Home Neuronal Signaling 5-HT Receptor agonist 8-OH-DPAT (8-Hydroxy-DPAT)

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8-OH-DPAT (8-Hydroxy-DPAT) 5-HT Receptor agonist

Cat.No.S8447

8-OH-DPAT (8-Hydroxy-DPAT) is a classic 5-HT1A agonist with a pIC50 of 8.19. This compound has a selectivity of almost-1000 fold for a subtype of the 5-HT1 binding site, and its biological half-life is 1.5 hours.
8-OH-DPAT (8-Hydroxy-DPAT) 5-HT Receptor agonist Chemical Structure

Chemical Structure

Molecular Weight: 247.38

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Quality Control

Batch: Purity: 99.03%
99.03

Solubility

In vitro
Batch:

DMSO : 49 mg/mL (198.07 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 49 mg/mL

Water : Insoluble

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In vivo
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Chemical Information, Storage & Stability

Molecular Weight 247.38 Formula

C16H25NO

 Storage (From the date of receipt)
CAS No. 78950-78-4 Download SDF Storage of Stock Solutions

Synonyms N/A Smiles CCCN(CCC)C1CCC2=C(C1)C(=CC=C2)O

Mechanism of Action

Targets/IC50/Ki
5-HT1A
(Cell-free)
8.19(pIC50)
In vitro
8-OH-DPAT (8-Hydroxy-DPAT) is only weakly effective at the 5-HT1B subtype, with a pIC50 of 5.42 ± 0.08 (n = 5), and has no effect on 5-HT1B binding at concentrations lower than 100 nM. This compound is able to reduce the accumulation of both autophagic-derived and photoreceptor outer segment-derived lipofuscin, increase antioxidant protection and reduce oxidative damage in cultured human RPE cells.
In vivo
The selective 5-HT1A-receptor agonist 8-OH-DPAT (8-Hydroxy-DPAT) rapidly reverses the hypotensive and bradycardic responses established during severe hemorrhage with relatively little variability after intravenous administration. It is relatively lipophilic and readily crosses the blood-brain barrier.
References
  • [4] https://pubmed.ncbi.nlm.nih.gov/22509307/

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