Perifosine (KRX-0401)

For research use only.

Catalog No.S1037 Synonyms: NSC639966, D21266

150 publications

Perifosine (KRX-0401) Chemical Structure

CAS No. 157716-52-4

Perifosine (KRX-0401, NSC639966, D21266) is a novel Akt inhibitor with IC50 of 4.7 μM in MM.1S cells, targets pleckstrin homology domain of Akt. Phase 3.

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Selleck's Perifosine (KRX-0401) has been cited by 150 publications

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Biological Activity

Description Perifosine (KRX-0401, NSC639966, D21266) is a novel Akt inhibitor with IC50 of 4.7 μM in MM.1S cells, targets pleckstrin homology domain of Akt. Phase 3.
Targets
Akt [1]
(MM.1S cells)
4.7 μM
In vitro

Perifosine develops anti-proliferative properties with IC50 of 0.6-8.9 μM in immortalized keratinocytes (HaCaT), and head and neck squamous carcinoma cells. [1] Perifosine strongly reduces phosphorylation levels of Akt and extracellular signal-regulated kinase (Erk) 1/2, induces cell cycle arrest in G1 and G2, and causes dose-dependent growth inhibition of mouse glial progenitors. [2] Perifosine (10 μM) completely inhibits the phosphorylation of Akt in MM.1S cells. [3] A recent study demonstrates Perifosine induces cell cycle arrest and apoptosis in human hepatocellular carcinoma cell lines by blockade of Akt phosphorylation. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HL-60 MlvnRZBweHSxc3nzJGF{e3OjeR?= MkDrNVDDqM7:TR?= NVHSdlk1OjRxNEigbC=> NGjuNpRqdmS3Y3XzJIFxd3C2b4Ppd{B1cW2nLXTldIVv\GWwdHz5 M{\vd|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyMUOwPVYxLz5{MEGzNFk3ODxxYU6=
MOLM NFXj[GJCeG:ydH;zbZMhSXO|c3H5 M3na[VExyqEQvF2= MV2yOE81QCCq NF\iT|VqdmS3Y3XzJIFxd3C2b4Ppd{B1cW2nLXTldIVv\GWwdHz5 MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODF|MEm2NEc,OjBzM{C5OlA9N2F-
OCI MVzBdI9xfG:|aYOgRZN{e2G7 M{TDdFExyqEQvF2= NXvLNVN3OjRxNEigbC=> NF;xR4tqdmS3Y3XzJIFxd3C2b4Ppd{B1cW2nLXTldIVv\GWwdHz5 MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODF|MEm2NEc,OjBzM{C5OlA9N2F-
BJAB MlzJRZBweHSxc3nzJGF{e3OjeR?= MVWxNOKh|ryP NFvHN5AzPC92ODDo MkjQbY5lfWOnczDhdI9xfG:|aYOgeIlu\S2mZYDlcoRmdnSueR?= NES2[FM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEGzNFk3OCd-MkCxN|A6PjB:L3G+
MAVER MYfBdI9xfG:|aYOgRZN{e2G7 MXGxNOKh|ryP MVKyOE81QCCq NGXPVHJqdmS3Y3XzJIFxd3C2b4Ppd{B1cW2nLXTldIVv\GWwdHz5 MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODF|MEm2NEc,OjBzM{C5OlA9N2F-
SKW6.4 MXvBdI9xfG:|aYOgRZN{e2G7 NIjrWVcyOMLizszN NVrTR3B5OjRxNEigbC=> NGDWUVNqdmS3Y3XzJIFxd3C2b4Ppd{B1cW2nLXTldIVv\GWwdHz5 NIHhfWM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEGzNFk3OCd-MkCxN|A6PjB:L3G+
HL-60 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEnFcWkzNTFywrFOwG0> NV7Cd4EzPDkEoHi= NV;YO3gycW6qaXLpeJMh[2WubDDndo94fGhiaX6gZUBld3OnIHTldIVv\GWwdDDtZY5v\XJ? NXjsVXBiRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCxN|A6PjBpPkKwNVMxQTZyPD;hQi=>
MOLM NImyZVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHPOcIYzNTFywrFOwG0> M3zxeVQ5yqCq NWDGUZdjcW6qaXLpeJMh[2WubDDndo94fGhiaX6gZUBld3OnIHTldIVv\GWwdDDtZY5v\XJ? M1HTb|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyMUOwPVYxLz5{MEGzNFk3ODxxYU6=
OCI MkXvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVGyMVExyqEQvF2= MVm0POKhcA>? NFPCS|dqdmirYnn0d{Bk\WyuIHfyc5d1cCCrbjDhJIRwe2ViZHXw[Y5l\W62IH3hco5meg>? NGDJfJo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEGzNFk3OCd-MkCxN|A6PjB:L3G+
BJAB NITrXZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1P2bVIuOTEEoN88US=> NGXmSGM1QMLiaB?= NEfEcGxqdmirYnn0d{Bk\WyuIHfyc5d1cCCrbjDhJIRwe2ViZHXw[Y5l\W62IH3hco5meg>? NFzYNYQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEGzNFk3OCd-MkCxN|A6PjB:L3G+
