diABZI STING agonist(compound 3)

Catalog No.S8796

diABZI STING agonist(compound 3) Chemical Structure

Molecular Weight(MW): 849.95

STING agonist 1 (compound 3) is a potent non-nucleotide STING agonist and has tremendous potential to improve treatment of cancer in humans.

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Biological Activity

Description STING agonist 1 (compound 3) is a potent non-nucleotide STING agonist and has tremendous potential to improve treatment of cancer in humans.
Targets
STING [1]
()
In vitro

In human PBMCs, compound 3 induces dose-dependent activation of STING and secretion of IFNβ with an EC50app of 130 nM[1].

In vivo

Compound 3 activates secretion of IFNβ, IL-6, TNF, and KC/GROα (also known as CXCL1) in wild-type but not Sting−/− mice. In BALB/c mice administrated 3 mg/kg compound 3 via intravenous injection, compound 3 exhibits systemic exposure with a half-life of 1.4 h and achieves systemic concentrations greater than the half-maximal effective concentration (EC50) for mouse STING (~200 ng/ml). In mice bearing subcutaneous CT-26 tumours, treatment with compound 3 results in significant tumour growth inhibition as measured by tumour volume AUC analysis (P<0.001), and significantly improves survival (P<0.001) with 8 out of 10 mice remaining tumour free at the end of the study on day 43[1].

Protocol

Animal Research:

[1]

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  • Animal Models: BALB/c mice
  • Formulation: --
  • Dosages: 3 mg/kg
  • Administration: IV
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 100 mg/mL (117.65 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 849.95
Formula

C42H51N13O7

CAS No. 2138498-18-5
Storage powder
in solvent
Synonyms N/A

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID