Perifosine (KRX-0401)

Catalog No.S1037 Synonyms: NSC639966, D21266

For research use only.

Perifosine (KRX-0401, NSC639966, D21266) is a novel Akt inhibitor with IC50 of 4.7 μM in MM.1S cells, targets pleckstrin homology domain of Akt. Phase 3.

Perifosine (KRX-0401) Chemical Structure

CAS No. 157716-52-4

Selleck's Perifosine (KRX-0401) has been cited by 158 publications

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Biological Activity

Description Perifosine (KRX-0401, NSC639966, D21266) is a novel Akt inhibitor with IC50 of 4.7 μM in MM.1S cells, targets pleckstrin homology domain of Akt. Phase 3.
Targets
Akt [1]
(MM.1S cells)
4.7 μM
In vitro

Perifosine develops anti-proliferative properties with IC50 of 0.6-8.9 μM in immortalized keratinocytes (HaCaT), and head and neck squamous carcinoma cells. [1] Perifosine strongly reduces phosphorylation levels of Akt and extracellular signal-regulated kinase (Erk) 1/2, induces cell cycle arrest in G1 and G2, and causes dose-dependent growth inhibition of mouse glial progenitors. [2] Perifosine (10 μM) completely inhibits the phosphorylation of Akt in MM.1S cells. [3] A recent study demonstrates Perifosine induces cell cycle arrest and apoptosis in human hepatocellular carcinoma cell lines by blockade of Akt phosphorylation. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HL-60 NUL0S2VQSXCxcITvd4l{KEG|c4PhfS=> NG\1eYwyOMLizszN NXXI[Hd[OjRxNEigbC=> MojkbY5lfWOnczDhdI9xfG:|aYOgeIlu\S2mZYDlcoRmdnSueR?= Mn63QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjBzM{C5OlAoRjJyMUOwPVYxRC:jPh?=
MOLM NUnnelRWSXCxcITvd4l{KEG|c4PhfS=> MVKxNOKh|ryP MoK2NlQwPDhiaB?= MYnpcoR2[2W|IHHwc5B1d3OrczD0bY1mNWSncHXu[IVvfGy7 MlXnQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjBzM{C5OlAoRjJyMUOwPVYxRC:jPh?=
OCI MmLyRZBweHSxc3nzJGF{e3OjeR?= MVqxNOKh|ryP NGfaVWEzPC92ODDo M2XhU4lv\HWlZYOgZZBweHSxc3nzJJRqdWVvZHXw[Y5l\W62bIm= MXG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODF|MEm2NEc,OjBzM{C5OlA9N2F-
BJAB MnHHRZBweHSxc3nzJGF{e3OjeR?= MWexNOKh|ryP NX\iRVNMOjRxNEigbC=> NInTUFhqdmS3Y3XzJIFxd3C2b4Ppd{B1cW2nLXTldIVv\GWwdHz5 M3jPXlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyMUOwPVYxLz5{MEGzNFk3ODxxYU6=
MAVER Mof4RZBweHSxc3nzJGF{e3OjeR?= Mn3uNVDDqM7:TR?= M{SwRVI1NzR6IHi= NUnHdXY{cW6mdXPld{BieG:ydH;zbZMhfGmvZT3k[ZBmdmSnboTsfS=> MV:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODF|MEm2NEc,OjBzM{C5OlA9N2F-
SKW6.4 NEe1SohCeG:ydH;zbZMhSXO|c3H5 Ml\ONVDDqM7:TR?= NIjoe|UzPC92ODDo MonrbY5lfWOnczDhdI9xfG:|aYOgeIlu\S2mZYDlcoRmdnSueR?= NWrL[pAyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCxN|A6PjBpPkKwNVMxQTZyPD;hQi=>
HL-60 MlPRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH7ROmIzNTFywrFOwG0> M{nEWVQ5yqCq M2D0cIlvcGmkaYTzJINmdGxiZ4Lve5RpKGmwIHGg[I9{\SCmZYDlcoRmdnRibXHucoVz NVXje2I{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCxN|A6PjBpPkKwNVMxQTZyPD;hQi=>
MOLM NWPpS2FsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUKw[3JJOi1zMNMg{txO NITYcYc1QMLiaB?= NH;0T3FqdmirYnn0d{Bk\WyuIHfyc5d1cCCrbjDhJIRwe2ViZHXw[Y5l\W62IH3hco5meg>? MmjaQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjBzM{C5OlAoRjJyMUOwPVYxRC:jPh?=
OCI MljRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHHsd5gzNTFywrFOwG0> NVKwOYhWPDkEoHi= NYfFW3JlcW6qaXLpeJMh[2WubDDndo94fGhiaX6gZUBld3OnIHTldIVv\GWwdDDtZY5v\XJ? MlPFQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjBzM{C5OlAoRjJyMUOwPVYxRC:jPh?=
BJAB NH:3[pZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV:yMVExyqEQvF2= M4XhTlQ5yqCq M{\GUIlvcGmkaYTzJINmdGxiZ4Lve5RpKGmwIHGg[I9{\SCmZYDlcoRmdnRibXHucoVz MnWzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjBzM{C5OlAoRjJyMUOwPVYxRC:jPh?=
