For research use only.

Catalog No.S7221

5 publications

GS-9620 Chemical Structure

CAS No. 1228585-88-3

GS-9620 is a potent and selective orally active small molecule agonist of Toll-like receptor 7.

Selleck's GS-9620 has been cited by 5 publications

Purity & Quality Control

Choose Selective TLR Inhibitors

Biological Activity

Description GS-9620 is a potent and selective orally active small molecule agonist of Toll-like receptor 7.
TLR7 [1]
In vitro

GS-9620 potently inhibited viral replication in peripheral blood mononuclear cells(PBMCs), particularly when added 24 to 48 hours prior to HIV infection (EC50= 27 nM). Depletion of pDCs, but not other immune cell subsets from PBMC cultures, suppressed GS-9620 antiviral activity[2].

In vivo Short-term oral administration of GS-9620 provides long-term suppression of serum and liver HBV DNA. GS-9620 administration induces production of IFN-α and other cytokines and chemokines, and activates ISGs, natural killer cells, and lymphocyte subsets. Its treatment reduces viral DNA, Serum levels of HB surface antigen, HB e antigen and numbers of HBV antigen-positive hepatocytes while hepatocyte apoptosis increases[1]. Currently, GS-9620 is under clinical evaluation for treating chronic HBV infection and for reducing latent reservoirs in virally-suppressed HIV-infected patients[2].


Cell Research:


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  • Cell lines: Human PBMCs
  • Concentrations: serial dilutions
  • Incubation Time: 5 days
  • Method:

    Uninfected PBMCs from individual donors are first activated in bulk using PHA and IL-2 at 37°C for 48 hours and then seeded into 96-well plates at a density of 2 x 105 cells per well before being dosed in triplicate with 4-fold serial dilutions of compounds prepared in RPMI cell culture medium. Cells are incubated in a 5% CO2 incubator at 37°C for a period of 5 days. At the end of the assay,
    cell viability is assessed.

    (Only for Reference)
Animal Research:


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  • Animal Models: chimpanzees
  • Dosages: 1 mg/kg and 2 mg/kg
  • Administration: oral administration
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 1 mg/mL (2.43 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 410.51


CAS No. 1228585-88-3
Storage powder
in solvent
Smiles CCCCOC1=NC(=C2C(=N1)N(CC(=O)N2)CC3=CC=CC(=C3)CN4CCCC4)N

In vivo Formulation Calculator (Clear solution)

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Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and SDS / COA (available on product pages).

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This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID