H-151

Catalog No.S6652

For research use only.

H-151 is a highly potent and covalent antagonist of STING that has noteworthy inhibitory activity both in human cells and in vivo.

H-151 Chemical Structure

CAS No. 941987-60-6

Selleck's H-151 has been cited by 9 Publications

Purity & Quality Control

Choose Selective STING Inhibitors

Biological Activity

Description H-151 is a highly potent and covalent antagonist of STING that has noteworthy inhibitory activity both in human cells and in vivo.
Targets
STING [1]
In vivo

After intraperitoneal administration, H-151 reachs effective systemic levels, displays a short half-life in the serum and formed an adduct to mmSTING. Notably, pretreatment of H-151 markedly reduces systemic cytokine responses in CMA-treated mice. Moreover, H-151 exhibits notable efficacy in Trex1−/− mice that expressed a bioluminescent IFNβ reporter, when administered for one week.[1]

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 279.34
Formula

C17H17N3O

CAS No. 941987-60-6
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CCC1=CC=C(C=C1)NC(=O)NC2=CNC3=CC=CC=C32

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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