Name: Deudextromethorphan (AVP-786)
Brand: Selleck Chemicals
SKU: S3535
Availability: InStock
Rating: 5 (1 reviews)

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Quality Control

Batch: S353501 DMSO]55 mg/mL]false]Ethanol]55 mg/mL]false]Water]14 mg/mL]false Purity: 99.94%

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COA
HPLC
SDS
Datasheet

99.94

Related Targets	Adrenergic Receptor AChR 5-HT Receptor COX Calcium Channel Histamine Receptor Dopamine Receptor GABA Receptor TRP Channel Cholinesterase (ChE)
Other NMDAR Inhibitors	(+)-Dizocilpine (MK 801) Maleate (-)-Dizocilpine (MK 801) Maleate NMDA (N-Methyl-D-aspartic acid) Ifenprodil Tartrate Memantine HCl Spermidine trihydrochloride Kynurenic acid Mephenesin Quinolinic acid Radiprodil (RGH-896)

Solubility

In vitro
Batch:

DMSO : 55 mg/mL (198.24 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 55 mg/mL

Water : 14 mg/mL

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	2.75mg/ml (9.91mM)	Taking the 1 mL working solution as an example, add 50 μL of 55 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Clear solution	5% DMSO 1 95% Corn oil Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	0.13mg/ml (0.47mM)	Taking the 1 mL working solution as an example, add 50 μL of 2.6 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

%

% Tween 80

% ddH₂O

% DMSO

+

%

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	277.43	Formula	C₁₈H₁₉D₆NO	Storage (From the date of receipt)	3 years -20°C powder
CAS No.	1079043-55-2	--		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	N/A			Smiles	C(OC1=CC=C2CC3C4CCCCC4(CCN3C([2H])([2H])[2H])C2=C1)([2H])([2H])[2H]

Mechanism of Action

Targets/IC₅₀/Ki	NMDA receptor
References	[1] https://pubmed.ncbi.nlm.nih.gov/33904154/

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT02446132	Recruiting	Agitation in Patients With Dementia of the Alzheimer''s Type	Otsuka Pharmaceutical Development & Commercialization Inc.	December 2015	Phase 3
NCT02402595	Completed	Healthy	Avanir Pharmaceuticals	March 2015	Phase 1
NCT02336347	Completed	Healthy Volunteer	Avanir Pharmaceuticals	May 2014	Phase 1
NCT02174822	Completed	Drug-drug Interaction	Otsuka Pharmaceutical Development & Commercialization Inc.	January 2014	Phase 1
NCT02174835	Completed	Healthy	Avanir Pharmaceuticals	September 2013	Phase 1

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Handling Instructions

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Deudextromethorphan (AVP-786) NMDAR antagonist

Chemical Structure

Molecular Weight: 277.43