1KGi{cx?=	MUPDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDLRXRQKEmLSTDj[YxteyCjZoTldkAzPCCqcoOgZpkhTkGFUzDhcoFtgXOrczygTWM2OD1zMj64{txO	M2jPOVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{MUO4N\|A6Lz5{MkGzPFMxQTxxYU6=
MCF7	Mn;ZR5l1d3SxeHnjbZR6KGG\|c3H5		M17WOlI1KGi{cx?=	MnzhR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWNHPyClZXzsd{Bi\nSncjCyOEBpenNiYomgSmFEWyCjbnHsfZNqeyxiSVO1NF0yOy5\|zszN	NVHtR5dLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKxN\|g{ODlpPkKyNVM5OzB7PD;hQi=>
PC3	NUfTUoM4T3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=			MV;Hdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDQR\|Mh[2WubIOgZpkhW1KEIHHzd4F6NCCJSUWwQVAvPDUQvF2=	Mn32QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN{Nk[xPFEoRjJ\|Mk[2NVgyRC:jPh?=
NUGC3	MXfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?			NV;uT2t5T3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hVlWJQ{OgZ4VtdHNiYomgV3JDKGG\|c3H5MEBIUTVyPUCuOVTPxE1?	MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzJ4NkG4NUc,OjN{Nk[xPFE9N2F-
HCT15	NV;u[5BqT3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=			NXHsdWRxT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hUEOWMUWgZ4VtdHNiYomgV3JDKGG\|c3H5MEBIUTVyPUGuNlXPxE1?	Mnf1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN{Nk[xPFEoRjJ\|Mk[2NVgyRC:jPh?=
MDA-MB-231	NYLuPXRJT3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=			M2fHWGdzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJG1FSS2PQj2yN\|Eh[2WubIOgZpkhW1KEIHHzd4F6NCCJSUWwQVIvQDcQvF2=	Mn31QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN{Nk[xPFEoRjJ\|Mk[2NVgyRC:jPh?=
NCI-H23	NHXyUY5Iem:5dHigbY5pcWKrdHnvckBie3OjeR?=			M2\6[Gdzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KMkOgZ4VtdHNiYomgV3JDKGG\|c3H5MEBIUTVyPUSuNlHPxE1?	NGjKeY09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{K2OlE5OSd-MkOyOlYyQDF:L3G+
ACHN	NEPHS45Iem:5dHigbY5pcWKrdHnvckBie3OjeR?=			MkezS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gRWNJViClZXzsd{BjgSCVUlKgZZN{[XluIFfJOVA:PC53Nt88US=>	NVjJVHNDRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOyOlYyQDFpPkKzNlY3OThzPD;hQi=>
A549	MkC1SpVv[3Srb36gZZN{[Xl?		MljoNkBpenN?	NIGye4xKdmirYnn0bY9vKG:oIFHreEBxcG:\|cHjvdplt[XSrb36gbY4hcHWvYX6gbY5{fWyrbj3zeIlufWyjdHXkJGE2PDliY3XscJMhcW6ldXLheIVlKG[xcjCyJIhzeyCycnnvdkB1dyCrboP1cIlvNWmwZIXjeIlwdiCvZXHzeZJm\CCjZoTldkA{OCCvaX7zJIJ6KEWOSWPBMEBKSzVyPUWuN:69VQ>?	NUTZV25kRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO0NVUxQDNpPkKzOFE2ODh\|PD;hQi=>
A549	MWjDfZRwfG:6aXPpeJkh[XO\|YYm=			NGrvT2lEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCPTR7IHPlcIx{KGK7IH\sc5ch[3m2b33leJJq[yCjbnHsfZNqeyxiSVO1NF04\|ryP	MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzRzNUC4N{c,OjN2MUWwPFM9N2F-
KATO III	MVPDfZRwfG:6aXPpeJkh[XO\|YYm=			MVfDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDLRXRQKEmLSTDj[YxteyCkeTDmcI94KGO7dH;t[ZRzcWNiYX7hcJl{cXNuIFnDOVA:OTJwON88US=>	M1[wR\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|NEG1NFg{Lz5{M{SxOVA5OzxxYU6=
MCF7	Mn7wR5l1d3SxeHnjbZR6KGG\|c3H5			NHPrSpdEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOS0Z5IHPlcIx{KGK7IH\sc5ch[3m2b33leJJq[yCjbnHsfZNqeyxiSVO1NF0yOy5\|zszN	MmTKQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN2MUWwPFMoRjJ\|NEG1NFg{RC:jPh?=
PC3	M1;SWGFvfGmycn;sbYZmemG2aY\lJIF{e2G7			M1\iTGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iUFOzJINmdGy\|IHL5JHNTSiCjc4PhfUwhT0l3ME2wMlQ1\|ryP	MnfCQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN3Nke5OVAoRjJ\|NU[3PVUxRC:jPh?=
