Bacterial

Choose Selective Bacterial Inhibitors

Bacterial Products

  • All (223)
  • Bacterial Inhibitors (48)
  • New Bacterial Products
Catalog No. Product Name Information Product Use Citations Product Validations
E0010New Hypocrellin A Hypocrellin A (HA) is a perylenequinone isolated from Shiraia bambusicola that shows antiviral, antimicrobial and anticancer activity through mediating multiple signaling pathways. Hypocrellin A also is a selective and potent inhibitor of PKC.
E0052New Merafloxacin Merafloxacin (CI-934) is a fluoroquinolone antibacterial thats inhibit -1 frameshifting efficiency of SARS-CoV-2 and other betacoronaviruses.
E0365New Fucoidan

Fucoidan is an anionic sulfated polysaccharide extracted from marine brown algae with a large range of biological activities, including anti-inflammatory, anti-cancer, anti-viral, anti-oxidation, anticoagulant, antithrombotic, anti-angiogenic and anti-Helicobacter pylori, etc.

S0147 KKL-10 KKL-10 is an inhibitor of ribosome rescue that exhibits exceptional broad-spectrum antimicrobial activity against bacteria.
S0195 Walrycin B Walrycin B is an antibacterial compound and a potent inhibitor of WalR targeting the WalR response regulator.
S1162 Pretomanid (PA-824) PA-824 is an anti-tuberculosis drug for tuberculosis with MIC less than 2.8 μM.Phase 2.
S1618 Sulfameter Sulfameter is a long-acting sulfonamide antibacterial.
S1677 Chloramphenicol Chloramphenicol (Chloromycetin) is a bacteriostatic by inhibiting protein synthesis.
EMBO Rep, 2021, e53081
Cell Rep, 2021, 34(3):108631
Oncotarget, 2018, 9(40):26086-26095
S1685 Sulfanilamide Sulfanilamide (Sulphanilamide) is a competitive inhibitor for bacterial enzyme dihydropteroate synthetase with IC50 of 320 μM.
S1762 Pyrazinamide Pyrazinamide (Pyrazinoic Acid Amide) is an agent used to treat tuberculosis.
S1791 Bacitracin Zinc Bacitracin is an antibiotic that interferes with the dephosphorylation of C55-isoprenyl pyrophosphate, a membrane carrier molecule that transports the building-blocks of the peptidoglycan bacterial cell wall outside of the inner membrane. It inhibits cleavage of Tyr from Met-enkephalin with IC50 of 10 μM.
S1881 Protionamide Protionamide (Prothionamide, 1321-TH) is a drug used in the treatment of tuberculosis.
Mol Imaging Biol, 2021, 10.1007/s11307-021-01689-8
S2457 Clindamycin HCl Clindamycin HCl inhibits protein synthesis by acting on the 50S ribosomal, used for the treatment of bacterial infections.
Proc Natl Acad Sci U S A, 2016, 113(50):14408-14413
S2830 Clindamycin Clindamycin inhibits protein synthesis by acting on the 50S ribosomal, used for the treatment of bacterial infections.
S2908 Hygromycin B Hygromycin B (Hygrovetine), a selective antibiotic that is effective on most bacteria, fungi and higher eukaryotes, inhibits protein synthesis by interfering with translocation and causing mistranslation at the 70S ribosome.
Autophagy, 2021, 1-17
PLoS Pathog, 2021, 17(4):e1009530
Cell Res, 2020,
S3021 Rimonabant (SR141716) Rimonabant (SR141716) is a selective antagonist of CB1 with IC50 of 13.6 nM and EC50 of 17.3 nM in hCB1 transfected HEK 293 membrane. Rimonabant is also a dual inhibitor of acyl CoA:cholesterol acyltransferases(ACAT) 1 and 2 and inhibits mycobacterial MmpL3.
Nat Commun, 2020, 11(1):5962
Sci Rep, 2020, 10(1):15556
Microbiol Immunol, 2020, 10.1111/1348-0421.12777
S3295 Taxifolin 7-rhamnoside Taxifolin 7-rhamnoside (TR, Taxifolin 7-O-rhamnoside, Taxifolin 7-O-α-L-rhamnoside), a flavonoid isolated from Hypericum japonicum, shows antibacterial activity against clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA).
S3496 Lefamulin acetate (Xenleta) Lefamulin acetate (Xenleta, BC-3781 acetate) is a pleuromutilin antibiotic for community-acquired bacterial pneumonia (CABP) treatment. Lefamulin acetate inhibits protein synthesis by binding to the peptidyl transferase center of the 50S bacterial ribosome, thus preventing the binding of transfer RNA for peptide transfer.
S3499New Monocaprylin Monocaprylin (2,3-dihydroxypropyl octanoate, Monoctanoin, 1-Octanoyl-rac-glycerol, MC) exhibits an excellent antibacterial activity against Staphylococcus aureus and Escherichia coli.
S3710 Fosfomycin calcium Fosfomycin (phosphomycin, phosphonomycin) is bactericidal and inhibits bacterial cell wall biogenesis by inactivating the enzyme UDP-N-acetylglucosamine-3-enolpyruvyltransferase, also known as MurA. It enters the bacterial cell through the glycerophosphate transporter.
S4105 Closantel Sodium Closantel is a gram positive antibacterial activity inhibitor, inhibiting the KinA/Spo0F system with IC50 of 3.8 μM.
S4106 Closantel Closantel (R-31520) is a gram positive antibacterial activity inhibitor, inhibiting the KinA/Spo0F system with IC50 of 3.8 μM.
S4198 Aminothiazole Aminothiazole can be used as a thyroid inhibitor and it has antibacterial activity.
J Electroanal Chem (Lausanne), 2020, 878:114733
S4307 Auranofin Auranofin (Ridaura, SKF-39162) is an inhibitor of thioredoxin reductase (TrxR) with IC50 of 88 nM for purified H. pylori TrxR in cell-free assay. Auranofin has anti-cancer activity and can completely inhibit bacterial growth at 1.2 μM. Auranofin is an FDA-approved gold-containing compound used for the treatment of rheumatoid arthritis.
Oncotarget, 2018,
S4404 Pasiniazid Pasiniazid is a composition of isoniazid and 4-aminosalicylic acid, used to treat tuberculosis patients.
S4425New Rifamycin S Rifamycin S, a quinone and an antibiotic against Gram-positive bacteria (including MRSA), is a clinical drug used to treat tuberculosis and leprosy. Rifamycin S generates reactive oxygen species (ROS) and inhibits microsomal lipid peroxidation.
S4436New Pleuromutilin Pleuromutilin (Drosophilin B, Mutilin 14-glycolate), the lead compound for novel antibiotics, inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit of bacteria.
S4490New Tetracycline Tetracycline (TC) is a broad-spectrum antibiotic that exhibits activity against a wide range of microorganisms including gram-positive and gram-negative bacteria, chlamydiae, mycoplasmas, rickettsiae, and protozoan parasites.
S4602 Acetohydroxamic acid Acetohydroxamic acid (N-Hydroxyacetamide, Methylhydroxamic acid, Acetic acid|oxime, Lithostat) is an Urease Inhibitor. In the urine, it acts as an antagonist of the bacterial enzyme urease.
S4647 Cefmenoxime hydrochloride Cefmenoxime (SCE-1365), a potent inhibitor of Enterobacteriaceae, is a cephalosporin antibiotic that is administered intravenously or intramuscularly.
S4780 7-Methoxy-4-methylcoumarin 7-Methoxy-4-methylcoumarin is a coumarin derivative and fluorescent label. 7-Methoxy-4-methylcoumarin has an antimicrobial activitiy against both gram positive and gram negative bacterial stains. 4-Methylherniarin displays good activity against B. subtilis and S.sonnei with IC50 of 11.76 μg/ml and 13.47 μg/ml, respectively.
S4854 Bedaquiline fumarate Bedaquiline fumarate (TMC-207), an oral diarylquinoline, is a bactericidal antimycobacterial drug. It is a proton-translocating ATP synthetase inhibitor.
S4861 Oxindole Oxindole (2-indolone, 2-Oxindole, Indolin-2-one) is an aromatic heterocyclic organic compound which causes sedation, muscle weakness, hypotension, and coma when dosed in excess. Oxindole has anti-cancer, anti-HIV, anti-diabetic, antibacterial and other pharmacological activities.
S4983 Sorbic acid Sorbic acid (2,4-Hexadienoic acid) is a naturally occurring compound that originated from the unripe berries of the Rowan Tree. It inhibits various bacteria, including sporeformers, at various stages of their life cycle (germination, outgrowth and cell division).
S5008New Ciprofloxacin hydrochloride Ciprofloxacin (CPX, Cetraxal, Ciloxan, Cipro, Bay-09867) hydrochloride, a fluorinated quinolone, is a β-diketone antibiotic with a broad spectrum antibacterial activity. Ciprofloxacin is an inhibitor of bacterial DNA gyrase (a subclass of Type II topoisomerases).
S5166 Benzoyleneurea Benzoyleneurea (2,4-Dihydroxyquinazoline, Quinazolinedione, Quinazoline-2,4-diol) scaffold is used in the synthesis of novel protein geranylgeranyltransferase-I inhibitors. Benzoyleneurea possesses anti-bacterial activity.
S5186New Cefpiramide Cefpiramide (Cefpiramide acid, Cefpiramido, Cefpiramidum, WY-44635, SM-1652) is a pseudomonas-active cephalosporin with a broad spectrum of antibacterial activity.
S5199New Oxytetracycline hydrochloride Oxytetracycline (OTC, Oxycycin, Stevacin, Terramycin) hydrochloride is a prescription antibiotic, interfering with the ability of bacteria to produce essential proteins.
Front Microbiol, 2016, 7:1765
S5201 Acetylisovaleryltylosin Tartrate Acetylisovaleryltylosin tartrate (AK105039) is an antimicrobial of the macrolide group with antibacterial activity against Gram-positive bacteria.
S5495New Ceftiofur sodium Ceftiofur sodium is a semisynthetic, beta-lactamase-stable, broad-spectrum cephalosporin with antibacterial activity.
S6090New JFD01307SC JFD01307SC ([(1,1-dioxidotetrahydrothien-3-yl)amino]acetic acid) shows activity against M.tuberculosis with minimum inhibitory concentrations (MICs) in the range of 8 to 16 µg/ml. JFD01307SC may targets enzymes involved in glutamine biosynthesis.
S6464 Ftaxilide Ftaxilide is a novel antituberculosis agent.
S6549 PBTZ169 PBTZ169 (macozinone), an antibiotic with antimycobacterial activity, is an irreversible inhibitor of DprE1.
Cell Death Dis, 2019, 10(4):319
S6584New Amdinocillin Amdinocillin (Mecillinam, Coactin, FL 1060) is a β-lactam antibiotic with a broad spectrum of antibacterial activity. Amdinocillin is active alone against many gram-negative organisms.
S6867 Glyceryl monocaprate (Monocaprin) Monocaprin (Glyceryl caprate) is a 1-monoglyceride of capric acid that has antimicrobial activity against enveloped viruses, certain bacteria, and the yeast Candida albicans.
S7550 Erythromycin Cyclocarbonate Erythromycin Cyclocarbonate, derivative of Erythromycin, inhibits protein synthesis of bacteria by binding to the 50S ribosome.
S7739 Telacebec (Q203) Telacebec (Q203, IAP6) is a novel antituberculosis drug that targets Mycobacterium tuberculosis cellular energy production through inhibition of the mycobacterial cytochrome bc1 complex. Telacebec (Q203, IAP6) is active against Mycobacterium tuberculosis H37Rv with MIC50 of 2.7 nM in culture broth medium.
S9226 Steviolbioside Steviolbioside (CCRIS-6025), a natural sweetener, exhibits moderate antituberculosis activity against M. tuberculosis strain H37RV in vitro.
S0906 6-Methoxydihydroavicine 6-Methoxydihydroavicine (6-Methoxy Dihydrosanguinarine), an lkaloid isolated from the fruits of M.cordata, exhibits antibacterial, insecticidal and anti-tumor activities.
S1097 BTZ043 Racemate BTZ043 racemate is a decaprenylphosphoryl-β-D-ribose 2'-epimerase (DprE1) inhibitor acting as a new antimycobacterial agent that kill Mycobacterium tuberculosis.
Drug Deliv Transl Res, 2021, 11(4):1766-1778
J Med Chem, 2020, 28;63(10):5367-5386
Biochem Pharmacol, 2019, 162:41-54
S1370 Biapenem Biapenem (L-627, LJC10627) is a carbapenem antibiotic with activity against both Gram-positive and Gram-negative bacterial strains.
S1373 Daptomycin (LY146032) Daptomycin (LY146032) is a novel antibiotic with rapid in vitro bactericidal activity against gram-positive organisms.
J Phys Chem B, 2021, 125(22):5775-5785
Sci Adv, 2020, 6(34):eaba8968
Front Microbiol, 2020, 21;11:646
S1399 Teicoplanin Teicoplanin (Teichomycin) is a glycopeptide antibiotic, used to treat serious infections caused by Gram-positive bacteria.
ACS Appl Mater Interfaces, 2020, 12(14):16150-16158
Clin Exp Dent Res, 2016, 2(1):35-43
S1403 Tigecycline (GAR-936) Tigecycline (GAR-936) is bacteriostatic and is a protein synthesis inhibitor by binding to the 30S ribosomal subunit of bacteria and thereby blocking entry of Aminoacyl-tRNA into the A site of the ribosome during prokaryotic translation. Tigecycline induces autophagy by downregulating the PI3K-AKT-mTOR pathway.
iScience, 2021, 24(11):103350
Biomolecules, 2020, 10(10)E1395
Aging (Albany NY), 2020, 12(12):11364-11385
S1502 Cephalexin Cephalexin (Cefalexin) is an antibiotic that can treat a number of bacterial infections.
Clin Cancer Res, 2018, 24(3):659-673
Theranostics, 2017, 7(7):2092-2107
Blood Cancer J, 2017, 10.1038/bcj.2017.61
S1505 Aztreonam Aztreonam (SQ 26776) is a synthetic monocyclic beta-lactam antibiotic, used to treat Gram-negative aerobic bacteria infection.
PLoS Pathog, 2016, 12(10):e1005932
Expert Opinion on Orphan Drugs, 2013, 1(7):549-556
S1605 Cefdinir Cefdinir (FK 482, PD 134393, CI-983) is an oral cephalosporin antibiotic, used to treat bacterial infections in many different parts of the body.
S1617 Sulfapyridine Sulfapyridine is a sulfonamide antibacterial.
S1741 Rifabutin (LM427) Rifabutin (LM427, Ansamycin) is a semisynthetic ansamycin antibiotic, used in the treatment of Mycobacterium avium intracellulare (MAI) and tuberculosis.
Antibiotics (Basel), 2020, 9(2)
Antimicrob Agents Chemother, 2020, AAC.00363-20
S1768 Cefditoren Pivoxil Cefditoren Pivoxil (ME-1207) is a broad-spectrum antibiotic against Gram-negative and Gram-positive bacteria.
S1773 Oxytetracycline (Terramycin) Oxytetracycline is a broad-spectrum tetracycline antibiotic, used to treat infections with bacteria.
Sci Rep, 2018, 8(1):7653
Front Microbiol, 2016, 7: 1765
S1835 Azithromycin (CP-62993) Azithromycin (CP-62993, XZ-450) is an antibiotic by inhibiting protein synthesis, used for the treatment of bacterial infections.
Hum Cell, 2021, 10.1007/s13577-021-00579-z
Hum Cell, 2021, 10.1007/s13577-021-00639-4
Biomolecules, 2020, 10(10)E1395
S1839 Chloroxine Chloroxine is a synthetic antibacterial compound that is effective in the treatment of dandruff and seborrheic dermatitis when incorporated in a shampoo.
Hum Mol Genet, 2020, ddaa244
Front Microbiol, 2020, 10:2936
S1855 Pefloxacin Mesylate Pefloxacin Mesylate is a synthetic chemotherapeutic agent and an antibacterial agent with IC50 of 6.7 nM.
J Biol Chem, 2019, 294(49):18624-18638
S1884 Sparfloxacin Sparfloxacin (AT-4140, CI-978, PD 131501) is a fluoroquinolone antibiotic, shows broad and potent antibacterial activity.
S1915 Sulfamethoxazole Sulfamethoxazole is a sulfonamide bacteriostatic antibiotic with an IC50 of 2.7 μM.
S1916 Sulfisoxazole Sulfisoxazole (NU-445) is a sulfonamide antibacterial with an oxazole substituent.
S1957 Sulfamethizole Sulfamethizole is a sulfathiazole antibacterial agent.
S2052 Oxytetracycline Dihydrate Oxytetracycline Dihydrate is a prescription antibiotic, interfering with the ability of bacteria to produce essential proteins.
Front Microbiol, 2016, 7:1765
S2335 Oridonin (NSC-250682) Oridonin (Isodonol, Rubescenin, NSC-250682), a diterpenoid purified from Rabdosia rubescens, is a traditional agent with antitumor, anti-bacterial and anti-inflammatory effects. Oridonin inhibits AKT1 and AKT2 kinase activity with IC50 of 8.4 μM and 8.9 μM, respectively.
Int Immunopharmacol, 2022, 102:108387
J Exp Med, 2021, 218(9)e20202637
J Nat Prod, 2021, 10.1021/acs.jnatprod.0c01231
S2385 Hordenine Hordenine (N,N-dimethyl-4-hydroxyphenylethylamine) is a phenylethylamine alkaloid with antibacterial and antibiotic properties.
S2420 Aloperine Aloperine is an isolated alkaloid in sophora plants such as Sophora alopecuroides L, and exhibits anti-inflammatory, antibacterial, antiviral, and anti-tumor properties.
Cancer Cell Int, 2021, 21(1):662
Tissue Cell, 2021, 74:101706
J Cancer Res Clin Oncol, 2020, 10.1007/s00432-020-03157-2
S2543 Ceftiofur HCl Ceftiofur HCl (U-67279A) is a cephalosporin antibiotic, used to treat both Gram-positive and Gram-negative bacteria infection.
S2544 Cefprozil hydrate Cefprozil hydrate is a semi-synthetic broad-spectrum cephalosporin antibiotic, used to treat certain infections caused by bacteria, such as bronchitis and infections of the ears, throat, sinuses, and skin.
S2563 Oxacillin sodium monohydrate Oxacillin sodium monohydrate (Methicillin) is an antibacterial agent and is a narrow spectrum beta-lactam antibiotic of the penicillin class.
S2565 Amoxicillin Sodium Amoxicillin Sodium (Clavulanate) is a moderate- spectrum, bacteriolytic, β-lactam antibiotic.
PLoS Comput Biol, 2020, 16(12):e1008489
Toxicol Appl Pharmacol, 2015, 285(1):51-60
S2568 Neomycin sulfate Neomycin sulfate is an aminoglycoside antibiotic, used to treat bacteria infections.
Mol Cell, 2020, 22 pii: S1097-2765(20)30231-8
S2575 Vancomycin HCl Vancomycin HCl is a hydrochloride of vancomycin that is a narrow-spectrum glycopeptide antibacterial agent.
Elife, 2021, 10e64237
Gut Microbes, 2020, 12(1):1-20
Oncotarget, 2018, 9(40):26086-26095
S3015 Amoxicillin Amoxicillin (Amoxycillin) is a moderate-spectrum, bacteriolytic, β-lactam antibiotic used to treat bacterial infections caused by susceptible microorganisms.
PLoS Comput Biol, 2020, 16(12):e1008489
Toxicol Appl Pharmacol, 2015, 285(1):51-60
S3058 Danofloxacin Mesylate Danofloxacin (CP-76136-27) is a fluoroquinolone antibacterial for veterinary use, with MIC90 of 0.28 μM.
S3065 Amikacin disulfate Amikacin sulfate (BB-K8) binds to 16S rRNA (bacterial 30S ribosome), causing misreading of mRNA and supressing proteins synthesis.
S3121 Ornidazole Ornidazole (Ro7-0207, NSC 95075) is a 5-nitroimidazole derivative with antiprotozoal and antibacterial properties against anaerobic bacteria.
S3122 Amikacin hydrate Amikacin is an aminoglycoside antibiotic used to treat different types of bacterial infections.
Molecules, 2019, 25(1)
S3129 Trimethoprim Trimethoprim (BW 56-72, NIH 204, NSC-106568) is a bacteriostatic antibiotic mainly used in the prophylaxis and treatment of urinary tract infections.
S3132 Sulfamerazine Sulfamerazine (RP 2632) is a sulfonamide antibacterial.
S3133 Sulfamethazine Sulfamethazine is a sulfonamide antibacterial.
S3179 Carbenicillin disodium Carbenicillin (BRL-2064) is a semi-synthetic penicillin antibiotic which interferes with cell wall synthesis of gram-negative bacteria while displaying low toxicity.
S3193 Ticarcillin sodium Ticarcillin (AB 2288, BRL 2288) is a semisynthetic antibiotic with a broad spectrum of bactericidal activity against many gram-positive and gram-negative aerobic and anaerobic bacteria.
S3195 Azlocillin sodium salt Azlocillin is an acylampicillin with a broad spectrum against bacteria.
S3280 Linderene Linderene (Lindenenol) is a furanosesquiterpenoid isolated from Lindera pulcherrima with antibacterial and antioxidant activities.
S3350 Cholesteryl linoleate

Cholesteryl linoleate is less polar lipid in human nasal fluid that contributes to the inherent antibacterial activity.

S3621 Pazufloxacin mesylate Pazufloxacin Mesylate (T-3762, Pazucross), also known as Pazucross and T-3762, is a quinolone antibacterial agent used for the intravenous therapy of several infections.
S3623 Ceftibuten dihydrate Ceftibuten Dihydrate is the dihydrate form of ceftibuten, a semisynthetic, beta-lactamase-stable, third-generation cephalosporin with antibacterial activity.
S3636 Cefadroxil hydrate Cefadroxil is a broad-spectrum antibiotic of the cephalosporin type, effective in Gram-positive and Gram-negative bacterial infections.
S3637 Cefpirome sulfate Cefpirome is a fourth-generation cephalosporin and is considered highly active against Gram-negative bacteria.
S3638 Cefamandole nafate Cefamandole Nafate is the sodium salt form of cefamandole formyl ester. Cefamandole binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall, interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.
S3644 Sulfamonomethoxine Sulfamonomethoxine is a long-acting sulfonamide antibacterial agent and blocks the synthesis of folic acid by inhibiting synthetase of dihydropteroate.
S3650 Penicillin V potassium salt Phenoxymethylpenicillin, also known as penicillin V, is an antibiotic useful for the treatment of a number of bacterial infections. It acts by inhibiting the biosynthesis of cell-wall peptidoglycan.
S3655 Cefepime Dihydrochloride Monohydrate Cefepime is a cephalosporin antibacterial drug used to treat pneumonia, urinary tract, skin, and intra-abdominal infections.
ACS Chem Neurosci, 2021, 10.1021/acschemneuro.1c00608
S3672 Cefonicid sodium Cefonicid sodium (Monocid) is a cephalosporin antibiotic. It interferes with cell wall biosynthesis in bacteria, leading to lysis of the infectious organism.
S3708 Sulfachloropyridazine Sulfachloropyridazine is an antibiotic used to treat a variety of bacterial infections.
S3709 Furagin Furagin (NF-416, F-35, Akritoin, Furazidin, Furazidine) is 2-substituted 5-nitrofuran, chemically and structurally similar to well-known antibacterial compound nitrofurantoin with antimicrobial activities.
S4004 Ethambutol 2HCl Ethambutol 2HCl (CL40881) is a bacteriostatic antimycobacterial agent, which obstructs the formation of cell wall by inhibiting arabinosyl transferases.
Molecules, 2019, 25(1)
S4029 Colistin Sulfate Colistin (Polymixin E) is a cyclic cationic decapeptide linked to a fatty acid side chain, it belongs to a group of similarly structured bacterial antimicrobial peptides.
Front Pharmacol, 2021, 12:744494
Biogerontology, 2016, 17(5-6):907-920
S4060 Erythromycin Ethylsuccinate Erythromycin Ethylsuccinate, an oral macrolide antibiotic produced by Streptomyces erythreus, reversibly binds to the 50S ribosome of bacteria, and inhibits protein synthesis.
S4093 Bismuth Subcitrate Potassium Bismuth Subcitrate is an antibiotic used to treat stomach ulcers associated with Helicobacter pylori, a bacterial infection.
J Clin Invest, 2020, 130(7):3901-3918
S4146 Bacitracin Bacitracin is a mixture of related cyclic polypeptides produced by organisms of the licheniformis group of Bacillus subtilis var Tracy, which disrupts both gram positive and gram negative bacteria by interfering with cell wall and peptidoglycan synthesis.
Onco Targets Ther, 2020, 13:9543-9558
Anal Chem, 2017, 89(16):8501-8508
Chem Res Toxicol, 2017, 30(10):1804-1814
S4148 Ampicillin Trihydrate Ampicillin Trihydrate (NCI-C56086) is a β-lactam antibiotic, which inhibits bacterial cell-wall synthesis (peptidoglycan cross-linking) by inactivating transpeptidases on the inner surface of the bacterial cell membrane.
Bone Joint Res, 2020, 16;9(4):152-161
S4179 Mezlocillin Sodium Mezlocillin sodium is a penicillin beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive, organisms.
S4201 Florfenicol Florfenicol (SCH-25298) is a fluorinated synthetic analog of thiamphenicol with broad-spectrum, primarily bacteriostatic activity.
S4203 Furaltadone HCl Furaltadone HCl is an antibacterial and has distinct curative effect in the treatment of coccidiosis.
Eur J Pharmacol, 2018, 828:119-125
S4213 Dirithromycin Dirithromycin (LY-237216, ASE 136) is a macrolide glycopeptide antibiotic by binding to the 50S subunit of the 70S bacterial ribosome to inhibit the translocation of peptides.
S4216 Valnemulin HCl Valnemulin HCl is a broad-spectrum bacteriostatic agent inhibiting protein synthesis in bacteria by binding to the peptidyl transferase component of the 50S subunit of ribosomes.
S4271 Isepamicin Sulphate Isepamicin Sulphate (Isepamicine, Isepamycin, sch21420) is an aminoglycoside antibiotic, which inhibits bacterial protein synthesis by targeting the bacterial 30S ribosomal subunit.
S4279 Demeclocycline HCl Demeclocycline HCl is a tetracycline antibiotic via inhibition of protein synthesis by bacteria, used for the treatment of bacterial infections.
J Biol Chem, 2020, 10.1074/jbc.RA119.011633.
Sci Rep, 2018, 8(1):7653
S4393 Cephapirin Sodium Cephapirin Sodium (Cefapirin) is the sodium salt form of cephapirin, a semi-synthetic, first-generation cephalosporin antibiotic with bactericidal activity.Cephapirin Sodium is effective against gram-negative and gram-positive organisms.
S4408 Procodazole Procodazole (Propazol, 2-Benzimidazolepropionic acid, 3-(1H-benzimidazole-2) propanoic acid) is used as a potentiator which is non-specific active immunoprotective against viral and bacterial infections.
S4517 Cefotaxime sodium Cefotaxime sodium salt is a third-generation cephalosporin antibiotic; broad-spectrum antibiotic with activity against numerous Gram-positive and Gram-negative bacteria.
S4518 Chloroxylenol Chloroxylenol is a broad-spectrum antimicrobial chemical compound used to control bacteria, algae, fungi and virus.
S4522 Dehydroacetic acid Dehydroacetic acid (Biocide 470F, Methylacetopyronone) is an organic compound, used mostly as a fungicide and bactericide.
S4523 Dihydrostreptomycin sulfate Dihydrostreptomycin sulfate is an aminoglycoside antibiotic, used to treat bacterial diseases in cattle, pigs and sheep. Dihydrostreptomycin is a derivative of streptomycin.
S4528 Furazolidone Furazolidone is a synthetic nitrofuran derivative with bactericidal or bacteriostatic activity when used against Gram-positive and Gram-negative bacteria.
Kaohsiung J Med Sci, 2020, 10.1002/kjm2.12281
S4536 Nitrofurantoin Nitrofurantoin (Macrodantin, Furadantine, Furadonine) is an antibiotic used to treat bladder infections.It inhibits bacterial DNA, RNA, and cell wall protein synthesis.
S4541 Triclosan Triclosan (Irgasan, Cloxifenolum) is a diphenyl ether derivative used in cosmetics and toilet soaps as an antiseptic. It has some bacteriostatic and fungistatic action.
FASEB J, 2019, 10.1096/fj.201802603RR
Onco Targets Ther, 2018, 11:2945-2954
S4547 8-Hydroxyquinoline 8-Hydroxyquinoline (8-Oxychinolin, 8-Quinolinol, Oxine) is an antiseptic with mild fungistatic, bacteriostatic, anthelmintic, and amebicidal action. It is also used as a reagent and metal chelator, as a carrier for radio-indium for diagnostic purposes.
S4550 Azelaic acid Azelaic acid (Nonanedioic acid, Finacea, Azelex, Anchoic acid) is an organic compound produced by the ozonolysis of oleic acid and possesses antibacterial, keratolytic, comedolytic, and anti-oxidant activity.
S4553 Bronopol Bronopol (2-bromo-2-nitropropane-1,3-diol) is antibacterial agent, used as preservative in cosmetic industry.
S4565 Diiodohydroxyquinoline Diiodohydroxyquinoline (Iodoquinol) is a topical therapeutic agent,a quinoline derivative, with satisfactory antibacterial properties.
S4576 Sulfabenzamide Sulfabenzamide (Sultrin, N-Sulfanilylbenzamide) is an antibacterial/antimicrobial which also exhibit their antitumor effects through multiple mechanisms including inhibition of membrane bound carbonic anhydrases, prevention of microtubule assembly, cell cycle arrest, and inhibition of angiogenesis.
S4594 Cephalothin sodium Cephalothin (Cefalotin, Cephalotin) sodium is a semisynthetic, beta-lactam, first-generation cephalosporin antibiotic with bactericidal activity. Cephalothin binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall.
S4595 Cefazolin Sodium Cefazolin Sodium (cefazoline, cephazolin, Ancef) is a semisynthetic cephalosporin analog with broad-spectrum antibiotic action due to inhibition of bacterial cell wall synthesis. It attains high serum levels and is excreted quickly via the urine.
S4596 Cefixime Cefixime (Cefixima, Cefiximum, Cephoral, Cefspan, FR-17027, FK-027, CL-284635) is an antibiotic useful for the treatment of a number of bacterial infections. It is a third generation cephalosporin.
S4634 Sodium sulfadiazine Sodium Sulfadiazine (Sulfadiazin-natrium) is a sodium salt form of sulfadiazine, an intermediate-acting bacteriostatic, synthetic sulfanilamide derivative.
S4663 Fusidate Sodium Fusidate Sodium (Fucidin, SQ-16360) is a sodium salt form of fusidic acid, a bacteriostatic antibiotic derived from the fungus Fusidium coccineum and used as a topical medication to treat skin infections.
S4720 Cefotaxime Cefotaxime is a third-generation cephalosporin antibiotic and has broad spectrum activity against Gram positive and Gram negative bacteria.
S4750 Sulfacetamide sodium salt hydrate Sulfacetamide is a sulfonamide antibiotic that blocks the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase(DHPS) with IC50 of 9.5 μM. Sulfacetamide is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), which is required for bacterial synthesis of folic acid.
S4813 Cefuroxime axetil Cefuroxime axetil, a prodrug of the cephalosporin cefuroxime, is a second generation oral cephalosporin antibiotic with in vitro antibacterial activity against several gram-positive and gram-negative organisms.
S4822 Silver Sulfadiazine Silver sulfadiazine is a bactericidal for many gram- negative and gram-positive bacteria as well as being effective against yeast.
S4833 Cefoxitin sodium Cefoxitin Sodium is the sodium salt form of cefoxitin, a beta-lactam, second-generation cephalosporin antibiotic with bactericidal activity.
S4844 Cefcapene Pivoxil Hydrochloride Cefcapene Pivoxil is the pivalate ester prodrug form of cefcapene, a semi-synthetic third-generation cephalosporin with antibacterial activity.
S4846 Meropenem Trihydrate Meropenem is a broad-spectrum antibacterial agent of the carbapenem family with a broad spectrum of in vitro activity against Gram-positive and Gram-negative pathogens.
S4848 Dalbavancin Dalbavancin (Zeven, BI 397, MDL 63397) is a lipoglycopeptide antibiotic that has bactericidal activity against Gram-positive bacteria including various staphylococci.
S4850 Flucloxacillin sodium Flucloxacillin sodium (Floxacillin sodium) is the sodium salt of flucloxacillin, a penicillin antibiotic used to treat bacterial infections.
S4869 Sulfamethoxazole sodium Sulfamethoxazole sodium is an antibiotic used for bacterial infections.
S4874 Cefazedone Cefazedone (Refosporen, Cefazedonum) is a semisynthetic first-generation cephalosporin with antibacterial activity.
S4875 Cephapirin Benzathine Cephapirin Benzathine is the benzathine salt form of cephapirin, which is a semisynthetic, broad-spectrum, first-generation cephalosporin with antibacterial activity.
S4880 Cefathiamidine Cefathiamidine is the first generation of cephalosporin antibacterial used for the treatment of respiratory, liver, five senses, urinary tract infections, endocarditis and sepsis.
S4885 Taurolidine Taurolidine (Taurolin, Tauroline, Tauroflex) is a synthetic broad-spectrum antibiotic with antibacterial, anticoagulant and potential antiangiogenic activities.
S4959 Skatole Skatole (3-methylindole, Scatole) is a mildly toxic white crystalline organic compound that occurs naturally in feces. It has a fairly broad bacteriostatic effect.
S4986 Latamoxef sodium Latamoxef sodium (Moxalactam Disodium, FestamoxinLy, Shiomarin, Ly 127935, 6059 S) is an antibiotic and has anti-bacterial and anti-inflammation effects.
S5007 Delamanid Delamanid (OPC-67683) is a new anti-tuberculosis drug with an excellent intracellular bactericidal activity and a high accumulation rate.
S5012 Octenidine Dihydrochloride Octenidine, a cationic surfactant, is active against gram-positive and gram-negative bacteria.
S5036 Nisin Nisin (Ambicin N) is a ribosomally synthesized peptide that has broad-spectrum antibacterial activity, including activity against many bacteria that are food-spoilage pathogens.
S5048 Fosfomycin Disodium Fosfomycin (Phosphonemycin) is a bactericidal, low-molecular weight, broad-spectrum antibiotic, with putative activity against several bacteria, including multidrug-resistant Gram-negative bacteria, by irreversibly inhibiting an early stage in cell wall synthesis.
S5051 Pipemidic acid Pipemidic acid (Acido pipemidico) is a pyridopyrimidine antibiotic derivative of piromidic acid with activity against gram-negative and some gram-positive bacteria.
Hum Mol Genet, 2020, ddaa244
S5054 Rifamycin sodium salt Rifamycin sodium is an antibacterial drug used for treatment of mycobacterium infections.
S5070 Mupirocin calcium Mupirocin Calcium (Pseudomonic acid A) is the calcium salt form of mupirocin, a natural crotonic acid derivative extracted from Pseudomonas fluorescens,which inhibits bacterial protein synthesis and is used as an antibiotic.
S5081 Ceforanide Ceforanide is a new cephalosporin with antibacterial activity and has a longer elimination half-life than any currently available cephalosporin.
S5095 Olaquindox Olaquindox (Bisergon, Bayernox, Bayonox, Olachindox) is an oral anti-bacterial agent used as an additive to animal food.
S5159 Doxycycline Doxycycline (Vibramycin, Doxytetracycline, Doxiciclina, Doxycyclinum) is an antibiotic that is used in the treatment of a number of types of infections caused by bacteria and protozoa. Doxycycline is also a nonspecific matrix metalloproteinase (MMP) inhibitor.
Nucleic Acids Res, 2021, gkab034
Autophagy, 2021, 1-16
J Int Med Res, 2021, 49(10):3000605211044368
S5202 Quinocetone Quinocetone is a novel veterinary chemicals that is also bacteriocide and potential anti-tumor agent.
S5208 Ciprofloxacin hydrochloride hydrate Ciprofloxacin Hydrochloride (Ciloxan, Ceprimax, Oftacilox) is the hydrochloride salt form of ciprofloxacin, which is an antibiotic used to treat a number of bacterial infections.
S5209 Enoxacin Sesquihydrate Enoxacin sesquihydrate (Enoxacin hydrate) is a broad-spectrum 6-fluoronaphthyridinone antibacterial agent.
S5211 4-Aminosalicylic acid 4-Aminosalicylic acid (Para-aminosalicylic acid, Aminosalicylic acid, 4-aminosalicylate) is an antitubercular agent with bacteriostatic activity against Mycobacterium tuberculosis.
S5227 Erythromycin thiocyanate Erythromycin is a macrolide antibiotic that inhibits bacterial protein synthesis by binding to bacterial 50S ribosomal subunits and inhibits peptidyl transferase activity and interferes with translocation of amino acids during translation and assembly of proteins.
S5235New Cefodizime Cefodizime (CEF, CDZ) is an aminothiazolyl cephalosporin with a broad spectrum of antibacterial activity.
S5268 Solithromycin Solithromycin (CEM-101, OP-1068), belonging to the well-known class of macrolide antibiotics that also includes azithromycin, is a potent bacterial protein synthesis inhibitor.
S5278 Tedizolid (TR-700) Tedizolid is an oxazolidinone-class antibiotic prodrug used for the treatment of acute bacterial skin and skin structure infections caused by susceptible isolates of several Gram-positive bacteria.
S5289 Ceftezole Ceftezole (Celoslin, Falomesin) is a semi-synthetic first-generation cephalosporin with antibacterial activity.
S5291 sulfaisodimidine Sulfaisodimidine (Sulfamethin) is a sulfonamide antibacterial.
S5296 Cephradine monohydrate Cefradine is a beta-lactam, first-generation cephalosporin antibiotic with bactericidal activity.
S5298 Amoxicillin trihydrate Amoxicillin (Amoxil, Amoxipen, Moxaline) is a broad-spectrum, semisynthetic aminopenicillin antibiotic with bactericidal activity.
PLoS Comput Biol, 2020, 16(12):e1008489
S5330New Amikacin Sulfate Salt Amikacin (BAY 41-6551) sulfate, a semisynthetic analog of kanamycin, is an aminoglycoside antibiotic which is very active against most gram-negative bacteria including gentamicin- and tobramycin-resistant strains.
S5331 Ceftezole sodium Ceftezole Sodium (Celoslin sodium, Falomesin sodium) is the sodium salt form of ceftezole, a semi-synthetic first-generation cephalosporin with antibacterial activity.
S5332 Cefquinome sulfate Cefquinome sulphate is a veterinary, parenteral, and fourth-generation cephalosporin. Its antimicrobial potency and extensive antibacterial spectrum result from the introduction of a methoxyimino-aminothiazolyl moiety into the acyl side chain.
S5350 Cefpodoxime proxetil Cefpodoxime Proxetil is a third generation semi-synthetic cephalosporin and a beta-lactam antibiotic with bactericidal activity.
S5352 Cefminox Sodium Cefminox Sodium (Meicelin, MT-141) is the sodium salt form of cefminox, a semi-synthetic, second-generation, beta-lactamase-stable cephalosporin with antibacterial activity.
S5353 Cefpiramide sodium Cefpiramide sodium (CPMS, SM-1652,wy-44635) is an anionic β-lactam antibiotic. It exhibits antibacterial activity against gram-positive and gram-negative bacteria, in particular, to Pseudomonas aeruginosa, which can result in achronic life-threatening infection in the lungs of cystic fibrosis patients.
S5354 Cefteram pivoxil Cefteram Pivoxil is the pivalate ester prodrug of cefteram, a semi-synthetic, broad-spectrum, third-generation cephalosporin with antibacterial activity.
S5356 Ceftiofur Ceftiofur is a semisynthetic, beta-lactamase-stable, broad-spectrum cephalosporin with antibacterial activity.
Vet J, 2018, 234:24-26
S5406 Sultamicillin Tosylate Sultamicillin Tosylate is the tosylate salt of the double ester of sulbactam plus ampicillin. Sulbactam is a semisynthetic beta-lactamase inhibitor which, in combination with ampicillin, extends the antibacterial activity of the latter to include some beta-lactamase-producing strains of bacteria that would otherwise be resistant.
S5410 Chloramphenicol sodium succinate Chloramphenicol Sodium Succinate is the sodium succinate salt form of chloramphenicol, a nitrobenzene derivate and broad-spectrum antibiotic with antibacterial activity.