MAVER M4XFUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXO2SW5GOi1zMNMg{txO MknPOFjDqGh? MlPrbY5pcWKrdIOgZ4VtdCCpcn;3eIghcW5iYTDkc5NmKGSncHXu[IVvfCCvYX7u[ZI> MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODF|MEm2NEc,OjBzM{C5OlA9N2F-
SKW6.4 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3PGOlIuOTEEoN88US=> Ml[1OFjDqGh? NFTMWm5qdmirYnn0d{Bk\WyuIHfyc5d1cCCrbjDhJIRwe2ViZHXw[Y5l\W62IH3hco5meg>? MmfaQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjBzM{C5OlAoRjJyMUOwPVYxRC:jPh?=
A2780cis  MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnXZNE0zOCEQvF2= Mn;nOFgwPzJiaB?= NF3sWlNKSzVywrC9xsA3yqEQvH2= NG\XRpc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MESwOVI6Pid-MkC0NFUzQTZ:L3G+
A2780 MlvVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFq2RXgxNTJyIN88US=> NFTvVVE1QC95MjDo MnztTWM2OMLiPdMgN:Kh|ryv NH3mWWQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MESwOVI6Pid-MkC0NFUzQTZ:L3G+
SKOV3  NYrac3FxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3\VOlAuPDBizszN MXu3NuKhcA>? M1zrWmlEPTC-M{Cg{txONCCrbnjpZol1eyClZXzsJIdzd3e2aDDpckBiKGSxc3Wg[IVx\W6mZX70JI1idm6nch?= Mo\sQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB2MEWyPVYoRjJyNEC1Nlk3RC:jPh?=
PA-1  NGXBPINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mm\TNE01OCEQvF2= MmrOO|LDqGh? MW\JR|UxhjJ3IN88UUwhcW6qaXLpeJMh[2WubDDndo94fGhiaX6gZUBld3OnIHTldIVv\GWwdDDtZY5v\XJ? NFn3bZM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MESwOVI6Pid-MkC0NFUzQTZ:L3G+
OAW-42 M3nLU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MojBNE01OCEQvF2= M2jBd|czyqCq Mo\lTWM2OH5zMDFOwG0tKGmwaHnibZR{KGOnbHyg[5Jwf3SqIHnuJIEh\G:|ZTDk[ZBmdmSnboSgcYFvdmW{ MnvZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB2MEWyPVYoRjJyNEC1Nlk3RC:jPh?=
Bel-7402 NUHUSHFHSXCxcITvd4l{KEG|c4PhfS=> MmXkOU8yOC9{MDFOwG0> NYLrSoh6OjRxNEigbC=> M2jFOYlv\HWlZYOgZZBweHSxc3nzJIF1KHSqZTDsc45oNXSrbXWg[Zhxd3O3cnW= M4rZOFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyOESyOFI2Lz5{MEi0NlQzPTxxYU6=
HepG2  M1;scGFxd3C2b4Ppd{BCe3O|YYm= MWK1M|ExNzJyIN88US=> MWGyOE81QCCq MmX5bY5lfWOnczDhdI9xfG:|aYOgZZQhfGinIHzvcocufGmvZTDlfJBwe3W{ZR?= NF[4ZVc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEi0NlQzPSd-MkC4OFI1OjV:L3G+
Bel-7402 MkDUSpVv[3Srb36gRZN{[Xl? NUHvbGhQPS9zMD:yNEDPxE1? MYeyOEBp NY\LeZpGemW|dXz0d{BqdiC2aHWgZYNkfW23bHH0bY9vKG:oIHPlcIwhdnWvYnXyJIlvKHSqZTDHNk9OKHCqYYPl NWnnOXFVRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC4OFI1OjVpPkKwPFQzPDJ3PD;hQi=>
HepG2  MmLJSpVv[3Srb36gRZN{[Xl? NEHUbpo2NzFyL{KwJO69VQ>? MYeyOEBp MV;y[ZN2dHS|IHnuJJRp\SCjY3P1cZVt[XSrb36gc4Yh[2WubDDueY1j\XJiaX6geIhmKEd{L12gdIhie2V? MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODh2MkSyOUc,OjB6NEK0NlU9N2F-
Bel-7402 MnHUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWPJTll6PS9zMD:yNE81OCEQvF2= M3LqdlI1NzR6L{eyJIg> MWDpcohq[mm2czDj[YxtKGe{b4f0bEBqdiCkb4ToJJRqdWViYX7kJIRwe2ViZHXw[Y5l\W62IH3hco5meg>? MnPqQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB6NEK0NlUoRjJyOESyOFI2RC:jPh?=
HepG2  NHfqXXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXPnOZVqPS9zMD:yNE81OCEQvF2= Ml3XNlQwPDhxN{KgbC=> NXPQU21kcW6qaXLpeJMh[2WubDDndo94fGhiaX6gZo91cCC2aX3lJIFv\CCmb4PlJIRmeGWwZHXueEBu[W6wZYK= NUmxS3pqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC4OFI1OjVpPkKwPFQzPDJ3PD;hQi=>
CWR22RV1 NYTDU|NtTnWwY4Tpc44hSXO|YYm= NI[zTHU2KM7:TR?= NETv[4QzPCCq NIDkVYdz\WS3Y3XkJJBpd3OyaH;yfYxifGmxbjDv[kBCc3Ric3nncolncWOjboTsfS=> NEfYflA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUS5OlI4Oyd-MkG0PVYzPzN:L3G+
CWR22RV1 MWPBdI9xfG:|aYOgRZN{e2G7 MkXnNVAh|ryP M13H[FI1KGh? NX7QOI9t\W6qYX7j[ZMhemGmaXH0bY9vKGmwZIXj[YQh[XCxcITvd4l{ NWLFclFnRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG0PVYzPzNpPkKxOFk3Ojd|PD;hQi=>
CWR22RV1 NFW4fmVE\WyuIG\pZYJqdGm2eTDBd5NigQ>? MkX6NVAh|ryP MlfPNlQhcA>? NUezd4d2cW6lcnXhd4V{KHOnboPpeIl3cXS7IH;mJIh2dWGwIFPXVlIzWlZzIHPlcIx{KHSxIILh[IlifGmxbh?= MkLyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF2OU[yO|MoRjJzNEm2Nlc{RC:jPh?=
A498 M{LLfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWKwMVIxKM7:TR?= MnHpO|IhcA>? NGLFVGNqdmirYnn0d{Bk\WyuIHfyc5d1cCCrbjDhJIRwe2ViZHXw[Y5l\W62IH3hco5meg>? NHLzRnQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MU[0OFA2OCd-MkG2OFQxPTB:L3G+
769-P NV;ZXppwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnT2NE0zOCEQvF2= M4PMTlczKGh? M1\VTYlvcGmkaYTzJINmdGxiZ4Lve5RpKGmwIHGg[I9{\SCmZYDlcoRmdnRibXHucoVz NV[5cId3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG2OFQxPTBpPkKxOlQ1ODVyPD;hQi=>
CAKI-1 M{W2UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWXHUFQ3OC1{MDFOwG0> NH31SlE4OiCq NH\RZpVqdmirYnn0d{Bk\WyuIHfyc5d1cCCrbjDhJIRwe2ViZHXw[Y5l\W62IH3hco5meg>? MlHzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF4NESwOVAoRjJzNkS0NFUxRC:jPh?=
786-O MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2LkelAuOjBizszN NVPNeIdvPzJiaB?= MVjpcohq[mm2czDj[YxtKGe{b4f0bEBqdiCjIHTvd4Uh\GWyZX7k[Y51KG2jbn7ldi=> NEnLUJk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MU[0OFA2OCd-MkG2OFQxPTB:L3G+
786-0 M{j6Vmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUTDdZpnOC12MDFOwG0> MmjnO|IhcA>? MYfJR|UxhjVizszN NUnXN5ZFRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG2OFQxPTBpPkKxOlQ1ODVyPD;hQi=>
769-P NFjNN2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWewMVQxKM7:TR?= NHzYZWU4OiCq NILaeXNKSzVyfkWtNVAh|ryP MmfsQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF4NESwOVAoRjJzNkS0NFUxRC:jPh?=
CAKI-1 NGjuW3dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M17RdFAuPDBizszN NG[xSWg4OiCq MnrwTWM2OH5zMDFOwG0> MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTZ2NEC1NEc,OjF4NESwOVA9N2F-
A498 MnfCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX3BcY9ROC12MDFOwG0> MkPIO|IhcA>? M1\Dc4lvcGmkaYTzJINmdGxiZ4Lve5RpKGmwIHGg[I9{\SCmZYDlcoRmdnRibXHucoVz NECwco89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MU[0OFA2OCd-MkG2OFQxPTB:L3G+
HT-29  M1fsUWN6fG:2b4jpZ4l1gSCDc4PhfS=> NH74TWU2KM7:TR?= MYq0PEBp MX\lcohidmOnczDwZYNtcXSjeHXsJIlv\HWlZXSgc5ZiemmjbjDjZY5k\XJiY3XscEBl\WG2aNMg NHjVSm09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUe3OVA2PCd-MkG3O|UxPTR:L3G+
A2780 NWHCVpVNS3m2b4TvfIlkcXS7IFHzd4F6 MYO1JO69VQ>? NVjIeYpPPDhiaB?= NH7xT|hmdmijbnPld{Bx[WOuaYThfIVtKGmwZIXj[YQhd3[jcnnhckBk[W6lZYKgZ4VtdCCmZXH0bOKh M1vodFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzN{e1NFU1Lz5{MUe3OVA2PDxxYU6=
SKOV3 NYrVclJxS3m2b4TvfIlkcXS7IFHzd4F6 MmP6OUDPxE1? M3S5WlQ5KGh? MWnlcohidmOnczDwZYNtcXSjeHXsJIlv\HWlZXSgc5ZiemmjbjDjZY5k\XJiY3XscEBl\WG2aNMg NFfKUGI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUe3OVA2PCd-MkG3O|UxPTR:L3G+
CaOV3 NH7JOG5E\WyuIG\pZYJqdGm2eTDBd5NigQ>? NVjnV3FJOS93L{GwJO69VQ>? MUi0PEBp M2KyOYRm[3KnYYPld{Bk\WyuII\pZYJqdGm2eTDpckBiKGSxc3Wg[IVx\W6mZX70JI1idm6ncjDjc5Rz\WG2ZXSge4l1cCCyYXPsbZRigGWu MoX3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF5N{WwOVQoRjJzN{e1NFU1RC:jPh?=
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OVISE M2LWS2NmdGxiVnnhZoltcXS7IFHzd4F6 MkTDNU0{OCEQvF2= NF3VfpU1QCCq M{[1UYRm[3KnYYPld{Bk\WyuII\pZYJqdGm2eTDpckBiKGSxc3Wg[IVx\W6mZX70JI1idm6nch?= MVW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTVzOUG0PEc,OjV3MUmxOFg9N2F-
RMG2 M135RmNmdGxiVnnhZoltcXS7IFHzd4F6 M3y3T|EuOzBizszN NYLKOHhGPDhiaB?= NV7PWZZw\GWlcnXhd4V{KGOnbHygeoli[mmuaYT5JIlvKGFiZH;z[UBl\XCnbnTlcpQhdWGwbnXy NGLPflc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUWxPVE1QCd-MkW1NVkyPDh:L3G+
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KOC7C NFfITpZE\WyuIG\pZYJqdGm2eTDBd5NigQ>? MWKxMVMxKM7:TR?= NHixSlc4OiCq M2L5NIRm[3KnYYPld{Bk\WyuII\pZYJqdGm2eTDpckBiKGSxc3Wg[IVx\W6mZX70JI1idm6nch?= M3rSVlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3NUG5NVQ5Lz5{NUWxPVE1QDxxYU6=
