Home Immunology & Inflammation STING agonist E7766 diammonium salt

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E7766 diammonium salt STING agonist

Cat.No.S9618

E7766 diammonium salt, a macrocycle-bridged STING agonist with a Kd of 40 nM, shows potent pan-genotypic and antitumor activities.
E7766 diammonium salt STING agonist Chemical Structure

Chemical Structure

Molecular Weight: 780.66

Jump to Mechanism of Action Solubility Chemical Information, Storage & Stability Specificity

Quality Control

Batch: S961801 Water]45 mg/mL]false]]]false]]]false Purity: 99.87%
99.87

Chemical Information, Storage & Stability

Molecular Weight 780.66 Formula

C24H26F2N10O8P2S2.2H3N

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 2242635-03-4 -- Storage of Stock Solutions

Solubility

In vitro
Batch:

Water : 45 mg/mL

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
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Mechanism of Action

Targets/IC50/Ki
STING [1]
(in the isothermal titration calorimetry (ITC) assay)
40 nM(Kd)
References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04144140 Terminated
Lymphoma|Advanced Solid Tumors
Eisai Inc.|H3 Biomedicine Inc.
 February 24 2020 Phase 1
NCT04109092 Withdrawn
Urinary Bladder Neoplasms
Eisai Inc.|H3 Biomedicine Inc.
 February 13 2020 Phase 1

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