Perifosine (KRX-0401)

For research use only.

Catalog No.S1037 Synonyms: NSC639966, D21266

155 publications

Perifosine (KRX-0401) Chemical Structure

CAS No. 157716-52-4

Perifosine (KRX-0401, NSC639966, D21266) is a novel Akt inhibitor with IC50 of 4.7 μM in MM.1S cells, targets pleckstrin homology domain of Akt. Phase 3.

Selleck's Perifosine (KRX-0401) has been cited by 155 publications

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Biological Activity

Description Perifosine (KRX-0401, NSC639966, D21266) is a novel Akt inhibitor with IC50 of 4.7 μM in MM.1S cells, targets pleckstrin homology domain of Akt. Phase 3.
Targets
Akt [1]
(MM.1S cells)
4.7 μM
In vitro

Perifosine develops anti-proliferative properties with IC50 of 0.6-8.9 μM in immortalized keratinocytes (HaCaT), and head and neck squamous carcinoma cells. [1] Perifosine strongly reduces phosphorylation levels of Akt and extracellular signal-regulated kinase (Erk) 1/2, induces cell cycle arrest in G1 and G2, and causes dose-dependent growth inhibition of mouse glial progenitors. [2] Perifosine (10 μM) completely inhibits the phosphorylation of Akt in MM.1S cells. [3] A recent study demonstrates Perifosine induces cell cycle arrest and apoptosis in human hepatocellular carcinoma cell lines by blockade of Akt phosphorylation. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
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MOLM MYTBdI9xfG:|aYOgRZN{e2G7 NEewO|QyOMLizszN M3XQNFI1NzR6IHi= MUjpcoR2[2W|IHHwc5B1d3OrczD0bY1mNWSncHXu[IVvfGy7 NYfnXoRvRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCxN|A6PjBpPkKwNVMxQTZyPD;hQi=>
OCI NIH2UWVCeG:ydH;zbZMhSXO|c3H5 M3\4SlExyqEQvF2= M3i2VFI1NzR6IHi= NFjpVYFqdmS3Y3XzJIFxd3C2b4Ppd{B1cW2nLXTldIVv\GWwdHz5 MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODF|MEm2NEc,OjBzM{C5OlA9N2F-
BJAB MXrBdI9xfG:|aYOgRZN{e2G7 MnvZNVDDqM7:TR?= M1XrNFI1NzR6IHi= MlLzbY5lfWOnczDhdI9xfG:|aYOgeIlu\S2mZYDlcoRmdnSueR?= NYHKPWhlRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCxN|A6PjBpPkKwNVMxQTZyPD;hQi=>
MAVER NICxU|JCeG:ydH;zbZMhSXO|c3H5 NWf6c2FTOTEEoN88US=> Mlj5NlQwPDhiaB?= NUj2b403cW6mdXPld{BieG:ydH;zbZMhfGmvZT3k[ZBmdmSnboTsfS=> M3PJ[FxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyMUOwPVYxLz5{MEGzNFk3ODxxYU6=
SKW6.4 MlH0RZBweHSxc3nzJGF{e3OjeR?= NIrFVJUyOMLizszN NHywfWszPC92ODDo M3f1Solv\HWlZYOgZZBweHSxc3nzJJRqdWVvZHXw[Y5l\W62bIm= NYqxSVJURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCxN|A6PjBpPkKwNVMxQTZyPD;hQi=>
HL-60 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoP0Nk0yOMLizszN NFLSZmI1QMLiaB?= MUjpcohq[mm2czDj[YxtKGe{b4f0bEBqdiCjIHTvd4Uh\GWyZX7k[Y51KG2jbn7ldi=> MlKwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjBzM{C5OlAoRjJyMUOwPVYxRC:jPh?=
MOLM Mk[zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{XxUlIuOTEEoN88US=> NVj1[HBoPDkEoHi= NU\0TWJmcW6qaXLpeJMh[2WubDDndo94fGhiaX6gZUBld3OnIHTldIVv\GWwdDDtZY5v\XJ? M1z6UlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyMUOwPVYxLz5{MEGzNFk3ODxxYU6=
OCI NYjCZYgyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mnn5Nk0yOMLizszN MoT3OFjDqGh? Mn24bY5pcWKrdIOgZ4VtdCCpcn;3eIghcW5iYTDkc5NmKGSncHXu[IVvfCCvYX7u[ZI> NFLHVYY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEGzNFk3OCd-MkCxN|A6PjB:L3G+
BJAB NH7yXXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoPjNk0yOMLizszN MkDjOFjDqGh? MmnwbY5pcWKrdIOgZ4VtdCCpcn;3eIghcW5iYTDkc5NmKGSncHXu[IVvfCCvYX7u[ZI> MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODF|MEm2NEc,OjBzM{C5OlA9N2F-
