Topo IV Selective Inhibitors

Catalog No. Product Name Information Selective / Pan IC50 / Ki
S2027 Ciprofloxacin

Ciprofloxacin is a fluoroquinolone antibiotic, shows broad and potent antibacterial activity, with MIC90 of 0.024-6 μM.

S1463 Ofloxacin

Ofloxacin is a synthetic broad-spectrum antimicrobial agent.

S1464 Marbofloxacin

Marbofloxacin is a potent antibiotic inhibiting bacterial DNA replication.

S2328 Nalidixic acid

Nalidixic acid is a synthetic 1,8-naphthyridine antimicrobial agent with a limited bacteriocidal spectrum. It is an inhibitor of the A subunit of bacterial DNA gyrase.

S2492 Novobiocin Sodium

Novobiocin Sodium is a very potent bacterial DNA gyrase and human organic anion transporters with Ki of 14.87 ± 0.40 μM for hOAT1, 4.77 ± 1.12 μM for hOAT3 and 90.50 ± 7.50 μM for hOAT4.

S1465 Moxifloxacin HCl

Moxifloxacin is a fourth-generation synthetic fluoroquinolone antibacterial agent.

S4006 Clinafloxacin

Clinafloxacin is a fluoroquinolone that inhibits both DNA gyrase and topoisomerase IV dually in Streptococcus pneumoniae.

S1940 Levofloxacin

Levofloxacin is a broad-spectrum antibiotic topoisomerase II and topoisomerase IV inhibitor, used to treat respiratory, urinary tract, gastrointestinal, and abdominal infections.

S1509 Norfloxacin

Norfloxacin is a broad-spectrum antibiotic.

S1756 Enoxacin

Enoxacin is an oral broad-spectrum fluoroquinolone antibacterial agent used in the treatment of urinary tract infections and gonorrhea. Insomnia is a common adverse effect.

S1340 Gatifloxacin

Gatifloxacin is an antibiotic of the fourth-generation fluoroquinolone family, and inhibits the bacterial enzymes DNA gyrase and topoisomerase IV.