RMG2 Mne4R4VtdCCYaXHibYxqfHliQYPzZZk> MnO3NU0{OCEQvF2= MV[3NkBp NV\u[GxV\GWlcnXhd4V{KGOnbHygeoli[mmuaYT5JIlvKGFiZH;z[UBl\XCnbnTlcpQhdWGwbnXy MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTVzOUG0PEc,OjV3MUmxOFg9N2F-
RMG1 MV\D[YxtKF[rYXLpcIl1gSCDc4PhfS=> M1HRWlEuOzBizszN MkXNO|IhcA>? MlXz[IVkemWjc3XzJINmdGxidnnhZoltcXS7IHnuJIEh\G:|ZTDk[ZBmdmSnboSgcYFvdmW{ NX\mZ5Q2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW1NVkyPDhpPkK1OVE6OTR6PD;hQi=>
H460 M{LlNWZ2dmO2aX;uJGF{e2G7 NXvRRYVXOyEQvF2= MXe4JIg> NUXyOXl3[myxY3vzJI1VV1KFMTygZY5lKEWUSz3NRXBMKGGldHn2ZZRqd25iY3;tZolv\WRid3n0bEBOTUtvMU[y NXfZXXJIRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW2PVc5QTlpPkK1Olk4QDl7PD;hQi=>
A549 MYXGeY5kfGmxbjDBd5NigQ>? NWTjXWhbOyEQvF2= MkDTPEBp Ml70Zoxw[2u|IH3UU3JEOSxiYX7kJGVTUy2PQWDLJIFkfGm4YYTpc44h[2:vYnnu[YQhf2m2aDDNSWsuOTZ{ Mmm4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV4OUe4PVkoRjJ3Nkm3PFk6RC:jPh?=
H460 NXPjTZJlTnWwY4Tpc44hSXO|YYm= MkexN{DPxE1? NEXtdmI5KGh? NUnzbHNI[myxY3vzJGFMXCCjY4TpeoF1cW:w M2nVOVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3Nkm3PFk6Lz5{NU[5O|g6QTxxYU6=
A549 MnfFSpVv[3Srb36gRZN{[Xl? MlfsN{DPxE1? NWX2R3BkQCCq NYXaUnp2[myxY3vzJGFMXCCjY4TpeoF1cW:w MkDpQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV4OUe4PVkoRjJ3Nkm3PFk6RC:jPh?=
H460 NHTiS2JCeG:ydH;zbZMhSXO|c3H5 MlHvNU8{KM7:TR?= NH\Qcpg1QCCq MWHpcoR2[2W|IHHwc5B1d3Orcx?= M2D3bFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3Nkm3PFk6Lz5{NU[5O|g6QTxxYU6=
A549 M4L0cWFxd3C2b4Ppd{BCe3O|YYm= NX2weI9kOS9|IN88US=> NXjPcoFQPDhiaB?= MoDJbY5lfWOnczDhdI9xfG:|aYO= NU[yfnNsRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW2PVc5QTlpPkK1Olk4QDl7PD;hQi=>
H460 M2nV[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml:yNE4{NTFyIN88US=> NV\PRphCOjRxN{KgbC=> MkPabY5pcWKrdIOgZ4VtdCCpcn;3eIghcW5iYn;0bEB1cW2nIHHu[EBld3OnIHTldIVv\GWwdDDtZY5v\XJ? M33V[|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3Nkm3PFk6Lz5{NU[5O|g6QTxxYU6=
A549 NYHudHRjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF\NZXcxNjNvMUCg{txO M4f5R|I1Nzd{IHi= NIrRSYZqdmirYnn0d{Bk\WyuIHfyc5d1cCCrbjDic5RpKHSrbXWgZY5lKGSxc3Wg[IVx\W6mZX70JI1idm6nch?= M4frNFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3Nkm3PFk6Lz5{NU[5O|g6QTxxYU6=
U-87 MG  M2DnNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVWyNE81OCEQvF2= NFzqUGozPC92ODDo M1S2c4lvcGmkaYTzJINmdGxiZ4Lve5RpKGmwIHLveIghfGmvZTDhcoQh\G:|ZTDk[ZBmdmSnboSgcYFvdmW{ NVuwbHBMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW5N|QzOzJpPkK1PVM1OjN{PD;hQi=>
HepG2 NHnjUJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWTGN2RoOjBxNECg{txO NUXXPXRLOjRxNEigbC=> NXrvT2p{cW6qaXLpeJMh[2WubDDndo94fGhiaX6gZo91cCC2aX3lJIFv\CCmb4PlJIRmeGWwZHXueEBu[W6wZYK= M{\kUVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3OUO0NlMzLz5{NUmzOFI{OjxxYU6=
U-87 MG  MVnGeY5kfGmxbjDBd5NigQ>? NIPS[FEzOMLizszN MnX6Ok8zPCCq M12zeolv[3KnYYPld{B1cGViYYX0c5Bp[WerYzDmcJV5KCCjdDC2JIghf2irbHWgbY5pcWKrdIOgeIhqeyCobIX4JIF1KDJ2aB?= M{C1U|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3OUO0NlMzLz5{NUmzOFI{OjxxYU6=
HepG2 NGnqR5NHfW6ldHnvckBCe3OjeR?= MofmNlDDqM7:TR?= NY\H[2h5Pi9{NDDo NX3qOYhX\GWlcnXhd4V{KEyFMz3JTUBl\We{YXTheIlwdsLiZoLvcUA3KGh? M3fy[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3OUO0NlMzLz5{NUmzOFI{OjxxYU6=
U-87 MG  NGLNeVZHfW6ldHnvckBCe3OjeR?= NWTDfXpnOjEEoN88US=> NIqzeYc3NzJ2IHi= MknLbY5kemWjc3XzJJRp\SCuZY\lcJMhd2ZiTFOzMWlKKGOxdILlZZRm\CC5aYToJGNS NEfEPYE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUmzOFI{Oid-MkW5N|QzOzJ:L3G+
