Ibrutinib (PCI-32765)

Name: Ibrutinib (PCI-32765)
Brand: Selleck Chemicals
SKU: S2680
Rating: 5 (439 reviews)

For research use only.

Catalog No.S2680

439 publications

Ibrutinib (PCI-32765) Chemical Structure

CAS No. 936563-96-1

Ibrutinib (PCI-32765) is a potent and highly selective Brutons tyrosine kinase (Btk) inhibitor with IC50 of 0.5 nM in cell-free assays, modestly potent to Bmx, CSK, FGR, BRK, HCK, less potent to EGFR, Yes, ErbB2, JAK3, etc. Ibrutinib is applicable as a Btk ligand in the synthesis of a series of PROTACs including P13I.

Selleck's Ibrutinib (PCI-32765) has been cited by 439 publications

Cancer Cell, 2021, 39(3):380-393.e8

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Cancer Cell, 2020, 13;37(4):551-568e14

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Nat Mater, 2019, 18(3):289-297

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Cell, 2019, 36(2):179-193

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Cancer Cell, 2019, 35(5):752-766

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Cancer Cell, 2019, 36(2):179-193

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Cancer Cell, 2019, 10.1016/j.ccell.2019.09.001

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Cancer Cell, 2019, 35(2):283-296

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Gastroenterology, 2019, 156(6):1890-1904

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Nature, 2018, 560(7718):387-391

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Nat Med, 2018, 24(5):638-646

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Cell, 2018, 175(1):85-100

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Cancer Cell, 2018, 34(6):982-995

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Nature, 2017, 23;542(7642):489-493.

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Cancer Discov, 2017, 7(9):1018-1029

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Cancer Cell, 2017, 31(6):833-843

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Cancer Cell, 2012, 22(5):656-67

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Mol Cell, 2021, S1097-2765(21)00264-1

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Nat Commun, 2021, 12(1):2877

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Leukemia, 2021, 10.1038/s41375-021-01326-x

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Cell Rep, 2021, 34(11):108870

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Aging Cell, 2021, 20(3):e13332

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Haematologica, 2021, 10.3324/haematol.2021.278743

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Cancers (Basel), 2021, 13(9)2146

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Thromb Haemost, 2021, 121(2):192-205

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J Immunol, 2021, ji2000569

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Front Oncol, 2021, 11:668617

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Int J Mol Sci, 2021, 22(3)1194

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Int J Mol Sci, 2021, 22(5)2276

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Acta Pharmacol Sin, 2021, 10.1038/s41401-020-00578-0

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Drug Metab Dispos, 2021, 49(1):53-61

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Toxicol Appl Pharmacol, 2021, 424:115595

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Am J Physiol Cell Physiol, 2021, 320(5):C902-C915

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Biochem Biophys Res Commun, 2021, 555:196-201

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Biomed Chromatogr, 2021, e5139

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Pharmazie, 2021, 76(2):92-96

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Blood Adv, 2021, 5(10):2467-2480

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J Biol Chem, 2021, S0021-9258(21)00238-6

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Blood Adv, 2021, 5(1):185-197

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Leukemia, 2021, 10.1038/s41375-021-01123-6

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Prostaglandins Other Lipid Mediat, 2021, 156:106575

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J Clin Invest, 2020, 2;138448

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Leukemia, 2020, 14

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Proc Natl Acad Sci U S A, 2020, 117(11):6092-6102

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Blood Cancer J, 2020, 10(1):12

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Aging Cell, 2020, 19(1):e13079

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Elife, 2020, 9e60470

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Oncogene, 2020, 10.1038/s41388-020-1183-x

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J Exp Clin Cancer Res, 2020, 39(1):228

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Cancers (Basel), 2020, 2;12(5) pii: E1143

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Cancers (Basel), 2020, 12(10)E2725

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Cancers (Basel), 2020, 7;12(4)

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Br J Cancer, 2020, 18

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Cell Chem Biol, 2020, 27(10):1285-1295.e4

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Front Immunol, 2020, 11:581758

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Aging (Albany NY), 2020, 12(16):16083-16098

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Br J Haematol, 2020, 10.1111/bjh.17139

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Br J Haematol, 2020, 10.1111/bjh.16386

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Eur J Med Chem, 2020, 190:112092

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Oncol Res, 2020, 10.3727/096504020X15825405463920

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J Immunol, 2020, 205(10):2629-2639

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Arthritis Res Ther, 2020, 30;22(1):66

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Int J Mol Sci, 2020, 26;21(9) pii: E3065

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J Genet Genomics, 2020, 47(7):389-395

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J Biol Chem, 2020, 10;295(15):5163-5174

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J Biol Chem, 2020, 10.1074/jbc.RA119.011946

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Cancer Cell Int, 2020, 20:458

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Cancer Cell Int, 2020, 19;20:58

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J Immunother, 2020, 43(4):107-120

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Biomed Pharmacother, 2020, 21;128:110133

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Cancer Genomics Proteomics, 2020, 17(1):77-89

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Hum Cell, 2020, 10.1007/s13577-020-00425-8

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Hum Cell, 2020, 10.1007/s13577-020-00420-z

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Clin Transl Immunology, 2020, 9(7):e1156

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Leukemia, 2020, 10.1038/s41375-020-0977-8

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JCI Insight, 2020, 5(19)139930

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Blood Adv, 2020, 4(24):6106-6116

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Oncogene, 2020, 10.1038/s41388-020-01394-w

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[email protected], 2020, 51

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Blood Adv, 2020, 9;4(11):2439-2450

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EJHaem, 2020, 1(1):122-132

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Haematologica, 2020, haematol.2020.248112

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Blood Adv, 2020, 4(18):4382-4392

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[email protected], 2020, None

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Leukemia, 2020, 10.1038/s41375-020-01025-z

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Int J Cancer, 2020, 10.1002/ijc.33212

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Blood Adv, 2020, 4(5):819-829

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Blood, 2019, 134(21):1821-1831

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Nat Chem Biol, 2019, 15(3):232-240

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Clin Cancer Res, 2019, 25(13):3974-3985

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Clin Cancer Res, 2019, 10.1158/1078-0432.CCR-19-1009

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Leukemia, 2019, 10.1038/s41375-019-0381-4

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Leukemia, 2019, 10.1038/s41375-019-0569-7

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Leukemia, 2019, 10.1038/s41375-019-0556-z

PubMed: 31462739 ( click the link to review the publication )

Cancer Res, 2019, 79(2):360-371

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Haematologica, 2019, 10.3324/haematol.2019.219550

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Haematologica, 2019, 10.3324/haematol.2018.207183

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Haematologica, 2019, 104(10):2040-2052

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Clin Cancer Res, 2019, 10.1158/1078-0432.CCR-19-2202

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J Immunother Cancer, 2019, 7(1):111

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Cell Rep, 2019,

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Haematologica, 2019, 10.3324/haematol.2019.216218

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Haematologica, 2019, 10.3324/haematol.2019.224956

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Oncogene, 2019, 10.1038/s41388-019-0903-6

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Cancers (Basel), 2019, 11(6)

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Cancers (Basel), 2019, 11(10)

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J Neurosci, 2019, 39(44):8730-8743

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FASEB J, 2019, 33(11):12036-12046

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Front Immunol, 2019, 1.8951388889

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Br J Haematol, 2019, 10.1111/bjh.16118

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Mol Cancer Res, 2019, 17(6):1365-1377

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J Immunol, 2019, 203(8):2100-2109

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Lab Invest, 2019, 10.1038/s41374-019-0262-5

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Biochem Pharmacol, 2019, 169:113616

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Sci Rep, 2019, 9(1):7193

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Sci Rep, 2019, 9(1):11069

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Cancer Cell Int, 2019, 19:67

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Front Mol Neurosci, 2019, 0.50138888889

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Invest New Drugs, 2019, 10.1007/s10637-019-00837-w

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Mol Carcinog, 2019, 58(6):944-956

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Mol Med, 2019, 25(1):3

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Oncol Rep, 2019, 10.3892/or.2019.7282

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J Bone Oncol, 2019, 17:100253

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J Pharm Biomed Anal, 2019, 177:112871

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Thromb Res, 2019, 179:64-68

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Leuk Lymphoma, 2019, 60(7):1632-1643

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Biochem Biophys Res Commun, 2019, 515(1):92-98

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Virol Sin, 2019, 10.1007/s12250-019-00145-w

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Vet Comp Oncol, 2019, 10.1111/vco.12520

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Cell Biochem Funct, 2019, 37(3):153-160

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Anticancer Res, 2019, 39(10):5461-5471

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Biomed Chromatogr, 2019, 33(5):e4507

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Biomed Chromatogr, 2019, 10.1002/bmc.4575

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Mol Imaging, 2019, 18:1536012119870899

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Oncotarget, 2019,

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Sci Rep, 2019, 9(1):7193

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Blood Adv, 2019, 3(1):51-62

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Oncotarget, 2019, 10(20):1943-1956

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Sci Rep, 2019, 9(1):11069

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JCI Insight, 2019, 4(12)

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Methods Mol Biol, 2019, 1881:19-25

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Leukemia, 2019, 10.1038/s41375-019-0682-7

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Blood Adv, 2019, 3(20):2920-2933

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Matter, 2019,

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Nat Cell Biol, 2018, 20(5):586-596

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Blood, 2018, 1;132(18):1985-1988

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Blood, 2018, 131(4):426-438

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Blood, 2018, 132(22):2401-2405

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Nat Chem Biol, 2018, 14(3):291-298

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J Clin Invest, 2018, 128(1):427-445

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J Clin Invest, 2018, 128(9):4132-4147

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J Clin Invest, 2018, 128(12):5517-5530

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Nat Commun, 2018, 9(1):727

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Nat Commun, 2018, 9(1):2434

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J Exp Med, 2018, 215(10):2586-2599

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Clin Cancer Res, 2018, 24(4):950-962

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Clin Cancer Res, 2018, 24(6):1436-1447

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Clin Cancer Res, 2018, 24(24):6408-6420

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Leukemia, 2018, 32(4):960-970

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Pharmacol Ther, 2018, 187:45-60

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Cancer Immunol Res, 2018, 6(10):1150-1160

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Haematologica, 2018, 103(3):e119-e122

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Haematologica, 2018, 103(4):679-687

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Haematologica, 2018, 10.3324/haematol.2018.189399

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Haematologica, 2018, 103(1):116-125

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Int J Cancer, 2018, 142(2):322-333

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Oncogene, 2018, 37(41):5520-5533

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Oncogene, 2018, 37(39):5325-5339

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Oncogene, 2018, 37(11):1534-1550

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Oncogene, 2018, 37(41):5520-5533

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MBio, 2018, 9(6)

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Sci Signal, 2018, 11(549)

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Cancers (Basel), 2018, 10(12)

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Arterioscler Thromb Vasc Biol, 2018, 38(12):2793-2805

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Cell Death Dis, 2018, 9(2):86

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Cell Chem Biol, 2018, 25(1):88-99

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Front Immunol, 2018, 2.4166666667

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Oncoimmunology, 2018, 8(1):e1512455

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Oncoimmunology, 2018, 7(4):e1341032

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Mol Cancer Ther, 2018, 17(12):2564-2574

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Mol Cancer Ther, 2018, 17(10):2156-2163

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J Neuroinflammation, 2018, 15(1):271

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Br J Haematol, 2018, 182(5):654-669

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Biochem Pharmacol, 2018, 156:291-301

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Sci Rep, 2018, 8(1):17651

PubMed: 30518828 ( click the link to review the publication )

Sci Rep, 2018, 8(1):14216

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Am J Physiol Lung Cell Mol Physiol, 2018, 315(1):L52-L58

PubMed: 29516781 ( click the link to review the publication )

Curr Med Chem, 2018, 10.2174/0929867325666180622143548

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J Pharmacol Exp Ther, 2018, 365(3):460-466

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Int J Mol Sci, 2018, 19(2)

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Clin Chem Lab Med, 2018, 56(5):e118-e120

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J Cell Biochem, 2018, 119(7):5843-5851

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Int J Oncol, 2018, 53(2):823-834

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BMC Cancer, 2018, 18(1):466

PubMed: 29695239 ( click the link to review the publication )

J Cancer Res Clin Oncol, 2018, 144(4):697-706

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Fish Shellfish Immunol, 2018, 77:91-99

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Int Immunopharmacol, 2018, 58:145-153

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Transl Oncol, 2018, 11(6):1406-1418

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Biochemistry, 2018, 57(26):3564-3575

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Biochemistry, 2018, 57(8):1369-1379

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J Cell Biochem, 2018, 119(7):5843-5851

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Dig Dis Sci, 2018, 63(12):3367-3375

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PLoS One, 2018, 13(8):e0200725

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PLoS One, 2018, 13(2):e0193098

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PLoS One, 2018, 13(11):e0207915

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Leuk Lymphoma, 2018, 59(4):931-940

PubMed: 28750570 ( click the link to review the publication )

Cancer Genomics Proteomics, 2018, 15(3):213-223

PubMed: 29695404 ( click the link to review the publication )

Oncotarget, 2018, 9(40):26019-26031

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Oncotarget, 2018, 9(80):35123-35140

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Sci Rep, 2018, 8(1):12046

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Oncotarget, 2018, 9(31):21820-21830

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Oncotarget, 2018, 9(89):35875-35890

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Sci Rep, 2018, 8(1):9472

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Tumour Biol, 2018, 40(1):1010428317731369

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Sci Rep, 2018, 8(1):14216

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Oncotarget, 2018, 9(41):26353-26369

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JCI Insight, 2018, 3(19)

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Adv Biol Regul, 2018, 67:190-211

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Oncotarget, 2018, 9(80):35123-35140

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Oncotarget, 2018, 9(40):26019-26031

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JCI Insight, 2018, 3(22)125568

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Blood, 2017, 129(18):2507-2518

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Blood, 2017, 129(6):759-770

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Blood, 2017, 130(14):1649-1660

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Nat Chem Biol, 2017, 13(2):168-173

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Clin Cancer Res, 2017, 23(14):3734-3743

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Clin Cancer Res, 2017, 23(4):1049-1059

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Clin Cancer Res, 2017, 23(12):3084-3096

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Clin Cancer Res, 2017, 23(10):2506-2515

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Leukemia, 2017, 31(2):350-360

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Leukemia, 2017, 31(3):614-624

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J Hematol Oncol, 2017, 10(1):80

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Oncogene, 2017,

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J Exp Clin Cancer Res, 2017, 36(1):96

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Mol Cancer Res, 2017, 15(12):1692-1703

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PLoS ONE, 2015,

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Purity & Quality Control

Choose Selective Target Protein Ligand Inhibitors

Biological Activity

Description

Targets

BTK ^[1] (Cell-free assay)	BLK ^[1] (Cell-free assay)	Bmx ^[1] (Cell-free assay)	CSK ^[1] (Cell-free assay)	FGR ^[1] (Cell-free assay)	View More
0.5 nM	0.5 nM	0.8 nM	2.3 nM	2.3 nM	View More

In vitro

Ibrutinib shows the potent and irreversible inhibitory effect and selectivity for Btk enzymatic activity. In BCR pathway-activated DOHH2 cell line, Ibrutinib inhibits autophosphorylation of Btk, phosphorylation of Btk's physiological substrate PLCγ, and phosphorylation of further downstream kinase, ERK with IC50 of 11 nM, 29 nM and 13 nM, respectively. ^[1] Ibrutinib exhibits a significant dose-dependent and time-dependent induction of cytotoxicity in chronic lymphocytic leukemia (CLL) cells. In addition, Ibrutinib induces cell death depending on caspase pathway activation and antagonizes the ability of CLL cells to proliferate after TLR signaling. ^[2] A recent study shows that Ibrutinib inhibits BCR-activated primary B cell proliferation with IC50 of 8 nM and results in inhibition of TNFα, IL-1β and IL-6 production in primary monocytes with IC50 of 2.6 nM, 0.5 nM and 3.9 nM, respectively. ^[3]

Cell Data

Cell Lines	Assay Type	Concentration	Incubation Time	Activity Description	PMID
human Rec1 cells	MmLiSpVv[3Srb36gZZN{[Xl?	NIrscFYzNjVizszN	NVy4S3ZRPiCq	NITXOVlKdmirYnn0bY9vKG:oIFz5ckBxcG:\|cHjvdplt[XSrb36gbY4hcHWvYX6gVoVkOSClZXzsd{BifCB{LkWgeW0hcW6ldXLheIVlKG[xcjC2JIhzeyCkeTDX[ZN1\XKwIHLsc5R1cW6pIH3leIhw\A>?	NVLsbZkyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWyNlI5PzdpPkK1NlIzQDd5PD;hQi=>
human WSU-NHL cells	M1\RS2N6fG:2b4jpZ:Kh[XO\|YYm=		NYrjXm5IPzJiaB?=	NX7GdYFlS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hX1OXLV7IUEBk\WyuczDhd5Nme3OnZDDhd{Boem:5dHigbY5pcWKrdHnvckBi\nSncjC3NkBpenNiYomgR4VtdFSrdHXyMWdtdyCudX3pcoV{[2WwdDDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xMlA6KM7:TR?=	MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDlzNUK5NUc,OjR7MUWyPVE9N2F-
human SU-DHL6 cells	M4\3NWN6fG:2b4jpZ:Kh[XO\|YYm=		MUW3NkBp	MXXDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDTWU1FUEx4IHPlcIx{KGG\|c3Xzd4VlKGG\|IHfyc5d1cCCrbnjpZol1cW:wIHHmeIVzKDd{IHjyd{BjgSCFZXzsWIl1\XJvR3zvJIx2dWmwZYPj[Y51KGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR\|UxRTBwNUig{txONg>?	NX35c4ZQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS5NVUzQTFpPkK0PVE2OjlzPD;hQi=>
human DOHH2 cells	NWW1bo9JS3m2b4TvfIlkyqCjc4PhfS=>		MlrSO\|IhcA>?	NFXNVnBEgXSxdH;4bYNqfHliYXfhbY5{fCCqdX3hckBFV0iKMjDj[YxteyCjc4Pld5Nm\CCjczDndo94fGhiaX7obYJqfGmxbjDh[pRmeiB5MjDodpMh[nliQ3XscHRqfGW{LVfsc{BtfW2rbnXzZ4VvfCClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1yLkSxJO69VS5?	M1LodVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OUG1NlkyLz5{NEmxOVI6OTxxYU6=
Sf9 cells	NXOwVIR3TnWwY4Tpc44h[XO\|YYm=		MXmxJIg>	NWLiW3NJUW6qaXLpeIlwdiCxZjDMXW4uSSCneIDy[ZN{\WRiaX6gV4Y6KGOnbHzzJIFnfGW{IE[wJI1qdnNiYomgWHIuTlKHVDDBd5NigSxiSVO1NF0xNjJizszNMi=>	M4fLR\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzOUW4OVQ4Lz5{MUm1PFU1PzxxYU6=
human Ramos cells	M4Xz[2Z2dmO2aX;uJIF{e2G7		NH\kZ5oyKGh?	NXruRnRJUW6qaXLpeIlwdiCxZjDCeIshcW5iaIXtZY4hWmGvb4OgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iCSTFOt[4FudWF{IIDoc5NxcG:{eXzheIlwdiCjdDDUfZIyOjF5IHHmeIVzKDFiaIKgZpkhX2W\|dHXyckBjdG:2IHHuZYx6e2m\|LDDJR\|UxRTF2IH7NMi=>	MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDlzNUK5NUc,OjR7MUWyPVE9N2F-
human Pfeiffer cells	M4\4WWZ2dmO2aX;uJIF{e2G7		MX63NkBp	NVXKSHFpS3m2b4TvfIlkcXS7IHHnZYlve3RiaIXtZY4hWG[naX\m[ZIh[2WubIOgZZN{\XO\|ZXSgZZMh\3Kxd4ToJIlvcGmkaYTpc44h[W[2ZYKgO\|IhcHK\|IHL5JGNmdGyWaYTldk1IdG9ibIXtbY5me2OnboSgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NkBvVS5?	M3\GSlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OUG1NlkyLz5{NEmxOVI6OTxxYU6=
Sf9 cells	NGm3[XhHfW6ldHnvckBie3OjeR?=		Mn7MNUBp	MnvBTY5pcWKrdHnvckBw\iCqdX3hckBnfWyuLXzlcod1cCCEVFug[ZhxemW\|c3XkJIlvKFOoOTDj[YxteyC3c3nu[{BHSU1vU4LjeIll\SCyZYD0bYRmKGG\|IIP1ZpN1emG2ZTDh[pRmeiB4MDDtbY5{KGK7IGTSMWZTTVRiQYPzZZnwxIxiSVO1NF0xNjVibl2u	Ml7nQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF7NUi1OFcoRjJzOUW4OVQ4RC:jPh?=
Sf9 insect cells	NHXwSIhHfW6ldHnvckBie3OjeR?=		MVG2NEBucW6\|	Mn62TWM2OCB;IECuNFAxOyEQvF2=	M3vpcFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7MUS2NVM3Lz5{OUG0OlE{PjxxYU6=
sf9 cells	NH;zW25HfW6ldHnvckBie3OjeR?=			M1rpS2lEPTBiPTCwMlAxODNizszN	M1[2c\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5OUm0O\|M3Lz5{N{m5OFc{PjxxYU6=
Sf9 insect cells	NIL6VI5HfW6ldHnvckBie3OjeR?=		NH6xOlg3OCCvaX7z	MV;JR\|UxKD1iMD6wNFA{PCEQvF2=	MnezQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd7MUKxO\|UoRjJ5OUGyNVc2RC:jPh?=
Sf9 insect cells	NHe4W5FHfW6ldHnvckBie3OjeR?=		NV7ibFlKPjBibXnudy=>	NFzPcmpKSzVyIE2gNE4xODB\|NDFOwG0>	MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDR\|Mkm0Okc,Ojh2M{K5OFY9N2F-
Sf9 insect cells	MYjGeY5kfGmxbjDhd5NigQ>?		M1TpT\|YxKG2rboO=	MnrtTWM2OCB;IECuNFAxOzRizszN	MkH2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd7NU[wN\|coRjJ5OUW2NFM4RC:jPh?=
Sf9 cells	NU[5R5ZYTnWwY4Tpc44h[XO\|YYm=		MlTvOlAhdWmwcx?=	NVzlXY81UUN3MDC9JFAvODByNDFOwG0>	MlXTQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzByME[xOFMoRjNyMEC2NVQ{RC:jPh?=
Sf9 cells	MYTGeY5kfGmxbjDhd5NigQ>?		NIKxbYk3OCCvaX7z	MorvTWM2OCB;IECuNFAxPSEQvF2=	MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTl3OEW0O{c,OjF7NUi1OFc9N2F-
Ramos cells	NXfodXFDTnWwY4Tpc44h[XO\|YYm=		NILXepEyKGh?	MoH1TWM2OCB;IECuNFAxPSEQvF2=	NYXSN4t4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiyPFAzPjFpPkK4NlgxOjZzPD;hQi=>
Sf9 cells	Mm\pSpVv[3Srb36gZZN{[Xl?		MVy2NEBucW6\|	M2SwdGlEPTBiPTCwMlAxOSEQvF2=	NXvJcnZFRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CwO\|c3ODhpPkOwNFc4PjB6PD;hQi=>
Pfeiffer cells	MlvRR5l1d3SxeHnjbZR6KGG\|c3H5		MnWyO\|IhcA>?	NVmycpFkT0l3MDC9JFAvODB{IN88US=>	NYLMbHZJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS5NVUzQTFpPkK0PVE2OjlzPD;hQi=>
B cells	M4TneWZ2dmO2aX;uJIF{e2G7		NFfCdXQyKGh?	MUnJR\|UxKD1iMD6wNFQ3KM7:TR?=	MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODJ7MEm4PEc,OzB{OUC5PFg9N2F-
Sf9 insect cells	MWHGeY5kfGmxbjDhd5NigQ>?		MWGyJJRwKDZyIH3pcpM>	NVnpb4lxU2liPTCwMlAxPDhizszN	M{m1b\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6M{G1OVk4Lz5{OEOxOVU6PzxxYU6=
Ramos cells	M4frXmZ2dmO2aX;uJIF{e2G7		NFXaOnUyKGh?	NVPJTFNrUUN3MDC9JFAvODB5NTFOwG0>	NEHGSmk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEmxOVI6OSd-MkS5NVUzQTF:L3G+
Sf9 insect cells	MUTGeY5kfGmxbjDhd5NigQ>?		Mk\UOlAhdWmwcx?=	MlfTTWM2OCB;IECuNFA5KM7:TR?=	M4DYdFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6M{G1OVk4Lz5{OEOxOVU6PzxxYU6=
TMD8 cells	NFzSWmtCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?=		NWXMXXlNPzJiaB?=	NYrVfHNKUUN3MDC9JFAvODFizszN	NGLkeJo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUexOVAzOyd-Mkm3NVUxOjN:L3G+
CD19+ B cells	MkW2SpVv[3Srb36gZZN{[Xl?		NYXNZYVuOSCq	M1[5[2lEPTBiPTCwMlAyOiEQvF2=	NFTD[2o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUS1O\|k5Oid-Mkm0OVc6QDJ:L3G+
Sf9 insect cells	MoHPSpVv[3Srb36gZZN{[Xl?		NIjvT5M3OCCvaX7z	NH20fYhKSzVyIE2gNE4xOTJizszN	NInjNFU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEOxOVU6Pyd-MkizNVU2QTd:L3G+
Ramos cells	M3O5bWZ2dmO2aX;uJIF{e2G7		NV[ydXRjOSCq	NILPWGlKSzVyIE2gNE4xOTRizszN	M{LBT\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OUG1NlkyLz5{NEmxOVI6OTxxYU6=