MAVER M3fmd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn;UNk0yOMLizszN NFnIOGI1QMLiaB?= NIPWOXFqdmirYnn0d{Bk\WyuIHfyc5d1cCCrbjDhJIRwe2ViZHXw[Y5l\W62IH3hco5meg>? NIXDWIE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEGzNFk3OCd-MkCxN|A6PjB:L3G+
SKW6.4 NXPvOVF4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmTBNk0yOMLizszN NInoWXc1QMLiaB?= NVTRXlBRcW6qaXLpeJMh[2WubDDndo94fGhiaX6gZUBld3OnIHTldIVv\GWwdDDtZY5v\XJ? NU\LVZE4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCxN|A6PjBpPkKwNVMxQTZyPD;hQi=>
A2780cis  Ml3OS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXTKfmhJOC1{MDFOwG0> Mo\rOFgwPzJiaB?= NYX4cYpMUUN3MNMgQeKhPsLizszt NV[0RXFzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC0NFUzQTZpPkKwOFA2Ojl4PD;hQi=>
A2780 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnHwNE0zOCEQvF2= MkLIOFgwPzJiaB?= NW\TRlZvUUN3MNMgQeKhO8Lizszt MoTEQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB2MEWyPVYoRjJyNEC1Nlk3RC:jPh?=
SKOV3  NXnMXlNGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEK4fWwxNTRyIN88US=> MnnGO|LDqGh? M1S4OGlEPTC-M{Cg{txONCCrbnjpZol1eyClZXzsJIdzd3e2aDDpckBiKGSxc3Wg[IVx\W6mZX70JI1idm6nch?= NXKye3NkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC0NFUzQTZpPkKwOFA2Ojl4PD;hQi=>
PA-1  MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVKwMVQxKM7:TR?= MXW3NuKhcA>? NUTPe5cyUUN3MI6yOUDPxE1uIHnubIljcXS|IHPlcIwh\3Kxd4ToJIlvKGFiZH;z[UBl\XCnbnTlcpQhdWGwbnXy M2e4T|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyNEC1Nlk3Lz5{MESwOVI6PjxxYU6=
OAW-42 NFfxZXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX6wMVQxKM7:TR?= M4jZ[FczyqCq MWnJR|UxhjFyIN88UUwhcW6qaXLpeJMh[2WubDDndo94fGhiaX6gZUBld3OnIHTldIVv\GWwdDDtZY5v\XJ? NVm4fXZ4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC0NFUzQTZpPkKwOFA2Ojl4PD;hQi=>
Bel-7402 MnruRZBweHSxc3nzJGF{e3OjeR?= NHe4XG42NzFyL{KwJO69VQ>? M4PJTVI1NzR6IHi= NUDLbGo4cW6mdXPld{BieG:ydH;zbZMh[XRidHjlJIxwdmdvdHnt[UBmgHCxc4Xy[S=> MUm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODh2MkSyOUc,OjB6NEK0NlU9N2F-
HepG2  NUDVOYVbSXCxcITvd4l{KEG|c4PhfS=> M3myXlUwOTBxMkCg{txO Ml3INlQwPDhiaB?= NELBeldqdmS3Y3XzJIFxd3C2b4Ppd{BifCC2aHWgcI9v\y22aX3lJIV5eG:|dYLl M1\OWFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyOESyOFI2Lz5{MEi0NlQzPTxxYU6=
Bel-7402 M{LYVWZ2dmO2aX;uJGF{e2G7 M2n3WlUwOTBxMkCg{txO MYqyOEBp NEC0UZBz\XO3bITzJIlvKHSqZTDhZ4N2dXWuYYTpc44hd2ZiY3XscEBvfW2kZYKgbY4hfGinIFeyM20heGijc3W= M{mxWlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyOESyOFI2Lz5{MEi0NlQzPTxxYU6=
HepG2  NULnZog1TnWwY4Tpc44hSXO|YYm= M{G0dFUwOTBxMkCg{txO MWGyOEBp MWny[ZN2dHS|IHnuJJRp\SCjY3P1cZVt[XSrb36gc4Yh[2WubDDueY1j\XJiaX6geIhmKEd{L12gdIhie2V? NV\6VJNqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC4OFI1OjVpPkKwPFQzPDJ3PD;hQi=>
Bel-7402 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXXIcmxGPS9zMD:yNE81OCEQvF2= Ml3ONlQwPDhxN{KgbC=> MmSzbY5pcWKrdIOgZ4VtdCCpcn;3eIghcW5iYn;0bEB1cW2nIHHu[EBld3OnIHTldIVv\GWwdDDtZY5v\XJ? MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODh2MkSyOUc,OjB6NEK0NlU9N2F-
HepG2  MlnzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M17lU|UwOTBxMkCvOFAh|ryP MnT4NlQwPDhxN{KgbC=> MoTybY5pcWKrdIOgZ4VtdCCpcn;3eIghcW5iYn;0bEB1cW2nIHHu[EBld3OnIHTldIVv\GWwdDDtZY5v\XJ? NEjNd|I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEi0NlQzPSd-MkC4OFI1OjV:L3G+
CWR22RV1 M1HPT2Z2dmO2aX;uJGF{e2G7 MV[1JO69VQ>? MX[yOEBp Mn3PdoVlfWOnZDDwbI9{eGixconsZZRqd25ib3[gRYt1KHOrZ37p[olk[W62bIm= NF7nNmU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUS5OlI4Oyd-MkG0PVYzPzN:L3G+
CWR22RV1 MkfpRZBweHSxc3nzJGF{e3OjeR?= NFWxR5YyOCEQvF2= MXSyOEBp NGPOOXlmdmijbnPld{Bz[WSrYYTpc44hcW6mdXPl[EBieG:ydH;zbZM> NXz6dXQ{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG0PVYzPzNpPkKxOFk3Ojd|PD;hQi=>
CWR22RV1 MoPLR4VtdCCYaXHibYxqfHliQYPzZZk> M135S|ExKM7:TR?= MYKyOEBp Mn;nbY5kemWjc3XzJJNmdnOrdHn2bZR6KG:oIHj1cYFvKEOZUkKyVnYyKGOnbHzzJJRwKHKjZHnheIlwdg>? NYPLdW9ERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG0PVYzPzNpPkKxOFk3Ojd|PD;hQi=>
