Ibrutinib (PCI-32765)

Name: Ibrutinib (PCI-32765)
Brand: Selleck Chemicals
SKU: S2680
Rating: 5 (421 reviews)

For research use only.

Catalog No.S2680

421 publications

Ibrutinib (PCI-32765) Chemical Structure

CAS No. 936563-96-1

Ibrutinib (PCI-32765) is a potent and highly selective Brutons tyrosine kinase (Btk) inhibitor with IC50 of 0.5 nM in cell-free assays, modestly potent to Bmx, CSK, FGR, BRK, HCK, less potent to EGFR, Yes, ErbB2, JAK3, etc. Ibrutinib is applicable as a Btk ligand in the synthesis of a series of PROTACs including P13I.

Selleck's Ibrutinib (PCI-32765) has been cited by 421 publications

Cancer Cell, 2020, 13;37(4):551-568e14

PubMed: 32289277 ( click the link to review the publication )

Nat Mater, 2019, 18(3):289-297

PubMed: 30664693 ( click the link to review the publication )

Cell, 2019, 36(2):179-193

PubMed: 28162770 ( click the link to review the publication )

Cancer Cell, 2019, 35(5):752-766

PubMed: 31085176 ( click the link to review the publication )

Cancer Cell, 2019, 36(2):179-193

PubMed: 31378681 ( click the link to review the publication )

Cancer Cell, 2019, 10.1016/j.ccell.2019.09.001

PubMed: 31588020 ( click the link to review the publication )

Cancer Cell, 2019, 35(2):283-296

PubMed: 30712845 ( click the link to review the publication )

Gastroenterology, 2019, 156(6):1890-1904

PubMed: 30711627 ( click the link to review the publication )

Nature, 2018, 560(7718):387-391

PubMed: 29925955 ( click the link to review the publication )

Nat Med, 2018, 24(5):638-646

PubMed: 29686424 ( click the link to review the publication )

Cell, 2018, 175(1):85-100

PubMed: 30173916 ( click the link to review the publication )

Cancer Cell, 2018, 34(6):982-995

PubMed: 30503705 ( click the link to review the publication )

Nature, 2017, 23;542(7642):489-493.

PubMed: 28199309 ( click the link to review the publication )

Cancer Discov, 2017, 7(9):1018-1029

PubMed: 28619981 ( click the link to review the publication )

Cancer Cell, 2017, 31(6):833-843

PubMed: 28552327 ( click the link to review the publication )

Cancer Cell, 2012, 22(5):656-67

PubMed: 23153538 ( click the link to review the publication )

J Immunol, 2021, ji2000569

PubMed: 33431658 ( click the link to review the publication )

Int J Mol Sci, 2021, 22(3)1194

PubMed: 33530480 ( click the link to review the publication )

Acta Pharmacol Sin, 2021, 10.1038/s41401-020-00578-0

PubMed: 33441995 ( click the link to review the publication )

Drug Metab Dispos, 2021, 49(1):53-61

PubMed: 33148688 ( click the link to review the publication )

J Biol Chem, 2021, S0021-9258(21)00238-6

PubMed: 33639170 ( click the link to review the publication )

Leukemia, 2021, 10.1038/s41375-021-01123-6

PubMed: 33526860 ( click the link to review the publication )

J Clin Invest, 2020, 2;138448

PubMed: 32484802 ( click the link to review the publication )

Leukemia, 2020, 14

PubMed: 32409689 ( click the link to review the publication )
Proc Natl Acad Sci U S A, 2020, 117(11):6092-6102

PubMed: 32127472 ( click the link to review the publication )

Blood Cancer J, 2020, 10(1):12

PubMed: 32005797 ( click the link to review the publication )

Aging Cell, 2020, 19(1):e13079

PubMed: 31736210 ( click the link to review the publication )

Elife, 2020, 9e60470

PubMed: 33226337 ( click the link to review the publication )

Oncogene, 2020, 10.1038/s41388-020-1183-x

PubMed: 32034308 ( click the link to review the publication )

J Exp Clin Cancer Res, 2020, 39(1):228

PubMed: 33115525 ( click the link to review the publication )

Cancers (Basel), 2020, 2;12(5) pii: E1143

PubMed: 32370190 ( click the link to review the publication )

Cancers (Basel), 2020, 12(10)E2725

PubMed: 32977449 ( click the link to review the publication )

Cancers (Basel), 2020, 7;12(4)

PubMed: 32272741 ( click the link to review the publication )

Br J Cancer, 2020, 18

PubMed: 32418995 ( click the link to review the publication )

Cell Chem Biol, 2020, 27(10):1285-1295.e4

PubMed: 32783966 ( click the link to review the publication )

Front Immunol, 2020, 11:581758

PubMed: 33162995 ( click the link to review the publication )

Aging (Albany NY), 2020, 12(16):16083-16098

PubMed: 32855355 ( click the link to review the publication )

Br J Haematol, 2020, 10.1111/bjh.17139

PubMed: 33216963 ( click the link to review the publication )

Br J Haematol, 2020, 10.1111/bjh.16386

PubMed: 32057093 ( click the link to review the publication )

Eur J Med Chem, 2020, 190:112092

PubMed: 32014679 ( click the link to review the publication )

Oncol Res, 2020, 10.3727/096504020X15825405463920

PubMed: 32093809 ( click the link to review the publication )

J Immunol, 2020, 205(10):2629-2639

PubMed: 33067379 ( click the link to review the publication )

Arthritis Res Ther, 2020, 30;22(1):66

PubMed: 32228672 ( click the link to review the publication )

Int J Mol Sci, 2020, 26;21(9) pii: E3065

PubMed: 32357562 ( click the link to review the publication )

J Genet Genomics, 2020, 47(7):389-395

PubMed: 33004309 ( click the link to review the publication )

J Biol Chem, 2020, 10;295(15):5163-5174

PubMed: 32144207 ( click the link to review the publication )

J Biol Chem, 2020, 10.1074/jbc.RA119.011946

PubMed: 32184360 ( click the link to review the publication )

Cancer Cell Int, 2020, 20:458

PubMed: 32963499 ( click the link to review the publication )
Cancer Cell Int, 2020, 19;20:58

PubMed: 32099531 ( click the link to review the publication )

J Immunother, 2020, 43(4):107-120

PubMed: 31899702 ( click the link to review the publication )

Biomed Pharmacother, 2020, 21;128:110133

PubMed: 32447207 ( click the link to review the publication )

Cancer Genomics Proteomics, 2020, 17(1):77-89

PubMed: 31882553 ( click the link to review the publication )

Hum Cell, 2020, 10.1007/s13577-020-00425-8

PubMed: 32886306 ( click the link to review the publication )

Hum Cell, 2020, 10.1007/s13577-020-00420-z

PubMed: 32870449 ( click the link to review the publication )

Clin Transl Immunology, 2020, 9(7):e1156

PubMed: 32685149 ( click the link to review the publication )

Leukemia, 2020, 10.1038/s41375-020-0977-8

PubMed: 32684632 ( click the link to review the publication )

JCI Insight, 2020, 5(19)139930

PubMed: 32853177 ( click the link to review the publication )

Blood Adv, 2020, 4(24):6106-6116

PubMed: 33351104 ( click the link to review the publication )

Oncogene, 2020, 10.1038/s41388-020-01394-w

PubMed: 32709923 ( click the link to review the publication )

[email protected], 2020, 51

PubMed: N/A ( click the link to review the publication )

Blood Adv, 2020, 9;4(11):2439-2450

PubMed: 32492159 ( click the link to review the publication )

EJHaem, 2020, 1(1):122-132

PubMed: 33073261 ( click the link to review the publication )

Haematologica, 2020, haematol.2020.248112

PubMed: 32732361 ( click the link to review the publication )

Blood Adv, 2020, 4(18):4382-4392

PubMed: 32926124 ( click the link to review the publication )

Leukemia, 2020, 10.1038/s41375-020-01025-z

PubMed: 32826957 ( click the link to review the publication )

Int J Cancer, 2020, 10.1002/ijc.33212

PubMed: 32683672 ( click the link to review the publication )

Blood Adv, 2020, 4(5):819-829

PubMed: 32126142 ( click the link to review the publication )

Blood, 2019, 134(21):1821-1831

PubMed: 31527074 ( click the link to review the publication )

Nat Chem Biol, 2019, 15(3):232-240

PubMed: 30692684 ( click the link to review the publication )

Clin Cancer Res, 2019, 25(13):3974-3985

PubMed: 30940652 ( click the link to review the publication )

Clin Cancer Res, 2019, 10.1158/1078-0432.CCR-19-1009

PubMed: 31578228 ( click the link to review the publication )

Leukemia, 2019, 10.1038/s41375-019-0381-4

PubMed: 30696950 ( click the link to review the publication )
Leukemia, 2019, 10.1038/s41375-019-0569-7

PubMed: 31471562 ( click the link to review the publication )

Leukemia, 2019, 10.1038/s41375-019-0556-z

PubMed: 31462739 ( click the link to review the publication )

Cancer Res, 2019, 79(2):360-371

PubMed: 30498085 ( click the link to review the publication )

Haematologica, 2019, 10.3324/haematol.2019.219550

PubMed: 31371416 ( click the link to review the publication )

Haematologica, 2019, 10.3324/haematol.2018.207183

PubMed: 30819914 ( click the link to review the publication )

Haematologica, 2019, 104(10):2040-2052

PubMed: 30819907 ( click the link to review the publication )

Clin Cancer Res, 2019, 10.1158/1078-0432.CCR-19-2202

PubMed: 31831562 ( click the link to review the publication )

J Immunother Cancer, 2019, 7(1):111

PubMed: 31014395 ( click the link to review the publication )

Cell Rep, 2019,

PubMed: 31801079 ( click the link to review the publication )

Haematologica, 2019, 10.3324/haematol.2019.216218

PubMed: 31471373 ( click the link to review the publication )

Haematologica, 2019, 10.3324/haematol.2019.224956

PubMed: 31624110 ( click the link to review the publication )

Oncogene, 2019, 10.1038/s41388-019-0903-6

PubMed: 31399645 ( click the link to review the publication )

Cancers (Basel), 2019, 11(6)

PubMed: 31167506 ( click the link to review the publication )

Cancers (Basel), 2019, 11(10)

PubMed: 31601046 ( click the link to review the publication )

J Neurosci, 2019, 39(44):8730-8743

PubMed: 31530645 ( click the link to review the publication )

FASEB J, 2019, 33(11):12036-12046

PubMed: 31365830 ( click the link to review the publication )

Front Immunol, 2019, 1.8951388889

PubMed: 31552054 ( click the link to review the publication )

Br J Haematol, 2019, 10.1111/bjh.16118

PubMed: 31355927 ( click the link to review the publication )

Mol Cancer Res, 2019, 17(6):1365-1377

PubMed: 30862686 ( click the link to review the publication )

J Immunol, 2019, 203(8):2100-2109

PubMed: 31511358 ( click the link to review the publication )

Lab Invest, 2019, 10.1038/s41374-019-0262-5

PubMed: 31197205 ( click the link to review the publication )

Biochem Pharmacol, 2019, 169:113616

PubMed: 31445021 ( click the link to review the publication )

Sci Rep, 2019, 9(1):7193

PubMed: 31076643 ( click the link to review the publication )

Sci Rep, 2019, 9(1):11069

PubMed: 31363127 ( click the link to review the publication )
Cancer Cell Int, 2019, 19:67

PubMed: 30948927 ( click the link to review the publication )

Front Mol Neurosci, 2019, 0.50138888889

PubMed: 30733667 ( click the link to review the publication )

Invest New Drugs, 2019, 10.1007/s10637-019-00837-w

PubMed: 31375978 ( click the link to review the publication )

Mol Carcinog, 2019, 58(6):944-956

PubMed: 30693983 ( click the link to review the publication )

