Palonosetron HCl

For research use only.

Catalog No.S3050 Synonyms: RS 25259, RS 25259 197

Palonosetron HCl Chemical Structure

CAS No. 135729-62-3

Palonosetron HCl (RS 25259, RS 25259 197) is a 5-HT3 antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting.

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Biological Activity

Description Palonosetron HCl (RS 25259, RS 25259 197) is a 5-HT3 antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting.
5-HT3 [1]
In vitro

Palonosetron is a highly potent, selective, second-generation 5-HT3 receptor antagonist with a 5-HT3 receptor binding affinity that is ∼100-fold higher than other 5-HT3 receptor antagonists (pKi 10.5 compared with 8.91 for granisetron, 8.81 for tropisetron, 8.39 for ondansetron, 7.6 for dolasetron). Palonosetron also has an extended plasma elimination half-life of ∼40 h, significantly longer than others in its class (ondansetron, 4 h; tropisetron, 7.3 h; dolasetron, 7.5 h; ranisetron, 8.9 h).


Solubility (25°C)

In vitro Water 67 mg/mL (201.27 mM)
DMSO Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 332.87


CAS No. 135729-62-3
Storage powder
in solvent
Synonyms RS 25259, RS 25259 197
Smiles C1CC2CN(C(=O)C3=CC=CC(=C23)C1)C4CN5CCC4CC5.Cl

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04486157 Completed Drug: IN-A012|Drug: Akynzeo 300Mg-0.5Mg Capsule Healthy HK inno.N Corporation March 18 2021 Phase 1
NCT03148704 Unknown status Drug: palonosetron hydrochloride capsules Palonosetron Cttq March 8 2017 --
NCT00982995 Terminated Drug: Palonosetron Nausea|Vomiting|Terminally Ill University of Michigan Rogel Cancer Center November 2010 Phase 2
NCT01074697 Completed Drug: Fosaprepitant dimeglumine|Drug: Placebo Nausea|Vomiting|Genital Neoplasms Female Odense University Hospital|Helsinn Healthcare SA April 2010 Phase 3
NCT01046240 Completed Drug: Palonosetron Emesis Clinica Universidad de Navarra Universidad de Navarra October 2009 Phase 1|Phase 2

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5-HT Receptor Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID