Home Neuronal Signaling NMDAR antagonist Radiprodil (RGH-896)

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Radiprodil (RGH-896) NMDAR antagonist

Cat.No.S6644

Radiprodil (RGH-896) is a NR2B-selective NMDA receptor antagonist, initially developed for the treatment of neuropathic pain.
Radiprodil (RGH-896) NMDAR antagonist Chemical Structure

Chemical Structure

Molecular Weight: 397.40

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Quality Control

Batch: S664401 DMSO]79 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 99.7%
99.7

Solubility

In vitro
Batch:

DMSO : 79 mg/mL (198.79 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : Insoluble

Ethanol : Insoluble

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Dilution Calculator Molecular Weight Calculator

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
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Chemical Information, Storage & Stability

Molecular Weight 397.40 Formula

C21H20FN3O4

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 496054-87-6 -- Storage of Stock Solutions

Synonyms N/A Smiles C1CN(CCC1CC2=CC=C(C=C2)F)C(=O)C(=O)NC3=CC4=C(C=C3)NC(=O)O4

Mechanism of Action

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06392009 Recruiting
Tuberous Sclerosis Complex|Focal Cortical Dysplasia
GRIN Therapeutics Inc.
 May 2024 Phase 1|Phase 2
NCT05818943 Recruiting
GRIN-related Disorders
GRIN Therapeutics Inc.
 March 7 2023 Phase 1
NCT02829827 Terminated
Infantile Spasms (IS)
UCB Biopharma S.P.R.L.|UCB Pharma
 December 4 2017 Phase 2
NCT02647697 Completed
Healthy Volunteers
UCB Biopharma S.P.R.L.|PRA Health Sciences|UCB Pharma
 January 2016 Phase 1

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