NUGC3	MlS4RY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl?			NYP5To5FSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDOWWdEOyClZXzsd{BjgSCVUlKgZZN{[XluIFfJOVA:OC53NN88US=>	MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzV4N{m1NEc,OjN3Nke5OVA9N2F-
HCT15	M3z5RWFvfGmycn;sbYZmemG2aY\lJIF{e2G7			NEHUeIdCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjDWFE2KGOnbHzzJIJ6KFOUQjDhd5NigSxiR1m1NF0yNjJ3zszN	MljTQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN3Nke5OVAoRjJ\|NU[3PVUxRC:jPh?=
MDA-MB-231	M4CwbWFvfGmycn;sbYZmemG2aY\lJIF{e2G7			NFu1T41CdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3ERU1OSi1{M{GgZ4VtdHNiYomgV3JDKGG\|c3H5MEBIUTVyPUKuPFbPxE1?	MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzV4N{m1NEc,OjN3Nke5OVA9N2F-
NCI-H23	NFqyXYZCdnSrcILvcIln\XKjdHn2[UBie3OjeR?=			MW\BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE6FST3INlMh[2WubIOgZpkhW1KEIHHzd4F6NCCJSUWwQVQvOjIQvF2=	M37oSVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|NU[3PVUxLz5{M{W2O\|k2ODxxYU6=
ACHN	MVTBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>?			NH7tb4FCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFHDTG4h[2WubIOgZpkhW1KEIHHzd4F6NCCJSUWwQVQvPTcQvF2=	M4XiU\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ\|NU[3PVUxLz5{M{W2O\|k2ODxxYU6=
PC3	MVzHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?		M4S4dFQ5KGi{cx?=	NEfQdphIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBRSzNiY3XscJMh[W[2ZYKgOFghcHK\|IHL5JHNTSiCjc4PhfUwhT0l3ME2wMlQ1\|ryP	NXzwOGhmRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSwPVU4PTlpPkK0NFk2PzV7PD;hQi=>
NUGC3	NVzUeIRLT3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=		MnfCOFghcHK\|	MV3Hdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDOWWdEOyClZXzsd{Bi\nSncjC0PEBpenNiYomgV3JDKGG\|c3H5MEBIUTVyPUCuOVTPxE1?	M4PSdlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MEm1O\|U6Lz5{NEC5OVc2QTxxYU6=
HCT15	NITFPIZIem:5dHigbY5pcWKrdHnvckBie3OjeR?=		MojzOFghcHK\|	NFHHeFdIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBJS1RzNTDj[YxteyCjZoTldkA1QCCqcoOgZpkhW1KEIHHzd4F6NCCJSUWwQVEvOjYQvF2=	NF:4bZI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEC5OVc2QSd-MkSwPVU4PTl:L3G+
MDA-MB-231	M3uyXGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7		NWqyOmM4PDhiaILz	NXj4d3hQT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hVUSDLV3CMVI{OSClZXzsd{Bi\nSncjC0PEBpenNiYomgV3JDKGG\|c3H5MEBIUTVyPUKuPFbPxE1?	MkHjQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjRyOUW3OVkoRjJ2MEm1O\|U6RC:jPh?=
NCI-H23	MVjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?		NV7WPFVQPDhiaILz	NEn6SXNIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEKzJINmdGy\|IHHmeIVzKDR6IHjyd{BjgSCVUlKgZZN{[XluIFfJOVA:PC5{Md88US=>	M2q4RlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MEm1O\|U6Lz5{NEC5OVc2QTxxYU6=
ACHN	M{T1WWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7		MlrWOFghcHK\|	NXjTR2ZIT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hSUOKTjDj[YxteyCjZoTldkA1QCCqcoOgZpkhW1KEIHHzd4F6NCCJSUWwQVQvPTcQvF2=	NGXNWIM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEC5OVc2QSd-MkSwPVU4PTl:L3G+
A549	MnfFR5l1d3SxeHnjbZR6KGG\|c3H5		MYeyOEB1dyB5MjDodpM>	Mm\4R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRVU1QSClZXzsd{Bi\nSncjCyOEB1dyB5MjDodpMh[nliaHHlcY9kgXSxbXX0dpktKEmFNUC9OE4yP87:TR?=	NHfzUng9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEmwNFYzOCd-MkS5NFA3OjB:L3G+
Rosetta cells	MX7GeY5kfGmxbjDhd5NigQ>?			NHjlWIpKdmirYnn0bY9vKG:oIIfpcIQufHmyZTDoeY1idiCSM{jhcJBp[SCPQWDLJIV5eHKnc4Pl[EBqdiCHc3Po[ZJq[2irYTDjc4xqKFKxc3X0eIEh[2WubIOsJGlEPTB;MT6y{txO	MkjvQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzF{N{SzNVYoRjNzMke0N\|E3RC:jPh?=

Click to View More Cell Line Experimental Data

Assay

Methods	Test Index	PMID

Western blot	p-AKT / AKT / p-S6K1 / S6K1 ; PARP ; p-mTOR / mTOR / Raptor / Rictor / p-p70S6K / p70S6K / p-4EBP1 / 4EBP1 / c-Myc / Cyclin D1 ; p-PDK1 / p-GSK3α/β / p-S6R	25519148 19920197 17761832
Growth inhibition assay	Cell viability	28332584

In vivo

Perifosine combining with temozolomide reduces tumor proliferation (a PDGF-driven gliomagenesis) in vivo. The results indicate that Perifosine is an effective drug in gliomas in which Akt and Ras-Erk 1/2 pathways are frequently activated, and may be new candidate for glima treatment in the clinic. ^[2] Both oral daily and weekly administration of Perifosine significantly reduce human MM tumor growth and increase survival, compared with control animals treated with PBS vehicle only. ^[3] Perifosine induces thrombocytosis and leukocytosis and increases myelopoiesis in murine marrow and spleen, whereas it causes apoptosis in myeloma xenografts. ^[5]

Protocol (from reference)

Kinase Assay:^[3]	Akt kinase assay: MM.1S cells are cultured in the presence or absence of perifosine (5 μM, 6 hours) and then stimulated with IL-6 (20 ng/mL, 10 minutes). In vitro akt kinase assay is then carried out using the Akt Kinase Assay Kit.
Cell Research:^[2]	Cell lines: Human glioma cell lines Concentrations: 0, 15, 30 and 45 μM Incubation Time: 48 hours Method: Cells are incubated in the medium with 10% FCS for 48 hours with indicated concentration of Periosine. Cell viability is determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. (Cell Proliferation Kit I; Roche). The absorbance at 590 nm is recorded using the 96-well plate reader. (Only for Reference)
Animal Research:^[3]	Animal Models: MM.1S MM cells are inoculated subcutaneously in the right flank of Beige-nude-xid (BNX) mice (5 to 6 weeks old). Dosages: 250 mg/kg/wk or 36 mg/kg/d Administration: Oral gavage (Only for Reference)

References

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Solubility (25°C)

In vitro	Water	8 mg/mL (17.32 mM)
	DMSO	Insoluble
	Ethanol	'15 mg/mL
In vivo	Add solvents to the product individually and in order (Data is from Selleck tests instead of citations): water For best results, use promptly after mixing.	8mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight	461.66
Formula	C₂₅H₅₂NO₄P
CAS No.	157716-52-4
Storage	3 years	-20°C	powder
Storage	2 years	-80°C	in solvent
Smiles	CCCCCCCCCCCCCCCCCCOP(=O)([O-])OC1CC[N+](CC1)(C)C

Download Perifosine (KRX-0401) SDF

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Dilution Calculator Molecular Weight Calculator

Clinical Trial Information

NCT Number	Recruitment	Interventions	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT01224730	Completed	Drug: perifosine	Cancer	AEterna Zentaris	January 24 2012	Phase 1
NCT01049841	Completed	Drug: perifosine + temsirolimus	Pediatric Solid Tumors	Memorial Sloan Kettering Cancer Center\|University of Wisconsin Madison\|Duke University\|NATL COMP CA NETWORK\|Pfizer\|AEterna Zentaris	January 2010	Phase 1
NCT01048580	Completed	Drug: Perifosine\|Drug: Capecitabine	Colon Cancer	AEterna Zentaris\|SCRI Development Innovations LLC	October 2009	Phase 1
NCT00776867	Completed	Drug: perifosine	Solid Tumors	Memorial Sloan Kettering Cancer Center\|University of Wisconsin Madison\|Duke University\|AEterna Zentaris	October 2008	Phase 1

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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