HepG2 MnrLSpVv[3Srb36gRZN{[Xl? MXuyNOKh|ryP NIDlR4s3NzJ2IHi= M1;XbYlv[3KnYYPld{B1cGVibHX2[Yx{KG:oIFzDN{1KUSClb4Ty[YF1\WRid3n0bEBEWQ>? MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTl|NEKzNkc,OjV7M{SyN|I9N2F-
U-87 MG  NWL0U2k2TnWwY4Tpc44hSXO|YYm= NE\yeWozOMLizszN NIP3N4gzPMLiaB?= NVLPbW56cW6lcnXhd4V{KGSxdXLs[U1u\W2kcnHu[UBjd3WwZDDzeJJ2[3S3cnXz MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTl|NEKzNkc,OjV7M{SyN|I9N2F-
HepG2 MWjGeY5kfGmxbjDBd5NigQ>? M4eyWFIxyqEQvF2= Mm[4NlTDqGh? MlXQdJJw\HWlZYOgZY4hcW62ZX7z[UBkgXSxcHzhd41q[yC4YXP1c4xqgmG2aX;uJINwenKnc4DvcoRqdmdidH:gZUBvd3SjYnzlJIRqdGG2YYTpc44hd2ZidHjlJGVTKGOrc4Tldo5{ NETld5E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUmzOFI{Oid-MkW5N|QzOzJ:L3G+
T24 BC  NHjDSlJCeG:ydH;zbZMhSXO|c3H5 MXyyMlUh|ryP NVn4PHlLOjRiaB?= M2rBVJNmdnOrdHn6[ZMhSkNiY3XscJMhfG9ic3;yZYZmdmmkLXnu[JVk\WRiYYDvdJRwfGmlwrC= NU\OSYN[RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[wPVc5PzNpPkK2NFk4QDd|PD;hQi=>
T24 BC  M1ztVmNmdGxiVnnhZoltcXS7IFHzd4F6 NWDMNGRFOC53L{GvNk42KM7:TR?= MV[yOEBp MWXlcohidmOnczDzc5Ji\mWwaXKtbY5lfWOnZDDj[YxtKH[rYXLpcIl1gSCmZXPy[YF{\Q>? M1Lh[|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4MEm3PFc{Lz5{NkC5O|g4OzxxYU6=
T24 BC  NWXhTGR5TnWwY4Tpc44hSXO|YYm= MVywMlUwOS9{LkWg{txO MoLBN{Bp MV;y[YR2[2W|IITo[UBj[XOjbDDDRkB1gXKxc3nu[UBxcG:|cHjvdplt[XSrb36gcIV3\Wy|IHnuJIEh\G:|ZT3k[ZBmdmSnboSgcYFvdmW{ MV:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjB7N{i3N{c,OjZyOUe4O|M9N2F-
RBL2H3 Mm\tSpVv[3Srb36gZZN{[Xl? M2PMW3RwgGmlaYT5JIlvKHKjdDDSRmwzUDNiY3XscJMtKE2WRE2yOe69VQ>? NEjZelc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEG1N|U3PSd-MkCxOVM2PjV:L3G+
PC3 Mn\SS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NGDaVpVIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBRSzNiY3XscJMh[nlic4Xs[o9zcG:mYX3pcoUhSiCjc4PhfUwhT0l3ME2wMlQ1|ryP MlLJQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF3NEOxOFEoRjJzNUSzNVQyRC:jPh?=
NUGC3 MVLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MWnHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDOWWdEOyClZXzsd{BjgSC|dXzmc5Jpd2SjbXnu[UBDKGG|c3H5MEBIUTVyPUCuOVTPxE1? NHPZTYM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUW0N|E1OSd-MkG1OFMyPDF:L3G+
HCT15 M4DXNmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NGnSboRIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBJS1RzNTDj[YxteyCkeTDzeYxnd3Kqb3ThcYlv\SCEIHHzd4F6NCCJSUWwQVEvOjYQvF2= M3nhb|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzNUSzNVQyLz5{MUW0N|E1OTxxYU6=
MDA-MB-231 NHf1TItIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MnrJS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gUWRCNU2ELUKzNUBk\WyuczDifUB{fWyob4Loc4RidWmwZTDCJIF{e2G7LDDHTVUxRTJwOEdOwG0> Mn;GQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF3NEOxOFEoRjJzNUSzNVQyRC:jPh?=
NCI-H23 NEDGe2tIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MX7Hdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDOR2kuUDJ|IHPlcIx{KGK7IIP1cIZwemixZHHtbY5mKEJiYYPzZZktKEeLNUC9OE4zOc7:TR?= NXfs[3RXRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG1OFMyPDFpPkKxOVQ{OTRzPD;hQi=>
ACHN Ml20S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MmXkS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gRWNJViClZXzsd{BjgSC|dXzmc5Jpd2SjbXnu[UBDKGG|c3H5MEBIUTVyPUSuOVbPxE1? NWGze4ZZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG1OFMyPDFpPkKxOVQ{OTRzPD;hQi=>
A549 MVrGeY5kfGmxbjDhd5NigQ>? MlnGN|AhdWmwcx?= MlLyTY5pcWKrdHnvckBw\iCDa4SgdIhwe3Cqb4L5cIF1cW:wIHnuJIlve3WuaX6td5RqdXWuYYTl[EBpfW2jbjDBOVQ6KGOnbHzzJJRz\WG2ZXSgNkBpenNiYnXmc5JmKGmwc4XsbY4he3SrbYXsZZRqd25ibXXhd5Vz\WRiYX\0[ZIhOzBibXnud{BjgSCHTFnTRUwhUUN3ME21MlPPxE1? M{WwW|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{MUO4N|A6Lz5{MkGzPFMxQTxxYU6=
A549 MULDfZRwfG:6aXPpeJkh[XO|YYm= NYT5SmM1OjRiaILz M3q1cGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJGE2PDliY3XscJMh[W[2ZYKgNlQhcHK|IHL5JGZCS1NiYX7hcJl{cXNuIFnDOVA:P87:TR?= M1fBOlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{MUO4N|A6Lz5{MkGzPFMxQTxxYU6=
KATO III NVz4[VB2S3m2b4TvfIlkcXS7IHHzd4F6 M1G2flI1KGi{cx?= MYHDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDLRXRQKEmLSTDj[YxteyCjZoTldkAzPCCqcoOgZpkhTkGFUzDhcoFtgXOrczygTWM2OD1zMj64{txO M4W5N|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{MUO4N|A6Lz5{MkGzPFMxQTxxYU6=
MCF7 NXrzNo5nS3m2b4TvfIlkcXS7IHHzd4F6 MnnyNlQhcHK| M1fF[WN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1ETjdiY3XscJMh[W[2ZYKgNlQhcHK|IHL5JGZCS1NiYX7hcJl{cXNuIFnDOVA:OTNwM988US=> NIL1bJM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkGzPFMxQSd-MkKxN|g{ODl:L3G+
PC3 NFX5SINIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NGXtNnBIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBRSzNiY3XscJMh[nliU2LCJIF{e2G7LDDHTVUxRTBwNEVOwG0> NWTTR4QxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOyOlYyQDFpPkKzNlY3OThzPD;hQi=>
NUGC3 MYLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MVrHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDOWWdEOyClZXzsd{BjgSCVUlKgZZN{[XluIFfJOVA:OC53NN88US=> NXXXNmM1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOyOlYyQDFpPkKzNlY3OThzPD;hQi=>
HCT15 M1PIZWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M3fCbWdzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJGhEXDF3IHPlcIx{KGK7IGPSRkBie3OjeTygS2k2OD1zLkK1{txO NVv1cll{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOyOlYyQDFpPkKzNlY3OThzPD;hQi=>
MDA-MB-231 Mn7yS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NH[0dotIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBOTEFvTVKtNlMyKGOnbHzzJIJ6KFOUQjDhd5NigSxiR1m1NF0zNjh4zszN MmjtQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN{Nk[xPFEoRjJ|Mk[2NVgyRC:jPh?=
NCI-H23 MYPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MYPHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDOR2kuUDJ|IHPlcIx{KGK7IGPSRkBie3OjeTygS2k2OD12LkKx{txO M4[zXFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|Mk[2NVgyLz5{M{K2OlE5OTxxYU6=
ACHN NG\ucHpIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NIj3UmRIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBCS0iQIHPlcIx{KGK7IGPSRkBie3OjeTygS2k2OD12LkW2{txO MkHGQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN{Nk[xPFEoRjJ|Mk[2NVgyRC:jPh?=
A549 M1TGZ2Z2dmO2aX;uJIF{e2G7 M3;TWVIhcHK| MYPJcohq[mm2aX;uJI9nKEGtdDDwbI9{eGixconsZZRqd25iaX6gbJVu[W5iaX7zeYxqdi2|dHnteYxifGWmIFG1OFkh[2WubIOgbY5kfWKjdHXkJIZweiB{IHjyd{BxemmxcjD0c{BqdnO3bHnuMYlv\HWldHnvckBu\WG|dYLl[EBi\nSncjCzNEBucW6|IHL5JGVNUVODLDDJR|UxRTVwM988US=> MWS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzRzNUC4N{c,OjN2MUWwPFM9N2F-
A549 NV3WRo9WS3m2b4TvfIlkcXS7IHHzd4F6 MYDDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDBOVQ6KGOnbHzzJIJ6KG[ub4egZ5l1d22ndILpZ{BidmGueYPpd{whUUN3ME23{txO NEmyWYU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{SxOVA5Oyd-MkO0NVUxQDN:L3G+
KATO III Moe3R5l1d3SxeHnjbZR6KGG|c3H5 NIT0U5ZEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBMSVSRIFnJTUBk\WyuczDifUBndG:5IHP5eI9u\XS{aXOgZY5idHm|aYOsJGlEPTB;MUKuPO69VQ>? NX3uO2pJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO0NVUxQDNpPkKzOFE2ODh|PD;hQi=>
MCF7 MWrDfZRwfG:6aXPpeJkh[XO|YYm= M1zRXWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1ETjdiY3XscJMh[nliZnzve{BkgXSxbXX0dolkKGGwYXz5d4l{NCCLQ{WwQVE{NjQQvF2= MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzRzNUC4N{c,OjN2MUWwPFM9N2F-
PC3 MnTZRY51cXC{b3zp[oVz[XSrdnWgZZN{[Xl? MnviRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCSQ{OgZ4VtdHNiYomgV3JDKGG|c3H5MEBIUTVyPUCuOFTPxE1? NFX3S5A9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{W2O|k2OCd-MkO1Olc6PTB:L3G+
