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SGLT Inhibitors

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Isoform-selective Products

Cat.No. Product Name Information Product Use Citations Product Validations
S8022 BI-10773 (Empagliflozin) Empagliflozin is a potent and selective SGLT-2 inhibitor with IC50 of 3.1 nM, exhibits >300-fold selectivity over SGLT-1, 4, 5 and 6. Phase 3.
Redox Biol, 2024, 69:103010
Biomed Pharmacother, 2024, 180:117453
Sci Rep, 2024, 14(1):16459
Verified customer review of BI-10773 (Empagliflozin)
S2760 Canagliflozin (JNJ-28431754) Canagliflozin (TA 7284, JNJ 28431754) is a highly potent and selective SGLT2 inhibitor for hSGLT2 with IC50 of 2.2 nM in a cell-free assay, exhibits 413-fold selectivity over hSGLT1.
Redox Biol, 2024, 71:103103
Toxicol Appl Pharmacol, 2024, 495:117183
J Clin Invest, 2023, 133(1)e154754
Verified customer review of Canagliflozin (JNJ-28431754)
S1548 Dapagliflozin (BMS-512148) Dapagliflozin is a potent and selective hSGLT2 inhibitor with EC50 of 1.1 nM, exhibiting 1200-fold selectivity over hSGLT1. Phase 4.
Cell Death Dis, 2025, 16(1):79
Sci Adv, 2025, 11(31):eadu3700
Eur Heart J, 2024, 31:ehae472.
Verified customer review of Dapagliflozin (BMS-512148)
S8103 Sotagliflozin (LX4211) Sotagliflozin is an oral dual SGLT1/SGLT2 inhibitor with IC50 of 36 nM and 1.8 nM, respectively. Phase 3.
Cell Rep, 2024, 43(2):113675
Front Endocrinol (Lausanne), 2023, 14:1069715
Front Cardiovasc Med, 2023, 10:1064290
S2343 Phlorizin Phlorizin (Phloridzin) is a dihydrochalcone found in the bark of pear (Pyrus communis), apple, cherry and other fruit trees. This compound is a non-selective SGLT inhibitor with Ki of 300 nM and 39 nM for hSGLT1 and hSGLT2, respectively. It is also a Na+/K+-ATPase inhibitor.
Mol Ther Methods Clin Dev, 2022, 24:11-19
J Ginseng Res, 2022, 46(5):700-709
J Med Virol, 2019, 91(8):1440-1447
Verified customer review of Phlorizin
S2342 Phloretin (RJC 02792) Phloretin (RJC 02792, NSC 407292, Dihydronaringenin) is a dihydrochalcone found in apple tree leaves, and it shows beneficial effects on diabetes.
Br J Pharmacol, 2022, 10.1111/bph.15896
Food Funct, 2020, 10.1039/d0fo02362k
J Med Virol, 2019, 91(8):1440-1447
Verified customer review of Phloretin (RJC 02792)
S5901 Canagliflozin hemihydrate Canagliflozin hemihydrate is the hemihydrate form of canagliflozin, which is a SGLT2 inhibitor with IC50 of 2.2 nM for hSGLT2 in a cell-free assay, exhibits 413-fold selectivity over hSGLT1.
Front Pharmacol, 2022, 13:848310
Yonsei Med J, 2022, 63(7):619-631
Cell Death Dis, 2018, 9(2):226
S5566 Dapagliflozin propanediol monohydrate Dapagliflozin propanediol belongs to the class of orally administered antidiabetic agents designated as sodiumglucose cotransporter 2 (SGLT2) inhibitors.
J Cell Mol Med, 2025, 29(11):e70581
Am J Physiol Renal Physiol, 2019, 316(5):F1078-F1089
S8558 Tofogliflozin(CSG 452) Tofogliflozin (CSG 452) is a novel sodium-glucose co-transporter 2(SGLT2) inhibitor, with IC50 values of 2.9 nM and 8444 nM for hSGLT2 and hSGLT1, respectively.
S0994 Ipragliflozin L-Proline Ipragliflozin L-Proline is an orally active and selective inhibitor of SGLT2 with IC50 of 7.38 nM, 6.73 nM and 5.64 nM for human SGLT2, rat SGLT2 and mouse SGLT2, respectively.

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