A498 NVnTdnh1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVrZVVJqOC1{MDFOwG0> MmLxO|IhcA>? NWO3cpFZcW6qaXLpeJMh[2WubDDndo94fGhiaX6gZUBld3OnIHTldIVv\GWwdDDtZY5v\XJ? M1H1dVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzNkS0NFUxLz5{MU[0OFA2ODxxYU6=
769-P M1jOe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIDXcXkxNTJyIN88US=> NH7Eb2Y4OiCq M{Die4lvcGmkaYTzJINmdGxiZ4Lve5RpKGmwIHGg[I9{\SCmZYDlcoRmdnRibXHucoVz M3zhUlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzNkS0NFUxLz5{MU[0OFA2ODxxYU6=
CAKI-1 NUfvXmxsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2XCelAuOjBizszN M4jD[VczKGh? NF[wbpNqdmirYnn0d{Bk\WyuIHfyc5d1cCCrbjDhJIRwe2ViZHXw[Y5l\W62IH3hco5meg>? MWC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTZ2NEC1NEc,OjF4NESwOVA9N2F-
786-O M4HFZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXuwMVIxKM7:TR?= M2T1U|czKGh? MmHFbY5pcWKrdIOgZ4VtdCCpcn;3eIghcW5iYTDkc5NmKGSncHXu[IVvfCCvYX7u[ZI> MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTZ2NEC1NEc,OjF4NESwOVA9N2F-
786-0 NWCwZZdiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{LSRVAuPDBizszN NEXGZpE4OiCq NXHjbYhpUUN3MI61JO69VQ>? NYfzemVrRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG2OFQxPTBpPkKxOlQ1ODVyPD;hQi=>
769-P NIrvc3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmLQNE01OCEQvF2= Mlr2O|IhcA>? M1zlTGlEPTC-NT2xNEDPxE1? MmnZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF4NESwOVAoRjJzNkS0NFUxRC:jPh?=
CAKI-1 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MknDNE01OCEQvF2= MmnMO|IhcA>? MXrJR|UxhjFyIN88US=> MkXvQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF4NESwOVAoRjJzNkS0NFUxRC:jPh?=
A498 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEXHRXIxNTRyIN88US=> M37mZlczKGh? MVPpcohq[mm2czDj[YxtKGe{b4f0bEBqdiCjIHTvd4Uh\GWyZX7k[Y51KG2jbn7ldi=> NV7Lb4NtRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG2OFQxPTBpPkKxOlQ1ODVyPD;hQi=>
HT-29  M2jVN2N6fG:2b4jpZ4l1gSCDc4PhfS=> M{fjPVUh|ryP NVLkWFBOPDhiaB?= NH3ndIRmdmijbnPld{Bx[WOuaYThfIVtKGmwZIXj[YQhd3[jcnnhckBk[W6lZYKgZ4VtdCCmZXH0bOKh Mnf2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF5N{WwOVQoRjJzN{e1NFU1RC:jPh?=
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SKOV3 MkTlR5l1d3SxeHnjbZR6KEG|c3H5 M1vOb|Uh|ryP M13EOFQ5KGh? M1W0bIVvcGGwY3XzJJBi[2yrdHH4[YwhcW6mdXPl[EBwfmG{aXHuJINidmOncjDj[YxtKGSnYYToxsA> MXu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTd5NUC1OEc,OjF5N{WwOVQ9N2F-
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OCUT1 M3TQRmZ2dmO2aX;uJGF{e2G7 MYmzJO69dQ>? NIWybVkzPCCq M3XQOYNifXOnczDhJIRz[W2jdHnjJIlv[3KnYYPlJIlvKEd{L12gdIhie2V? MXq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjB7MEK3NUc,OjJyOUCyO|E9N2F-
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RMG2 MVfD[YxtKF[rYXLpcIl1gSCDc4PhfS=> NV7vfZNNOS1|MDFOwG0> MUi0PEBp NHe2VIVl\WO{ZXHz[ZMh[2WubDD2bYFjcWyrdImgbY4h[SCmb4PlJIRmeGWwZHXueEBu[W6wZYK= NGL3N|U9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUWxPVE1QCd-MkW1NVkyPDh:L3G+
HAC2 M3zNW2NmdGxiVnnhZoltcXS7IFHzd4F6 MUixMVMxKM7:TR?= NUPvTHpPPzJiaB?= M3zhdoRm[3KnYYPld{Bk\WyuII\pZYJqdGm2eTDpckBiKGSxc3Wg[IVx\W6mZX70JI1idm6nch?= MoniQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV3MUmxOFgoRjJ3NUG5NVQ5RC:jPh?=
KOC7C NIO1bmZE\WyuIG\pZYJqdGm2eTDBd5NigQ>? NYrUSGtnOS1|MDFOwG0> NFrENmY4OiCq M1rFfIRm[3KnYYPld{Bk\WyuII\pZYJqdGm2eTDpckBiKGSxc3Wg[IVx\W6mZX70JI1idm6nch?= M1f4TlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3NUG5NVQ5Lz5{NUWxPVE1QDxxYU6=
RMG2 NFXZTFdE\WyuIG\pZYJqdGm2eTDBd5NigQ>? MkG0NU0{OCEQvF2= M1;ibVczKGh? NEjFNJNl\WO{ZXHz[ZMh[2WubDD2bYFjcWyrdImgbY4h[SCmb4PlJIRmeGWwZHXueEBu[W6wZYK= MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTVzOUG0PEc,OjV3MUmxOFg9N2F-
