Fluoxetine HCl

For research use only.

Catalog No.S1333 Synonyms: Lilly110140

13 publications

Fluoxetine HCl Chemical Structure

CAS No. 56296-78-7

Fluoxetine HCl (Lilly110140) is a selective serotonin-reuptake inhibitor (SSRI) at the neuronal membrane, used in the treatment of depression.

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10mM (1mL in DMSO) USD 77 In stock
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Selleck's Fluoxetine HCl has been cited by 13 publications

3 Customer Reviews

  • The SWIP phenotype in hlh-17(ns204) animals is unaffected by pretreatment with fluoxetine (C). In all panels, n = 30 animals/rep/strain; dark bars = minus inhibitor; and light bars = plus inhibitor. *P< 0.05; **P<0.005; ***P<0.0005.

    G3 (Bethesda), 2014, 4(6):1081-9.. Fluoxetine HCl purchased from Selleck.

  • Representative photomicrographs of PI-positive neural cells in different groups at 24 h after SAH (n = 3/group). Fluorescence colors: DAPI: blue and PI: red. Scale bar = 100 μm.

    J Neuroinflammation, 2017, 14(1):186. Fluoxetine HCl purchased from Selleck.

  • Immunofluorescence test confirmed the activation of microglia with higher level of TNFα expression. Ipt and Flu treatment clearly reversed the all significant changes to normal levels. White arrows indicate TNFα, CD11b and Hoechst co-located.

    Brain Res Bull, 2017, 130:146-155. Fluoxetine HCl purchased from Selleck.

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Biological Activity

Description Fluoxetine HCl (Lilly110140) is a selective serotonin-reuptake inhibitor (SSRI) at the neuronal membrane, used in the treatment of depression.
5-HT [1]
In vitro

Fluoxetine blocks the downregulation of cell proliferation resulting from inescapable shock (IS) of hippocampal cell. [1] Fluoxetine increases the number of newborn cells in the dentate gyrus of the hippocampus of adult rat. Fluoxetine also increases the number of proliferating cells in the prelimbic cortex. [2] Fluoxetine accelerates the maturation of immature neurons. Fluoxetine enhances neurogenesis-dependent long-term potentiation (LTP) in the dentate gyrus. [3] Fluoxetine, but not citalopram, fluvoxamine, paroxetine and sertraline, increases norepinephrine and dopamine extracellular levels in prefrontal cortex. Fluoxetine produces robust and sustained increases in extracellular concentrations of norepinephrine and dopamine after acute systemic administration. [4]

In vivo Fluoxetine treatment also reverses the deficit in escape latency observed in animals exposed to inescapable shock in adult male Sprague–Dawley rats. [1] Fluoxetine combined with Olanzapine produces robust, sustained increases of extracellular levels of dopamine ([DA](ex)) and norepinephrine ([NE](ex)) up to 361% and 272% of the baseline, respectively, which are significantly greater than either drug alone. [5]


Solubility (25°C)

In vitro DMSO 69 mg/mL (199.54 mM)
Ethanol 69 mg/mL (199.54 mM)
Water 4 mg/mL (11.56 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 345.79


CAS No. 56296-78-7
Storage powder
in solvent
Synonyms Lilly110140
Smiles CNCCC(C1=CC=CC=C1)OC2=CC=C(C=C2)C(F)(F)F.Cl

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04676139 Recruiting Drug: Fluoxetine|Drug: Placebo Nocturnal Enuresis Mansoura University July 1 2020 Phase 3
NCT01615055 Withdrawn Drug: Fluoxetine|Other: Placebo Cognitive Dysfunction University of California Los Angeles|City of Hope Medical Center June 2018 Early Phase 1
NCT03390933 Recruiting Drug: Fluoxetine Depression|Hemodialysis-Induced Symptom MetroHealth Medical Center March 1 2018 Phase 4
NCT02767999 Recruiting Drug: Fluoxetine|Drug: Placebo|Radiation: fMRI Stroke University Hospital Toulouse February 27 2017 Phase 4
NCT03476525 Recruiting Drug: Fluoxetine Obesity Morbid Norwegian University of Science and Technology|St. Olavs Hospital|Volvat Medisinsk Senter Stokkan|Namsos Hospital|Alesund Hospital November 2 2016 --
NCT02063425 Terminated Drug: Fluoxetine|Drug: Placebo of fluoxetine Cerebral Infarction Centre Hospitalier St Anne February 2014 Not Applicable

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