Fluoxetine (Lilly 110140) HCl

Catalog No.S1333 Synonyms: Prozac, Sarafem,LY-110140

For research use only.

Fluoxetine HCl (Prozac, Sarafem,LY-110140) is a selective serotonin-reuptake inhibitor (SSRI) at the neuronal membrane, used in the treatment of depression.

Fluoxetine (Lilly 110140) HCl Chemical Structure

CAS No. 56296-78-7

Selleck's Fluoxetine (Lilly 110140) HCl has been cited by 16 publications

Purity & Quality Control

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Biological Activity

Description Fluoxetine HCl (Prozac, Sarafem,LY-110140) is a selective serotonin-reuptake inhibitor (SSRI) at the neuronal membrane, used in the treatment of depression.
Targets
5-HT [1]
In vitro

Fluoxetine blocks the downregulation of cell proliferation resulting from inescapable shock (IS) of hippocampal cell. [1] Fluoxetine increases the number of newborn cells in the dentate gyrus of the hippocampus of adult rat. Fluoxetine also increases the number of proliferating cells in the prelimbic cortex. [2] Fluoxetine accelerates the maturation of immature neurons. Fluoxetine enhances neurogenesis-dependent long-term potentiation (LTP) in the dentate gyrus. [3] Fluoxetine, but not citalopram, fluvoxamine, paroxetine and sertraline, increases norepinephrine and dopamine extracellular levels in prefrontal cortex. Fluoxetine produces robust and sustained increases in extracellular concentrations of norepinephrine and dopamine after acute systemic administration. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
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HEK293 NHjLVmlHfW6ldHnvckBie3OjeR?= MnOzNVUhdWmwcx?= M2r6N2lvcGmkaYTpc44hd2ZiaIXtZY4hTEGWIHX4dJJme3OnZDDpckBJTUt{OUOgZ4VtdHNiYYSgbY5kfWKjdHXkJIZweiBzNTDtbY5{KGK7IH7leZJwfHKjboPtbZR1\XJicnX1dJRic2ViYYPzZZktKEmFNUC9NVgvPM7:TR?= MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTJ{MU[1Okc,OjV{MkG2OVY9N2F-
HEK293 NULYb2lnTnWwY4Tpc44h[XO|YYm= NYPye|d5UW6qaXLpeIlwdiCxZjDv[kBpfW2jbjDUVmVMOSCneIDy[ZN{\WRiaX6gTGVMOjl|IHPlcIx{KGG|c3Xzd4VlKGG|IILl[JVkfGmxbjDpckBkcGGwbnXsJIN2enKnboTzMEBKSzVyPUG0{txO Mo\6QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ3OEiwOFUoRjJ4NUi4NFQ2RC:jPh?=
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RD NG\jRphEgXSxdH;4bYNqfHliYYPzZZk> MXmzJIRigXN? MWnDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDSSEBk\WyuczDh[pRmeiB|IHThfZMh[nlibnX1eJJidCC{ZXSg[JlmNWKjc3XkJJBpd3SxbXX0dolkKG2ndHjv[EwhS0N3ME2xNU46|ryP MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODlzMkm0OEc,OzB7MUK5OFQ9N2F-
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In vivo

Fluoxetine treatment also reverses the deficit in escape latency observed in animals exposed to inescapable shock in adult male Sprague–Dawley rats. [1] Fluoxetine combined with Olanzapine produces robust, sustained increases of extracellular levels of dopamine ([DA](ex)) and norepinephrine ([NE](ex)) up to 361% and 272% of the baseline, respectively, which are significantly greater than either drug alone. [5]

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 345.79
Formula

C17H18F3NO.HCl

CAS No. 56296-78-7
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CNCCC(C1=CC=CC=C1)OC2=CC=C(C=C2)C(F)(F)F.Cl

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04676139 Recruiting Drug: Fluoxetine|Drug: Placebo Nocturnal Enuresis Mansoura University July 1 2020 Phase 3
NCT01615055 Withdrawn Drug: Fluoxetine|Other: Placebo Cognitive Dysfunction University of California Los Angeles|City of Hope Medical Center June 2018 Early Phase 1
NCT03390933 Recruiting Drug: Fluoxetine Depression|Hemodialysis-Induced Symptom MetroHealth Medical Center March 1 2018 Phase 4
NCT02767999 Unknown status Drug: Fluoxetine|Drug: Placebo|Radiation: fMRI Stroke University Hospital Toulouse February 27 2017 Phase 4
NCT03476525 Recruiting Drug: Fluoxetine Obesity Morbid Norwegian University of Science and Technology|St. Olavs Hospital|Volvat Medisinsk Senter Stokkan|Namsos Hospital|Alesund Hospital November 2 2016 --

(data from https://clinicaltrials.gov, updated on 2022-11-29)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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