RMG1 NUC1b2dqS2WubDDWbYFjcWyrdImgRZN{[Xl? NFfocYIyNTNyIN88US=> M2DU[VczKGh? NG\qepNl\WO{ZXHz[ZMh[2WubDD2bYFjcWyrdImgbY4h[SCmb4PlJIRmeGWwZHXueEBu[W6wZYK= MnPaQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV3MUmxOFgoRjJ3NUG5NVQ5RC:jPh?=
H460 MVLGeY5kfGmxbjDBd5NigQ>? MYOzJO69VQ>? MX[4JIg> MUHicI9kc3NibWTPVmMyNCCjbnSgSXJMNU2DUFugZYN1cX[jdHnvckBkd22kaX7l[EB4cXSqIF3FT{0yPjJ? NX3UN5d6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW2PVc5QTlpPkK1Olk4QDl7PD;hQi=>
A549 NWfTZo9{TnWwY4Tpc44hSXO|YYm= M163UFMh|ryP NYrBTWMyQCCq M1nQNoJtd2OtczDtWG9TSzFuIHHu[EBGWktvTVHQT{Bi[3SrdnH0bY9vKGOxbXLpcoVlKHerdHigUWVMNTF4Mh?= MnG3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV4OUe4PVkoRjJ3Nkm3PFk6RC:jPh?=
H460 M1jFbGZ2dmO2aX;uJGF{e2G7 M3HzbFMh|ryP NXLZXopmQCCq NW\sOpFQ[myxY3vzJGFMXCCjY4TpeoF1cW:w NHL2W3c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NU[5O|g6QSd-MkW2PVc5QTl:L3G+
A549 NWDOcJI2TnWwY4Tpc44hSXO|YYm= MWezJO69VQ>? MYi4JIg> NEfBdnBjdG:la4OgRWtVKGGldHn2ZZRqd25? M1TnOVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3Nkm3PFk6Lz5{NU[5O|g6QTxxYU6=
H460 M4PyW2Fxd3C2b4Ppd{BCe3O|YYm= M3rrNlEwOyEQvF2= MWm0PEBp NHHrZ4VqdmS3Y3XzJIFxd3C2b4Ppdy=> M3XjU|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3Nkm3PFk6Lz5{NU[5O|g6QTxxYU6=
A549 NXTtR3ZsSXCxcITvd4l{KEG|c4PhfS=> MXixM|Mh|ryP MorxOFghcA>? M{Hicolv\HWlZYOgZZBweHSxc3nz Ml;wQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV4OUe4PVkoRjJ3Nkm3PFk6RC:jPh?=
H460 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWj4W|llOC5|LUGwJO69VQ>? MnzINlQwPzJiaB?= MYjpcohq[mm2czDj[YxtKGe{b4f0bEBqdiCkb4ToJJRqdWViYX7kJIRwe2ViZHXw[Y5l\W62IH3hco5meg>? MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTZ7N{i5PUc,OjV4OUe4PVk9N2F-
A549 NHfCVGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHPLcYkxNjNvMUCg{txO NULXdJdCOjRxN{KgbC=> MVXpcohq[mm2czDj[YxtKGe{b4f0bEBqdiCkb4ToJJRqdWViYX7kJIRwe2ViZHXw[Y5l\W62IH3hco5meg>? NIPaVJg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NU[5O|g6QSd-MkW2PVc5QTl:L3G+
U-87 MG  M3WzSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXGyNE81OCEQvF2= M1vuV|I1NzR6IHi= NEPKfXVqdmirYnn0d{Bk\WyuIHfyc5d1cCCrbjDic5RpKHSrbXWgZY5lKGSxc3Wg[IVx\W6mZX70JI1idm6nch?= NWq1XZRJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW5N|QzOzJpPkK1PVM1OjN{PD;hQi=>
HepG2 M33sXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2TnPVIxNzRyIN88US=> NVKxUnpiOjRxNEigbC=> NFTRVHFqdmirYnn0d{Bk\WyuIHfyc5d1cCCrbjDic5RpKHSrbXWgZY5lKGSxc3Wg[IVx\W6mZX70JI1idm6nch?= NYfNSnhNRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW5N|QzOzJpPkK1PVM1OjN{PD;hQi=>
U-87 MG  M4mxRmZ2dmO2aX;uJGF{e2G7 MXSyNOKh|ryP MXu2M|I1KGh? MmrDbY5kemWjc3XzJJRp\SCjdYTvdIhi\2mlIH\seZghKGG2IE[gbEB4cGmuZTDpcohq[mm2czD0bIl{KG[udYigZZQhOjSq M3f1OVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3OUO0NlMzLz5{NUmzOFI{OjxxYU6=
HepG2 Mn3aSpVv[3Srb36gRZN{[Xl? M4e4RlIxyqEQvF2= MWO2M|I1KGh? NHfse3pl\WO{ZXHz[ZMhVEN|LVnJJIRm\3KjZHH0bY9vyqCocn;tJFYhcA>? MoPyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV7M{SyN|IoRjJ3OUO0NlMzRC:jPh?=
U-87 MG  MUXGeY5kfGmxbjDBd5NigQ>? MlPhNlDDqM7:TR?= NFTCS5k3NzJ2IHi= MnzQbY5kemWjc3XzJJRp\SCuZY\lcJMhd2ZiTFOzMWlKKGOxdILlZZRm\CC5aYToJGNS NXLWUWNpRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW5N|QzOzJpPkK1PVM1OjN{PD;hQi=>
HepG2 MmizSpVv[3Srb36gRZN{[Xl? MXSyNOKh|ryP MkHYOk8zPCCq NHGyNWhqdmO{ZXHz[ZMhfGinIHzleoVteyCxZjDMR|MuUUliY3;0doVifGWmIIfpeIghS1F? NX;4eIFpRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW5N|QzOzJpPkK1PVM1OjN{PD;hQi=>
U-87 MG  M1HBbGZ2dmO2aX;uJGF{e2G7 MX2yNOKh|ryP M4jIS|I1yqCq M{fYUolv[3KnYYPld{Bld3WkbHWtcYVu[nKjbnWgZo92dmRic4TyeYN1fXKncx?= NE\Sd|Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUmzOFI{Oid-MkW5N|QzOzJ:L3G+
HepG2 NHv5N5pHfW6ldHnvckBCe3OjeR?= MmLlNlDDqM7:TR?= NF;W[VIzPMLiaB?= MXvwdo9lfWOnczDhckBqdnSnboPlJIN6fG:ybHHzcYlkKH[jY4XvcIl7[XSrb36gZ49zemW|cH;u[Ilv\yC2bzDhJI5wfGGkbHWg[Ilt[XSjdHnvckBw\iC2aHWgSXIh[2m|dHXycpM> NUXzN|VDRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW5N|QzOzJpPkK1PVM1OjN{PD;hQi=>