Sf9 insect cells	MYTGeY5kfGmxbjDhd5NigQ>?		Mk\oNUBp	MWnJR\|UxKD1iMD6wNVQ1KM7:TR?=	Mmm5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl5MUWwNlMoRjJ7N{G1NFI{RC:jPh?=
Sf9 insect cells	NFHHWmRHfW6ldHnvckBie3OjeR?=		MYC2NEBucW6\|	NF;ES21KSzVyIE2gNE4xOTZzIN88US=>	M4PT[\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7MUS2NVM3Lz5{OUG0OlE{PjxxYU6=
HCC827 cells	Mny4RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl?		NH;uV4c4OiCq	M4LIeGlEPTBiPTCwMlA{QSEQvF2=	MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDd\|NEW4NUc,Ojh5M{S1PFE9N2F-
PC9 cells	M3K2TGZ2dmO2aX;uJIF{e2G7		MV63NkBp	M{HM[2dKPTBiPTCwMlA2KM7:TR?=	MWi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDJ6MkGyNkc,Ojh{OEKxNlI9N2F-
Sf9 cells	NUTRRm11TnWwY4Tpc44h[XO\|YYm=		M1fz[lYxKG2rboO=	MlHiTWM2OCB;IECuNUDPxE1?	NHfoNpg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9\|MECwOlE1Oyd-M{CwNFYyPDN:L3G+
H3255 cells	M3TSS2Z2dmO2aX;uJIF{e2G7		MWi3NkBp	MYPHTVUxKD1iMD6xNUDPxE1?	NXXG[GhiRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiyPFIyOjJpPkK4NlgzOTJ{PD;hQi=>
BaF3 cells	M17tSmZ2dmO2aX;uJIF{e2G7		NWfZUVRZPzJiaB?=	MV3HTVUxKD1iMD6xNkDPxE1?	NVrLZ2pORGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[2N\|A2PTNpPkK2OlMxPTV\|PD;hQi=>
BAF3 cells	MmfGRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl?		M{DKclczKGh?	MlHYS2k2OCB;IECuNVIh\|ryP	MnzjQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh7NU[5NlMoRjJ6OUW2PVI{RC:jPh?=
Sf9 insect cells	NXi1SnhTTnWwY4Tpc44h[XO\|YYm=		M{K0dlYxKG2rboO=	MUXJR\|UxKD1iMD6xNlMh\|ryP	MoDNQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh\|MUW1PVcoRjJ6M{G1OVk4RC:jPh?=
Sf9 insect cells	NH7DeW1HfW6ldHnvckBie3OjeR?=		MX:2NEBucW6\|	NIjxXHhKSzVyIE2gNE4yPDZizszN	NYTOWIp3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkizNVU2QTdpPkK4N\|E2PTl5PD;hQi=>
BAF3 cells	NWPmbpVCTnWwY4Tpc44h[XO\|YYm=		MXu3NkBp	MV\HTVUxKD1iMD6xOkDPxE1?	NGrNbIQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEK4NlEzOid-MkiyPFIyOjJ:L3G+
Sf9 cells	M1nvPWZ2dmO2aX;uJIF{e2G7		M1PQeFYxKG2rboO=	MlPNTWM2OCB;IECuNkDPxE1?	MlvaQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjF7NUi1OFcoRjJzOUW4OVQ4RC:jPh?=
MV411 cells	MVzHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?			M2rwW2dKPTBiPTCwMlI2KM7:TR?=	NYXQOWZMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkizNVU2QTdpPkK4N\|E2PTl5PD;hQi=>
MV4-11 cells	NF\LSFdCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?=		MXe3NkBp	MYPHTVUxKD1iMD6zN{DPxE1?	NX3WepFGRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[2N\|A2PTNpPkK2OlMxPTV\|PD;hQi=>
MV4-11 cells	NH:zPIdCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?=		NHTDUZk4OiCq	NHXnT2hIUTVyIE2gNE4{OyEQvF2=	MoTvQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh7NU[5NlMoRjJ6OUW2PVI{RC:jPh?=
DOHH2 cells	NF;ZdpNEgXSxdH;4bYNqfHliYYPzZZk>		NIHLSnE4OiCq	NUXhVGZFT0l3MDC9JFAvPDFizszN	NF;teFc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEmxOVI6OSd-MkS5NVUzQTF:L3G+
HCC827 cells	MWLBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>?		MV[5OkBp	MonrSWM2OCB;IECuOFUh\|ryP	M3nve\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6OEWzOVc2Lz5{OEi1N\|U4PTxxYU6=
SU-DHL6 cells	Mnu4R5l1d3SxeHnjbZR6KGG\|c3H5		MU[3NkBp	MoPZS2k2OCB;IECuOVgh\|ryP	Mn61QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR7MUWyPVEoRjJ2OUG1NlkyRC:jPh?=
M07e cells	M3HBOWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7			MoPFS2k2OCB;IECuOVkh\|ryP	NIPHNo49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEOxOVU6Pyd-MkizNVU2QTd:L3G+
NCI-H1975 cells	M2LiUWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7		NVL1VmxPQTZiaB?=	NHfGSVRGSzVyIE2gNE43PCEQvF2=	M3PpdFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6OEWzOVc2Lz5{OEi1N\|U4PTxxYU6=
SU-DHL-2 cells	NH\yToVIem:5dHigbY5pcWKrdHnvckBie3OjeR?=			MmXZS2k2OCB;IECuOlQh\|ryP	NX;sNolmRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkizNVU2QTdpPkK4N\|E2PTl5PD;hQi=>
HEK293T cells	MnWySpVv[3Srb36gZZN{[Xl?		M1m4VVEhcA>?	NHexeYNKSzVyIE2gNE46KM7:TR?=	M{jHO\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MkiwNlYyLz5{OEK4NFI3OTxxYU6=
Ramos cells	M3PteWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7		NXXySW1UPzJiaB?=	MlvyTWM2OCB;IECuPVIh\|ryP	NVnvXWdLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm3NVUxOjNpPkK5O\|E2ODJ\|PD;hQi=>
BA/F3 cells	MV7BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>?		M1v3ZVczKGh?	MkXuTWM2OCB;IEGg{txO	NGTm[Xo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkK1PFUzOSd-Mk[yOVg2OjF:L3G+
WSU-NHL cells	NHS0dlhEgXSxdH;4bYNqfHliYYPzZZk>		MXO3NkBp	MoXES2k2OCB;IEGuNFkh\|ryP	M{S2blxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OUG1NlkyLz5{NEmxOVI6OTxxYU6=
NCI-H1975 cells	M13iZ2Z2dmO2aX;uJIF{e2G7		NF[4T4w4OiCq	MojES2k2OCB;IEGuNkDPxE1?	MmW2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh{OEKxNlIoRjJ6MkiyNVIzRC:jPh?=
NCI-H1975 cells	NYm0R\|hvSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO\|YYm=		NUH2RWZuPzJiaB?=	MX3JR\|UxKD1iMT6yO{DPxE1?	M{PCcVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6N{O0OVgyLz5{OEezOFU5OTxxYU6=
Raji cells	MlTkRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl?		MXS0PEBp	M1;GPGlEPTBiPTCxMlQ6KM7:TR?=	NXjkOIpJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm1OlczQTVpPkK5OVY4Ojl3PD;hQi=>
Pfeiffer cells	NH7rVG5Iem:5dHigbY5pcWKrdHnvckBie3OjeR?=			MWHHTVUxKD1iMT62JO69VQ>?	MYO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDNzNUW5O{c,Ojh\|MUW1PVc9N2F-
A431 cells	NETxdWtCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?=		MkX5PVYhcA>?	NWKxeox{TUN3MDC9JFIvOzhizszN	MYi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDh3M{W3OUc,Ojh6NUO1O\|U9N2F-
BAF3 cells	NEDI[YdCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?=		NYfuVnV[PzJiaB?=	NVHtZotlT0l3MDC9JFIvPSEQvF2=	MXO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDl3NkmyN{c,Ojh7NU[5NlM9N2F-
U937 cells	MW\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?			NVH4[Y5wT0l3MDC9JFIvQSEQvF2=	MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDNzNUW5O{c,Ojh\|MUW1PVc9N2F-
NB4 cells	NVizVWV{T3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=			NGXzXIxIUTVyIE2gN{DPxE1?	MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDNzNUW5O{c,Ojh\|MUW1PVc9N2F-
