Ibrutinib (PCI-32765)

Name: Ibrutinib (PCI-32765)
Brand: Selleck Chemicals
SKU: S2680
Rating: 5 (447 reviews)

For research use only.

Catalog No.S2680

447 publications

Ibrutinib (PCI-32765) Chemical Structure

CAS No. 936563-96-1

Ibrutinib (PCI-32765) is a potent and highly selective Brutons tyrosine kinase (Btk) inhibitor with IC50 of 0.5 nM in cell-free assays, modestly potent to Bmx, CSK, FGR, BRK, HCK, less potent to EGFR, Yes, ErbB2, JAK3, etc. Ibrutinib is applicable as a Btk ligand in the synthesis of a series of PROTACs including P13I.

Selleck's Ibrutinib (PCI-32765) has been cited by 447 publications

Cancer Cell, 2021, 39(3):380-393.e8

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Cancer Cell, 2020, 13;37(4):551-568e14

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Nat Mater, 2019, 18(3):289-297

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Cell, 2019, 36(2):179-193

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Cancer Cell, 2019, 35(5):752-766

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Cancer Cell, 2019, 36(2):179-193

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Cancer Cell, 2019, 10.1016/j.ccell.2019.09.001

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Cancer Cell, 2019, 35(2):283-296

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Gastroenterology, 2019, 156(6):1890-1904

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Nature, 2018, 560(7718):387-391

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Nat Med, 2018, 24(5):638-646

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Cell, 2018, 175(1):85-100

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Cancer Cell, 2018, 34(6):982-995

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Nature, 2017, 23;542(7642):489-493.

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Cancer Discov, 2017, 7(9):1018-1029

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Cancer Cell, 2017, 31(6):833-843

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Cancer Cell, 2012, 22(5):656-67

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Blood, 2021, blood.2021011787

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Mol Cell, 2021, S1097-2765(21)00264-1

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Nat Commun, 2021, 12(1):2877

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Leukemia, 2021, 10.1038/s41375-021-01326-x

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Cell Rep, 2021, 34(11):108870

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Aging Cell, 2021, 20(3):e13332

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Haematologica, 2021, 10.3324/haematol.2021.278743

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Cancers (Basel), 2021, 13(9)2146

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Thromb Haemost, 2021, 121(2):192-205

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J Immunol, 2021, ji2000569

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Front Oncol, 2021, 11:668617

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Int J Mol Sci, 2021, 22(3)1194

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Acta Pharmacol Sin, 2021, 10.1038/s41401-020-00578-0

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Drug Metab Dispos, 2021, 49(1):53-61

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Toxicol Appl Pharmacol, 2021, 424:115595

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Am J Physiol Cell Physiol, 2021, 320(5):C902-C915

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Biochem Biophys Res Commun, 2021, 555:196-201

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Hum Cell, 2021, 10.1007/s13577-021-00579-z

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Biomed Chromatogr, 2021, e5139

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Pharmazie, 2021, 76(2):92-96

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Blood Adv, 2021, 5(10):2467-2480

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Bio Protoc, 2021, 11(13):e4068

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J Biol Chem, 2021, S0021-9258(21)00238-6

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Blood Adv, 2021, 5(1):185-197

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iScience, 2021, 24(8):102871

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Leukemia, 2021, 10.1038/s41375-021-01123-6

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Blood Adv, 2021, 5(17):3497-3510

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Prostaglandins Other Lipid Mediat, 2021, 156:106575

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J Clin Invest, 2020, 2;138448

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Leukemia, 2020, 14

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Proc Natl Acad Sci U S A, 2020, 117(11):6092-6102

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Blood Cancer J, 2020, 10(1):12

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Aging Cell, 2020, 19(1):e13079

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Elife, 2020, 9e60470

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Oncogene, 2020, 10.1038/s41388-020-1183-x

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J Exp Clin Cancer Res, 2020, 39(1):228

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Cancers (Basel), 2020, 2;12(5) pii: E1143

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Cancers (Basel), 2020, 12(10)E2725

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Cancers (Basel), 2020, 7;12(4)

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Br J Cancer, 2020, 18

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Cell Chem Biol, 2020, 27(10):1285-1295.e4

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Front Immunol, 2020, 11:581758

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Aging (Albany NY), 2020, 12(16):16083-16098

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Br J Haematol, 2020, 10.1111/bjh.17139

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Br J Haematol, 2020, 10.1111/bjh.16386

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Eur J Med Chem, 2020, 190:112092

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Oncol Res, 2020, 10.3727/096504020X15825405463920

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J Immunol, 2020, 205(10):2629-2639

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Arthritis Res Ther, 2020, 30;22(1):66

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Int J Mol Sci, 2020, 26;21(9) pii: E3065

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J Genet Genomics, 2020, 47(7):389-395

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J Biol Chem, 2020, 10;295(15):5163-5174

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J Biol Chem, 2020, 10.1074/jbc.RA119.011946

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Cancer Cell Int, 2020, 20:458

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Cancer Cell Int, 2020, 19;20:58

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J Immunother, 2020, 43(4):107-120

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Biomed Pharmacother, 2020, 21;128:110133

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Cancer Genomics Proteomics, 2020, 17(1):77-89

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Hum Cell, 2020, 10.1007/s13577-020-00425-8

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Hum Cell, 2020, 10.1007/s13577-020-00420-z

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Clin Transl Immunology, 2020, 9(7):e1156

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Leukemia, 2020, 10.1038/s41375-020-0977-8

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JCI Insight, 2020, 5(19)139930

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Blood Adv, 2020, 4(24):6106-6116

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Oncogene, 2020, 10.1038/s41388-020-01394-w

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[email protected], 2020, 51

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Blood Adv, 2020, 9;4(11):2439-2450

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EJHaem, 2020, 1(1):122-132

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Haematologica, 2020, haematol.2020.248112

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Blood Adv, 2020, 4(18):4382-4392

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Leukemia, 2020, 10.1038/s41375-020-01025-z

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Int J Cancer, 2020, 10.1002/ijc.33212

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Blood Adv, 2020, 4(5):819-829

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Blood, 2019, 134(21):1821-1831

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Nat Chem Biol, 2019, 15(3):232-240

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Clin Cancer Res, 2019, 25(13):3974-3985

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Clin Cancer Res, 2019, 10.1158/1078-0432.CCR-19-1009

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Leukemia, 2019, 10.1038/s41375-019-0381-4

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Leukemia, 2019, 10.1038/s41375-019-0569-7

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Cancer Res, 2019, 79(2):360-371

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Haematologica, 2019, 10.3324/haematol.2019.219550

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Haematologica, 2019, 10.3324/haematol.2018.207183

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Haematologica, 2019, 104(10):2040-2052

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Clin Cancer Res, 2019, 10.1158/1078-0432.CCR-19-2202

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J Immunother Cancer, 2019, 7(1):111

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Cell Rep, 2019,

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Haematologica, 2019, 104(7):e288-e292

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Haematologica, 2019, 10.3324/haematol.2019.216218

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Haematologica, 2019, 10.3324/haematol.2019.224956

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Oncogene, 2019, 10.1038/s41388-019-0903-6

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Cancers (Basel), 2019, 11(6)

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Cancers (Basel), 2019, 11(10)

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J Neurosci, 2019, 39(44):8730-8743

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FASEB J, 2019, 33(11):12036-12046

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Front Immunol, 2019, 1.8951388889

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Br J Haematol, 2019, 10.1111/bjh.16118

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Mol Cancer Res, 2019, 17(6):1365-1377

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J Immunol, 2019, 203(8):2100-2109

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Lab Invest, 2019, 10.1038/s41374-019-0262-5

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Biochem Pharmacol, 2019, 169:113616

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Sci Rep, 2019, 9(1):7193

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Sci Rep, 2019, 9(1):11069

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Cancer Cell Int, 2019, 19:67

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Front Mol Neurosci, 2019, 0.50138888889

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Invest New Drugs, 2019, 10.1007/s10637-019-00837-w

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Mol Carcinog, 2019, 58(6):944-956

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Mol Med, 2019, 25(1):3

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Oncol Rep, 2019, 10.3892/or.2019.7282

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J Bone Oncol, 2019, 17:100253

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J Pharm Biomed Anal, 2019, 177:112871

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Thromb Res, 2019, 179:64-68

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Leuk Lymphoma, 2019, 60(7):1632-1643

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Biochem Biophys Res Commun, 2019, 515(1):92-98

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Virol Sin, 2019, 10.1007/s12250-019-00145-w

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Vet Comp Oncol, 2019, 10.1111/vco.12520

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Cell Biochem Funct, 2019, 37(3):153-160

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Anticancer Res, 2019, 39(10):5461-5471

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Biomed Chromatogr, 2019, 33(5):e4507

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Biomed Chromatogr, 2019, 10.1002/bmc.4575

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Mol Imaging, 2019, 18:1536012119870899

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Oncotarget, 2019,

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Sci Rep, 2019, 9(1):7193

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Blood Adv, 2019, 3(1):51-62

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Oncotarget, 2019, 10(20):1943-1956

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Sci Rep, 2019, 9(1):11069

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JCI Insight, 2019, 4(12)

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Methods Mol Biol, 2019, 1881:19-25

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Leukemia, 2019, 10.1038/s41375-019-0682-7

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Blood Adv, 2019, 3(20):2920-2933

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Matter, 2019,

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Nat Cell Biol, 2018, 20(5):586-596

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Blood, 2018, 1;132(18):1985-1988

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Blood, 2018, 131(4):426-438

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Blood, 2018, 132(22):2401-2405

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Nat Chem Biol, 2018, 14(3):291-298

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J Clin Invest, 2018, 128(1):427-445

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J Clin Invest, 2018, 128(9):4132-4147

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J Clin Invest, 2018, 128(12):5517-5530

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Nat Commun, 2018, 9(1):727

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Nat Commun, 2018, 9(1):2434

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Clin Cancer Res, 2018, 24(4):950-962

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Clin Cancer Res, 2018, 24(24):6408-6420

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Leukemia, 2018, 32(4):960-970

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Pharmacol Ther, 2018, 187:45-60

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Cancer Immunol Res, 2018, 6(10):1150-1160

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Haematologica, 2018, 103(3):e119-e122

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Haematologica, 2018, 103(4):679-687

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Haematologica, 2018, 10.3324/haematol.2018.189399

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Haematologica, 2018, 103(1):116-125

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Int J Cancer, 2018, 142(2):322-333

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Oncogene, 2018, 37(41):5520-5533

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Oncogene, 2018, 37(39):5325-5339

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Oncogene, 2018, 37(11):1534-1550

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Oncogene, 2018, 37(41):5520-5533

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MBio, 2018, 9(6)

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Sci Signal, 2018, 11(549)

PubMed: 30254057 ( click the link to review the publication )

Cancers (Basel), 2018, 10(12)

PubMed: 30572654 ( click the link to review the publication )

Arterioscler Thromb Vasc Biol, 2018, 38(12):2793-2805

PubMed: 30571167 ( click the link to review the publication )

Cell Death Dis, 2018, 9(2):86

PubMed: 29367645 ( click the link to review the publication )

Cell Chem Biol, 2018, 25(1):88-99

PubMed: 29129717 ( click the link to review the publication )

Front Immunol, 2018, 2.4166666667

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Oncoimmunology, 2018, 8(1):e1512455

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Oncoimmunology, 2018, 7(4):e1341032

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Mol Cancer Ther, 2018, 17(12):2564-2574

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Mol Cancer Ther, 2018, 17(10):2156-2163

PubMed: 30065099 ( click the link to review the publication )

J Neuroinflammation, 2018, 15(1):271

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Br J Haematol, 2018, 182(5):654-669

PubMed: 29978459 ( click the link to review the publication )

Int J Mol Sci, 2018, 19(2)E343

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Biochem Pharmacol, 2018, 156:291-301

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Sci Rep, 2018, 8(1):17651

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Sci Rep, 2018, 8(1):14216

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Am J Physiol Lung Cell Mol Physiol, 2018, 315(1):L52-L58

PubMed: 29516781 ( click the link to review the publication )

Curr Med Chem, 2018, 10.2174/0929867325666180622143548

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J Pharmacol Exp Ther, 2018, 365(3):460-466

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Clin Chem Lab Med, 2018, 56(5):e118-e120

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J Cell Biochem, 2018, 119(7):5843-5851

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Int J Oncol, 2018, 53(2):823-834

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BMC Cancer, 2018, 18(1):466

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J Cancer Res Clin Oncol, 2018, 144(4):697-706

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Fish Shellfish Immunol, 2018, 77:91-99

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Int Immunopharmacol, 2018, 58:145-153

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Transl Oncol, 2018, 11(6):1406-1418

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Biochemistry, 2018, 57(26):3564-3575

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Biochemistry, 2018, 57(8):1369-1379

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Dig Dis Sci, 2018, 63(12):3367-3375

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PLoS One, 2018, 13(8):e0200725

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PLoS One, 2018, 13(2):e0193098

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PLoS One, 2018, 13(11):e0207915

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Leuk Lymphoma, 2018, 59(4):931-940

PubMed: 28750570 ( click the link to review the publication )

Cancer Genomics Proteomics, 2018, 15(3):213-223

PubMed: 29695404 ( click the link to review the publication )

Oncotarget, 2018, 9(40):26019-26031

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Oncotarget, 2018, 9(80):35123-35140

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Sci Rep, 2018, 8(1):12046

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Oncotarget, 2018, 9(31):21820-21830

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Oncotarget, 2018, 9(89):35875-35890

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Sci Rep, 2018, 8(1):9472

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Tumour Biol, 2018, 40(1):1010428317731369

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Sci Rep, 2018, 8(1):14216

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Oncotarget, 2018, 9(41):26353-26369

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JCI Insight, 2018, 3(19)

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Adv Biol Regul, 2018, 67:190-211

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Tumour Biol, 2018, 40(1):1010428317731369

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Oncotarget, 2018, 9(40):26019-26031

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JCI Insight, 2018, 3(22)125568

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Blood, 2017, 129(18):2507-2518

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Blood, 2017, 129(6):759-770

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Blood, 2017, 130(14):1649-1660

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Blood, 2017, 129(18):2507-2518

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Nat Chem Biol, 2017, 13(2):168-173

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Clin Cancer Res, 2017, 23(14):3734-3743

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Purity & Quality Control

Choose Selective Target Protein Ligand Inhibitors

Biological Activity

Description

Targets

BTK ^[1] (Cell-free assay)	BLK ^[1] (Cell-free assay)	Bmx ^[1] (Cell-free assay)	CSK ^[1] (Cell-free assay)	FGR ^[1] (Cell-free assay)	View More
0.5 nM	0.5 nM	0.8 nM	2.3 nM	2.3 nM	View More

In vitro

Ibrutinib shows the potent and irreversible inhibitory effect and selectivity for Btk enzymatic activity. In BCR pathway-activated DOHH2 cell line, Ibrutinib inhibits autophosphorylation of Btk, phosphorylation of Btk's physiological substrate PLCγ, and phosphorylation of further downstream kinase, ERK with IC50 of 11 nM, 29 nM and 13 nM, respectively. ^[1] Ibrutinib exhibits a significant dose-dependent and time-dependent induction of cytotoxicity in chronic lymphocytic leukemia (CLL) cells. In addition, Ibrutinib induces cell death depending on caspase pathway activation and antagonizes the ability of CLL cells to proliferate after TLR signaling. ^[2] A recent study shows that Ibrutinib inhibits BCR-activated primary B cell proliferation with IC50 of 8 nM and results in inhibition of TNFα, IL-1β and IL-6 production in primary monocytes with IC50 of 2.6 nM, 0.5 nM and 3.9 nM, respectively. ^[3]

Cell Data

Cell Lines	Assay Type	Concentration	Incubation Time	Activity Description	PMID
human Rec1 cells	MUjGeY5kfGmxbjDhd5NigQ>?	M3OxUlIvPSEQvF2=	Mlu2OkBp	MWnJcohq[mm2aX;uJI9nKEy7bjDwbI9{eGixconsZZRqd25iaX6gbJVu[W5iUnXjNUBk\WyuczDheEAzNjVidV2gbY5kfWKjdHXkJIZweiB4IHjyd{BjgSCZZYP0[ZJvKGKub4T0bY5oKG2ndHjv[C=>	NHTHUXE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUKyNlg4Pyd-MkWyNlI5Pzd:L3G+
human WSU-NHL cells	Mlz0R5l1d3SxeHnjxsBie3OjeR?=		M3faWFczKGh?	NHvQdZFEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBYW1VvTljMJINmdGy\|IHHzd4V{e2WmIHHzJIdzd3e2aDDpcohq[mm2aX;uJIFnfGW{IEeyJIhzeyCkeTDD[YxtXGm2ZYKtS4xwKGy3bXnu[ZNk\W62IHPlcIwhfmmjYnnsbZR6KGG\|c3H5MEBKSzVyPUGuNFkh\|ryP	MkXzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR7MUWyPVEoRjJ2OUG1NlkyRC:jPh?=
human SU-DHL6 cells	M17JO2N6fG:2b4jpZ:Kh[XO\|YYm=		M3T5Z\|czKGh?	M4[wWWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHNWNUSKTE[gZ4VtdHNiYYPz[ZN{\WRiYYOg[5Jwf3SqIHnubIljcXSrb36gZYZ1\XJiN{KgbJJ{KGK7IFPlcIxVcXSncj3HcI8hdHWvaX7ld4NmdnRiY3XscEB3cWGkaXzpeJkh[XO\|YYmsJGlEPTB;MD61PEDPxE1w	NWrpeFUzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS5NVUzQTFpPkK0PVE2OjlzPD;hQi=>
human DOHH2 cells	NWrkOHNjS3m2b4TvfIlkyqCjc4PhfS=>		MlHHO\|IhcA>?	NV7Bd5o5S3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hTE:KSEKgZ4VtdHNiYYPz[ZN{\WRiYYOg[5Jwf3SqIHnubIljcXSrb36gZYZ1\XJiN{KgbJJ{KGK7IFPlcIxVcXSncj3HcI8hdHWvaX7ld4NmdnRiY3XscEB3cWGkaXzpeJkh[XO\|YYmsJGlEPTB;MD60NUDPxE1w	NXrtcohtRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS5NVUzQTFpPkK0PVE2OjlzPD;hQi=>
Sf9 cells	NVXMbo5YTnWwY4Tpc44h[XO\|YYm=		NF;5cXQyKGh?	M1zhR2lvcGmkaYTpc44hd2ZiTGnOMWEh\XiycnXzd4VlKGmwIGPmPUBk\WyuczDh[pRmeiB4MDDtbY5{KGK7IGTSMWZTTVRiQYPzZZktKEmFNUC9NE4zKM7:TT6=	MYC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTl3OEW0O{c,OjF7NUi1OFc9N2F-
human Ramos cells	Mn:1SpVv[3Srb36gZZN{[Xl?		NXOzfHpVOSCq	MkD6TY5pcWKrdHnvckBw\iCEdHugbY4hcHWvYX6gVoFud3NiY3XscJMh[XO\|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBRVENvZ3HtcYEzKHCqb4PwbI9zgWyjdHnvckBifCCWeYKxNlE4KGGodHXyJFEhcHJiYomgW4V{fGW{bjDicI91KGGwYXz5d4l{NCCLQ{WwQVE1KG6PLh?=	MlvIQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR7MUWyPVEoRjJ2OUG1NlkyRC:jPh?=
human Pfeiffer cells	M3n6T2Z2dmO2aX;uJIF{e2G7		NX7xN2czPzJiaB?=	MVzDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDQ[oVq\m[ncjDj[YxteyCjc4Pld5Nm\CCjczDndo94fGhiaX7obYJqfGmxbjDh[pRmeiB5MjDodpMh[nliQ3XscHRqfGW{LVfsc{BtfW2rbnXzZ4VvfCClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{IH7NMi=>	M1zZdVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OUG1NlkyLz5{NEmxOVI6OTxxYU6=
Sf9 cells	NUfKfWtiTnWwY4Tpc44h[XO\|YYm=		NGDRVmEyKGh?	MkD3TY5pcWKrdHnvckBw\iCqdX3hckBnfWyuLXzlcod1cCCEVFug[ZhxemW\|c3XkJIlvKFOoOTDj[YxteyC3c3nu[{BHSU1vU4LjeIll\SCyZYD0bYRmKGG\|IIP1ZpN1emG2ZTDh[pRmeiB4MDDtbY5{KGK7IGTSMWZTTVRiQYPzZZnwxIxiSVO1NF0xNjVibl2u	MmrIQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF7NUi1OFcoRjJzOUW4OVQ4RC:jPh?=
Sf9 insect cells	NHfTR2dHfW6ldHnvckBie3OjeR?=		MmnXOlAhdWmwcx?=	Ml;xTWM2OCB;IECuNFAxOyEQvF2=	NIXMW4k9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUG0OlE{Pid-MkmxOFYyOzZ:L3G+
sf9 cells	NFvHcJFHfW6ldHnvckBie3OjeR?=			M2G3SGlEPTBiPTCwMlAxODNizszN	M3XwTlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5OUm0O\|M3Lz5{N{m5OFc{PjxxYU6=
Sf9 insect cells	M{WwV2Z2dmO2aX;uJIF{e2G7		M3[wUVYxKG2rboO=	M4LGO2lEPTBiPTCwMlAxODN2IN88US=>	MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzlzMkG3OUc,Ojd7MUKxO\|U9N2F-
Sf9 insect cells	NHTifHVHfW6ldHnvckBie3OjeR?=		MoXjOlAhdWmwcx?=	M4DUVGlEPTBiPTCwMlAxODN2IN88US=>	NUHze2NGRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki0N\|I6PDZpPkK4OFMzQTR4PD;hQi=>
Sf9 insect cells	MX\GeY5kfGmxbjDhd5NigQ>?		NVHpWY1oPjBibXnudy=>	M3ziWGlEPTBiPTCwMlAxODN2IN88US=>	M3Xie\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5OUW2NFM4Lz5{N{m1OlA{PzxxYU6=
Sf9 cells	MVXGeY5kfGmxbjDhd5NigQ>?		NH3jbIw3OCCvaX7z	NILoNZNKSzVyIE2gNE4xODB2IN88US=>	NW\6eGRiRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CwNFYyPDNpPkOwNFA3OTR\|PD;hQi=>
Sf9 cells	M1\2WWZ2dmO2aX;uJIF{e2G7		MYO2NEBucW6\|	MUnJR\|UxKD1iMD6wNFA2KM7:TR?=	MljUQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF7NUi1OFcoRjJzOUW4OVQ4RC:jPh?=
Ramos cells	MY\GeY5kfGmxbjDhd5NigQ>?		MYKxJIg>	MoH5TWM2OCB;IECuNFAxPSEQvF2=	MWW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDJ6MEK2NUc,Ojh{OECyOlE9N2F-
Sf9 cells	M4nOOWZ2dmO2aX;uJIF{e2G7		NYj2WXB[PjBibXnudy=>	M4nPXmlEPTBiPTCwMlAxOSEQvF2=	NX\1enVPRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CwO\|c3ODhpPkOwNFc4PjB6PD;hQi=>
Pfeiffer cells	Mn;uR5l1d3SxeHnjbZR6KGG\|c3H5		MlKwO\|IhcA>?	MWDHTVUxKD1iMD6wNFIh\|ryP	MorZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR7MUWyPVEoRjJ2OUG1NlkyRC:jPh?=
B cells	Ml3XSpVv[3Srb36gZZN{[Xl?		MUKxJIg>	M{TEc2lEPTBiPTCwMlAxPDZizszN	NHzhbYY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9\|MEK5NFk5QCd-M{CyPVA6QDh:L3G+
Sf9 insect cells	M{O2UmZ2dmO2aX;uJIF{e2G7		NYjvWmd{OiC2bzC2NEBucW6\|	MYfLbUA:KDBwMEC0PEDPxE1?	M4npUFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6M{G1OVk4Lz5{OEOxOVU6PzxxYU6=
Ramos cells	MYfGeY5kfGmxbjDhd5NigQ>?		NUXiTFRiOSCq	NGTKNotKSzVyIE2gNE4xODd3IN88US=>	NY\mbohxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS5NVUzQTFpPkK0PVE2OjlzPD;hQi=>
Sf9 insect cells	NUjsdmY1TnWwY4Tpc44h[XO\|YYm=		NGPie2M3OCCvaX7z	M1vOOmlEPTBiPTCwMlAxQCEQvF2=	M1;Qe\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6M{G1OVk4Lz5{OEOxOVU6PzxxYU6=
TMD8 cells	NIjpVVlCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?=		NIDyPFQ4OiCq	NX7KT2pVUUN3MDC9JFAvODFizszN	NW\0cpJYRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm3NVUxOjNpPkK5O\|E2ODJ\|PD;hQi=>
CD19+ B cells	NGLSeXpHfW6ldHnvckBie3OjeR?=		NI\wOlMyKGh?	MoHoTWM2OCB;IECuNFEzKM7:TR?=	M3TI[FxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NEW3PVgzLz5{OUS1O\|k5OjxxYU6=
Sf9 insect cells	M1nhWWZ2dmO2aX;uJIF{e2G7		NIfYSXI3OCCvaX7z	MlvaTWM2OCB;IECuNFEzKM7:TR?=	M1LEOlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6M{G1OVk4Lz5{OEOxOVU6PzxxYU6=
Ramos cells	M4nkRWZ2dmO2aX;uJIF{e2G7		NVPxUmczOSCq	NUTJUXlpUUN3MDC9JFAvODF2IN88US=>	M2Tae\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OUG1NlkyLz5{NEmxOVI6OTxxYU6=
Sf9 insect cells	MWfGeY5kfGmxbjDhd5NigQ>?		NVK1O5FZOSCq	Ml;6TWM2OCB;IECuNFE1PCEQvF2=	MkH2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl5MUWwNlMoRjJ7N{G1NFI{RC:jPh?=
Sf9 insect cells	NHm4XpRHfW6ldHnvckBie3OjeR?=		Ml;vOlAhdWmwcx?=	MUjJR\|UxKD1iMD6wNVYyKM7:TR?=	NH[yflQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUG0OlE{Pid-MkmxOFYyOzZ:L3G+
HCC827 cells	MmLHRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl?		NY\xRnl7PzJiaB?=	MYXJR\|UxKD1iMD6wN\|kh\|ryP	MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDd\|NEW4NUc,Ojh5M{S1PFE9N2F-
PC9 cells	NFu2T3NHfW6ldHnvckBie3OjeR?=		MmjtO\|IhcA>?	M2fqbGdKPTBiPTCwMlA2KM7:TR?=	NH3EN3A9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEK4NlEzOid-MkiyPFIyOjJ:L3G+
Sf9 cells	NILWVFlHfW6ldHnvckBie3OjeR?=		NHLBb4c3OCCvaX7z	NF74OpNKSzVyIE2gNE4yKM7:TR?=	M{fwbFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMEC2NVQ{Lz5\|MECwOlE1OzxxYU6=
H3255 cells	MlfYSpVv[3Srb36gZZN{[Xl?		M3TqUVczKGh?	NHWzZZhIUTVyIE2gNE4yOSEQvF2=	NYW3XHo4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiyPFIyOjJpPkK4NlgzOTJ{PD;hQi=>
BaF3 cells	M{f2ZmZ2dmO2aX;uJIF{e2G7		NFz6PXE4OiCq	MXrHTVUxKD1iMD6xNkDPxE1?	MmX3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZ4M{C1OVMoRjJ4NkOwOVU{RC:jPh?=
BAF3 cells	MoW2RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl?		NFzkcWo4OiCq	NGL0WphIUTVyIE2gNE4yOiEQvF2=	NGXqVXI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEm1OlkzOyd-Mki5OVY6OjN:L3G+
Sf9 insect cells	NXfqZ2pYTnWwY4Tpc44h[XO\|YYm=		NHPldJI3OCCvaX7z	NFPCS\|lKSzVyIE2gNE4yOjNizszN	MluxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh\|MUW1PVcoRjJ6M{G1OVk4RC:jPh?=
Sf9 insect cells	NW\m[3pMTnWwY4Tpc44h[XO\|YYm=		MXu2NEBucW6\|	NFnCdo9KSzVyIE2gNE4yPDZizszN	NH[yfm89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEOxOVU6Pyd-MkizNVU2QTd:L3G+
BAF3 cells	NH\DNVdHfW6ldHnvckBie3OjeR?=		M{LBe\|czKGh?	NELSNXpIUTVyIE2gNE4yPiEQvF2=	NWGzTW1wRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiyPFIyOjJpPkK4NlgzOTJ{PD;hQi=>
Sf9 cells	MX3GeY5kfGmxbjDhd5NigQ>?		MnKzOlAhdWmwcx?=	NEPMNmRKSzVyIE2gNE4zKM7:TR?=	M1i4dlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzOUW4OVQ4Lz5{MUm1PFU1PzxxYU6=
MV411 cells	MWPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?			MoHmS2k2OCB;IECuNlUh\|ryP	M2naXFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6M{G1OVk4Lz5{OEOxOVU6PzxxYU6=
MV4-11 cells	MUPBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>?		M1HwUVczKGh?	MWLHTVUxKD1iMD6zN{DPxE1?	NH\tbVk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Nk[zNFU2Oyd-Mk[2N\|A2PTN:L3G+
MV4-11 cells	NVzlXI9sSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO\|YYm=		NHLnO4U4OiCq	NGjte\|BIUTVyIE2gNE4{OyEQvF2=	MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDl3NkmyN{c,Ojh7NU[5NlM9N2F-
DOHH2 cells	M2PJR2N6fG:2b4jpZ4l1gSCjc4PhfS=>		M1fJNFczKGh?	M{XTbWdKPTBiPTCwMlQyKM7:TR?=	NU[3O3VtRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS5NVUzQTFpPkK0PVE2OjlzPD;hQi=>
HCC827 cells	NIPDdHJCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?=		MV25OkBp	NVPTbXBbTUN3MDC9JFAvPDVizszN	M4XZ[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6OEWzOVc2Lz5{OEi1N\|U4PTxxYU6=
SU-DHL6 cells	NV24epk{S3m2b4TvfIlkcXS7IHHzd4F6		NEP0NJQ4OiCq	M1[yNGdKPTBiPTCwMlU5KM7:TR?=	NGDGcnc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEmxOVI6OSd-MkS5NVUzQTF:L3G+
M07e cells	M4rqbmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7			MWHHTVUxKD1iMD61PUDPxE1?	MXG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDNzNUW5O{c,Ojh\|MUW1PVc9N2F-
NCI-H1975 cells	NW\MbZFCSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO\|YYm=		M3L3eFk3KGh?	MoThSWM2OCB;IECuOlQh\|ryP	NFvxe249[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEi1N\|U4PSd-Mki4OVM2PzV:L3G+
SU-DHL-2 cells	M13sNWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7			NXPlRmQ4T0l3MDC9JFAvPjRizszN	MnHmQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh\|MUW1PVcoRjJ6M{G1OVk4RC:jPh?=
HEK293T cells	NYHMSWxsTnWwY4Tpc44h[XO\|YYm=		MUWxJIg>	M1jjTWlEPTBiPTCwMlkh\|ryP	M175RVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MkiwNlYyLz5{OEK4NFI3OTxxYU6=
Ramos cells	NIi5d\|dCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?=		MU[3NkBp	NULMeJdmUUN3MDC9JFAvQTJizszN	NXe2V5BXRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm3NVUxOjNpPkK5O\|E2ODJ\|PD;hQi=>
BA/F3 cells	NIDMTXFCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?=		MV63NkBp	MYLJR\|UxKD1iMTFOwG0>	M4e0ZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4MkW4OVIyLz5{NkK1PFUzOTxxYU6=
WSU-NHL cells	NFXDO4pEgXSxdH;4bYNqfHliYYPzZZk>		MYG3NkBp	MlnFS2k2OCB;IEGuNFkh\|ryP	NFq5WZg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEmxOVI6OSd-MkS5NVUzQTF:L3G+
NCI-H1975 cells	NF;vN\|JHfW6ldHnvckBie3OjeR?=		NF\ZdXA4OiCq	NYT5Z2FtT0l3MDC9JFEvOiEQvF2=	Mk\UQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh{OEKxNlIoRjJ6MkiyNVIzRC:jPh?=
NCI-H1975 cells	M4jXeWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7		NVPO[4lrPzJiaB?=	NH;SRYJKSzVyIE2gNU4zPyEQvF2=	NXuxU4FTRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki3N\|Q2QDFpPkK4O\|M1PThzPD;hQi=>
Raji cells	MV;BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>?		MYC0PEBp	M4jJZmlEPTBiPTCxMlQ6KM7:TR?=	MoPmQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl3NkeyPVUoRjJ7NU[3Nlk2RC:jPh?=
Pfeiffer cells	MULHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?			MmftS2k2OCB;IEGuOkDPxE1?	MknsQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh\|MUW1PVcoRjJ6M{G1OVk4RC:jPh?=
A431 cells	M1zlWmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7		M{n2Slk3KGh?	NYDXeIFoTUN3MDC9JFIvOzhizszN	MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDh3M{W3OUc,Ojh6NUO1O\|U9N2F-
BAF3 cells	MXzBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>?		MXu3NkBp	M1rvRmdKPTBiPTCyMlUh\|ryP	NE\wTGo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEm1OlkzOyd-Mki5OVY6OjN:L3G+
U937 cells	MWrHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?			NUf5VIJnT0l3MDC9JFIvQSEQvF2=	M17PWVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6M{G1OVk4Lz5{OEOxOVU6PzxxYU6=
NB4 cells	NEniRWpIem:5dHigbY5pcWKrdHnvckBie3OjeR?=			NHrJVGhIUTVyIE2gN{DPxE1?	MljNQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh\|MUW1PVcoRjJ6M{G1OVk4RC:jPh?=
Ramos cells	NX;kV4NNT3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=			NV25T4xRT0l3MDC9JFMvPCEQvF2=	NX;CO5IxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkizNVU2QTdpPkK4N\|E2PTl5PD;hQi=>
SKM1 cells	NGjEOnBIem:5dHigbY5pcWKrdHnvckBie3OjeR?=			NGLa[\|JIUTVyIE2gN{43KM7:TR?=	M1\I[FxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6M{G1OVk4Lz5{OEOxOVU6PzxxYU6=
U2932 cells	M3TZZ2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7			NHXlSYJIUTVyIE2gOE41KM7:TR?=	MkPyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh\|MUW1PVcoRjJ6M{G1OVk4RC:jPh?=
Ramos cells	MnPDRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl?		MoPaO\|IhcA>?	NFjoU3VKSzVyIE2gOU4yPCEQvF2=	NFqxSYg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9\|MECwOlE1Oyd-M{CwNFYyPDN:L3G+
Ramos cells	MnPhRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl?		Mof6OFghcA>?	MX;JR\|UxKD1iNT6xOEDPxE1?	MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzl3NkCzO{c,Ojd7NU[wN\|c9N2F-
Ramos cells	MVnBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>?		MUK0PEBp	NEG1Z2VKSzVyIE2gOU45QCEQvF2=	NG\tVWg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OESzNlk1Pid-Mki0N\|I6PDZ:L3G+
Ramos cells	NHfVXFVCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?=		MmPUO\|IhcA>?	Mlr3TWM2OCB;IE[uOlIh\|ryP	MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTF2NkGzOkc,OjlzNE[xN\|Y9N2F-
K562 cells	NFvEXIZCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?=		MkjLOFghcA>?	MX;JR\|UxKD1iNz61JO69VQ>?	M4KxPVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMEe3OlA5Lz5\|MEC3O\|YxQDxxYU6=
HL60 cells	MWfBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>?		Mlv2OFghcA>?	NH3pb21KSzVyIE2gPEDPxE1?	NGjhbVc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9\|MEC3O\|YxQCd-M{CwO\|c3ODh:L3G+
Ramos cells	Mn\jRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl?		Ml2yOFghcA>?	MWrJR\|UxKD1iOD6xNUDPxE1?	NVHSfmF5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke5PVQ4OzZpPkK3PVk1PzN4PD;hQi=>
Ramos cells	MUDBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>?		NIPH[Y41QCCq	MWLJR\|UxKD1iOD6yOkDPxE1?	MWS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTV4N{K5OUc,Ojl3NkeyPVU9N2F-
OCI-AML3 cells	NGnmUGdIem:5dHigbY5pcWKrdHnvckBie3OjeR?=			M3XLVWdKPTBiPTC5MlIh\|ryP	M2D5cVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6M{G1OVk4Lz5{OEOxOVU6PzxxYU6=
BAF3 cells	NUXEZYlSS3m2b4TvfIlkcXS7IHHzd4F6		MYW3NkBp	NUfzWnlDT0l3MDC9JFExKM7:TR?=	M1u5flxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4NkOwOVU{Lz5{Nk[zNFU2OzxxYU6=
BAF3 cells	M4P0PWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7		NES2cVM4OiCq	MnSwS2k2OCB;IEGwJO69VQ>?	NVP2VVZERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki5OVY6OjNpPkK4PVU3QTJ\|PD;hQi=>
BAF3 cells	MVTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?		MWq3NkBp	Mnu5S2k2OCB;IEGwJO69VQ>?	NF7VVZY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEK4NlEzOid-MkiyPFIyOjJ:L3G+
NAMALWA cells	MVjBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>?		NU\QcI11PzJiaB?=	NVvvXXduUUN3MDC9JFExNjR3IN88US=>	M3myZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7MUS2NVM3Lz5{OUG0OlE{PjxxYU6=
Ramos cells	NUTp[W92SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO\|YYm=		NF;l[Ws1QCCq	Mo\ZTWM2OCB;IEGyMlYh\|ryP	M1jTZ\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5OUGyNVc2Lz5{N{mxNlE4PTxxYU6=
Raji cells	NYO2VIRXSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO\|YYm=		NUPyVW5nPDhiaB?=	MY\JR\|UxKD1iMUSuNkDPxE1?	M1G4XVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMEe3OlA5Lz5\|MEC3O\|YxQDxxYU6=
Raji cells	M{C1WWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7		NG\3TFA1QCCq	Mlr5TWM2OCB;IEG1MlIh\|ryP	MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzl7NEezOkc,Ojd7OUS3N\|Y9N2F-
MIAPaCa2 cells	NYntPYZwS3m2b4TvfIlkcXS7IHHzd4F6		Mkf5N{Bl[Xm\|	MmjRTWM2OCB;IEG2MlYh\|ryP	M3z1VFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEe3NlI5Lz5{N{C3O\|IzQDxxYU6=
HeLa cells	MlfwR5l1d3SxeHnjbZR6KGG\|c3H5		MlHUN{Bl[Xm\|	MWfJR\|UxKD1iMU[uPEDPxE1?	M3HmbFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5MEe3NlI5Lz5{N{C3O\|IzQDxxYU6=
Raji cells	M4\ZV2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7		MV:0PEBp	M4nxd2lEPTBiPTCxPU4{KM7:TR?=	MYG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzlzMkG3OUc,Ojd7MUKxO\|U9N2F-
Raji cells	MVrBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>?		NYrZXYJJPDhiaB?=	MWDJR\|UxKD1iMUmuN{DPxE1?	NF;5XJA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OESzNlk1Pid-Mki0N\|I6PDZ:L3G+
Raji cells	NGna[IZCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?=		MV:3NkBp	MkD2TWM2OCB;IEG5MlUh\|ryP	MmjrQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzByME[xOFMoRjNyMEC2NVQ{RC:jPh?=
Raji cells	NEDuXXlCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?=		NFvnOpU1QCCq	NUXmXWptUUN3MDC9JFE6NjVizszN	MnLDQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd7NU[wN\|coRjJ5OUW2NFM4RC:jPh?=
NAMALWA cells	MX;BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>?		NEm0RmY4OiCq	NYH2[Ws1UUN3MDC9JFE6NjZizszN	NUPwT3kxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CwNFYyPDNpPkOwNFA3OTR\|PD;hQi=>
A2780 cells	Ml\3R5l1d3SxeHnjbZR6KGG\|c3H5		NV\pd21GOyCmYYnz	NGXjS3pGSzVyIE2gNlAvOSEQvF2=	MYK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzB5N{KyPEc,OjdyN{eyNlg9N2F-
Raji cells	MYPBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>?		MoXNO\|IhcA>?	M2X1dWlEPTBiPTCyNE45QCEQvF2=	MVG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTF2NkGzOkc,OjlzNE[xN\|Y9N2F-
A549 cells	NFXXOGZCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?=		M{HtdVczKGh?	NXW0PIMzUUN3MDC9JFIyNjd7IN88US=>	MYW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDd\|NEW4NUc,Ojh5M{S1PFE9N2F-
SW480 cells	M1L3SmN6fG:2b4jpZ4l1gSCjc4PhfS=>		MlnWN{Bl[Xm\|	MVHJR\|UxKD1iMkWuOkDPxE1?	MlXVQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyN{eyNlgoRjJ5MEe3NlI5RC:jPh?=
Ramos cells	MUTDfZRwfG:6aXPpeJkh[XO\|YYm=		NETDXYQzPCCq	MVLJR\|UxKD1iMkiuO{DPxE1?	M4fxblxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6Mke0Olc2Lz5{OEK3OFY4PTxxYU6=

... Click to View More Cell Line Experimental Data

Assay

Methods	Test Index	PMID
Western blot	pEGFR(Tyr1068) / EGFR; PubMed: 28061447 Oncotarget Ibrutinib inhibitory effects on EGFRY1068 auto-phosphorylation in the HCC827 cell line at different time points by removal of drug after 4 h pretreatment. pBTK / pPLCγ2 / pAKT / pERK / pJNK; PubMed: 23940282 Blood Mino (left panel) or Jeko1 (right panel) cells pretreated with vehicle or ibrutinib 10, 100, or 1000 nM were either stimulated with anti-IgM, CXCL12, or CXCL13 or treated with medium (Med) for 15 minutes and then immunoblotted for pBTK, pPLCγ2, pAKT, pERK, and pJNK.	28061447 23940282
Immunofluorescence	CD11b; PubMed: 30231870 J Neuroinflammation BV2 microglial cells were pretreated with ibrutinib (1 μM) or vehicle (1% DMSO) for 30 min, followed by treatment with LPS (1 μg/ml) or PBS for 5.5 h and immunostaining with an anti-CD11b antibody. Scale bar = 20 μm. COX-2; PubMed: 30231870 J Neuroinflammation BV2 microglial cells were treated with vehicle (1% DMSO) or ibrutinib (1 μM) for 30 min, followed by PBS or LPS (1 μg/ml) for 5.5 h, and immunocytochemistry was conducted with anti-CD11b and anti-COX-2 antibodies.	30231870
ELISA	hTNFα; PubMed: 26627823 J Biol Chem PBMs were isolated and pretreated with 1, 5, or 10 μm ibrutinib (IB) or left untreated (UT, −). Pretreated PBMs were incubated for 24 h in 96-well plates precoated without (PBS) or with 10 μg/ml whole human IgG. Cleared supernatants were collected and analyzed by ELISA for TNFα (n = 3). IL-10; PubMed: 27792904 Virology LMP2A-negative (vector.1/.2) and -positive (express LMP2A) B cell lines were incubated in the absence or presence of increasing concentrations of Ibrutinib for 24 hours and supernatants were isolated for analysis using an IL-10 ELISA.	26627823 27792904

In vivo

In a collagen-induced arthritis model, Ibrutinib significantly reduces clinical arthritis scores reflecting paw swelling and joint inflammation by inhibiting B-cell activation. In a MRL-Fas(lpr) lupus model, Ibrutinib reduces renal disease and autoantibody production. ^[1] In an adoptive transfer TCL1 mouse model of CLL, Ibrutinib (25 mg/kg/day) causes a transient early lymphocytosis, and delays CLL disease progression. ^[4]

Protocol

Kinase Assay: ^[1]	- Collapse Kinase Assays : In vitro kinase IC50 values are measured using ³³P filtration binding assay after 1 hour incubation of kinase, ³³P-ATP, Ibrutinib, and substrate [0.2 mg/mL poly(EY)(4:1]. Assays are performed at Reaction Biology.
Cell Research: ^[2]	- Collapse Cell lines: Chronic lymphocytic leukemia (CLL) cells Concentrations: 0.01-100 μM Incubation Time: 48 hours Method: MTT (3'[4,5-dimethylthiazol-2-yl]-2,5-diphenyl-tetrazolium bromide) assays are performed to determine cytotoxicity. Briefly, cells (CLL B cells or healthy volunteer T cells or NK cells) are incubated for 48 hours with different concentrations of Ibrutinib, or vehicle control. MTT reagent is then added, and plates are incubated for an additional 20 hours before washing with protamine sulfate in phosphate-buffered saline. Dimethyl sulfoxide is added, and absorbance is measured by spectrophotometry at 540 nm in a Labsystems plate reader. Cell viability is also measured at various time points with the use of annexin/PI flow cytometry. Data are analyzed with Expo-ADC32 software package. Results are expressed as the percentage of total positive cells over untreated control. Experiments examining caspase-dependent apoptosis includes the addition of 100μM Z-VAD. (Only for Reference)
Animal Research: ^[1]	- Collapse Animal Models: MRL-Fas(lpr) lupus model and collagen-induced arthritis model. Dosages: ≤50 mg/kg Administration: Administered via p.o. (Only for Reference)

References

[4] Ponader S, et al. Blood. 2012, 119(5), 1182-1189.

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Solubility (25°C)

In vitro	DMSO	88 mg/mL (199.77 mM)
	Ethanol	45 mg/mL (102.15 mM)
	Water	Insoluble
In vivo	Add solvents to the product individually and in order(Data is from Selleck tests instead of citations): 5% DMSO+30% PEG 300+5% Tween 80+ddH2O For best results, use promptly after mixing.	10mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information Download Ibrutinib (PCI-32765) SDF

Molecular Weight	440.5
Formula	C₂₅H₂₄N₆O₂
CAS No.	936563-96-1
Storage	3 years-20°C powder 2 years-80°C in solvent
Synonyms	N/A
Smiles	C=CC(=O)N1CCCC(C1)N2C3=NC=NC(=C3C(=N2)C4=CC=C(C=C4)OC5=CC=CC=C5)N

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage

mg/kg

Average weight of animals

Dosing volume per animal

Number of animals

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO+ % + % Tween 80+ % ddH₂O

Calculate Reset

Calculation results:

Working concentration： mg/ml；

Method for preparing DMSO master liquid: ： mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL， Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation：Take μL DMSO master liquid, next addμL PEG300， mix and clarify, next addμL Tween 80，mix and clarify, next add μL ddH₂O，mix and clarify.

Note：1.Please make sure the liquid is clear before adding the next solvent.
2.Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

Bio Calculators

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and SDS / COA (available on product pages).

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration _(start) x Volume _(start) = Concentration _(final) x Volume _(final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / COA (available online).

The Serial Dilution Calculator Equation

Serial Dilutions
Concertration (start):
Dilution-folds:

Computed Result

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2021-09-06)

NCT Number	Recruitment	interventions	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT04876092	Recruiting	Drug: JNJ-67856633\|Drug: Ibrutinib	Leukemia Lymphocytic Chronic B-Cell\|Lymphoma Non-Hodgkin	Janssen Research & Development LLC	July 28 2021	Phase 1
NCT04665115	Not yet recruiting	Drug: Ibrutinib\|Other: Quality-of-Life Assessment	Asymptomatic COVID-19 Infection Laboratory-Confirmed\|B-Cell Neoplasm\|Chronic Lymphocytic Leukemia\|Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma\|Mantle Cell Lymphoma\|Marginal Zone Lymphoma\|Small Lymphocytic Lymphoma\|Symptomatic COVID-19 Infection Laboratory-Confirmed\|Waldenstrom Macroglobulinemia	Academic and Community Cancer Research United\|National Cancer Institute (NCI)	June 30 2021	Phase 2
NCT04294641	Recruiting	Drug: Ibrutinib	Chronic GVHD	National Cancer Institute (NCI)\|National Institutes of Health Clinical Center (CC)	May 10 2021	Phase 2
NCT04514393	Not yet recruiting	Drug: Methotrexate\|Drug: Ibrutinib\|Drug: Temozolomide	Primary Central Nervous System Lymphoma\|PCNSL\|Non Hodgkin Lymphoma	Huiqiang Huang\|Guangdong 999 Brain Hospital\|Nanfang Hospital of Southern Medical University\|Xian-Janssen Pharmaceutical Ltd.\|Sun Yat-sen University	December 1 2020	Phase 2
NCT03679624	Recruiting	Drug: Ibrutinib\|Drug: Daratumumab	Waldenstrom Macroglobulinemia\|Waldenstrom''s Disease\|Waldenström; Hypergammaglobulinemia\|Waldenstrom''s Macroglobulinemia Recurrent\|Waldenstrom''s Macroglobulinemia of Lymph Nodes\|Waldenstrom''s Macroglobulinaemia Without Mention of Remission\|Waldenstrom''s Macroglobulinemia Refractory	Weill Medical College of Cornell University\|Janssen Scientific Affairs LLC\|Mayo Clinic	July 30 2020	Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

Frequently Asked Questions

Question 1:
How to reconstitute the compound S2680 for in vivo studies?
Answer:
For in vivo study, we suggest to use 5% DMSO+30% PEG 300+5% Tween 80+ddH2O up to 10mg/ml.

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Ibrutinib (PCI-32765)