T24 BC  M2K5cmFxd3C2b4Ppd{BCe3O|YYm= MWiyMlUh|ryP NX\jdItKOjRiaB?= NWLDWItye2Wwc3n0bZpmeyCEQzDj[YxteyC2bzDzc5Ji\mWwaXKtbY5lfWOnZDDhdI9xfG:2aXRCpC=> M37nOVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4MEm3PFc{Lz5{NkC5O|g4OzxxYU6=
T24 BC  MU\D[YxtKF[rYXLpcIl1gSCDc4PhfS=> NVzD[plKOC53L{GvNk42KM7:TR?= M2HKNVI1KGh? MoXr[Y5p[W6lZYOgd49z[W[nbnniMYlv\HWlZXSgZ4VtdCC4aXHibYxqfHliZHXjdoVie2V? MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjB7N{i3N{c,OjZyOUe4O|M9N2F-
T24 BC  NF3ydVZHfW6ldHnvckBCe3OjeR?= NV;HRpRSOC53L{GvNk42KM7:TR?= M1rhXVMhcA>? MmLWdoVlfWOnczD0bIUh[mG|YXygR2IhfHm{b4PpcoUheGixc4Doc5J6dGG2aX;uJIxmfmWuczDpckBiKGSxc3Wt[IVx\W6mZX70JI1idm6nch?= M2\T[|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4MEm3PFc{Lz5{NkC5O|g4OzxxYU6=
RBL2H3 Mn\MSpVv[3Srb36gZZN{[Xl? MnXiWI95cWOrdImgbY4hemG2IGLCUFJJOyClZXzsd{whVVSGPUK1{txO NUnZOpE{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCxOVM2PjVpPkKwNVU{PTZ3PD;hQi=>
PC3 MVnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NFfGbnFIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBRSzNiY3XscJMh[nlic4Xs[o9zcG:mYX3pcoUhSiCjc4PhfUwhT0l3ME2wMlQ1|ryP MkDzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF3NEOxOFEoRjJzNUSzNVQyRC:jPh?=
NUGC3 NXXTbFI4T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MU\Hdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDOWWdEOyClZXzsd{BjgSC|dXzmc5Jpd2SjbXnu[UBDKGG|c3H5MEBIUTVyPUCuOVTPxE1? M1jq[|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzNUSzNVQyLz5{MUW0N|E1OTxxYU6=
HCT15 MoH1S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NXLzXJc4T3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hUEOWMUWgZ4VtdHNiYomgd5Vt\m:{aH;kZY1qdmViQjDhd5NigSxiR1m1NF0yNjJ3zszN MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTV2M{G0NUc,OjF3NEOxOFE9N2F-
MDA-MB-231 MXXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MkflS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gUWRCNU2ELUKzNUBk\WyuczDifUB{fWyob4Loc4RidWmwZTDCJIF{e2G7LDDHTVUxRTJwOEdOwG0> NEXwcmM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUW0N|E1OSd-MkG1OFMyPDF:L3G+
NCI-H23 Mn7JS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NFj2eoxIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEKzJINmdGy|IHL5JJN2dG[xcnjv[IFucW6nIFKgZZN{[XluIFfJOVA:PC5{Md88US=> M3nUflxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzNUSzNVQyLz5{MUW0N|E1OTxxYU6=
ACHN MVjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NFO5e2hIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBCS0iQIHPlcIx{KGK7IIP1cIZwemixZHHtbY5mKEJiYYPzZZktKEeLNUC9OE42Ps7:TR?= MmrWQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF3NEOxOFEoRjJzNUSzNVQyRC:jPh?=
A549 Ml:2SpVv[3Srb36gZZN{[Xl? NI\nTHo{OCCvaX7z MmPpTY5pcWKrdHnvckBw\iCDa4SgdIhwe3Cqb4L5cIF1cW:wIHnuJIlve3WuaX6td5RqdXWuYYTl[EBpfW2jbjDBOVQ6KGOnbHzzJJRz\WG2ZXSgNkBpenNiYnXmc5JmKGmwc4XsbY4he3SrbYXsZZRqd25ibXXhd5Vz\WRiYX\0[ZIhOzBibXnud{BjgSCHTFnTRUwhUUN3ME21MlPPxE1? M3LFXFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{MUO4N|A6Lz5{MkGzPFMxQTxxYU6=
A549 NHjoXHNEgXSxdH;4bYNqfHliYYPzZZk> NUTrenpQOjRiaILz M{jMU2N6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGE2PDliY3XscJMh[W[2ZYKgNlQhcHK|IHL5JGZCS1NiYX7hcJl{cXNuIFnDOVA:P87:TR?= NWPr[4J1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKxN|g{ODlpPkKyNVM5OzB7PD;hQi=>
KATO III NGHieGdEgXSxdH;4bYNqfHliYYPzZZk> M2P3clI1KGi{cx?= MUPDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDLRXRQKEmLSTDj[YxteyCjZoTldkAzPCCqcoOgZpkhTkGFUzDhcoFtgXOrczygTWM2OD1zMj64{txO M2jPOVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{MUO4N|A6Lz5{MkGzPFMxQTxxYU6=
