Home Immunology & Inflammation TLR activator Lipopolysaccharides (LPS)

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Lipopolysaccharides (LPS) Endotoxin

Cat.No.S7850

Lipopolysaccharides (LPSs, Endotoxin,LPS) is an endotoxin derived from the outer leaflet of the outer membrane of Gram-negative bacteria. Lipopolysaccharides consists of an antigen O-specific chain, a core oligosaccharide and lipid A. Lipopolysaccharides is a pathogenic associated molecular pattern (PAMP) that activates the immune system. Lipopolysaccharides activates TLR-4 on immune cells. Lipopolysaccharides induces secretion of cell migrasome.
Lipopolysaccharides (LPS) TLR activator Chemical Structure

Chemical Structure

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Quality Control

Batch: Purity: 98%
98

Solubility

In vitro
Batch:

Water : 15 mg/mL

DMSO : Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : Insoluble

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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Chemical Information, Storage & Stability

Molecular Weight Formula Storage (From the date of receipt) 3 years -20°C powder
CAS No. 93572-42-0 -- Storage of Stock Solutions

Mechanism of Action

References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
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Jiangsu Hansoh Pharmaceutical Co. Ltd.
 May 2024 Phase 1|Phase 2
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Narcolepsy Type 1|Bacterial Translocation
Centre Hospitalier Universitaire de Nīmes
 May 2024 --
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All Types of Solid Cancer
Hospices Civils de Lyon
 April 1 2024 Not Applicable
NCT06342050 Not yet recruiting
Obesity|Metabolic Syndrome
University of Texas Southwestern Medical Center|National Institute on Minority Health and Health Disparities (NIMHD)
 April 2024 --

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