Oncotarget, 2018, 9(40):26086-26095
S5417New Spectinomycin dihydrochloride pentahydrate Spectinomycin dihydrochloride pentahydrate (Trobicin) is a widely used antibiotic that inhibits bacterial protein synthesis by blocking translocation of messenger RNA and transfer RNAs on the ribosome.
S5420 Clindamycin alcoholate Clindamycin alcoholate is a crystallizable compound of Clindamycin with alcohol. Clindamycin is a semisynthetic lincosamide antibiotic that inhibits bacterial protein synthesis by binding to bacterial 50S ribosomal subunits.
S5440 Berberine Sulfate Berberine sulfate (Umbellatine), an alkaloid extracted from several plants, possesses antimicrobial activity against a wide variety of microorganisms including Gram-positive and Gram-negative bacteria, fungi, and protozoa.
Front Pharmacol, 2021, 12:632201
Biology (Basel), 2021, 10(3)250
S5456 Isobavachalcone Isobavachalcone (Corylifolinin), a naturally occurring chalcone compound derived from the seeds of Psoralea corylifolia L., has long been used in traditional Chinese medicine as anthelmintic, antibacterial, aphrodisiac, astringent and antiplatelet agent.
S5473 Pivmecillinam hydrochloride Pivmecillinam is a β-lactam antibiotic and a prodrug of mecillinam. It has selective activity against Gram-negative bacteria and is used primarily in the treatment of lower urinary tract infections.
S5487 Cefoperazone sodium Cefoperazone Sodium is the sodium salt form of cefoperazone, which is a semi-synthetic, broad-spectrum, beta-lactamase resistant antibiotic with bactericidal activity.
S5491 Lomefloxacin Lomefloxacin is a fluoroquinolone antibiotic used to treat bacterial infections.
S5492 Econazole Econazole is a broad spectrum antimycotic with some action against Gram positive bacteria.
Am J Cancer Res, 2020, 10(1):263-274
Biomol Ther (Seoul), 2020, 25
S5515 Penicillin G Procaine Procaine benzylpenicillin (Procaine benzylpenicillin), also known as Procaine benzylpenicillin, is an antibiotic useful for the treatment of a number of bacterial infections.
S5532 Erythromycin estolate Erythromycin (Lubomycine B), a naturally occurring macrolide, is derived from Streptomyces erythrus. It inhibits bacterial protein synthesis by binding to bacterial 50S ribosomal subunits.
S5533 Tobramycin sulfate Tobramycin sulfate is the sulfate salt of tobramycin, an aminoglycoside antibiotic derived from the bacterium Streptomyces tenebrarius with bactericidal activity.
Oncotarget, 2018, 9(40):26086-26095
S5535 Moxifloxacin Moxifloxacin is an antibiotic used to treat a number of bacterial infections, active against Mycobacterium tuberculosis in vitro.
Transl Vis Sci Technol, 2018, 7(2):11
J Pharmacol Toxicol Methods, 2017, 90:39-47
Circ Arrhythm Electrophysiol, 2016, 9(4):e003655
S5546 Sulfacetamide Sulfacetamide (Acetosulfamine) is a synthetic sulfanylacetamide derivative with bacteriostatic activity. It is an anti-infective agent that is used topically to treat skin infections and orally for urinary tract infections.
S5560 Midecamycin Midecamycin (Espinomycin A, Medecamycin A1, Platenomycin B1, Rubimycin, Turimycin P3) is a naturally occuring macrolide antibiotic that acts by inhibiting bacterial protein synthesis.
S5625 Ammonium lactate Ammonium lactate (Lac-hydrin) is the ammonium salt of lactic acid with mild anti-bacterial properties.
S5637 Cefotiam Hexetil Hydrochloride Cefotiam Hexetil Hydrochloride is the hydrochloride salt of cefotiam hexetil. Cefotiam is a semi-synthetic, beta-lactam cephalosporin antibiotic with antibacterial activity.
S5638 Cefozopran hydrochloride Cefozopran Hydrochloride is the hydrochloride salt form of cefozopran, a semi-synthetic, broad-spectrum, fourth-generation cephalosporin with antibacterial activity.
S5644 Ceftriaxone Sodium Ceftriaxone Sodium is the sodium salt form of ceftriaxone, a beta-lactam, third-generation cephalosporin antibiotic with bactericidal activity.
S5736 Benzathine penicilline Benzathine penicilline (Benzathine penicillin G) is an antibiotic useful for the treatment of a number of bacterial infections.
S5776 Proflavine Proflavine (3,6-Diaminoacridine) is a disinfectant bacteriostatic against many gram-positive bacteria. It is a topical antiseptic used mainly in wound dressings.
S5784 Vancomycin Vancomycin is an antibiotic used to treat serious bacterial infections. It works by stopping the growth of bacteria.
Gut Microbes, 2020, 12(1):1-20
Oncotarget, 2018, 9(40):26086-26095
S5863 Metronidazole Benzoate Metronidazole Benzoate (Benzoyl metronidazole) is the benzoate ester of metronidazole, a synthetic nitroimidazole derivative with antiprotozoal and antibacterial activities.
S5924 Olanexidine Hydrochloride semihydrate Olanexidine (OPB-2045, OPB-2045G) is a monobiguanide compound with bactericidal activity.
S5936 Cefazolin Cefazolin is a semisynthetic cephalosporin analog with broad-spectrum antibiotic action due to inhibition of bacterial cell wall synthesis. It attains high serum levels and is excreted quickly via the urine.
S5941 Besifloxacin Besifloxacin is a fourth generation fluoroquinolone-type opthalmic antibiotic for the treatment of bacterial conjunctivitis.
S5951 Cefoxitin Cefoxitin is a beta-lactam, second-generation cephalosporin antibiotic with bactericidal activity.
S6067 2,4-dichlorobenzyl alcohol 2,4-Dichlorobenzyl alcohol is a mild antiseptic, able to kill bacteria and viruses associated with mouth and throat infections.
S6235 Sodium dehydroacetate Sodium dehydroacetate is the sodium salt of dehydroacetic acid, a fungicide and bactericide that is commonly used as a food preservative. Sodium dehydroacetate is a preservative that is used in the formulation of cosmetics and personal care products in order to extend the shelf-life by preventing microbial contamination.
S6411 Nimorazole Nimorazole is a water soluble, 5-nitroimidazole compound with antibacterial and potential radiosensitizing activity.
S6444 Triclocarban Triclocarban is an antibacterial agent common used in personal care products.
S8871 Omadacycline tosylate Omadacycline tosylate is a first-in-class aminomethylcycline antibiotic, demonstrating antimicrobial activity in vitro against a range of Gram-positive and Gram-negative aerobes and some anaerobic bacteria.
S9046 Berberine Berberine (Umbellatine), an alkaloid isolated from Rhizoma coptidis, has broad applications, particularly as an antibacterial agent in the clinic.
Front Pharmacol, 2021, 12:632201
Brain Res Bull, 2021, 177:22-30
Biology (Basel), 2021, 10(3)250
S9099 Orientin Orientin (Lutexin, Luteolin-8-glucoside), isolated from medicinal plants, has various activities including anti-oxidant, anti-aging, anti-viral, anti-bacterial, anti-inflammation, vasodilatation and cardioprotective, antiadipogenesis, antinociceptive, radiation protective, neuroprotective, and antidepressant-like effects.
S9122 Tectorigenin Tectorigenin (TEC) is an isoflavone isolated from various medicinal plants, such as Pueraria thunbergiana Benth, Belamcanda chinensis, and Iris unguicularis. It has been reported to exert pharmacological actions, including antitumor and antibacterial effects, free radical neutralization, and selective estrogen receptor modulation.
S9135 Artemisic acid Artemisic acid (Artemisinic acid), an amorphane sesquiterpene isolated from Artemisia annua L., has a variety of pharmacological activity, such as antimalarial activity, anti-tumor activity, antipyretic effect, antibacterial activity, allelopathy effect and anti-adipogenesis effect.
ACS Infect Dis, 2020, 10.1021/acsinfecdis.0c00522
S9136 Neochlorogenic acid Neochlorogenic acid (Neochlorogenate, 5-O-Caffeoylquinic acid) is a natural polyphenolic compound found in some types of dried fruits and a variety of other plant sources such as peaches. It shows antioxidant, antibacterial, antiviral, and antipyretic activities and exerts neuroprotective effects through the inhibition of pro-inflammatory pathways in activated microglia.
S9224 Dehydroandrographolide Succinate Dehydroandrographolide succinate (DAS), extracted from herbal medicine Andrographis paniculata (Burm f) Nees, has antibacterial and antiviral effects.
S9292 Dictamnine Dictamnine, a natural plant product, has been reported to have antimicrobial activity against bacteria and fungi.
S9328 5,6,7-Trimethoxyflavone 5,6,7-Trimethoxyflavone (Baicalein Trimethyl Ether), methylations of the hydroxyl groups of oroxylin A or baicalein, has various pharmacological activities including antiviral, anticancer and antibacterial.
S9377 Eugenyl acetate Eugenyl acetate, an aromatic component of clove essential oil, exhibits various pharmacological activities, including antibacterial and anti-virulence activities against drug-resistant A. baumannii clinical isolates.
S9466 Methenamine Hippurate Methenamine Hippurate is the hippurate salt form of methenamine, a prodrug and inactive weak base that is hydrolyzed to formaldehyde in acid urine.Methenamine Hippurate is the component of Hiprex drug which has antibacterial activity.
E0010New Hypocrellin A Hypocrellin A (HA) is a perylenequinone isolated from Shiraia bambusicola that shows antiviral, antimicrobial and anticancer activity through mediating multiple signaling pathways. Hypocrellin A also is a selective and potent inhibitor of PKC.
E0052New Merafloxacin Merafloxacin (CI-934) is a fluoroquinolone antibacterial thats inhibit -1 frameshifting efficiency of SARS-CoV-2 and other betacoronaviruses.
E0365New Fucoidan

Fucoidan is an anionic sulfated polysaccharide extracted from marine brown algae with a large range of biological activities, including anti-inflammatory, anti-cancer, anti-viral, anti-oxidation, anticoagulant, antithrombotic, anti-angiogenic and anti-Helicobacter pylori, etc.

S0147 KKL-10 KKL-10 is an inhibitor of ribosome rescue that exhibits exceptional broad-spectrum antimicrobial activity against bacteria.
S0195 Walrycin B Walrycin B is an antibacterial compound and a potent inhibitor of WalR targeting the WalR response regulator.
S1162 Pretomanid (PA-824) PA-824 is an anti-tuberculosis drug for tuberculosis with MIC less than 2.8 μM.Phase 2.
S1618 Sulfameter Sulfameter is a long-acting sulfonamide antibacterial.
S1677 Chloramphenicol Chloramphenicol (Chloromycetin) is a bacteriostatic by inhibiting protein synthesis.
EMBO Rep, 2021, e53081
Cell Rep, 2021, 34(3):108631
Oncotarget, 2018, 9(40):26086-26095
S1685 Sulfanilamide Sulfanilamide (Sulphanilamide) is a competitive inhibitor for bacterial enzyme dihydropteroate synthetase with IC50 of 320 μM.
S1762 Pyrazinamide Pyrazinamide (Pyrazinoic Acid Amide) is an agent used to treat tuberculosis.
S1791 Bacitracin Zinc Bacitracin is an antibiotic that interferes with the dephosphorylation of C55-isoprenyl pyrophosphate, a membrane carrier molecule that transports the building-blocks of the peptidoglycan bacterial cell wall outside of the inner membrane. It inhibits cleavage of Tyr from Met-enkephalin with IC50 of 10 μM.
S1881 Protionamide Protionamide (Prothionamide, 1321-TH) is a drug used in the treatment of tuberculosis.
Mol Imaging Biol, 2021, 10.1007/s11307-021-01689-8
S2457 Clindamycin HCl Clindamycin HCl inhibits protein synthesis by acting on the 50S ribosomal, used for the treatment of bacterial infections.
Proc Natl Acad Sci U S A, 2016, 113(50):14408-14413
S2830 Clindamycin Clindamycin inhibits protein synthesis by acting on the 50S ribosomal, used for the treatment of bacterial infections.
S2908 Hygromycin B Hygromycin B (Hygrovetine), a selective antibiotic that is effective on most bacteria, fungi and higher eukaryotes, inhibits protein synthesis by interfering with translocation and causing mistranslation at the 70S ribosome.
Autophagy, 2021, 1-17
PLoS Pathog, 2021, 17(4):e1009530
Cell Res, 2020,
S3021 Rimonabant (SR141716) Rimonabant (SR141716) is a selective antagonist of CB1 with IC50 of 13.6 nM and EC50 of 17.3 nM in hCB1 transfected HEK 293 membrane. Rimonabant is also a dual inhibitor of acyl CoA:cholesterol acyltransferases(ACAT) 1 and 2 and inhibits mycobacterial MmpL3.
Nat Commun, 2020, 11(1):5962
Sci Rep, 2020, 10(1):15556
Microbiol Immunol, 2020, 10.1111/1348-0421.12777
S3295 Taxifolin 7-rhamnoside Taxifolin 7-rhamnoside (TR, Taxifolin 7-O-rhamnoside, Taxifolin 7-O-α-L-rhamnoside), a flavonoid isolated from Hypericum japonicum, shows antibacterial activity against clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA).
S3496 Lefamulin acetate (Xenleta) Lefamulin acetate (Xenleta, BC-3781 acetate) is a pleuromutilin antibiotic for community-acquired bacterial pneumonia (CABP) treatment. Lefamulin acetate inhibits protein synthesis by binding to the peptidyl transferase center of the 50S bacterial ribosome, thus preventing the binding of transfer RNA for peptide transfer.
S3499New Monocaprylin Monocaprylin (2,3-dihydroxypropyl octanoate, Monoctanoin, 1-Octanoyl-rac-glycerol, MC) exhibits an excellent antibacterial activity against Staphylococcus aureus and Escherichia coli.
S3710 Fosfomycin calcium Fosfomycin (phosphomycin, phosphonomycin) is bactericidal and inhibits bacterial cell wall biogenesis by inactivating the enzyme UDP-N-acetylglucosamine-3-enolpyruvyltransferase, also known as MurA. It enters the bacterial cell through the glycerophosphate transporter.
S4105 Closantel Sodium Closantel is a gram positive antibacterial activity inhibitor, inhibiting the KinA/Spo0F system with IC50 of 3.8 μM.
S4106 Closantel Closantel (R-31520) is a gram positive antibacterial activity inhibitor, inhibiting the KinA/Spo0F system with IC50 of 3.8 μM.
S4198 Aminothiazole Aminothiazole can be used as a thyroid inhibitor and it has antibacterial activity.
J Electroanal Chem (Lausanne), 2020, 878:114733
S4307 Auranofin Auranofin (Ridaura, SKF-39162) is an inhibitor of thioredoxin reductase (TrxR) with IC50 of 88 nM for purified H. pylori TrxR in cell-free assay. Auranofin has anti-cancer activity and can completely inhibit bacterial growth at 1.2 μM. Auranofin is an FDA-approved gold-containing compound used for the treatment of rheumatoid arthritis.
Oncotarget, 2018,
S4404 Pasiniazid Pasiniazid is a composition of isoniazid and 4-aminosalicylic acid, used to treat tuberculosis patients.
S4425New Rifamycin S Rifamycin S, a quinone and an antibiotic against Gram-positive bacteria (including MRSA), is a clinical drug used to treat tuberculosis and leprosy. Rifamycin S generates reactive oxygen species (ROS) and inhibits microsomal lipid peroxidation.
S4436New Pleuromutilin Pleuromutilin (Drosophilin B, Mutilin 14-glycolate), the lead compound for novel antibiotics, inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit of bacteria.
S4490New Tetracycline Tetracycline (TC) is a broad-spectrum antibiotic that exhibits activity against a wide range of microorganisms including gram-positive and gram-negative bacteria, chlamydiae, mycoplasmas, rickettsiae, and protozoan parasites.
S4602 Acetohydroxamic acid Acetohydroxamic acid (N-Hydroxyacetamide, Methylhydroxamic acid, Acetic acid|oxime, Lithostat) is an Urease Inhibitor. In the urine, it acts as an antagonist of the bacterial enzyme urease.
S4647 Cefmenoxime hydrochloride Cefmenoxime (SCE-1365), a potent inhibitor of Enterobacteriaceae, is a cephalosporin antibiotic that is administered intravenously or intramuscularly.
