Futibatinib (TAS-120)

Catalog No.S8848

For research use only.

Futibatinib (TAS-120) is an irreversible fibroblast growth factor receptor (FGFR) inhibitor which inhibits all 4 subtypes of FGFR with enzyme IC50 values of 1.8 nM, 1.4 nM, 1.6 nM and 3.7 nM for FGFR1, FGFR2, FGFR3 and FGFR4, respectively.

Futibatinib (TAS-120) Chemical Structure

CAS No. 1448169-71-8

Selleck's Futibatinib (TAS-120) has been cited by 4 Publications

Purity & Quality Control

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Biological Activity

Description Futibatinib (TAS-120) is an irreversible fibroblast growth factor receptor (FGFR) inhibitor which inhibits all 4 subtypes of FGFR with enzyme IC50 values of 1.8 nM, 1.4 nM, 1.6 nM and 3.7 nM for FGFR1, FGFR2, FGFR3 and FGFR4, respectively.
Targets
FGFR2 [1]
(Cell-free assay)
FGFR3 [1]
(Cell-free assay)
FGFR1 [1]
(Cell-free assay)
FGFR4 [1]
(Cell-free assay)
1.4 nM 1.6 nM 1.8 nM 3.7 nM

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 418.45
Formula

C22H22N6O3

CAS No. 1448169-71-8
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles COC1=CC(=CC(=C1)C#CC2=NN(C3=NC=NC(=C23)N)C4CCN(C4)C(=O)C=C)OC

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04965818 Recruiting Drug: Futibatinib and Binimetinib Advanced or Metastatic Solid Tumors Irrespective of Gene Alterations|Non-Small Cell Lung Cancer|KRAS Gene Mutation Taiho Oncology Inc. September 20 2021 Phase 1|Phase 2
NCT05036681 Recruiting Drug: Futibatinib|Drug: Pembrolizumab Metastatic Cancer|Endometrium Cancer|Endometrial Carcinoma M.D. Anderson Cancer Center|National Comprehensive Cancer Network September 30 2021 Phase 2
NCT04024436 Recruiting Drug: Futibatinib|Drug: Futibatinib plus Fulvestrant Metastatic Breast Cancer|FGFR 1 High Amplification|FGFR2 Amplification Taiho Oncology Inc. August 30 2019 Phase 2

(data from https://clinicaltrials.gov, updated on 2022-08-01)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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