MAVER NI\IZ41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkDsNk0yOMLizszN MUG0POKhcA>? MYfpcohq[mm2czDj[YxtKGe{b4f0bEBqdiCjIHTvd4Uh\GWyZX7k[Y51KG2jbn7ldi=> MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODF|MEm2NEc,OjBzM{C5OlA9N2F-
SKW6.4 M3uwV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVPldlIzOi1zMNMg{txO M4DWWVQ5yqCq MlrnbY5pcWKrdIOgZ4VtdCCpcn;3eIghcW5iYTDkc5NmKGSncHXu[IVvfCCvYX7u[ZI> NX7m[XR7RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCxN|A6PjBpPkKwNVMxQTZyPD;hQi=>
A2780cis  M4LpZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEP0Z|MxNTJyIN88US=> MYq0PE84OiCq NFyxSmxKSzVywrC9xsA3yqEQvH2= NU\XWpI6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC0NFUzQTZpPkKwOFA2Ojl4PD;hQi=>
A2780 MlnnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoDaNE0zOCEQvF2= M37XZ|Q5Nzd{IHi= MmfUTWM2OMLiPdMgN:Kh|ryv MonUQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB2MEWyPVYoRjJyNEC1Nlk3RC:jPh?=
SKOV3  MnLoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoSxNE01OCEQvF2= NXrPbFdpPzMEoHi= MYPJR|UxhjNyIN88UUwhcW6qaXLpeJMh[2WubDDndo94fGhiaX6gZUBld3OnIHTldIVv\GWwdDDtZY5v\XJ? NWXsZmJpRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC0NFUzQTZpPkKwOFA2Ojl4PD;hQi=>
PA-1  NHLtNGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFzXUGUxNTRyIN88US=> NVHzOoZUPzMEoHi= M1rxcWlEPTC-MkWg{txONCCrbnjpZol1eyClZXzsJIdzd3e2aDDpckBiKGSxc3Wg[IVx\W6mZX70JI1idm6nch?= NWOyO5pCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC0NFUzQTZpPkKwOFA2Ojl4PD;hQi=>
OAW-42 NIrJVVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHfVR2UxNTRyIN88US=> NInr[Ys4OsLiaB?= NIfyWIZKSzVyfkGwJO69VSxiaX7obYJqfHNiY3XscEBoem:5dHigbY4h[SCmb4PlJIRmeGWwZHXueEBu[W6wZYK= MnLjQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB2MEWyPVYoRjJyNEC1Nlk3RC:jPh?=
Bel-7402 MmDVRZBweHSxc3nzJGF{e3OjeR?= NULZXopVPS9zMD:yNEDPxE1? NIHkd4YzPC92ODDo NHrySnlqdmS3Y3XzJIFxd3C2b4Ppd{BifCC2aHWgcI9v\y22aX3lJIV5eG:|dYLl NUGxb2sxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkC4OFI1OjVpPkKwPFQzPDJ3PD;hQi=>
HepG2  M4TrZWFxd3C2b4Ppd{BCe3O|YYm= Mnf5OU8yOC9{MDFOwG0> M4GzTFI1NzR6IHi= MXnpcoR2[2W|IHHwc5B1d3OrczDheEB1cGVibH;u[{11cW2nIHX4dI9{fXKn NFH1NnY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEi0NlQzPSd-MkC4OFI1OjV:L3G+
Bel-7402 NWjMdmZETnWwY4Tpc44hSXO|YYm= NFPjXpA2NzFyL{KwJO69VQ>? MV:yOEBp NYfqcXJkemW|dXz0d{BqdiC2aHWgZYNkfW23bHH0bY9vKG:oIHPlcIwhdnWvYnXyJIlvKHSqZTDHNk9OKHCqYYPl Mm\xQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB6NEK0NlUoRjJyOESyOFI2RC:jPh?=
HepG2  NWrRO2dqTnWwY4Tpc44hSXO|YYm= MXy1M|ExNzJyIN88US=> Mk\yNlQhcA>? MljtdoV{fWy2czDpckB1cGViYXPjeY12dGG2aX;uJI9nKGOnbHygcpVu[mW{IHnuJJRp\SCJMj;NJJBp[XOn M4racVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyOESyOFI2Lz5{MEi0NlQzPTxxYU6=
Bel-7402 NInsXYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIPoTII2NzFyL{KwM|QxKM7:TR?= NIfqVm8zPC92OD:3NkBp NV72ZVBScW6qaXLpeJMh[2WubDDndo94fGhiaX6gZo91cCC2aX3lJIFv\CCmb4PlJIRmeGWwZHXueEBu[W6wZYK= MVi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODh2MkSyOUc,OjB6NEK0NlU9N2F-
HepG2  MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXy1M|ExNzJyL{SwJO69VQ>? MmP5NlQwPDhxN{KgbC=> M{TTXIlvcGmkaYTzJINmdGxiZ4Lve5RpKGmwIHLveIghfGmvZTDhcoQh\G:|ZTDk[ZBmdmSnboSgcYFvdmW{ MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODh2MkSyOUc,OjB6NEK0NlU9N2F-
CWR22RV1 MkW3SpVv[3Srb36gRZN{[Xl? NUDpW|FvPSEQvF2= M1zTUVI1KGh? M1P1N5Jm\HWlZXSgdIhwe3Cqb4L5cIF1cW:wIH;mJGFsfCC|aXfubYZq[2GwdHz5 NGLQXGk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUS5OlI4Oyd-MkG0PVYzPzN:L3G+
CWR22RV1 NV3R[WxXSXCxcITvd4l{KEG|c4PhfS=> MlvmNVAh|ryP NXn1TpI3OjRiaB?= MVzlcohidmOnczDyZYRq[XSrb36gbY5lfWOnZDDhdI9xfG:|aYO= MmHsQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF2OU[yO|MoRjJzNEm2Nlc{RC:jPh?=
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A498 NYGwNWF1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEex[GcxNTJyIN88US=> MnHKO|IhcA>? NX\Ec2ZHcW6qaXLpeJMh[2WubDDndo94fGhiaX6gZUBld3OnIHTldIVv\GWwdDDtZY5v\XJ? NF\DU2E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MU[0OFA2OCd-MkG2OFQxPTB:L3G+
769-P MkDzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVmwMVIxKM7:TR?= NITkcFc4OiCq MWrpcohq[mm2czDj[YxtKGe{b4f0bEBqdiCjIHTvd4Uh\GWyZX7k[Y51KG2jbn7ldi=> NX\rZWltRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG2OFQxPTBpPkKxOlQ1ODVyPD;hQi=>
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769-P MmPtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFfPWnQxNTRyIN88US=> MV23NkBp M4LPUGlEPTC-NT2xNEDPxE1? MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTZ2NEC1NEc,OjF4NESwOVA9N2F-
CAKI-1 NYDiXnJ5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnvZNE01OCEQvF2= MnzaO|IhcA>? M3XxN2lEPTC-MUCg{txO NEfT[nQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MU[0OFA2OCd-MkG2OFQxPTB:L3G+
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RMG2 MlftR4VtdCCYaXHibYxqfHliQYPzZZk> M3jsXlEuOzBizszN MV20PEBp NUjLR2hs\GWlcnXhd4V{KGOnbHygeoli[mmuaYT5JIlvKGFiZH;z[UBl\XCnbnTlcpQhdWGwbnXy NViwToxMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW1NVkyPDhpPkK1OVE6OTR6PD;hQi=>
HAC2 MYrD[YxtKF[rYXLpcIl1gSCDc4PhfS=> MmjPNU0{OCEQvF2= M1HqR|czKGh? NF7nbJdl\WO{ZXHz[ZMh[2WubDD2bYFjcWyrdImgbY4h[SCmb4PlJIRmeGWwZHXueEBu[W6wZYK= M1\XflxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3NUG5NVQ5Lz5{NUWxPVE1QDxxYU6=
KOC7C NEi4NWRE\WyuIG\pZYJqdGm2eTDBd5NigQ>? NXjKOW84OS1|MDFOwG0> NGHYVHY4OiCq NXnheoY{\GWlcnXhd4V{KGOnbHygeoli[mmuaYT5JIlvKGFiZH;z[UBl\XCnbnTlcpQhdWGwbnXy Mmi5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV3MUmxOFgoRjJ3NUG5NVQ5RC:jPh?=
RMG2 NVnKOYVlS2WubDDWbYFjcWyrdImgRZN{[Xl? NXLPcWdHOS1|MDFOwG0> NV;jOmdVPzJiaB?= NV7KRnFH\GWlcnXhd4V{KGOnbHygeoli[mmuaYT5JIlvKGFiZH;z[UBl\XCnbnTlcpQhdWGwbnXy Ml\kQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV3MUmxOFgoRjJ3NUG5NVQ5RC:jPh?=
RMG1 NXzFPYxDS2WubDDWbYFjcWyrdImgRZN{[Xl? NHrENnIyNTNyIN88US=> MlXVO|IhcA>? MUnk[YNz\WG|ZYOgZ4VtdCC4aXHibYxqfHliaX6gZUBld3OnIHTldIVv\GWwdDDtZY5v\XJ? NGnLUJo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUWxPVE1QCd-MkW1NVkyPDh:L3G+
H460 MnOzSpVv[3Srb36gRZN{[Xl? NYTKbmttOyEQvF2= Moj6PEBp MlfmZoxw[2u|IH3UU3JEOSxiYX7kJGVTUy2PQWDLJIFkfGm4YYTpc44h[2:vYnnu[YQhf2m2aDDNSWsuOTZ{ MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTZ7N{i5PUc,OjV4OUe4PVk9N2F-
A549 Mnf5SpVv[3Srb36gRZN{[Xl? NIPVRZA{KM7:TR?= NX7XeFRxQCCq MX3icI9kc3NibWTPVmMyNCCjbnSgSXJMNU2DUFugZYN1cX[jdHnvckBkd22kaX7l[EB4cXSqIF3FT{0yPjJ? M{j0[VxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3Nkm3PFk6Lz5{NU[5O|g6QTxxYU6=
H460 MonMSpVv[3Srb36gRZN{[Xl? NIjTW5Y{KM7:TR?= NF\6VpY5KGh? M{\DeIJtd2OtczDBT3Qh[WO2aY\heIlwdg>? M1HYTFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3Nkm3PFk6Lz5{NU[5O|g6QTxxYU6=
A549 NX3OXppNTnWwY4Tpc44hSXO|YYm= MkDxN{DPxE1? MYK4JIg> M3fEd4Jtd2OtczDBT3Qh[WO2aY\heIlwdg>? NH\xc4M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NU[5O|g6QSd-MkW2PVc5QTl:L3G+
H460 Ml7jRZBweHSxc3nzJGF{e3OjeR?= NXH6bFJkOS9|IN88US=> NXLTb4hUPDhiaB?= MYrpcoR2[2W|IHHwc5B1d3Orcx?= NFG4bG09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NU[5O|g6QSd-MkW2PVc5QTl:L3G+
A549 MXnBdI9xfG:|aYOgRZN{e2G7 MnfGNU8{KM7:TR?= M2n4XlQ5KGh? NYnVTGtZcW6mdXPld{BieG:ydH;zbZM> NU\JVHRqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW2PVc5QTlpPkK1Olk4QDl7PD;hQi=>
H460 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXfmfZJpOC5|LUGwJO69VQ>? M3Xac|I1Nzd{IHi= M{\oeYlvcGmkaYTzJINmdGxiZ4Lve5RpKGmwIHLveIghfGmvZTDhcoQh\G:|ZTDk[ZBmdmSnboSgcYFvdmW{ MnTDQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV4OUe4PVkoRjJ3Nkm3PFk6RC:jPh?=
A549 MnzLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEHCdXQxNjNvMUCg{txO MUSyOE84OiCq M4jYd4lvcGmkaYTzJINmdGxiZ4Lve5RpKGmwIHLveIghfGmvZTDhcoQh\G:|ZTDk[ZBmdmSnboSgcYFvdmW{ M1njbVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3Nkm3PFk6Lz5{NU[5O|g6QTxxYU6=
U-87 MG  NVr2NZdWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlfMNlAwPDBizszN NXL5bW5[OjRxNEigbC=> MWXpcohq[mm2czDj[YxtKGe{b4f0bEBqdiCkb4ToJJRqdWViYX7kJIRwe2ViZHXw[Y5l\W62IH3hco5meg>? MmjCQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV7M{SyN|IoRjJ3OUO0NlMzRC:jPh?=
HepG2 MkP4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFH6TG8zOC92MDFOwG0> MVGyOE81QCCq NIHpb4dqdmirYnn0d{Bk\WyuIHfyc5d1cCCrbjDic5RpKHSrbXWgZY5lKGSxc3Wg[IVx\W6mZX70JI1idm6nch?= MnLIQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV7M{SyN|IoRjJ3OUO0NlMzRC:jPh?=
U-87 MG  M1HHfmZ2dmO2aX;uJGF{e2G7 M4PrT|IxyqEQvF2= NEXyPIM3NzJ2IHi= M2fqWolv[3KnYYPld{B1cGViYYX0c5Bp[WerYzDmcJV5KCCjdDC2JIghf2irbHWgbY5pcWKrdIOgeIhqeyCobIX4JIF1KDJ2aB?= M1XRbVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3OUO0NlMzLz5{NUmzOFI{OjxxYU6=
HepG2 MYLGeY5kfGmxbjDBd5NigQ>? MXqyNOKh|ryP M{L3UlYwOjRiaB?= MUDk[YNz\WG|ZYOgUGM{NUmLIHTl[5Ji\GG2aX;uxsBnem:vIE[gbC=> NVj5Vlk3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW5N|QzOzJpPkK1PVM1OjN{PD;hQi=>
U-87 MG  Mo\kSpVv[3Srb36gRZN{[Xl? MlX4NlDDqM7:TR?= NHfId4o3NzJ2IHi= NXvOXndocW6lcnXhd4V{KHSqZTDs[ZZmdHNib3[gUGM{NUmLIHPveJJm[XSnZDD3bZRpKEOT MX[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTl|NEKzNkc,OjV7M{SyN|I9N2F-
HepG2 MnfQSpVv[3Srb36gRZN{[Xl? NEPMWIkzOMLizszN MVi2M|I1KGh? MWHpcoNz\WG|ZYOgeIhmKGyndnXsd{Bw\iCOQ{OtTWkh[2:2cnXheIVlKHerdHigR3E> NGPud2o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUmzOFI{Oid-MkW5N|QzOzJ:L3G+
U-87 MG  MVXGeY5kfGmxbjDBd5NigQ>? NYTrPG4zOjEEoN88US=> M1H1clI1yqCq MWXpcoNz\WG|ZYOg[I92[mynLX3lcYJz[W6nIHLveY5lKHO2coXjeJVz\XN? NEDzOZQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUmzOFI{Oid-MkW5N|QzOzJ:L3G+
HepG2 M13uTGZ2dmO2aX;uJGF{e2G7 NWjHbW13OjEEoN88US=> MlT2NlTDqGh? MYfwdo9lfWOnczDhckBqdnSnboPlJIN6fG:ybHHzcYlkKH[jY4XvcIl7[XSrb36gZ49zemW|cH;u[Ilv\yC2bzDhJI5wfGGkbHWg[Ilt[XSjdHnvckBw\iC2aHWgSXIh[2m|dHXycpM> NI\CWG89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUmzOFI{Oid-MkW5N|QzOzJ:L3G+
T24 BC  M3zsXmFxd3C2b4Ppd{BCe3O|YYm= NULNSXZiOi53IN88US=> NH65UGMzPCCq MX3z[Y5{cXSrenXzJGJEKGOnbHzzJJRwKHOxcnHm[Y5q[i2rbnT1Z4VlKGGyb4D0c5Rq[8Li NX;WPHZlRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[wPVc5PzNpPkK2NFk4QDd|PD;hQi=>
T24 BC  M3:wfGNmdGxiVnnhZoltcXS7IFHzd4F6 MmXtNE42NzFxMj61JO69VQ>? MofMNlQhcA>? M{XNSYVvcGGwY3XzJJNwemGoZX7pZk1qdmS3Y3XkJINmdGxidnnhZoltcXS7IHTlZ5Jm[XOn MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjB7N{i3N{c,OjZyOUe4O|M9N2F-
T24 BC  M1nvc2Z2dmO2aX;uJGF{e2G7 M2jMbFAvPS9zL{KuOUDPxE1? NFy3bmk{KGh? NWPSSGtkemWmdXPld{B1cGViYnHzZYwhS0JidInyc5NqdmVicHjvd5Bpd3K7bHH0bY9vKGyndnXsd{BqdiCjIHTvd4Uu\GWyZX7k[Y51KG2jbn7ldi=> MkL1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZyOUe4O|MoRjJ4MEm3PFc{RC:jPh?=
RBL2H3 M13R[mZ2dmO2aX;uJIF{e2G7 NVvETo9mXG:6aXPpeJkhcW5icnH0JHJDVDKKMzDj[YxteyxiTWTEQVI2|ryP NGX1dGg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEG1N|U3PSd-MkCxOVM2PjV:L3G+
PC3 M{TlZWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MkHNS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gVGM{KGOnbHzzJIJ6KHO3bH\vdohw\GGvaX7lJGIh[XO|YYmsJGdKPTB;MD60OO69VQ>? MnnZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF3NEOxOFEoRjJzNUSzNVQyRC:jPh?=
NUGC3 MnLqS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? Mn\ES5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gUnVISzNiY3XscJMh[nlic4Xs[o9zcG:mYX3pcoUhSiCjc4PhfUwhT0l3ME2wMlU1|ryP NG\uSng9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUW0N|E1OSd-MkG1OFMyPDF:L3G+
HCT15 MlPrS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NFLLPXRIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBJS1RzNTDj[YxteyCkeTDzeYxnd3Kqb3ThcYlv\SCEIHHzd4F6NCCJSUWwQVEvOjYQvF2= Mn\tQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF3NEOxOFEoRjJzNUSzNVQyRC:jPh?=
MDA-MB-231 M4O1VWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NHHWNJJIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBOTEFvTVKtNlMyKGOnbHzzJIJ6KHO3bH\vdohw\GGvaX7lJGIh[XO|YYmsJGdKPTB;Mj64Ou69VQ>? MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTV2M{G0NUc,OjF3NEOxOFE9N2F-
NCI-H23 MYDHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M2jNeGdzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KMkOgZ4VtdHNiYomgd5Vt\m:{aH;kZY1qdmViQjDhd5NigSxiR1m1NF01NjJzzszN MWC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTV2M{G0NUc,OjF3NEOxOFE9N2F-
ACHN MkTLS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MUHHdo94fGhiaX7obYJqfGmxbjDv[kBpfW2jbjDBR2hPKGOnbHzzJIJ6KHO3bH\vdohw\GGvaX7lJGIh[XO|YYmsJGdKPTB;ND61Ou69VQ>? MlHMQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF3NEOxOFEoRjJzNUSzNVQyRC:jPh?=
A549 NILObm5HfW6ldHnvckBie3OjeR?= MUezNEBucW6| MlOwTY5pcWKrdHnvckBw\iCDa4SgdIhwe3Cqb4L5cIF1cW:wIHnuJIlve3WuaX6td5RqdXWuYYTl[EBpfW2jbjDBOVQ6KGOnbHzzJJRz\WG2ZXSgNkBpenNiYnXmc5JmKGmwc4XsbY4he3SrbYXsZZRqd25ibXXhd5Vz\WRiYX\0[ZIhOzBibXnud{BjgSCHTFnTRUwhUUN3ME21MlPPxE1? NID2cnY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkGzPFMxQSd-MkKxN|g{ODl:L3G+
A549 MoXjR5l1d3SxeHnjbZR6KGG|c3H5 NWLMdmxuOjRiaILz MVLDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDBOVQ6KGOnbHzzJIFnfGW{IEK0JIhzeyCkeTDGRWNUKGGwYXz5d4l{NCCLQ{WwQVfPxE1? MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjF|OEOwPUc,OjJzM{izNFk9N2F-
KATO III MWfDfZRwfG:6aXPpeJkh[XO|YYm= NF3rUm0zPCCqcoO= MYTDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDLRXRQKEmLSTDj[YxteyCjZoTldkAzPCCqcoOgZpkhTkGFUzDhcoFtgXOrczygTWM2OD1zMj64{txO NVnFfllXRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKxN|g{ODlpPkKyNVM5OzB7PD;hQi=>
MCF7 MlLTR5l1d3SxeHnjbZR6KGG|c3H5 Ml3oNlQhcHK| M4r6UGN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJG1ETjdiY3XscJMh[W[2ZYKgNlQhcHK|IHL5JGZCS1NiYX7hcJl{cXNuIFnDOVA:OTNwM988US=> NY\GW5A{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKxN|g{ODlpPkKyNVM5OzB7PD;hQi=>