Ramos cells	M3;Ncmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7			MkT0S2k2OCB;IEOuOEDPxE1?	NVLUcZZoRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkizNVU2QTdpPkK4N\|E2PTl5PD;hQi=>
SKM1 cells	NX30TVhtT3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=			Mmr3S2k2OCB;IEOuOkDPxE1?	NVnse5NpRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkizNVU2QTdpPkK4N\|E2PTl5PD;hQi=>
U2932 cells	NFHkXYFIem:5dHigbY5pcWKrdHnvckBie3OjeR?=			Mn3wS2k2OCB;IESuOEDPxE1?	M2m3WFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6M{G1OVk4Lz5{OEOxOVU6PzxxYU6=
Ramos cells	MW\BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>?		Mny1O\|IhcA>?	NGHZOVRKSzVyIE2gOU4yPCEQvF2=	NVHiblN6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CwNFYyPDNpPkOwNFA3OTR\|PD;hQi=>
Ramos cells	MXfBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>?		NH3YTno1QCCq	MkfxTWM2OCB;IEWuNVQh\|ryP	MlT1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd7NU[wN\|coRjJ5OUW2NFM4RC:jPh?=
Ramos cells	NVO0clB4SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO\|YYm=		MmfrOFghcA>?	NEi5bZhKSzVyIE2gOU45QCEQvF2=	NYHYVlBVRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki0N\|I6PDZpPkK4OFMzQTR4PD;hQi=>
Ramos cells	NIXpeXZCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?=		M2XTZVczKGh?	MlTBTWM2OCB;IE[uOlIh\|ryP	NGHjO2E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUG0OlE{Pid-MkmxOFYyOzZ:L3G+
K562 cells	NVrQO3hoSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO\|YYm=		MmnrOFghcA>?	M4TyVWlEPTBiPTC3MlUh\|ryP	NEDSO\|I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9\|MEC3O\|YxQCd-M{CwO\|c3ODh:L3G+
HL60 cells	M3Xze2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7		MlzyOFghcA>?	NVTpZpRPUUN3MDC9JFgh\|ryP	MXy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODB5N{[wPEc,OzByN{e2NFg9N2F-
Ramos cells	M{XaNmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7		M3LUTFQ5KGh?	MXjJR\|UxKD1iOD6xNUDPxE1?	M4DqSVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5OUm0O\|M3Lz5{N{m5OFc{PjxxYU6=
Ramos cells	NYi2VGh1SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO\|YYm=		M4LGRVQ5KGh?	M1LHcWlEPTBiPTC4MlI3KM7:TR?=	M3L6OVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7NU[3Nlk2Lz5{OUW2O\|I6PTxxYU6=
OCI-AML3 cells	MXTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>?			MkP6S2k2OCB;IEmuNkDPxE1?	NFnNR5c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEOxOVU6Pyd-MkizNVU2QTd:L3G+
BAF3 cells	NVSxWpJSS3m2b4TvfIlkcXS7IHHzd4F6		Mn7sO\|IhcA>?	NXr5RVRRT0l3MDC9JFExKM7:TR?=	MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjZ\|MEW1N{c,OjZ4M{C1OVM9N2F-
BAF3 cells	MVXBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>?		NH3ZVJU4OiCq	MmPKS2k2OCB;IEGwJO69VQ>?	NVu4cFg{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki5OVY6OjNpPkK4PVU3QTJ\|PD;hQi=>
BAF3 cells	NHLDU3RIem:5dHigbY5pcWKrdHnvckBie3OjeR?=		MXq3NkBp	MlPrS2k2OCB;IEGwJO69VQ>?	M1;ydFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MkiyNVIzLz5{OEK4NlEzOjxxYU6=
NAMALWA cells	NV\OUnBJSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO\|YYm=		Ml24O\|IhcA>?	NIS2V2RKSzVyIE2gNVAvPDVizszN	M4LRRlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7MUS2NVM3Lz5{OUG0OlE{PjxxYU6=
Ramos cells	NFzp[ZZCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?=		M3fyVVQ5KGh?	NXj4UHFPUUN3MDC9JFEzNjZizszN	MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzlzMkG3OUc,Ojd7MUKxO\|U9N2F-
Raji cells	MVzBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>?		NFXPcGw1QCCq	NGTq[pVKSzVyIE2gNVQvOiEQvF2=	MnTrQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzByN{e2NFgoRjNyMEe3OlA5RC:jPh?=
Raji cells	MmfWRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl?		M{WxbFQ5KGh?	M1LURmlEPTBiPTCxOU4zKM7:TR?=	MljFQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd7OUS3N\|YoRjJ5OUm0O\|M3RC:jPh?=
MIAPaCa2 cells	MWfDfZRwfG:6aXPpeJkh[XO\|YYm=		M36xO\|Mh\GG7cx?=	MljpTWM2OCB;IEG2MlYh\|ryP	NVT4[ZNMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewO\|czOjhpPkK3NFc4OjJ6PD;hQi=>
HeLa cells	MnfYR5l1d3SxeHnjbZR6KGG\|c3H5		MlnNN{Bl[Xm\|	MYnJR\|UxKD1iMU[uPEDPxE1?	MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzB5N{KyPEc,OjdyN{eyNlg9N2F-
Raji cells	MUfBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>?		MV:0PEBp	MYHJR\|UxKD1iMUmuN{DPxE1?	MoLwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd7MUKxO\|UoRjJ5OUGyNVc2RC:jPh?=
Raji cells	NEWw[lZCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?=		NIfZ[I01QCCq	MnPsTWM2OCB;IEG5MlMh\|ryP	M3\ZV\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6NEOyPVQ3Lz5{OESzNlk1PjxxYU6=
Raji cells	M2LqcGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7		NVjBbI5IPzJiaB?=	MU\JR\|UxKD1iMUmuOUDPxE1?	MWW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODByNkG0N{c,OzByME[xOFM9N2F-
Raji cells	MYLBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>?		MYK0PEBp	M2G3dGlEPTBiPTCxPU42KM7:TR?=	M1zvbFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5OUW2NFM4Lz5{N{m1OlA{PzxxYU6=
NAMALWA cells	MXHBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>?		NV;TcYxuPzJiaB?=	NXjZbpV6UUN3MDC9JFE6NjZizszN	M4HHTlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMEC2NVQ{Lz5\|MECwOlE1OzxxYU6=
A2780 cells	NIDZTVJEgXSxdH;4bYNqfHliYYPzZZk>		MlrPN{Bl[Xm\|	M37YemVEPTBiPTCyNE4yKM7:TR?=	NX\FV4J1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewO\|czOjhpPkK3NFc4OjJ6PD;hQi=>
Raji cells	MWXBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>?		MUm3NkBp	NUnYPIJOUUN3MDC9JFIxNjh6IN88US=>	MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTF2NkGzOkc,OjlzNE[xN\|Y9N2F-
A549 cells	NXznW3l7SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO\|YYm=		NEexTmk4OiCq	MXjJR\|UxKD1iMkGuO\|kh\|ryP	NEHYS4Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEezOFU5OSd-Mki3N\|Q2QDF:L3G+
SW480 cells	MVPDfZRwfG:6aXPpeJkh[XO\|YYm=		M1PsU\|Mh\GG7cx?=	MXzJR\|UxKD1iMkWuOkDPxE1?	MnnlQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdyN{eyNlgoRjJ5MEe3NlI5RC:jPh?=
Ramos cells	MXPDfZRwfG:6aXPpeJkh[XO\|YYm=		M4C1elI1KGh?	NFPWdVdKSzVyIE2gNlgvPyEQvF2=	NGXoNZc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEK3OFY4PSd-MkiyO\|Q3PzV:L3G+

... Click to View More Cell Line Experimental Data

Assay

Methods	Test Index	PMID
Western blot	pEGFR(Tyr1068) / EGFR; PubMed: 28061447 Oncotarget Ibrutinib inhibitory effects on EGFRY1068 auto-phosphorylation in the HCC827 cell line at different time points by removal of drug after 4 h pretreatment. pBTK / pPLCγ2 / pAKT / pERK / pJNK; PubMed: 23940282 Blood Mino (left panel) or Jeko1 (right panel) cells pretreated with vehicle or ibrutinib 10, 100, or 1000 nM were either stimulated with anti-IgM, CXCL12, or CXCL13 or treated with medium (Med) for 15 minutes and then immunoblotted for pBTK, pPLCγ2, pAKT, pERK, and pJNK.	28061447 23940282
Immunofluorescence	CD11b; PubMed: 30231870 J Neuroinflammation BV2 microglial cells were pretreated with ibrutinib (1 μM) or vehicle (1% DMSO) for 30 min, followed by treatment with LPS (1 μg/ml) or PBS for 5.5 h and immunostaining with an anti-CD11b antibody. Scale bar = 20 μm. COX-2; PubMed: 30231870 J Neuroinflammation BV2 microglial cells were treated with vehicle (1% DMSO) or ibrutinib (1 μM) for 30 min, followed by PBS or LPS (1 μg/ml) for 5.5 h, and immunocytochemistry was conducted with anti-CD11b and anti-COX-2 antibodies.	30231870
ELISA	hTNFα; PubMed: 26627823 J Biol Chem PBMs were isolated and pretreated with 1, 5, or 10 μm ibrutinib (IB) or left untreated (UT, −). Pretreated PBMs were incubated for 24 h in 96-well plates precoated without (PBS) or with 10 μg/ml whole human IgG. Cleared supernatants were collected and analyzed by ELISA for TNFα (n = 3). IL-10; PubMed: 27792904 Virology LMP2A-negative (vector.1/.2) and -positive (express LMP2A) B cell lines were incubated in the absence or presence of increasing concentrations of Ibrutinib for 24 hours and supernatants were isolated for analysis using an IL-10 ELISA.	26627823 27792904

In vivo

In a collagen-induced arthritis model, Ibrutinib significantly reduces clinical arthritis scores reflecting paw swelling and joint inflammation by inhibiting B-cell activation. In a MRL-Fas(lpr) lupus model, Ibrutinib reduces renal disease and autoantibody production. ^[1] In an adoptive transfer TCL1 mouse model of CLL, Ibrutinib (25 mg/kg/day) causes a transient early lymphocytosis, and delays CLL disease progression. ^[4]

Protocol

Kinase Assay: ^[1]	- Collapse Kinase Assays : In vitro kinase IC50 values are measured using ³³P filtration binding assay after 1 hour incubation of kinase, ³³P-ATP, Ibrutinib, and substrate [0.2 mg/mL poly(EY)(4:1]. Assays are performed at Reaction Biology.
Cell Research: ^[2]	- Collapse Cell lines: Chronic lymphocytic leukemia (CLL) cells Concentrations: 0.01-100 μM Incubation Time: 48 hours Method: MTT (3'[4,5-dimethylthiazol-2-yl]-2,5-diphenyl-tetrazolium bromide) assays are performed to determine cytotoxicity. Briefly, cells (CLL B cells or healthy volunteer T cells or NK cells) are incubated for 48 hours with different concentrations of Ibrutinib, or vehicle control. MTT reagent is then added, and plates are incubated for an additional 20 hours before washing with protamine sulfate in phosphate-buffered saline. Dimethyl sulfoxide is added, and absorbance is measured by spectrophotometry at 540 nm in a Labsystems plate reader. Cell viability is also measured at various time points with the use of annexin/PI flow cytometry. Data are analyzed with Expo-ADC32 software package. Results are expressed as the percentage of total positive cells over untreated control. Experiments examining caspase-dependent apoptosis includes the addition of 100μM Z-VAD. (Only for Reference)
Animal Research: ^[1]	- Collapse Animal Models: MRL-Fas(lpr) lupus model and collagen-induced arthritis model. Dosages: ≤50 mg/kg Administration: Administered via p.o. (Only for Reference)

References

[4] Ponader S, et al. Blood. 2012, 119(5), 1182-1189.

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Solubility (25°C)

In vitro	DMSO	88 mg/mL (199.77 mM)
	Ethanol	45 mg/mL (102.15 mM)
	Water	Insoluble
In vivo	Add solvents to the product individually and in order(Data is from Selleck tests instead of citations): 5% DMSO+30% PEG 300+5% Tween 80+ddH2O For best results, use promptly after mixing.	10mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information Download Ibrutinib (PCI-32765) SDF

Molecular Weight	440.5
Formula	C₂₅H₂₄N₆O₂
CAS No.	936563-96-1
Storage	3 years-20°C powder 2 years-80°C in solvent
Synonyms	N/A
Smiles	C=CC(=O)N1CCCC(C1)N2C3=NC=NC(=C3C(=N2)C4=CC=C(C=C4)OC5=CC=CC=C5)N

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Number of animals

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO+ % + % Tween 80+ % ddH₂O

Calculate Reset

Calculation results:

Working concentration： mg/ml；

Method for preparing DMSO master liquid: ： mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL， Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation：Take μL DMSO master liquid, next addμL PEG300， mix and clarify, next addμL Tween 80，mix and clarify, next add μL ddH₂O，mix and clarify.

Note：1.Please make sure the liquid is clear before adding the next solvent.
2.Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

Bio Calculators

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and SDS / COA (available on product pages).

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration _(start) x Volume _(start) = Concentration _(final) x Volume _(final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / COA (available online).

The Serial Dilution Calculator Equation

Serial Dilutions
Concertration (start):
Dilution-folds:

Computed Result

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2021-05-17)

NCT Number	Recruitment	interventions	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT04665115	Not yet recruiting	Drug: Ibrutinib\|Other: Quality-of-Life Assessment	Asymptomatic COVID-19 Infection Laboratory-Confirmed\|B-Cell Neoplasm\|Chronic Lymphocytic Leukemia\|Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma\|Mantle Cell Lymphoma\|Marginal Zone Lymphoma\|Small Lymphocytic Lymphoma\|Symptomatic COVID-19 Infection Laboratory-Confirmed\|Waldenstrom Macroglobulinemia	Academic and Community Cancer Research United\|National Cancer Institute (NCI)	June 30 2021	Phase 2
NCT04876092	Not yet recruiting	Drug: JNJ-67856633\|Drug: Ibrutinib	Leukemia Lymphocytic Chronic B-Cell\|Lymphoma Non-Hodgkin	Janssen Research & Development LLC	June 11 2021	Phase 1
NCT04514393	Not yet recruiting	Drug: Methotrexate\|Drug: Ibrutinib\|Drug: Temozolomide	Primary Central Nervous System Lymphoma\|PCNSL\|Non Hodgkin Lymphoma	Huiqiang Huang\|Guangdong 999 Brain Hospital\|Nanfang Hospital of Southern Medical University\|Xian-Janssen Pharmaceutical Ltd.\|Sun Yat-sen University	December 1 2020	Phase 2
NCT04560322	Not yet recruiting	Drug: Venetoclax\|Drug: Obinutuzumab\|Drug: Ibrutinib	Chronic Lymphocytic Leukemia\|Small Lymphocytic Lymphoma	Massachusetts General Hospital\|Genentech Inc.	September 2020	Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

Frequently Asked Questions

Question 1:
How to reconstitute the compound S2680 for in vivo studies?
Answer:
For in vivo study, we suggest to use 5% DMSO+30% PEG 300+5% Tween 80+ddH2O up to 10mg/ml.

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Ibrutinib (PCI-32765)