HSP90α Selective Inhibitors
|Catalog No.||Product Name||Information||Selective / Pan||IC50 / Ki|
CH5138303 is an orally available Hsp90 inhibitor with Kd of 0.48 nM.
|Selective||HSP90α, Kd: 0.48 nM|
NVP-HSP990 (HSP990) is a novel, potent and selective HSP90 inhibitor for HSP90α/β with IC50 of 0.6 nM/0.8 nM.
|Pan||HSP90α, IC50: 0.6 nM|
|S1069||Luminespib (AUY-922, NVP-AUY922)||
Luminespib (AUY-922, NVP-AUY922) is a highly potent HSP90 inhibitor for HSP90α/β with IC50 of 13 nM /21 nM, weaker potency against the HSP90 family members GRP94 and TRAP-1, exhibits the tightest binding of any small-molecule HSP90 ligand. Phase 2.
|Pan||HSP90α, IC50: 13 nM|
SNX-2112 (PF-04928473) selectively binds to the ATP pocket of HSP90α and HSP90β with Ka of 30 nM and 30 nM, uniformly more potent than 17-AAG.
|Pan||HSP90α, Ka: 30 nM|
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