Fluoxetine HCl
Catalog No.S1333 Synonyms: Lilly110140
Molecular Weight(MW): 345.79
Fluoxetine is a selective serotonin-reuptake inhibitor (SSRI) at the neuronal membrane, used in the treatment of depression.
Cited by 5 Publications
3 Customer Reviews
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The SWIP phenotype in hlh-17(ns204) animals is unaffected by pretreatment with fluoxetine (C). In all panels, n = 30 animals/rep/strain; dark bars = minus inhibitor; and light bars = plus inhibitor. *P< 0.05; **P<0.005; ***P<0.0005.
G3 (Bethesda), 2014, 4(6):1081-9.. Fluoxetine HCl purchased from Selleck.
Representative photomicrographs of PI-positive neural cells in different groups at 24 h after SAH (n = 3/group). Fluorescence colors: DAPI: blue and PI: red. Scale bar = 100 μm.
J Neuroinflammation, 2017, 14(1):186. Fluoxetine HCl purchased from Selleck.
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Immunofluorescence test confirmed the activation of microglia with higher level of TNFα expression. Ipt and Flu treatment clearly reversed the all significant changes to normal levels. White arrows indicate TNFα, CD11b and Hoechst co-located.
Brain Res Bull, 2017, 130:146-155. Fluoxetine HCl purchased from Selleck.
Purity & Quality Control
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Biological Activity
| Description | Fluoxetine is a selective serotonin-reuptake inhibitor (SSRI) at the neuronal membrane, used in the treatment of depression. | |
|---|---|---|
| Targets |
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| In vitro |
Fluoxetine blocks the downregulation of cell proliferation resulting from inescapable shock (IS) of hippocampal cell. [1] Fluoxetine increases the number of newborn cells in the dentate gyrus of the hippocampus of adult rat. Fluoxetine also increases the number of proliferating cells in the prelimbic cortex. [2] Fluoxetine accelerates the maturation of immature neurons. Fluoxetine enhances neurogenesis-dependent long-term potentiation (LTP) in the dentate gyrus. [3] Fluoxetine, but not citalopram, fluvoxamine, paroxetine and sertraline, increases norepinephrine and dopamine extracellular levels in prefrontal cortex. Fluoxetine produces robust and sustained increases in extracellular concentrations of norepinephrine and dopamine after acute systemic administration. [4] |
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| In vivo | Fluoxetine treatment also reverses the deficit in escape latency observed in animals exposed to inescapable shock in adult male Sprague–Dawley rats. [1] Fluoxetine combined with Olanzapine produces robust, sustained increases of extracellular levels of dopamine ([DA](ex)) and norepinephrine ([NE](ex)) up to 361% and 272% of the baseline, respectively, which are significantly greater than either drug alone. [5] |
Protocol
Solubility (25°C)
| In vitro | DMSO | 69 mg/mL (199.54 mM) |
|---|---|---|
| Ethanol | 69 mg/mL (199.54 mM) | |
| Water | 4 mg/mL (11.56 mM) |
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Information
| Molecular Weight | 345.79 |
|---|---|
| Formula | C17H18F3NO.HCl |
| CAS No. | 56296-78-7 |
| Storage | powder |
| in solvent | |
| Synonyms | Lilly110140 |
Bio Calculators
Molarity Calculator
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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).
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Molarity Calculator
Clinical Trial Information
| NCT Number | Recruitment | interventions | Conditions | Sponsor/Collaborators | Start Date | Phases |
|---|---|---|---|---|---|---|
| NCT01615055 | Withdrawn | Drug: Fluoxetine|Other: Placebo | Cognitive Dysfunction | University of California Los Angeles|City of Hope Medical Center | June 2018 | Early Phase 1 |
| NCT03390933 | Recruiting | Drug: Fluoxetine | Depression|Hemodialysis-Induced Symptom | MetroHealth Medical Center | March 1 2018 | Phase 4 |
| NCT02767999 | Recruiting | Drug: Fluoxetine|Drug: Placebo|Radiation: fMRI | Stroke | University Hospital Toulouse | February 27 2017 | Phase 4 |
| NCT03476525 | Recruiting | Drug: Fluoxetine | Obesity Morbid | Norwegian University of Science and Technology|St. Olavs Hospital|Volvat Medisinsk Senter Stokkan|Namsos Hospital|Alesund Hospital | November 2 2016 | -- |
| NCT02063425 | Terminated | Drug: Fluoxetine|Drug: Placebo of fluoxetine | Cerebral Infarction | Centre Hospitalier St Anne | February 2014 | Not Applicable |
| NCT01967979 | Completed | Drug: RO5285119|Drug: fluoxetine|Drug: itraconazole | Healthy Volunteer | Hoffmann-La Roche | October 2013 | Phase 1 |
Tech Support
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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