PC3 NHHmNlJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NUHFNZZwT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hWEN|IHPlcIx{KGK7IGPSRkBie3OjeTygS2k2OD1yLkS0{txO NFzJV4k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{K2OlE5OSd-MkOyOlYyQDF:L3G+
NUGC3 MWPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M1jYbWdzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJG5WT0N|IHPlcIx{KGK7IGPSRkBie3OjeTygS2k2OD1yLkW0{txO NIfBXZI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{K2OlE5OSd-MkOyOlYyQDF:L3G+
HCT15 NYS5e2F5T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M1j4bGdzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJGhEXDF3IHPlcIx{KGK7IGPSRkBie3OjeTygS2k2OD1zLkK1{txO NHzo[m49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{K2OlE5OSd-MkOyOlYyQDF:L3G+
MDA-MB-231 Ml7mS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M171WWdzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJG1FSS2PQj2yN|Eh[2WubIOgZpkhW1KEIHHzd4F6NCCJSUWwQVIvQDcQvF2= M2X4fVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|Mk[2NVgyLz5{M{K2OlE5OTxxYU6=
NCI-H23 NFrMdVlIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M1qycmdzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KMkOgZ4VtdHNiYomgV3JDKGG|c3H5MEBIUTVyPUSuNlHPxE1? MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzJ4NkG4NUc,OjN{Nk[xPFE9N2F-
ACHN MoDhS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NFHoeFZIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBCS0iQIHPlcIx{KGK7IGPSRkBie3OjeTygS2k2OD12LkW2{txO NHLiTFM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{K2OlE5OSd-MkOyOlYyQDF:L3G+
A549 NVfGVVkzTnWwY4Tpc44h[XO|YYm= MlW5NkBpenN? MoXWTY5pcWKrdHnvckBw\iCDa4SgdIhwe3Cqb4L5cIF1cW:wIHnuJIh2dWGwIHnud5VtcW5vc4TpcZVt[XSnZDDBOVQ6KGOnbHzzJIlv[3WkYYTl[EBnd3JiMjDodpMheHKrb4KgeI8hcW6|dXzpck1qdmS3Y4Tpc44hdWWjc4Xy[YQh[W[2ZYKgN|AhdWmwczDifUBGVEmVQTygTWM2OD13LkROwG0> NG\VXYc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{SxOVA5Oyd-MkO0NVUxQDN:L3G+
A549 Mlz0R5l1d3SxeHnjbZR6KGG|c3H5 NFH1OoREgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCPTR7IHPlcIx{KGK7IH\sc5ch[3m2b33leJJq[yCjbnHsfZNqeyxiSVO1NF04|ryP NHfWOWk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{SxOVA5Oyd-MkO0NVUxQDN:L3G+
KATO III MVrDfZRwfG:6aXPpeJkh[XO|YYm= Mk\BR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gT2FVVyCLSVmgZ4VtdHNiYomg[oxwfyCleYTvcYV1emmlIHHuZYx6e2m|LDDJR|UxRTF{LklOwG0> MmXTQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN2MUWwPFMoRjJ|NEG1NFg{RC:jPh?=
MCF7 NHyxXZBEgXSxdH;4bYNqfHliYYPzZZk> NHzKSlhEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBOS0Z5IHPlcIx{KGK7IH\sc5ch[3m2b33leJJq[yCjbnHsfZNqeyxiSVO1NF0yOy5|zszN NGnwVnQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{SxOVA5Oyd-MkO0NVUxQDN:L3G+
PC3 NH\4PFhCdnSrcILvcIln\XKjdHn2[UBie3OjeR?= MlHGRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCSQ{OgZ4VtdHNiYomgV3JDKGG|c3H5MEBIUTVyPUCuOFTPxE1? MoXBQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN3Nke5OVAoRjJ|NU[3PVUxRC:jPh?=
NUGC3 MXfBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? MWXBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IHj1cYFvKE6XR1OzJINmdGy|IHL5JHNTSiCjc4PhfUwhT0l3ME2wMlU1|ryP NIXJXok9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{W2O|k2OCd-MkO1Olc6PTB:L3G+
HCT15 MVHBcpRqeHKxbHnm[ZJifGm4ZTDhd5NigQ>? Mo\uRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCKQ2SxOUBk\WyuczDifUBUWkJiYYPzZZktKEeLNUC9NU4zPc7:TR?= NUXqVY8zRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO1Olc6PTBpPkKzOVY4QTVyPD;hQi=>
MDA-MB-231 NXvFc2NbSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= Mm\ERY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPRFGtUWIuOjNzIHPlcIx{KGK7IGPSRkBie3OjeTygS2k2OD1{Lki2{txO MkHkQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN3Nke5OVAoRjJ|NU[3PVUxRC:jPh?=
NCI-H23 NUHMXYx5SW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= MkW4RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCQQ1mtTFI{KGOnbHzzJIJ6KFOUQjDhd5NigSxiR1m1NF01NjJzzszN NEPFT449[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{W2O|k2OCd-MkO1Olc6PTB:L3G+
ACHN NVztdnpqSW62aYDyc4xq\mW{YYTpeoUh[XO|YYm= M3XiVmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iQVPIUkBk\WyuczDifUBUWkJiYYPzZZktKEeLNUC9OE42Ps7:TR?= Mm\pQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN3Nke5OVAoRjJ|NU[3PVUxRC:jPh?=
PC3 NX;FVXpYT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M4PHZ|Q5KGi{cx?= Ml6xS5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gVGM{KGOnbHzzJIFnfGW{IES4JIhzeyCkeTDTVmIh[XO|YYmsJGdKPTB;MD60OO69VQ>? MWe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDB7NUe1PUc,OjRyOUW3OVk9N2F-
NUGC3 MV\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M37zVlQ5KGi{cx?= MmX3S5Jwf3SqIHnubIljcXSrb36gc4YhcHWvYX6gUnVISzNiY3XscJMh[W[2ZYKgOFghcHK|IHL5JHNTSiCjc4PhfUwhT0l3ME2wMlU1|ryP MoTPQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjRyOUW3OVkoRjJ2MEm1O|U6RC:jPh?=
HCT15 NH;0TZNIem:5dHigbY5pcWKrdHnvckBie3OjeR?= Mny5OFghcHK| NVHrc2RiT3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hUEOWMUWgZ4VtdHNiYX\0[ZIhPDhiaILzJIJ6KFOUQjDhd5NigSxiR1m1NF0yNjJ3zszN NFzu[Gg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEC5OVc2QSd-MkSwPVU4PTl:L3G+
MDA-MB-231 NHPiZndIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MU[0PEBpenN? M17Odmdzd3e2aDDpcohq[mm2aX;uJI9nKGi3bXHuJG1FSS2PQj2yN|Eh[2WubIOgZYZ1\XJiNEigbJJ{KGK7IGPSRkBie3OjeTygS2k2OD1{Lki2{txO NX:0fZB6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSwPVU4PTlpPkK0NFk2PzV7PD;hQi=>
NCI-H23 MVHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MWS0PEBpenN? NYmydIR4T3Kxd4ToJIlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLViyN{Bk\WyuczDh[pRmeiB2ODDodpMh[nliU2LCJIF{e2G7LDDHTVUxRTRwMkJOwG0> MorrQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjRyOUW3OVkoRjJ2MEm1O|U6RC:jPh?=
ACHN NVTvUGpQT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NXfJZWhXPDhiaILz NIPrfoRIem:5dHigbY5pcWKrdHnvckBw\iCqdX3hckBCS0iQIHPlcIx{KGGodHXyJFQ5KGi{czDifUBUWkJiYYPzZZktKEeLNUC9OE42Ps7:TR?= NXvpcZd{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSwPVU4PTlpPkK0NFk2PzV7PD;hQi=>
A549 NUHXd4NvS3m2b4TvfIlkcXS7IHHzd4F6 NFPkTXozPCC2bzC3NkBpenN? NG\HZmdEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBCPTR7IHPlcIx{KGGodHXyJFI1KHSxIEeyJIhzeyCkeTDoZYVud2O7dH;t[ZRzgSxiSVO1NF01NjF5zszN M3rVTVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OUCwOlIxLz5{NEmwNFYzODxxYU6=
Rosetta cells MUfGeY5kfGmxbjDhd5NigQ>? MX3Jcohq[mm2aX;uJI9nKHerbHSteJlx\SCqdX3hckBROzijbIDoZUBOSVCNIHX4dJJme3OnZDDpckBGe2OqZYLpZ4hq[SClb3zpJHJwe2W2dHGgZ4VtdHNuIFnDOVA:OS5{zszN NVTPUnlbRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{GyO|Q{OTZpPkOxNlc1OzF4PD;hQi=>

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
p-PDK1 / p-GSK3α/β / p-S6R ; 

PubMed: 17761832     


BCWM.1 cells were cultured with perifosine for 6 hours with doses that ranged from 2 to 20 μM. Whole cell lysates were subjecting to Western blotting using anti–p-Akt ser473, -Akt, –p-PDK1, –p-GSK3α/β, –p-S6R, and α-tubulin antibodies.

p-mTOR / mTOR / Raptor / Rictor / p-p70S6K / p70S6K / p-4EBP1 / 4EBP1 / c-Myc / Cyclin D1; 

PubMed: 19920197     


The indicated cell lines were treated with the given concentrations of perifosine (PRFS) for 8 h.

PARP; 

PubMed: 25519148     


Perifosine induces apoptosis. RMG1 and RMG2 cells were treated with or without 30 μM perifosine for 24 h. Cells were harvested, and the effect of perifosine was evaluated by western blotting

p-AKT / AKT / p-S6K1 / S6K1 ; 

PubMed: 25519148     


The effect of perifosine on AKT-mTOR activation in vitro. RMG1 and RMG2 cells were treated with 0, 3, 10, 30 or 50 μM perifosine for 6 h in the presence of 10% FBS. Cells were harvested, and equivalent amounts (30 μg) of protein were subjected to SDS-PAGE and blotted with anti-phospho-AKT (Ser473), anti-AKT, anti-phospho-S6K1 (Thr389), anti-S6K1, or anti-β-actin antibodies.

17761832 19920197 25519148
Growth inhibition assay
Cell viability; 

PubMed: 28332584     


Cell survival measured by MTT assay and IC50 of perifosine in a panel of eleven human cancer cells.

28332584
In vivo Perifosine combining with temozolomide reduces tumor proliferation (a PDGF-driven gliomagenesis) in vivo. The results indicate that Perifosine is an effective drug in gliomas in which Akt and Ras-Erk 1/2 pathways are frequently activated, and may be new candidate for glima treatment in the clinic. [2] Both oral daily and weekly administration of Perifosine significantly reduce human MM tumor growth and increase survival, compared with control animals treated with PBS vehicle only. [3] Perifosine induces thrombocytosis and leukocytosis and increases myelopoiesis in murine marrow and spleen, whereas it causes apoptosis in myeloma xenografts. [5]

Protocol

Kinase Assay:[3]
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Akt kinase assay:

MM.1S cells are cultured in the presence or absence of perifosine (5 μM, 6 hours) and then stimulated with IL-6 (20 ng/mL, 10 minutes). In vitro akt kinase assay is then carried out using the Akt Kinase Assay Kit.
Cell Research:[2]
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  • Cell lines: Human glioma cell lines
  • Concentrations: 0, 15, 30 and 45 μM
  • Incubation Time: 48 hours
  • Method: Cells are incubated in the medium with 10% FCS for 48 hours with indicated concentration of Periosine. Cell viability is determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. (Cell Proliferation Kit I; Roche). The absorbance at 590 nm is recorded using the 96-well plate reader.
    (Only for Reference)
Animal Research:[3]
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  • Animal Models: MM.1S MM cells are inoculated subcutaneously in the right flank of Beige-nude-xid (BNX) mice (5 to 6 weeks old).
  • Dosages: 250 mg/kg/wk or 36 mg/kg/d
  • Administration: Oral gavage
    (Only for Reference)

Solubility (25°C)

In vitro Water 8 mg/mL (17.32 mM)
DMSO Insoluble
Ethanol '15 mg/mL
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
water
For best results, use promptly after mixing.
8mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 461.66
Formula

C25H52NO4P

CAS No. 157716-52-4
Storage powder
in solvent
Synonyms NSC639966, D21266
Smiles CCCCCCCCCCCCCCCCCCOP(=O)([O-])OC1CC[N+](CC1)(C)C

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
Step 2: Enter the in vivo formulation ()
% DMSO % % Tween 80 % ddH2O
CalculateReset

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and SDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT01224730 Completed Drug: perifosine Cancer AEterna Zentaris January 24 2012 Phase 1
NCT01049841 Completed Drug: perifosine + temsirolimus Pediatric Solid Tumors Memorial Sloan Kettering Cancer Center|University of Wisconsin Madison|Duke University|NATL COMP CA NETWORK|Pfizer|AEterna Zentaris January 2010 Phase 1
NCT01048580 Completed Drug: Perifosine|Drug: Capecitabine Colon Cancer AEterna Zentaris|SCRI Development Innovations LLC October 2009 Phase 1
NCT00776867 Completed Drug: perifosine Solid Tumors Memorial Sloan Kettering Cancer Center|University of Wisconsin Madison|Duke University|AEterna Zentaris October 2008 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID