Name: Fluoxetine (Lilly 110140) HCl
Brand: Selleck Chemicals
SKU: S1333
Rating: 5 (15 reviews)

Fluoxetine (Lilly 110140) HCl Chemical Structure

CAS No. 56296-78-7

Selleck's Fluoxetine (Lilly 110140) HCl has been cited by 15 publications

Purity & Quality Control

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5-HT Receptor Signaling Pathway Map

Biological Activity

Description

Fluoxetine HCl (Lilly110140) is a selective serotonin-reuptake inhibitor (SSRI) at the neuronal membrane, used in the treatment of depression.

Targets

5-HT ^[1]

In vitro

Fluoxetine blocks the downregulation of cell proliferation resulting from inescapable shock (IS) of hippocampal cell. ^[1] Fluoxetine increases the number of newborn cells in the dentate gyrus of the hippocampus of adult rat. Fluoxetine also increases the number of proliferating cells in the prelimbic cortex. ^[2] Fluoxetine accelerates the maturation of immature neurons. Fluoxetine enhances neurogenesis-dependent long-term potentiation (LTP) in the dentate gyrus. ^[3] Fluoxetine, but not citalopram, fluvoxamine, paroxetine and sertraline, increases norepinephrine and dopamine extracellular levels in prefrontal cortex. Fluoxetine produces robust and sustained increases in extracellular concentrations of norepinephrine and dopamine after acute systemic administration. ^[4]

Cell Data

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID

HEK293	NVrWOnpMTnWwY4Tpc44h[XO\|YYm=	Mo\oN\|AhdWmwcx?=	MYPJcohq[mm2aX;uJI9nKGi3bXHuJHNGWlRiZYjwdoV{e2WmIHnuJGhGUzJ7MzDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKHOncn;0c45qdiC{ZYXweIFs\SCjZoTldkA{OCCvaX7zJIJ6KG[udX;y[ZNk\W6lZTDhd5NigSxiSVO1NF0xNjF3zszN	NGrvS4E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkmzPFA1QSd-MkK5N\|gxPDl:L3G+
HEK293	M3jscmZ2dmO2aX;uJIF{e2G7	MnXYN\|AhdWmwcx?=	MV7Jcohq[mm2aX;uJI9nKGi3bXHuJG5GXCCneIDy[ZN{\WRiaX6gTGVMOjl\|IHPlcIx{KGG\|c3Xzd4VlKGG\|IHnubIljcXSrb36gc4Yhdm:{YXTy[Y5idGmwZTDy[ZVxfGGtZTDh[pRmeiB\|MDDtbY5{KGK7IH\seY9z\XOlZX7j[UBie3OjeTygTWM2OD12LkSx{txO	M{jLOFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{OUO4NFQ6Lz5{MkmzPFA1QTxxYU6=
HEK293	MkLiSpVv[3Srb36gZZN{[Xl?	MoPKN\|AhdWmwcx?=	NHjZZ5VKdmirYnn0bY9vKG:oIHj1cYFvKESDVDDlfJBz\XO\|ZXSgbY4hUEWNMkmzJINmdGy\|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiZH;wZY1qdmVicnX1dJRic2ViYX\0[ZIhOzBibXnud{BjgSCobIXvdoV{[2WwY3WgZZN{[XluIFnDOVA:OThwNN88US=>	NIWwWXE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkmzPFA1QSd-MkK5N\|gxPDl:L3G+
mammalian cells	NWDwUJFwTnWwY4Tpc44h[XO\|YYm=		MVrJcohq[mm2aX;uJI9nKGi3bXHuJHBwfGG\|c3n1cUBkcGGwbnXsJGhGWkdiZYjwdoV{e2WmIHnuJI1idW2jbHnhckBk\WyuczygTWM2OD1zLkWxN\|U3\|ryP	MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yOjh5M{WxNkc,OTJ6N{O1NVI9N2F-
JAR	NUK2b4tvTnWwY4Tpc44h[XO\|YYm=		MW\Jcohq[mm2aX;uJINwdmOnboTyZZRqd25iYXfhbY5{fCCdM1jdOU1JXCC3cIThb4Uh[nliaIXtZY4he2W{b4TvcolvKHS{YX7zdI9zfGW{IHnuJGpCWiClZXzsd{whUUN3ME2wMlA{OjUQvF2=	M321fVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF3MkO5OlYyLz5zNUKzPVY3OTxxYU6=
K562	NF7XW4ZEgXSxdH;4bYNqfHliYYPzZZk>		NE\0PYtEgXSxdH;4bYNqfHlidH:gdoVlfWOnIHPodo9vcWNibYnlcI9q\CCuZYXr[Y1q[SCNIEW2NkBk\WyuczygR2M2OD1{Nd88US=>	NEDjdJg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNUK2O\|IzQSd-MUWyOlczOjl:L3G+
U937	NUm4UHdlS3m2b4TvfIlkcXS7IHHzd4F6		MWHDfZRwfG:6aXPpeJkhfG9icnXkeYNmKGi3bXHuJIhqe3SxbIn0bYMhdHmvcHjvcYEhXTl\|NzDj[YxteyxiQ1O1NF0{Oy5\|zszN	MoW1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTV{NkeyNlkoRjF3Mk[3NlI6RC:jPh?=
HEK293	MXLGeY5kfGmxbjDhd5NigQ>?		M3rGZ2lvcGmkaYTpc44hd2ZiW{PIYVUuUFRidYD0ZYtmKGG2IEXIWEB1emGwc4DvdpRmeiCneIDy[ZN{\WRiaX6gTGVMOjl\|IHPlcIx{NCCLQ{WwQVAvODF4zszN	NVrZToF4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[3OVA{PTlpPkG2O\|UxOzV7PD;hQi=>
HEK293	MoHISpVv[3Srb36gZZN{[Xl?		NHLZfnRKdmirYnn0bY9vKG:oIFTBJJRz[W6\|cH;yeIVzKGW6cILld5Nm\CCrbjDISWszQTNiY3XscJMtKEmFNUC9OE41\|ryP	NILpfJE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNke1NFM2QSd-MU[3OVA{PTl:L3G+
HEK293	NWPkUFRXTnWwY4Tpc44h[XO\|YYm=		MYPJcohq[mm2aX;uJI9nKFt\|SG3ORUB2eHSja3WgZZQhVkFidILhcpNxd3K2ZYKg[ZhxemW\|c3XkJIlvKEiHS{K5N{Bk\WyuczygTWM2OD13LkNOwG0>	NInLbJE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNke1NFM2QSd-MU[3OVA{PTl:L3G+
HEK293	NYiyeJJoTnWwY4Tpc44h[XO\|YYm=		MmG0TY5pcWKrdHnvckBw\iCdM1jdOU1JXCC{ZYXweIFs\SCjdDC1THQhfHKjboPwc5J1\XJiaX6gTGVMOjl\|IHPlcIx{NCCLQ{WwQVAvODF4zszN	NG\ORok9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zNke1NFM3Oyd-MU[3OVA{PjN:L3G+
HEK293	MWfGeY5kfGmxbjDhd5NigQ>?		NECzPYZKdmirYnn0bY9vKG:oIGuzTH1FSSC{ZYXweIFs\SCjdDDERUB1emGwc4DvdpRmeiCrbjDISWszQTNiY3XscJMtKEmFNUC9OE41\|ryP	MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPjd3MEO2N{c,OTZ5NUCzOlM9N2F-
HEK293	NX\NR457TnWwY4Tpc44h[XO\|YYm=		MW\Jcohq[mm2aX;uJI9nKFt\|SG3ORUBz\XWydHHr[UBifCCQQTD0doFve3CxcoTldkBqdiCKRVuyPVMh[2WubIOsJGlEPTB;NT6y{txO	M1XkdFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF4N{WwN\|Y{Lz5zNke1NFM3OzxxYU6=
Jar	NFLxfmJHfW6ldHnvckBie3OjeR?=		MnXmTY5pcWKrdHnvckBw\iCdM1jdOU1JXCC3cIThb4Uh[XRiaIXtZY4hPS2KVDD0doFve3CxcoTldkBmgHC{ZYPz[YQhcW5iSnHyJINmdGy\|LDDJR\|UxRTBwMEO5OO69VQ>?	NYjVc\|ZVRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMU[4OVQxQDZpPkG2PFU1ODh4PD;hQi=>
SK-N-MC	MVfGeY5kfGmxbjDhd5NigQ>?		NI\OVFlFcXOybHHj[Y1mdnRib3[gUk1cO0ifYXzwbIEudWW2aInsbIl{fGGvaX7lJIZzd21iaIXtZY4hcGm\|dHHtbY5mKEh\|IILlZ4VxfG:{IHX4dJJme3OnZDDpckBUUy2QLV3DJINmdGy\|LDDLbV04NjQQvF2=	M1u0cVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5M{C3N\|U5Lz5zN{OwO\|M2QDxxYU6=
CHO	M3zxfWZ2dmO2aX;uJIF{e2G7		NXvifXVQUW6qaXLpeIlwdiCxZjDoeY1idiCHUleg[ZhxemW\|c3XkJIlvKEOKTzDj[YxteyCkeTD3bI9t\SClZXzsJJBifGOqIHPsZY1xKHSnY3jubZF2\SxiSVO1NF0yNjVzM{W2{txO	NHzFXW49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOES0PFM1Oid-MUi0OFg{PDJ:L3G+
HEK293	NF;zbHFHfW6ldHnvckBie3OjeR?=		NGLxS5ZKdmirYnn0bY9vKG:oIIPldo91d26rbjD1dJRic2ViYYSgbJVu[W5iU1XSWEBqdiCqdX3hckBJTUt{OUOgZ4VtdHNuIFnDOVA:OC5yNEhOwG0>	MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDV3MEO2PUc,OTh3NUCzOlk9N2F-
HEK293	MUXGeY5kfGmxbjDhd5NigQ>?		NUPqOZJoUW6qaXLpeIlwdiCxZjDuc5JmeGmwZYDodolv\SC3cIThb4Uh[XRiaIXtZY4hVkWWIHnuJIh2dWGwIFjFT\|I6OyClZXzsd{whUUN3ME2y{txO	MXm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDV3MEO2PUc,OTh3NUCzOlk9N2F-
HEK293	NX36XGtQTnWwY4Tpc44h[XO\|YYm=		NVT4bIVSUW6qaXLpeIlwdiCxZjDkc5BidWmwZTD1dJRic2ViYYSgbJVu[W5iRFHUJIlvKGi3bXHuJGhGUzJ7MzDj[YxteyxiSVO1NF03\|ryP	NWWwTmszRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi1OVA{PjlpPkG4OVUxOzZ7PD;hQi=>
JAR	M3LHd2Z2dmO2aX;uJIF{e2G7		MVzJcohq[mm2aX;uJI9nKDWKVDD1dJRic2ViYYSgbJVu[W5iU1XSWEBmgHC{ZYPz[YQhcW5iaIXtZY4hUkGUIHPlcIx{NCCLQ{WwQVAvODB7NN88US=>	MV:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDV3N{[wPEc,OTh3NUe2NFg9N2F-
HEK	NXfSPJNZTnWwY4Tpc44h[XO\|YYm=		MVTJcohq[mm2aX;uJI9nKHOncn;0c45qdiC3cIThb4Uh[XRiaIXtZY4hW0WUVDDlfJBz\XO\|ZXSgbY4hUEWNIHPlcIx{NCCLQ{WwQVAvODR5zszN	MV68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQDZ4N{OwPUc,OTh4NkezNFk9N2F-
HEK	MWPGeY5kfGmxbjDhd5NigQ>?		M3n0XWlvcGmkaYTpc44hd2Zibn;y[ZBqdmWyaILpcoUhfXC2YXvlJIF1KGi3bXHuJG5GXCCneIDy[ZN{\WRiaX6gTGVMKGOnbHzzMEBKSzVyPUNOwG0>	NHz6dIQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOE[2O\|MxQSd-MUi2Olc{ODl:L3G+
HEK	NFixU49HfW6ldHnvckBie3OjeR?=		NHzDVJZKdmirYnn0bY9vKG:oIHTvdIFucW6nIIXweIFs\SCjdDDoeY1idiCGQWSg[ZhxemW\|c3XkJIlvKEiHSzDj[YxteyxiSVO1NF03\|ryP	MoHyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh4NkezNFkoRjF6Nk[3N\|A6RC:jPh?=
JAR	MmrJSpVv[3Srb36gZZN{[Xl?		NGrVTIZKdmirYnn0bY9vKG:oIIPldo91d26rbjD1dJRic2ViYYSgbJVu[W5iU1XSWEBmgHC{ZYPz[YQhcW5iSlHSJINmdGy\|LDDJR\|UxRTBwMEJOwG0>	MlTKQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh5N{G5NVYoRjF6N{exPVE3RC:jPh?=
MDCK	MVHGeY5kfGmxbjDhd5NigQ>?		NGLJRpBKdmirYnn0bY9vKG:oIH7vdoVxcW6ncHjybY5mKHWydHHr[UBifCCqdX3hckBPTVRiZYjwdoV{e2WmIHnuJG1FS0tiY3XscJMtKEmFNUC9NE42PjQQvF2=	Mmm0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh5N{G5NVYoRjF6N{exPVE3RC:jPh?=
Jar	NGTOTJRHfW6ldHnvckBie3OjeR?=		M1rhZmlvcGmkaYTpc44hd2ZiNT3IWEB1emGwc4DvdpRmei2vZXTpZZRm\CCdM1jdOWhVKHWydHHr[UBqdiCqdX3hckBL[XJiY3XscJMtKEmFNUC9NE4xOzl2zszN	NU\z[oY6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUi4N\|QyQDhpPkG4PFM1OTh6PD;hQi=>
JAR	MmXKSpVv[3Srb36gZZN{[Xl?		MV;Jcohq[mm2aX;uJI9nKHOncn;0c45qdiC3cIThb4Uh[XRiaIXtZY4hW0WUVDDlfJBz\XO\|ZXSgbY4hUkGUIHPlcIx{NCCLQ{WwQVAvODB7NN88US=>	M2\CelxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF6OUWxNFIxLz5zOEm1NVAzODxxYU6=
HEK293	NEXLN2dHfW6ldHnvckBie3OjeR?=		NITzSmxFcXOybHHj[Y1mdnRib3[gX\|EzPUmfUmTJOVUh\nKxbTDoeY1idiC{ZXPvcYJqdmGwdDDTSXJVKGW6cILld5Nm\CCrbjDISWszQTNiY3XscJMtKEurPUCuNFAyOc7:TR?=	MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTBzNEi4PEc,OTlyMUS4PFg9N2F-
HEK293	MlnjSpVv[3Srb36gZZN{[Xl?		NIHufpdKdmirYnn0bY9vKG:oIGuzTH02UFRiZoLvcUBpfW2jbjDy[YNwdWKrbnHueEBUTVKWIHX4dJJme3OnZDDpckBJTUt{OUOgZ4VtdHNuIFnDOVA:OC5yMEhOwG0>	NHPwcmE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zOUCxOFg5QCd-MUmwNVQ5QDh:L3G+
HEK293	MVrGeY5kfGmxbjDhd5NigQ>?		M{LvbmlvcGmkaYTpc44hd2ZiW{PIYW5GKG[{b32gbJVu[W5icnXjc41jcW6jboSgUmVVKGW6cILld5Nm\CCrbjDISWszQTNiY3XscJMtKEmFNUC9NU4xOs7:TR?=	MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTBzNEi4PEc,OTlyMUS4PFg9N2F-
HEK293	MmnJSpVv[3Srb36gZZN{[Xl?		M4nITGRqe3CuYXPlcYVvfCCxZjDbNVI2UV2UVFm1OUBnem:vIHj1cYFvKHKnY3;tZolv[W62IF7FWEBmgHC{ZYPz[YQhcW5iSFXLNlk{KGOnbHzzMEBMcT1zLkW2{txO	Mn\rQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTlyMUS4PFgoRjF7MEG0PFg5RC:jPh?=
HEK293	MnHqSpVv[3Srb36gZZN{[Xl?		MlLoSIl{eGyjY3Xt[Y51KG:oIGuxNlVKZVKWSUW1JIZzd21iaIXtZY4hemWlb33ibY5idnRiRFHUJIV5eHKnc4Pl[EBqdiCKRVuyPVMh[2WubIOsJGtqRTZwNkhOwG0>	NYPMW5ZyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUmwNVQ5QDhpPkG5NFE1QDh6PD;hQi=>
HEK293	NEjSeHJHfW6ldHnvckBie3OjeR?=		MkPnTY5pcWKrdHnvckBw\iCdM1jdSGEh\nKxbTDoeY1idiC{ZXPvcYJqdmGwdDDERXQh\XiycnXzd4VlKGmwIFjFT\|I6OyClZXzsd{whUUN3ME2xPU42\|ryP	MkSyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTlyMUS4PFgoRjF7MEG0PFg5RC:jPh?=
HEK293	MYfGeY5kfGmxbjDhd5NigQ>?		MmDISIl{eGyjY3Xt[Y51KG:oIGuxNlVKZVKWST21OUBnem:vIHj1cYFvKHKnY3;tZolv[W62IGPFVnQh\XiycnXzd4VlKGmwIFjFT\|I6OyClZXzsd{BjgSC\|Y3nueIltdGG2aX;uJINwfW62aX7nMEBMcT1yLkCwNVHPxE1?	MXy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yQTJ3NkWwNkc,OTl{NU[1NFI9N2F-
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HEK293	MW\GeY5kfGmxbjDhd5NigQ>?		M4TI[mlvcGmkaYTpc44hd2Zib3[gbJVu[W5iVGLFT\|Eh\XiycnXzd4VlKGmwIFjFT\|I6OyClZXzsd{Bie3Onc4Pl[EBieyC{ZXT1Z5Rqd25iaX6gZ4hidm6nbDDjeZJz\W62czygTWM2OD1zNN88US=>	MWi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjV6OEC0OUc,OjZ3OEiwOFU9N2F-
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Click to View More Cell Line Experimental Data

In vivo

Fluoxetine treatment also reverses the deficit in escape latency observed in animals exposed to inescapable shock in adult male Sprague–Dawley rats. ^[1] Fluoxetine combined with Olanzapine produces robust, sustained increases of extracellular levels of dopamine ([DA](ex)) and norepinephrine ([NE](ex)) up to 361% and 272% of the baseline, respectively, which are significantly greater than either drug alone. ^[5]

Protocol (from reference)

References

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Solubility (25°C)

In vitro	DMSO	69 mg/mL (199.54 mM)
	Water	4 mg/mL (11.56 mM)
	Ethanol	'69 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight	345.79
Formula	C₁₇H₁₈F₃NO.HCl
CAS No.	56296-78-7
Storage	3 years	-20°C	powder
Storage	2 years	-80°C	in solvent
Smiles	CNCCC(C1=CC=CC=C1)OC2=CC=C(C=C2)C(F)(F)F.Cl

Download Fluoxetine (Lilly 110140) HCl SDF

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Dilution Calculator Molecular Weight Calculator

Clinical Trial Information

NCT Number	Recruitment	Interventions	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT04676139	Recruiting	Drug: Fluoxetine\|Drug: Placebo	Nocturnal Enuresis	Mansoura University	July 1 2020	Phase 3
NCT01615055	Withdrawn	Drug: Fluoxetine\|Other: Placebo	Cognitive Dysfunction	University of California Los Angeles\|City of Hope Medical Center	June 2018	Early Phase 1
NCT03390933	Recruiting	Drug: Fluoxetine	Depression\|Hemodialysis-Induced Symptom	MetroHealth Medical Center	March 1 2018	Phase 4
NCT02767999	Recruiting	Drug: Fluoxetine\|Drug: Placebo\|Radiation: fMRI	Stroke	University Hospital Toulouse	February 27 2017	Phase 4
NCT03476525	Recruiting	Drug: Fluoxetine	Obesity Morbid	Norwegian University of Science and Technology\|St. Olavs Hospital\|Volvat Medisinsk Senter Stokkan\|Namsos Hospital\|Alesund Hospital	November 2 2016	--
NCT02063425	Terminated	Drug: Fluoxetine\|Drug: Placebo of fluoxetine	Cerebral Infarction	Centre Hospitalier St Anne	February 2014	Not Applicable

(data from https://clinicaltrials.gov, updated on 2021-09-06)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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