S4780 7-Methoxy-4-methylcoumarin 7-Methoxy-4-methylcoumarin is a coumarin derivative and fluorescent label. 7-Methoxy-4-methylcoumarin has an antimicrobial activitiy against both gram positive and gram negative bacterial stains. 4-Methylherniarin displays good activity against B. subtilis and S.sonnei with IC50 of 11.76 μg/ml and 13.47 μg/ml, respectively.
S4854 Bedaquiline fumarate Bedaquiline fumarate (TMC-207), an oral diarylquinoline, is a bactericidal antimycobacterial drug. It is a proton-translocating ATP synthetase inhibitor.
S4861 Oxindole Oxindole (2-indolone, 2-Oxindole, Indolin-2-one) is an aromatic heterocyclic organic compound which causes sedation, muscle weakness, hypotension, and coma when dosed in excess. Oxindole has anti-cancer, anti-HIV, anti-diabetic, antibacterial and other pharmacological activities.
S4983 Sorbic acid Sorbic acid (2,4-Hexadienoic acid) is a naturally occurring compound that originated from the unripe berries of the Rowan Tree. It inhibits various bacteria, including sporeformers, at various stages of their life cycle (germination, outgrowth and cell division).
S5008New Ciprofloxacin hydrochloride Ciprofloxacin (CPX, Cetraxal, Ciloxan, Cipro, Bay-09867) hydrochloride, a fluorinated quinolone, is a β-diketone antibiotic with a broad spectrum antibacterial activity. Ciprofloxacin is an inhibitor of bacterial DNA gyrase (a subclass of Type II topoisomerases).
S5166 Benzoyleneurea Benzoyleneurea (2,4-Dihydroxyquinazoline, Quinazolinedione, Quinazoline-2,4-diol) scaffold is used in the synthesis of novel protein geranylgeranyltransferase-I inhibitors. Benzoyleneurea possesses anti-bacterial activity.
S5186New Cefpiramide Cefpiramide (Cefpiramide acid, Cefpiramido, Cefpiramidum, WY-44635, SM-1652) is a pseudomonas-active cephalosporin with a broad spectrum of antibacterial activity.
S5199New Oxytetracycline hydrochloride Oxytetracycline (OTC, Oxycycin, Stevacin, Terramycin) hydrochloride is a prescription antibiotic, interfering with the ability of bacteria to produce essential proteins.
Front Microbiol, 2016, 7:1765
S5201 Acetylisovaleryltylosin Tartrate Acetylisovaleryltylosin tartrate (AK105039) is an antimicrobial of the macrolide group with antibacterial activity against Gram-positive bacteria.
S5495New Ceftiofur sodium Ceftiofur sodium is a semisynthetic, beta-lactamase-stable, broad-spectrum cephalosporin with antibacterial activity.
S6090New JFD01307SC JFD01307SC ([(1,1-dioxidotetrahydrothien-3-yl)amino]acetic acid) shows activity against M.tuberculosis with minimum inhibitory concentrations (MICs) in the range of 8 to 16 µg/ml. JFD01307SC may targets enzymes involved in glutamine biosynthesis.
S6464 Ftaxilide Ftaxilide is a novel antituberculosis agent.
S6549 PBTZ169 PBTZ169 (macozinone), an antibiotic with antimycobacterial activity, is an irreversible inhibitor of DprE1.
Cell Death Dis, 2019, 10(4):319
S6584New Amdinocillin Amdinocillin (Mecillinam, Coactin, FL 1060) is a β-lactam antibiotic with a broad spectrum of antibacterial activity. Amdinocillin is active alone against many gram-negative organisms.
S6867 Glyceryl monocaprate (Monocaprin) Monocaprin (Glyceryl caprate) is a 1-monoglyceride of capric acid that has antimicrobial activity against enveloped viruses, certain bacteria, and the yeast Candida albicans.
S7550 Erythromycin Cyclocarbonate Erythromycin Cyclocarbonate, derivative of Erythromycin, inhibits protein synthesis of bacteria by binding to the 50S ribosome.
S7739 Telacebec (Q203) Telacebec (Q203, IAP6) is a novel antituberculosis drug that targets Mycobacterium tuberculosis cellular energy production through inhibition of the mycobacterial cytochrome bc1 complex. Telacebec (Q203, IAP6) is active against Mycobacterium tuberculosis H37Rv with MIC50 of 2.7 nM in culture broth medium.
S9226 Steviolbioside Steviolbioside (CCRIS-6025), a natural sweetener, exhibits moderate antituberculosis activity against M. tuberculosis strain H37RV in vitro.
E0010New Hypocrellin A Hypocrellin A (HA) is a perylenequinone isolated from Shiraia bambusicola that shows antiviral, antimicrobial and anticancer activity through mediating multiple signaling pathways. Hypocrellin A also is a selective and potent inhibitor of PKC.
E0052New Merafloxacin Merafloxacin (CI-934) is a fluoroquinolone antibacterial thats inhibit -1 frameshifting efficiency of SARS-CoV-2 and other betacoronaviruses.
E0365New Fucoidan

Fucoidan is an anionic sulfated polysaccharide extracted from marine brown algae with a large range of biological activities, including anti-inflammatory, anti-cancer, anti-viral, anti-oxidation, anticoagulant, antithrombotic, anti-angiogenic and anti-Helicobacter pylori, etc.

S3499New Monocaprylin Monocaprylin (2,3-dihydroxypropyl octanoate, Monoctanoin, 1-Octanoyl-rac-glycerol, MC) exhibits an excellent antibacterial activity against Staphylococcus aureus and Escherichia coli.
S4425New Rifamycin S Rifamycin S, a quinone and an antibiotic against Gram-positive bacteria (including MRSA), is a clinical drug used to treat tuberculosis and leprosy. Rifamycin S generates reactive oxygen species (ROS) and inhibits microsomal lipid peroxidation.
S4436New Pleuromutilin Pleuromutilin (Drosophilin B, Mutilin 14-glycolate), the lead compound for novel antibiotics, inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit of bacteria.
S4490New Tetracycline Tetracycline (TC) is a broad-spectrum antibiotic that exhibits activity against a wide range of microorganisms including gram-positive and gram-negative bacteria, chlamydiae, mycoplasmas, rickettsiae, and protozoan parasites.
S5008New Ciprofloxacin hydrochloride Ciprofloxacin (CPX, Cetraxal, Ciloxan, Cipro, Bay-09867) hydrochloride, a fluorinated quinolone, is a β-diketone antibiotic with a broad spectrum antibacterial activity. Ciprofloxacin is an inhibitor of bacterial DNA gyrase (a subclass of Type II topoisomerases).
S5186New Cefpiramide Cefpiramide (Cefpiramide acid, Cefpiramido, Cefpiramidum, WY-44635, SM-1652) is a pseudomonas-active cephalosporin with a broad spectrum of antibacterial activity.
S5199New Oxytetracycline hydrochloride Oxytetracycline (OTC, Oxycycin, Stevacin, Terramycin) hydrochloride is a prescription antibiotic, interfering with the ability of bacteria to produce essential proteins.
Front Microbiol, 2016, 7:1765
S5495New Ceftiofur sodium Ceftiofur sodium is a semisynthetic, beta-lactamase-stable, broad-spectrum cephalosporin with antibacterial activity.
S6090New JFD01307SC JFD01307SC ([(1,1-dioxidotetrahydrothien-3-yl)amino]acetic acid) shows activity against M.tuberculosis with minimum inhibitory concentrations (MICs) in the range of 8 to 16 µg/ml. JFD01307SC may targets enzymes involved in glutamine biosynthesis.
S6584New Amdinocillin Amdinocillin (Mecillinam, Coactin, FL 1060) is a β-lactam antibiotic with a broad spectrum of antibacterial activity. Amdinocillin is active alone against many gram-negative organisms.
S5235New Cefodizime Cefodizime (CEF, CDZ) is an aminothiazolyl cephalosporin with a broad spectrum of antibacterial activity.
S5330New Amikacin Sulfate Salt Amikacin (BAY 41-6551) sulfate, a semisynthetic analog of kanamycin, is an aminoglycoside antibiotic which is very active against most gram-negative bacteria including gentamicin- and tobramycin-resistant strains.
S5417New Spectinomycin dihydrochloride pentahydrate Spectinomycin dihydrochloride pentahydrate (Trobicin) is a widely used antibiotic that inhibits bacterial protein synthesis by blocking translocation of messenger RNA and transfer RNAs on the ribosome.