For research use only. Not for use in humans.

Anti-FGFR4 / CD334

Synonyms: U3-1784 Cat.No.A2494 Purity:99%

Anti-FGFR4 / CD334 (U3-1784) is a human monoclonal antibody targeting FGFR4 (human fibroblast growth factor receptor 4), with potential antineoplastic activity. It blocks activation of FGFR4, which inhibits FGFR4-mediated signaling and leads to an inhibition of cell proliferation in FGFR4-overexpressing tumor cells. MW: 145.5 KD.

1 Citation

17 Nobel Prize winners have used Selleck products

Shimon Sakaguchi

Nature Communications 2025,16, Article number:1325

David Baker

Dev Cell 2023, 58(20):2163-2180.e9.

David Julius

Cell 2017, 185-198.e16

Michael Houghton

Cell Chem Biol, 2020, 27(7):780-792.e5

Charles M. Rice

Cell 2018, 172(3):423-438.e25

Quality Control

Batch: A249401 Purity: 99% Protein concentration: 4.85mg/ml Endotoxin Level: ＜1EU/mg

Cited in Nature Medicine for its top-tier quality
COA
SDS
Datasheet

Specificity

Name	Citation	FGFR	FGFR1	FGFR2	FGFR3	FGFR4	Others
PD173074	124		++				VEGFR2
Dovitinib (TKI-258)	52		+++		+++		FLT3,c-Kit,VEGFR3/FLT4
AZD4547 (Fexagratinib)	145		++++	+++	++++		KDR
Danusertib (PHA-739358)	46		++				Aurora A,Abl,TrkA
Brivanib (BMS-540215)	10		+				VEGFR2,Flk1,VEGFR1
ENMD-2076	9		+	+			FLT3,RET,Aurora A
MK-2461	4		+	++	+		c-Met (M1250T),c-Met (Y1235D),c-Met (Y1230H)
Brivanib Alaninate (BMS-582664)	2		+				VEGFR2,Flk1,VEGFR1
Tyrphostin AG 1296	14	+					PDGFR,c-Kit (Swiss 3T3)
SSR128129E	9		+
Irpagratinib	0					+++
R1530	0		++				VEGFR2
FIIN-3	0		+++	++	++	++
Lucitanib (E3810) hydrochloride	1		++	+			VEGFR1,VEGFR3,VEGFR2
Rogaratinib	0		++++	++++	+++	++++
Sulfatinib	1		++				VEGFR3,VEGFR1,CSF1R
ODM-203	0		+++	++	+++	++	VEGFR3,VEGFR2,VEGFR1
Futibatinib (TAS-120)	16		++++	++++	++++	+++
ASP5878	3		++++	++++	++++	+++
Derazantinib	4		+++	++++	+++	++	RET,DDR2,PDGFRβ
H3B-6527	12					++++
Roblitinib (FGF401)	6					++++
PRN1371	2		++++	++++	+++	++	CSF1R
PD-166866	15		+
Fisogatinib (BLU-554)	10					+++
S49076	1		++	++	++		Met,Mer,Axl
NSC12	2			+			FGF3,FGF8b,FGF22
ON123300	4		++				CDK4/CyclinD1,ARK5,RET
SU 5402	24		++				VEGFR2,PDGFRβ
BLU9931	21				+	+++
FIIN-2	5		+++	+++	++	++
Dovitinib (TKI258) Lactate monohydrate	31		+++		+++		FLT3,c-Kit,VEGFR3/FLT4
Zoligratinib (Debio-1347)	12		+++	+++	++	+
LY2874455	15		+++	+++	+++	+++	VEGFR2
Ferulic Acid	6		+	+
Resigratinib	0	✔
Lirafugratinib (RLY-4008)	0			✔
Masitinib mesylate	0				✔		FAK,human recombinant c-Kit,LynB
BO-264	0				✔		TACC3
SKLB 610	2			✔			PDGFR,VEGFR2
Alofanib (RPT835)	5			✔
Gambogenic acid	4	✔					EZH2

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1. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation. 2. "✔" indicates inhibitory effect, but without specific value.

Mechanism of Action

Description	Anti-FGFR4 / CD334 (U3-1784) is a human monoclonal antibody targeting FGFR4 (human fibroblast growth factor receptor 4), with potential antineoplastic activity. It blocks activation of FGFR4, which inhibits FGFR4-mediated signaling and leads to an inhibition of cell proliferation in FGFR4-overexpressing tumor cells. MW: 145.5 KD.

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID

Product Details

Molecular Weight	145.5 kDa
Isotype	Human IgG1
Source	CHO
Purification	AKTA
Sterility	0.2 μM filtered
Formulation	100 mM Pro-Ac, 20mM Arg, pH5.0
Storage (From the date of receipt)	Store the undiluted solution at -20°C in the dark to avoid freeze-thaw cycles.

Comparison of Clones for

^*Literature analysis of various clone (for this target) products available on the market shows that Selleck's selected clones are more frequently applied. (data until September 2024)

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