NUGC3 NFLiVndCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MnW1RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCQVVfDN{Bk\WyuczDifUBUWkJiYYPzZZktKEeLNUC9NE42PM7:TR?= M3SxUFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|NU[3PVUxLz5{M{W2O|k2ODxxYU6=
HCT15 NYG4bZZrSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= NF7ZTGdCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjDWFE2KGOnbHzzJIJ6KFOUQjDhd5NigSxiR1m1NF0yNjJ3zszN Ml\IQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN3Nke5OVAoRjJ|NU[3PVUxRC:jPh?=
MDA-MB-231 NF\BXIpCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NHHxfJlCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIF3ERU1OSi1{M{GgZ4VtdHNiYomgV3JDKGG|c3H5MEBIUTVyPUKuPFbPxE1? M3nUOlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|NU[3PVUxLz5{M{W2O|k2ODxxYU6=
NCI-H23 NHvRfVlCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= NXrIelZLSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[WejaX7zeEBpfW2jbjDOR2kuUDJ|IHPlcIx{KGK7IGPSRkBie3OjeTygS2k2OD12LkKx{txO NH\JO4k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{W2O|k2OCd-MkO1Olc6PTB:L3G+
ACHN MWTBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? NFLlPFJCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFHDTG4h[2WubIOgZpkhW1KEIHHzd4F6NCCJSUWwQVQvPTcQvF2= M4OxcFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|NU[3PVUxLz5{M{W2O|k2ODxxYU6=
PC3 NWDyTlVvT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NFO4[nc1QCCqcoO= NUiyU3JQT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hWEN|IHPlcIx{KGGodHXyJFQ5KGi{czDifUBUWkJiYYPzZZktKEeLNUC9NE41PM7:TR?= NXGwUnJIRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSwPVU4PTlpPkK0NFk2PzV7PD;hQi=>
NUGC3 MmLKS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MX60PEBpenN? Mn;aS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gUnVISzNiY3XscJMh[W[2ZYKgOFghcHK|IHL5JHNTSiCjc4PhfUwhT0l3ME2wMlU1|ryP MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDB7NUe1PUc,OjRyOUW3OVk9N2F-
HCT15 NU\IXVR5T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Ml3HOFghcHK| MlrnS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gTGNVOTViY3XscJMh[W[2ZYKgOFghcHK|IHL5JHNTSiCjc4PhfUwhT0l3ME2xMlI2|ryP MojVQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjRyOUW3OVkoRjJ2MEm1O|U6RC:jPh?=
MDA-MB-231 NVnmfIdVT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NFzWfG81QCCqcoO= NYKyZ|V6T3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hVUSDLV3CMVI{OSClZXzsd{Bi\nSncjC0PEBpenNiYomgV3JDKGG|c3H5MEBIUTVyPUKuPFbPxE1? NWfwUW5NRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSwPVU4PTlpPkK0NFk2PzV7PD;hQi=>
NCI-H23 NH74dJJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NGmybXg1QCCqcoO= MUDHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDOR2kuUDJ|IHPlcIx{KGGodHXyJFQ5KGi{czDifUBUWkJiYYPzZZktKEeLNUC9OE4zOc7:TR?= NEi2b3k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEC5OVc2QSd-MkSwPVU4PTl:L3G+
ACHN NU[x[VU3T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M4P5S|Q5KGi{cx?= MW\Hdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDBR2hPKGOnbHzzJIFnfGW{IES4JIhzeyCkeTDTVmIh[XO|YYmsJGdKPTB;ND61Ou69VQ>? NV3kUWdlRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSwPVU4PTlpPkK0NFk2PzV7PD;hQi=>
A549 M3u2fWN6fG:2b4jpZ4l1gSCjc4PhfS=> MX[yOEB1dyB5MjDodpM> NXSyc4hmS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hSTV2OTDj[YxteyCjZoTldkAzPCC2bzC3NkBpenNiYomgbIFmdW:leYTvcYV1enluIFnDOVA:PC5zN988US=> NYTXeZlsRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS5NFA3OjBpPkK0PVAxPjJyPD;hQi=>
Rosetta cells NGXKeXpHfW6ldHnvckBie3OjeR?= MWTJcohq[mm2aX;uJI9nKHerbHSteJlx\SCqdX3hckBROzijbIDoZUBOSVCNIHX4dJJme3OnZDDpckBGe2OqZYLpZ4hq[SClb3zpJHJwe2W2dHGgZ4VtdHNuIFnDOVA:OS5{zszN MmTpQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzF{N{SzNVYoRjNzMke0N|E3RC:jPh?=

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p-AKT / AKT / p-S6K1 / S6K1 ; 

PubMed: 25519148     


The effect of perifosine on AKT-mTOR activation in vitro. RMG1 and RMG2 cells were treated with 0, 3, 10, 30 or 50 μM perifosine for 6 h in the presence of 10% FBS. Cells were harvested, and equivalent amounts (30 μg) of protein were subjected to SDS-PAGE and blotted with anti-phospho-AKT (Ser473), anti-AKT, anti-phospho-S6K1 (Thr389), anti-S6K1, or anti-β-actin antibodies.

PARP; 

PubMed: 25519148     


Perifosine induces apoptosis. RMG1 and RMG2 cells were treated with or without 30 μM perifosine for 24 h. Cells were harvested, and the effect of perifosine was evaluated by western blotting

p-mTOR / mTOR / Raptor / Rictor / p-p70S6K / p70S6K / p-4EBP1 / 4EBP1 / c-Myc / Cyclin D1; 

PubMed: 19920197     


The indicated cell lines were treated with the given concentrations of perifosine (PRFS) for 8 h.

p-PDK1 / p-GSK3α/β / p-S6R ; 

PubMed: 17761832     


BCWM.1 cells were cultured with perifosine for 6 hours with doses that ranged from 2 to 20 μM. Whole cell lysates were subjecting to Western blotting using anti–p-Akt ser473, -Akt, –p-PDK1, –p-GSK3α/β, –p-S6R, and α-tubulin antibodies.

25519148 19920197 17761832
Growth inhibition assay
Cell viability; 

PubMed: 28332584     


Cell survival measured by MTT assay and IC50 of perifosine in a panel of eleven human cancer cells.

28332584
In vivo Perifosine combining with temozolomide reduces tumor proliferation (a PDGF-driven gliomagenesis) in vivo. The results indicate that Perifosine is an effective drug in gliomas in which Akt and Ras-Erk 1/2 pathways are frequently activated, and may be new candidate for glima treatment in the clinic. [2] Both oral daily and weekly administration of Perifosine significantly reduce human MM tumor growth and increase survival, compared with control animals treated with PBS vehicle only. [3] Perifosine induces thrombocytosis and leukocytosis and increases myelopoiesis in murine marrow and spleen, whereas it causes apoptosis in myeloma xenografts. [5]

Protocol

Kinase Assay:[3]
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Akt kinase assay:

MM.1S cells are cultured in the presence or absence of perifosine (5 μM, 6 hours) and then stimulated with IL-6 (20 ng/mL, 10 minutes). In vitro akt kinase assay is then carried out using the Akt Kinase Assay Kit.
Cell Research:[2]
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  • Cell lines: Human glioma cell lines
  • Concentrations: 0, 15, 30 and 45 μM
  • Incubation Time: 48 hours
  • Method: Cells are incubated in the medium with 10% FCS for 48 hours with indicated concentration of Periosine. Cell viability is determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. (Cell Proliferation Kit I; Roche). The absorbance at 590 nm is recorded using the 96-well plate reader.
    (Only for Reference)
Animal Research:[3]
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  • Animal Models: MM.1S MM cells are inoculated subcutaneously in the right flank of Beige-nude-xid (BNX) mice (5 to 6 weeks old).
  • Dosages: 250 mg/kg/wk or 36 mg/kg/d
  • Administration: Oral gavage
    (Only for Reference)

Solubility (25°C)

In vitro Water 8 mg/mL (17.32 mM)
DMSO Insoluble
Ethanol '15 mg/mL
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
water
For best results, use promptly after mixing.
8mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 461.66
Formula

C25H52NO4P

CAS No. 157716-52-4
Storage powder
in solvent
Synonyms NSC639966, D21266
Smiles CCCCCCCCCCCCCCCCCCOP(=O)([O-])OC1CC[N+](CC1)(C)C

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
Step 2: Enter the in vivo formulation ()
% DMSO % % Tween 80 % ddH2O
CalculateReset

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT01224730 Completed Drug: perifosine Cancer AEterna Zentaris January 24 2012 Phase 1
NCT01048580 Completed Drug: Perifosine|Drug: Capecitabine Colon Cancer AEterna Zentaris|SCRI Development Innovations LLC October 2009 Phase 1
NCT00498966 Completed Drug: Perifosine Kidney Cancer AEterna Zentaris July 2007 Phase 2
NCT00448721 Completed Drug: Perifosine Renal Cell Carcinoma AEterna Zentaris|Dana-Farber Cancer Institute March 2007 Phase 2
NCT00455559 Completed Drug: Perifosine|Drug: Imatinib Mesylate Gastrointestinal Stromal Tumors AEterna Zentaris|M.D. Anderson Cancer Center August 2006 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID