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Technical Data
| Formula | C18H21NO |
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| Molecular Weight | 267.37 | CAS No. | 115-46-8 | |
| Solubility (25°C)* | In vitro | DMSO | 53 mg/mL (198.22 mM) | |
| Ethanol | 53 mg/mL (198.22 mM) | |||
| Water | 2 mg/mL (7.48 mM) | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | Azacyclonol (MER 17, MDL 4829), also known as γ-pipradol, is a drug used to diminish hallucinations in psychotic individuals. |
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| In vitro | The formation of Azacyclonol in human intestinal microsomes is linear with respect to time up to 60 min. The rates of formation of Azacyclonol increases linearly with microsomal protein concentration up to 2 mg/mL. The apparent Km and Vmax values of Azacyclonol are 0.82 μM and 60 pmol/min/mg protein in microsomes from human liver. [1] The formation of Azacyclonol and terfenadine alcohol from terfenadine is confirmed to be catalyzed predominantly by CYP3A(4) isozyme, and the ratio of the rate of terfenadine alcohol formation to that of Azacyclonol is 3:1. [2] The amount of Azacyclonol eliminated renally increases on average 2-fold after rifampin dosing. [3] |
| In vivo | Azacyclonol (i.v.) impairs the response of the nictitating membrane to both post- and preganglionic stimulation. The activity of Azacyclonol in depressing transmission through the cat superior ceivical ganglion is 6.63%. [4] |
Protocol (from reference)
References
Selleck's Azacyclonol has been cited by 2 publications
| Long non-coding RNA SNHG22 facilitates hepatocellular carcinoma tumorigenesis and angiogenesis via DNA methylation of microRNA miR-16-5p [ Bioengineered, 2021, 12(1):7446-7458] | PubMed: 34652260 |
| Aberrant methylation‑mediated decrease of lncRNA HNF1A‑AS1 contributes to malignant progression of laryngeal squamous cell carcinoma via EMT [ Oncol Rep, 2020, 44(6):2503-2516] | PubMed: 33125127 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.