SGLT2 Selective Inhibitors

Catalog No. Product Name Information Selective / Pan IC50 / Ki
S1548 Dapagliflozin

Dapagliflozin is a potent and selective hSGLT2 inhibitor with EC50 of 1.1 nM, exhibiting 1200-fold selectivity over hSGLT1. Phase 4.

Selective hSGLT2, EC50: 1.1 nM
S2760 Canagliflozin

Canagliflozin is a highly potent and selective SGLT2 inhibitor for hSGLT2 with IC50 of 2.2 nM, exhibits 413-fold selectivity over hSGLT1.

Selective mSGLT2, IC50: 2 nM; rSGLT2, IC50: 3.7 nM; hSGLT2, IC50: 4.4 nM
S8022 Empagliflozin (BI 10773)

Empagliflozin (BI-10773) is a potent and selective SGLT-2 inhibitor with IC50 of 3.1 nM, exhibits >300-fold selectivity over SGLT-1, 4, 5 and 6. Phase 3.

Selective SGLT2, IC50: 3.1 nM