Prucalopride Succinate

For research use only.

Catalog No.S4247

4 publications

Prucalopride Succinate Chemical Structure

CAS No. 179474-85-2

Prucalopride is a selective, high affinity 5-HT4 receptor agonist. The Ki values of prucalopride for human 5-HT(4a) and 5-HT(4b) receptor are 2.5 nM and 8 nM, respectively.

Selleck's Prucalopride Succinate has been cited by 4 publications

1 Customer Review

  • Prucalopride in the presence of IBMX on the S2/S1 ratio of electrically induced total tritium outflow. Tissues were stimulated twice (S1 and S2; 1 millisecond, 15 V, 4 Hz, 2 minutes); IBMX was added 36 minutes and prucalopride 15 minutes before S2. Mean S2/S1±SEM; one‐way ANOVA followed by Bonferroni corrected t test with ns not significant, *P<.05 and ***P<.001.

    Neurogastroenterol Motil, 2018, 30(2). Prucalopride Succinate purchased from Selleck.

Purity & Quality Control

Choose Selective 5-HT Receptor Inhibitors

Biological Activity

Description Prucalopride is a selective, high affinity 5-HT4 receptor agonist. The Ki values of prucalopride for human 5-HT(4a) and 5-HT(4b) receptor are 2.5 nM and 8 nM, respectively.
5-HT4A [1] 5-HT4B [1]
2.5 nM(Ki) 8 nM(Ki)
In vitro

Prucalopride induces contractions in a concentration-dependent manner with pEC50 of 7.5. Prucalopride (1 mM) significantly amplifies the rebound contraction of the guinea-pig proximal colon after electrical field stimulation. Prucalopride induces relaxation of the rat oesophagus preparation of rat oesophagus tunica muscularis mucosae with pEC50 of 7.8, yielding a monophasic concentration–response curve. [1] Prucalopride (0.1 μM) concentration-dependently increases the amplitude of submaximal cholinergic contractions and of acetylcholine release induced by electrical field stimulation in pig gastric circular muscle, and the effect is induced and enhanced IBMX (10 μM). [2] Prucalopride (1 μM) significantly enhances the electrically induced cholinergic contractions in pig descending colon, and the facilitating effect is significantly enhanced by Rolipram. [3]

In vivo Prucalopride alters colonic contractile motility patterns in a dose-dependent fashion by stimulating high-amplitude clustered contractions in the proximal colon and by inhibiting contractile activity in the distal colon of fasted dogs. Prucalopride also causes a dose-dependent decrease in the time to the first giant migrating contraction (GMC); at higher doses of prucalopride, the first GMC generally occurres within the first half-hour after treatment. [4]


Solubility (25°C)

In vitro DMSO 97 mg/mL (199.6 mM)
Water 97 mg/mL (199.6 mM)
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 485.96


CAS No. 179474-85-2
Storage powder
in solvent
Synonyms N/A
Smiles COCCCN1CCC(CC1)NC(=O)C2=CC(=C(C3=C2OCC3)N)Cl.C(CC(=O)O)C(=O)O

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
Step 2: Enter the in vivo formulation ()
% DMSO % % Tween 80 % ddH2O

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and SDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04838522 Recruiting Other: No Intervention Chronic Constipation Takeda September 30 2021 --
NCT04429802 Completed Drug: Prucalopride Gastrointestinal Motility Disorder|Dyspepsia Universitaire Ziekenhuizen Leuven September 26 2013 Not Applicable
NCT01807000 Completed Drug: Radiolabeled Prucalopride Succinate Healthy Shire|Takeda March 18 2013 Phase 1
NCT01692132 Withdrawn Drug: Prucalopride Chronic Constipation Janssen Pharmaceutica February 2013 --
NCT03279341 Completed Drug: polyethylene glycol|Drug: Bisacodyl|Drug: Prucalopride Chronic Constipation University Hospital Gasthuisberg December 3 2012 Phase 4
NCT01117051 Terminated Drug: placebo|Drug: prucalopride Non-cancer Pain|Opioid Induced Constipation Shire|Takeda May 19 2010 Phase 3

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

5-HT Receptor Signaling Pathway Map

Related 5-HT Receptor Products

Tags: buy Prucalopride Succinate | Prucalopride Succinate ic50 | Prucalopride Succinate price | Prucalopride Succinate cost | Prucalopride Succinate solubility dmso | Prucalopride Succinate purchase | Prucalopride Succinate manufacturer | Prucalopride Succinate research buy | Prucalopride Succinate order | Prucalopride Succinate mouse | Prucalopride Succinate chemical structure | Prucalopride Succinate mw | Prucalopride Succinate molecular weight | Prucalopride Succinate datasheet | Prucalopride Succinate supplier | Prucalopride Succinate in vitro | Prucalopride Succinate cell line | Prucalopride Succinate concentration | Prucalopride Succinate nmr
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID