Palonosetron HCl

Catalog No.S3050 Synonyms: RS 25259, RS 25259 197

For research use only.

Palonosetron HCl (RS 25259, RS 25259 197) is a 5-HT3 antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting.

Palonosetron HCl Chemical Structure

CAS No. 135729-62-3

Purity & Quality Control

Choose Selective 5-HT Receptor Inhibitors

Other 5-HT Receptor Products

Biological Activity

Description Palonosetron HCl (RS 25259, RS 25259 197) is a 5-HT3 antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting.
5-HT3 [1]
In vitro

Palonosetron is a highly potent, selective, second-generation 5-HT3 receptor antagonist with a 5-HT3 receptor binding affinity that is ∼100-fold higher than other 5-HT3 receptor antagonists (pKi 10.5 compared with 8.91 for granisetron, 8.81 for tropisetron, 8.39 for ondansetron, 7.6 for dolasetron). Palonosetron also has an extended plasma elimination half-life of ∼40 h, significantly longer than others in its class (ondansetron, 4 h; tropisetron, 7.3 h; dolasetron, 7.5 h; ranisetron, 8.9 h).

Protocol (from reference)

Solubility (25°C)

In vitro

Water 67 mg/mL
(201.27 mM)
DMSO Insoluble
Ethanol Insoluble

Chemical Information

Molecular Weight 332.87


CAS No. 135729-62-3
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1CC2CN(C(=O)C3=CC=CC(=C23)C1)C4CN5CCC4CC5.Cl

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04486157 Completed Drug: IN-A012|Drug: Akynzeo 300Mg-0.5Mg Capsule Healthy HK inno.N Corporation March 18 2021 Phase 1
NCT03148704 Unknown status Drug: palonosetron hydrochloride capsules Palonosetron Cttq March 8 2017 --
NCT00982995 Terminated Drug: Palonosetron Nausea|Vomiting|Terminally Ill University of Michigan Rogel Cancer Center November 2010 Phase 2
NCT01074697 Completed Drug: Fosaprepitant dimeglumine|Drug: Placebo Nausea|Vomiting|Genital Neoplasms Female Odense University Hospital|Helsinn Healthcare SA April 2010 Phase 3
NCT01046240 Completed Drug: Palonosetron Emesis Clinica Universidad de Navarra Universidad de Navarra October 2009 Phase 1|Phase 2

(data from, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy Palonosetron HCl | Palonosetron HCl ic50 | Palonosetron HCl price | Palonosetron HCl cost | Palonosetron HCl solubility dmso | Palonosetron HCl purchase | Palonosetron HCl manufacturer | Palonosetron HCl research buy | Palonosetron HCl order | Palonosetron HCl mouse | Palonosetron HCl chemical structure | Palonosetron HCl mw | Palonosetron HCl molecular weight | Palonosetron HCl datasheet | Palonosetron HCl supplier | Palonosetron HCl in vitro | Palonosetron HCl cell line | Palonosetron HCl concentration | Palonosetron HCl nmr