MCF7 Mn;ZR5l1d3SxeHnjbZR6KGG|c3H5 M17WOlI1KGi{cx?= MnzhR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWNHPyClZXzsd{Bi\nSncjCyOEBpenNiYomgSmFEWyCjbnHsfZNqeyxiSVO1NF0yOy5|zszN NVHtR5dLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKxN|g{ODlpPkKyNVM5OzB7PD;hQi=>
PC3 NUfTUoM4T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MV;Hdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDQR|Mh[2WubIOgZpkhW1KEIHHzd4F6NCCJSUWwQVAvPDUQvF2= Mn32QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN{Nk[xPFEoRjJ|Mk[2NVgyRC:jPh?=
NUGC3 MXfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NV;uT2t5T3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hVlWJQ{OgZ4VtdHNiYomgV3JDKGG|c3H5MEBIUTVyPUCuOVTPxE1? MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzJ4NkG4NUc,OjN{Nk[xPFE9N2F-
HCT15 NV;u[5BqT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NXHsdWRxT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hUEOWMUWgZ4VtdHNiYomgV3JDKGG|c3H5MEBIUTVyPUGuNlXPxE1? Mnf1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN{Nk[xPFEoRjJ|Mk[2NVgyRC:jPh?=
MDA-MB-231 NYLuPXRJT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M2fHWGdzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJG1FSS2PQj2yN|Eh[2WubIOgZpkhW1KEIHHzd4F6NCCJSUWwQVIvQDcQvF2= Mn31QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN{Nk[xPFEoRjJ|Mk[2NVgyRC:jPh?=
NCI-H23 NHXyUY5Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= M2\6[Gdzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KMkOgZ4VtdHNiYomgV3JDKGG|c3H5MEBIUTVyPUSuNlHPxE1? NGjKeY09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{K2OlE5OSd-MkOyOlYyQDF:L3G+
ACHN NEPHS45Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= MkezS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gRWNJViClZXzsd{BjgSCVUlKgZZN{[XluIFfJOVA:PC53Nt88US=> NVjJVHNDRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOyOlYyQDFpPkKzNlY3OThzPD;hQi=>
A549 MkC1SpVv[3Srb36gZZN{[Xl? MljoNkBpenN? NIGye4xKdmirYnn0bY9vKG:oIFHreEBxcG:|cHjvdplt[XSrb36gbY4hcHWvYX6gbY5{fWyrbj3zeIlufWyjdHXkJGE2PDliY3XscJMhcW6ldXLheIVlKG[xcjCyJIhzeyCycnnvdkB1dyCrboP1cIlvNWmwZIXjeIlwdiCvZXHzeZJm\CCjZoTldkA{OCCvaX7zJIJ6KEWOSWPBMEBKSzVyPUWuN:69VQ>? NUTZV25kRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO0NVUxQDNpPkKzOFE2ODh|PD;hQi=>
A549 MWjDfZRwfG:6aXPpeJkh[XO|YYm= NGrvT2lEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCPTR7IHPlcIx{KGK7IH\sc5ch[3m2b33leJJq[yCjbnHsfZNqeyxiSVO1NF04|ryP MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzRzNUC4N{c,OjN2MUWwPFM9N2F-
KATO III MVPDfZRwfG:6aXPpeJkh[XO|YYm= MVfDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDLRXRQKEmLSTDj[YxteyCkeTDmcI94KGO7dH;t[ZRzcWNiYX7hcJl{cXNuIFnDOVA:OTJwON88US=> M1[wR|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|NEG1NFg{Lz5{M{SxOVA5OzxxYU6=
MCF7 Mn7wR5l1d3SxeHnjbZR6KGG|c3H5 NHPrSpdEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOS0Z5IHPlcIx{KGK7IH\sc5ch[3m2b33leJJq[yCjbnHsfZNqeyxiSVO1NF0yOy5|zszN MmTKQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN2MUWwPFMoRjJ|NEG1NFg{RC:jPh?=
PC3 M1;SWGFvfGmycn;sbYZmemG2aY\lJIF{e2G7 M1\iTGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iUFOzJINmdGy|IHL5JHNTSiCjc4PhfUwhT0l3ME2wMlQ1|ryP MnfCQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN3Nke5OVAoRjJ|NU[3PVUxRC:jPh?=
NUGC3 MlS4RY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? NYP5To5FSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDOWWdEOyClZXzsd{BjgSCVUlKgZZN{[XluIFfJOVA:OC53NN88US=> MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzV4N{m1NEc,OjN3Nke5OVA9N2F-
HCT15 M3z5RWFvfGmycn;sbYZmemG2aY\lJIF{e2G7 NEHUeIdCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjDWFE2KGOnbHzzJIJ6KFOUQjDhd5NigSxiR1m1NF0yNjJ3zszN MljTQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN3Nke5OVAoRjJ|NU[3PVUxRC:jPh?=
MDA-MB-231 M4CwbWFvfGmycn;sbYZmemG2aY\lJIF{e2G7 NFu1T41CdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3ERU1OSi1{M{GgZ4VtdHNiYomgV3JDKGG|c3H5MEBIUTVyPUKuPFbPxE1? MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzV4N{m1NEc,OjN3Nke5OVA9N2F-
NCI-H23 NFqyXYZCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MW\BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE6FST3INlMh[2WubIOgZpkhW1KEIHHzd4F6NCCJSUWwQVQvOjIQvF2= M37oSVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|NU[3PVUxLz5{M{W2O|k2ODxxYU6=
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PC3 MVzHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M4S4dFQ5KGi{cx?= NEfQdphIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBRSzNiY3XscJMh[W[2ZYKgOFghcHK|IHL5JHNTSiCjc4PhfUwhT0l3ME2wMlQ1|ryP NXzwOGhmRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSwPVU4PTlpPkK0NFk2PzV7PD;hQi=>
NUGC3 NVzUeIRLT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MnfCOFghcHK| MV3Hdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDOWWdEOyClZXzsd{Bi\nSncjC0PEBpenNiYomgV3JDKGG|c3H5MEBIUTVyPUCuOVTPxE1? M4PSdlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MEm1O|U6Lz5{NEC5OVc2QTxxYU6=
HCT15 NITFPIZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MojzOFghcHK| NFHHeFdIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBJS1RzNTDj[YxteyCjZoTldkA1QCCqcoOgZpkhW1KEIHHzd4F6NCCJSUWwQVEvOjYQvF2= NF:4bZI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEC5OVc2QSd-MkSwPVU4PTl:L3G+
MDA-MB-231 M3uyXGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NWqyOmM4PDhiaILz NXj4d3hQT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hVUSDLV3CMVI{OSClZXzsd{Bi\nSncjC0PEBpenNiYomgV3JDKGG|c3H5MEBIUTVyPUKuPFbPxE1? MkHjQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjRyOUW3OVkoRjJ2MEm1O|U6RC:jPh?=
NCI-H23 MVjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NV7WPFVQPDhiaILz NEn6SXNIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEKzJINmdGy|IHHmeIVzKDR6IHjyd{BjgSCVUlKgZZN{[XluIFfJOVA:PC5{Md88US=> M2q4RlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MEm1O|U6Lz5{NEC5OVc2QTxxYU6=
ACHN M{T1WWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MlrWOFghcHK| NXjTR2ZIT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hSUOKTjDj[YxteyCjZoTldkA1QCCqcoOgZpkhW1KEIHHzd4F6NCCJSUWwQVQvPTcQvF2= NGXNWIM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEC5OVc2QSd-MkSwPVU4PTl:L3G+
A549 MnfFR5l1d3SxeHnjbZR6KGG|c3H5 MYeyOEB1dyB5MjDodpM> Mm\4R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gRVU1QSClZXzsd{Bi\nSncjCyOEB1dyB5MjDodpMh[nliaHHlcY9kgXSxbXX0dpktKEmFNUC9OE4yP87:TR?= NHfzUng9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEmwNFYzOCd-MkS5NFA3OjB:L3G+
Rosetta cells MX7GeY5kfGmxbjDhd5NigQ>? NHjlWIpKdmirYnn0bY9vKG:oIIfpcIQufHmyZTDoeY1idiCSM{jhcJBp[SCPQWDLJIV5eHKnc4Pl[EBqdiCHc3Po[ZJq[2irYTDjc4xqKFKxc3X0eIEh[2WubIOsJGlEPTB;MT6y{txO MkjvQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzF{N{SzNVYoRjNzMke0N|E3RC:jPh?=
Assay
Methods Test Index PMID
Western blot p-AKT / AKT / p-S6K1 / S6K1 ; PARP ; p-mTOR / mTOR / Raptor / Rictor / p-p70S6K / p70S6K / p-4EBP1 / 4EBP1 / c-Myc / Cyclin D1 ; p-PDK1 / p-GSK3α/β / p-S6R 25519148 19920197 17761832
Growth inhibition assay Cell viability 28332584
In vivo Perifosine combining with temozolomide reduces tumor proliferation (a PDGF-driven gliomagenesis) in vivo. The results indicate that Perifosine is an effective drug in gliomas in which Akt and Ras-Erk 1/2 pathways are frequently activated, and may be new candidate for glima treatment in the clinic. [2] Both oral daily and weekly administration of Perifosine significantly reduce human MM tumor growth and increase survival, compared with control animals treated with PBS vehicle only. [3] Perifosine induces thrombocytosis and leukocytosis and increases myelopoiesis in murine marrow and spleen, whereas it causes apoptosis in myeloma xenografts. [5]

Protocol (from reference)

Kinase Assay:[3]
  • Akt kinase assay:

    MM.1S cells are cultured in the presence or absence of perifosine (5 μM, 6 hours) and then stimulated with IL-6 (20 ng/mL, 10 minutes). In vitro akt kinase assay is then carried out using the Akt Kinase Assay Kit.

Cell Research:[2]
  • Cell lines: Human glioma cell lines
  • Concentrations: 0, 15, 30 and 45 μM
  • Incubation Time: 48 hours
  • Method: Cells are incubated in the medium with 10% FCS for 48 hours with indicated concentration of Periosine. Cell viability is determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. (Cell Proliferation Kit I; Roche). The absorbance at 590 nm is recorded using the 96-well plate reader.
  • (Only for Reference)
Animal Research:[3]
  • Animal Models: MM.1S MM cells are inoculated subcutaneously in the right flank of Beige-nude-xid (BNX) mice (5 to 6 weeks old).
  • Dosages: 250 mg/kg/wk or 36 mg/kg/d
  • Administration: Oral gavage
  • (Only for Reference)

Solubility (25°C)

In vitro

Water 8 mg/mL
(17.32 mM)
DMSO Insoluble
Ethanol '15 mg/mL

In vivo

Add solvents to the product individually and in order
(Data is from Selleck tests instead of citations):
water
For best results, use promptly after mixing.

8mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 461.66
Formula

C25H52NO4P

CAS No. 157716-52-4
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CCCCCCCCCCCCCCCCCCOP(=O)([O-])OC1CC[N+](CC1)(C)C

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT01224730 Completed Drug: perifosine Cancer AEterna Zentaris January 24 2012 Phase 1
NCT01049841 Completed Drug: perifosine + temsirolimus Pediatric Solid Tumors Memorial Sloan Kettering Cancer Center|University of Wisconsin Madison|Duke University|NATL COMP CA NETWORK|Pfizer|AEterna Zentaris January 2010 Phase 1
NCT01048580 Completed Drug: Perifosine|Drug: Capecitabine Colon Cancer AEterna Zentaris|SCRI Development Innovations LLC October 2009 Phase 1
NCT00776867 Completed Drug: perifosine Solid Tumors Memorial Sloan Kettering Cancer Center|University of Wisconsin Madison|Duke University|AEterna Zentaris October 2008 Phase 1

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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