HSP90α Selective Inhibitors

Catalog No. Product Name Information Selective / Pan IC50 / Ki
S7340 CH5138303

CH5138303 is an orally available Hsp90 inhibitor with Kd of 0.48 nM.

Selective HSP90α, Kd: 0.48 nM
S7097 HSP990 (NVP-HSP990)

NVP-HSP990 (HSP990) is a novel, potent and selective HSP90 inhibitor for HSP90α/β with IC50 of 0.6 nM/0.8 nM.

Pan HSP90α, IC50: 0.6 nM
S1069 Luminespib (AUY-922, NVP-AUY922)

Luminespib (AUY-922, NVP-AUY922) is a highly potent HSP90 inhibitor for HSP90α/β with IC50 of 13 nM /21 nM, weaker potency against the HSP90 family members GRP94 and TRAP-1, exhibits the tightest binding of any small-molecule HSP90 ligand. Phase 2.

Pan HSP90α, IC50: 13 nM
S2639 SNX-2112 (PF-04928473)

SNX-2112 (PF-04928473) selectively binds to the ATP pocket of HSP90α and HSP90β with Ka of 30 nM and 30 nM, uniformly more potent than 17-AAG.

Pan HSP90α, Ka: 30 nM