Catalog No.S1333 Synonyms: Lilly110140
Molecular Weight(MW): 345.79
Fluoxetine is a selective serotonin-reuptake inhibitor (SSRI) at the neuronal membrane, used in the treatment of depression.
Cited by 5 Publications
3 Customer Reviews
The SWIP phenotype in hlh-17(ns204) animals is unaffected by pretreatment with fluoxetine (C). In all panels, n = 30 animals/rep/strain; dark bars = minus inhibitor; and light bars = plus inhibitor. *P< 0.05; **P<0.005; ***P<0.0005.
G3 (Bethesda), 2014, 4(6):1081-9.. Fluoxetine HCl purchased from Selleck.
Immunofluorescence test confirmed the activation of microglia with higher level of TNFα expression. Ipt and Flu treatment clearly reversed the all significant changes to normal levels. White arrows indicate TNFα, CD11b and Hoechst co-located.
Brain Res Bull, 2017, 130:146-155. Fluoxetine HCl purchased from Selleck.
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|Description||Fluoxetine is a selective serotonin-reuptake inhibitor (SSRI) at the neuronal membrane, used in the treatment of depression.|
Fluoxetine blocks the downregulation of cell proliferation resulting from inescapable shock (IS) of hippocampal cell.  Fluoxetine increases the number of newborn cells in the dentate gyrus of the hippocampus of adult rat. Fluoxetine also increases the number of proliferating cells in the prelimbic cortex.  Fluoxetine accelerates the maturation of immature neurons. Fluoxetine enhances neurogenesis-dependent long-term potentiation (LTP) in the dentate gyrus.  Fluoxetine, but not citalopram, fluvoxamine, paroxetine and sertraline, increases norepinephrine and dopamine extracellular levels in prefrontal cortex. Fluoxetine produces robust and sustained increases in extracellular concentrations of norepinephrine and dopamine after acute systemic administration. 
|In vivo||Fluoxetine treatment also reverses the deficit in escape latency observed in animals exposed to inescapable shock in adult male Sprague–Dawley rats.  Fluoxetine combined with Olanzapine produces robust, sustained increases of extracellular levels of dopamine ([DA](ex)) and norepinephrine ([NE](ex)) up to 361% and 272% of the baseline, respectively, which are significantly greater than either drug alone. |
-  Malberg JE, et al. Neuropsychopharmacology, 2003, 28(9), 1562-1571.
-  Kodama M, et al. Biol Psychiatry, 2004, 56(8), 570-580.
-  Wang JW, et al. J Neurosci, 2008, 28(6), 1374-1384.
|In vitro||DMSO||69 mg/mL (199.54 mM)|
|Ethanol||69 mg/mL (199.54 mM)|
|Water||4 mg/mL (11.56 mM)|
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Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT01615055||Withdrawn||Drug: Fluoxetine|Other: Placebo||Cognitive Dysfunction||University of California Los Angeles|City of Hope Medical Center||June 2018||Early Phase 1|
|NCT03390933||Recruiting||Drug: Fluoxetine||Depression|Hemodialysis-Induced Symptom||MetroHealth Medical Center||March 1 2018||Phase 4|
|NCT02767999||Recruiting||Drug: Fluoxetine|Drug: Placebo|Radiation: fMRI||Stroke||University Hospital Toulouse||February 27 2017||Phase 4|
|NCT03476525||Recruiting||Drug: Fluoxetine||Obesity Morbid||Norwegian University of Science and Technology|St. Olavs Hospital|Volvat Medisinsk Senter Stokkan|Namsos Hospital|Alesund Hospital||November 2 2016||--|
|NCT02063425||Terminated||Drug: Fluoxetine|Drug: Placebo of fluoxetine||Cerebral Infarction||Centre Hospitalier St Anne||February 2014||Not Applicable|
|NCT01967979||Completed||Drug: RO5285119|Drug: fluoxetine|Drug: itraconazole||Healthy Volunteer||Hoffmann-La Roche||October 2013||Phase 1|
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