Mol Med, 2019, 25(1):3

PubMed: 30646846 ( click the link to review the publication )

Oncol Rep, 2019, 10.3892/or.2019.7282

PubMed: 31432184 ( click the link to review the publication )

J Bone Oncol, 2019, 17:100253

PubMed: 31372333 ( click the link to review the publication )

J Pharm Biomed Anal, 2019, 177:112871

PubMed: 31539712 ( click the link to review the publication )

Thromb Res, 2019, 179:64-68

PubMed: 31082751 ( click the link to review the publication )

Leuk Lymphoma, 2019, 60(7):1632-1643

PubMed: 30648436 ( click the link to review the publication )

Biochem Biophys Res Commun, 2019, 515(1):92-98

PubMed: 31128919 ( click the link to review the publication )

Virol Sin, 2019, 10.1007/s12250-019-00145-w

PubMed: 31286365 ( click the link to review the publication )

Vet Comp Oncol, 2019, 10.1111/vco.12520

PubMed: 31286638 ( click the link to review the publication )

Cell Biochem Funct, 2019, 37(3):153-160

PubMed: 30907011 ( click the link to review the publication )

Anticancer Res, 2019, 39(10):5461-5471

PubMed: 31570440 ( click the link to review the publication )

Biomed Chromatogr, 2019, 33(5):e4507

PubMed: 30754071 ( click the link to review the publication )

Biomed Chromatogr, 2019, 10.1002/bmc.4575

PubMed: 31069837 ( click the link to review the publication )

Mol Imaging, 2019, 18:1536012119870899

PubMed: 31478435 ( click the link to review the publication )

Oncotarget, 2019,

PubMed: 30956776 ( click the link to review the publication )

Sci Rep, 2019, 9(1):7193

PubMed: 31076643 ( click the link to review the publication )

Blood Adv, 2019, 3(1):51-62

PubMed: 30617217 ( click the link to review the publication )

Oncotarget, 2019, 10(20):1943-1956

PubMed: 30956776 ( click the link to review the publication )

JCI Insight, 2019, 4(12)

PubMed: 31217352 ( click the link to review the publication )

Methods Mol Biol, 2019, 1881:19-25

PubMed: 30350194 ( click the link to review the publication )
Leukemia, 2019, 10.1038/s41375-019-0682-7

PubMed: 31862959 ( click the link to review the publication )

Blood Adv, 2019, 3(20):2920-2933

PubMed: 31648314 ( click the link to review the publication )

Matter, 2019,

PubMed: 32832885 ( click the link to review the publication )

Nat Cell Biol, 2018, 20(5):586-596

PubMed: 29695787 ( click the link to review the publication )

Blood, 2018, 1;132(18):1985-1988

PubMed: 30021784 ( click the link to review the publication )

Blood, 2018, 131(4):426-438

PubMed: 29187377 ( click the link to review the publication )

Blood, 2018, 132(22):2401-2405

PubMed: 30257882 ( click the link to review the publication )

Nat Chem Biol, 2018, 14(3):291-298

PubMed: 29355849 ( click the link to review the publication )

J Clin Invest, 2018, 128(1):427-445

PubMed: 29227286 ( click the link to review the publication )

J Clin Invest, 2018, 128(9):4132-4147

PubMed: 29990311 ( click the link to review the publication )

J Clin Invest, 2018, 128(12):5517-5530

PubMed: 30260324 ( click the link to review the publication )

Nat Commun, 2018, 9(1):727

PubMed: 29463802 ( click the link to review the publication )

Nat Commun, 2018, 9(1):2434

PubMed: 29934552 ( click the link to review the publication )

J Exp Med, 2018, 215(10):2586-2599

PubMed: 30158115 ( click the link to review the publication )

Clin Cancer Res, 2018, 24(4):950-962

PubMed: 29208667 ( click the link to review the publication )

Clin Cancer Res, 2018, 24(24):6408-6420

PubMed: 30126942 ( click the link to review the publication )

Clin Cancer Res, 2018, 24(6):1436-1447

PubMed: 29127119 ( click the link to review the publication )

Clin Cancer Res, 2018, 24(1):120-129

PubMed: 29066507 ( click the link to review the publication )

Clin Cancer Res, 2018, 24(4):950-962

PubMed: 29208667 ( click the link to review the publication )

Leukemia, 2018, 32(4):960-970

PubMed: 28972595 ( click the link to review the publication )

Pharmacol Ther, 2018, 187:45-60

PubMed: 29454854 ( click the link to review the publication )

Cancer Immunol Res, 2018, 6(10):1150-1160

PubMed: 30089638 ( click the link to review the publication )

Haematologica, 2018, 103(3):e119-e122

PubMed: 29242303 ( click the link to review the publication )

Haematologica, 2018, 103(4):679-687

PubMed: 29305415 ( click the link to review the publication )
Haematologica, 2018, 10.3324/haematol.2018.189399

PubMed: 29748445 ( click the link to review the publication )

Haematologica, 2018, 103(1):116-125

PubMed: 29079592 ( click the link to review the publication )

Int J Cancer, 2018, 142(2):322-333

PubMed: 28921505 ( click the link to review the publication )

Oncogene, 2018, 37(41):5520-5533

PubMed: 29895969 ( click the link to review the publication )

Oncogene, 2018, 37(39):5325-5339

PubMed: 29858601 ( click the link to review the publication )

Oncogene, 2018, 37(11):1534-1550

PubMed: 29326436 ( click the link to review the publication )

MBio, 2018, 9(6)

PubMed: 30401776 ( click the link to review the publication )

Sci Signal, 2018, 11(549)

PubMed: 30254057 ( click the link to review the publication )

Cancers (Basel), 2018, 10(12)

PubMed: 30572654 ( click the link to review the publication )

Arterioscler Thromb Vasc Biol, 2018, 38(12):2793-2805

PubMed: 30571167 ( click the link to review the publication )

Cell Death Dis, 2018, 9(2):86

PubMed: 29367645 ( click the link to review the publication )

Cell Chem Biol, 2018, 25(1):88-99

PubMed: 29129717 ( click the link to review the publication )

Front Immunol, 2018, 2.4166666667

PubMed: 30619300 ( click the link to review the publication )

Oncoimmunology, 2018, 8(1):e1512455

PubMed: 30546948 ( click the link to review the publication )

Oncoimmunology, 2018, 7(4):e1341032

PubMed: 29632712 ( click the link to review the publication )

Mol Cancer Ther, 2018, 17(12):2564-2574

PubMed: 30510142 ( click the link to review the publication )

Mol Cancer Ther, 2018, 17(10):2156-2163

PubMed: 30065099 ( click the link to review the publication )

J Neuroinflammation, 2018, 15(1):271

PubMed: 30231870 ( click the link to review the publication )

Br J Haematol, 2018, 182(5):654-669

PubMed: 29978459 ( click the link to review the publication )

Biochem Pharmacol, 2018, 156:291-301

PubMed: 30149015 ( click the link to review the publication )

Sci Rep, 2018, 8(1):17651

PubMed: 30518828 ( click the link to review the publication )

Sci Rep, 2018, 8(1):14216

PubMed: 30242208 ( click the link to review the publication )

Am J Physiol Lung Cell Mol Physiol, 2018, 315(1):L52-L58

PubMed: 29516781 ( click the link to review the publication )

Curr Med Chem, 2018, 10.2174/0929867325666180622143548

PubMed: 29932031 ( click the link to review the publication )
J Pharmacol Exp Ther, 2018, 365(3):460-466

PubMed: 29563327 ( click the link to review the publication )

Int J Mol Sci, 2018, 19(2)

PubMed: 29364178 ( click the link to review the publication )

Clin Chem Lab Med, 2018, 56(5):e118-e120

PubMed: 29306911 ( click the link to review the publication )

J Cell Biochem, 2018, 119(7):5843-5851

PubMed: 29575238 ( click the link to review the publication )

Int J Oncol, 2018, 53(2):823-834

PubMed: 29901111 ( click the link to review the publication )

BMC Cancer, 2018, 18(1):466

PubMed: 29695239 ( click the link to review the publication )

J Cancer Res Clin Oncol, 2018, 144(4):697-706

PubMed: 29392403 ( click the link to review the publication )

Fish Shellfish Immunol, 2018, 77:91-99

PubMed: 29567142 ( click the link to review the publication )

Int Immunopharmacol, 2018, 58:145-153

PubMed: 29587203 ( click the link to review the publication )

Transl Oncol, 2018, 11(6):1406-1418

PubMed: 30219696 ( click the link to review the publication )

Biochemistry, 2018, 57(26):3564-3575

PubMed: 29851337 ( click the link to review the publication )

Biochemistry, 2018, 57(8):1369-1379

PubMed: 29293322 ( click the link to review the publication )

Dig Dis Sci, 2018, 63(12):3367-3375

PubMed: 30155839 ( click the link to review the publication )

PLoS One, 2018, 13(8):e0200725

PubMed: 30067771 ( click the link to review the publication )

PLoS One, 2018, 13(2):e0193098

PubMed: 29489886 ( click the link to review the publication )

PLoS One, 2018, 13(11):e0207915

PubMed: 30481203 ( click the link to review the publication )

Leuk Lymphoma, 2018, 59(4):931-940

PubMed: 28750570 ( click the link to review the publication )

Cancer Genomics Proteomics, 2018, 15(3):213-223

PubMed: 29695404 ( click the link to review the publication )

Oncotarget, 2018, 9(40):26019-26031

PubMed: 29899839 ( click the link to review the publication )

Oncotarget, 2018, 9(80):35123-35140

PubMed: 30416684 ( click the link to review the publication )

Sci Rep, 2018, 8(1):12046

PubMed: 30104685 ( click the link to review the publication )

Oncotarget, 2018, 9(31):21820-21830

PubMed: 29774105 ( click the link to review the publication )

Oncotarget, 2018, 9(89):35875-35890

PubMed: 30542505 ( click the link to review the publication )

Sci Rep, 2018, 8(1):9472

PubMed: 29930256 ( click the link to review the publication )
Tumour Biol, 2018, 40(1):1010428317731369

PubMed: 29320977 ( click the link to review the publication )

Sci Rep, 2018, 8(1):14216

PubMed: 30242208 ( click the link to review the publication )

Oncotarget, 2018, 9(41):26353-26369

PubMed: 29899864 ( click the link to review the publication )

JCI Insight, 2018, 3(19)

PubMed: 30282833 ( click the link to review the publication )

Adv Biol Regul, 2018, 67:190-211

PubMed: 28988970 ( click the link to review the publication )

Tumour Biol, 2018, 40(1):1010428317731369

PubMed: 29320977 ( click the link to review the publication )

Oncotarget, 2018, 9(40):26019-26031

PubMed: 29899839 ( click the link to review the publication )

JCI Insight, 2018, 3(22)125568

PubMed: 30429379 ( click the link to review the publication )

Blood, 2017, 129(18):2507-2518

PubMed: 28202459 ( click the link to review the publication )

Blood, 2017, 129(6):759-770

PubMed: 28011673 ( click the link to review the publication )

Blood, 2017, 130(14):1649-1660

PubMed: 28733324 ( click the link to review the publication )

Blood, 2017, 129(18):2507-2518

PubMed: 28202459 ( click the link to review the publication )

Nat Chem Biol, 2017, 13(2):168-173

PubMed: 27918558 ( click the link to review the publication )

Clin Cancer Res, 2017, 23(14):3734-3743

PubMed: 28034907 ( click the link to review the publication )

Clin Cancer Res, 2017, 23(4):1049-1059

PubMed: 27535981 ( click the link to review the publication )

Clin Cancer Res, 2017, 23(12):3084-3096

PubMed: 27993968 ( click the link to review the publication )

Clin Cancer Res, 2017, 23(10):2506-2515

PubMed: 27780854 ( click the link to review the publication )

Leukemia, 2017, 31(2):350-360

PubMed: 27480387 ( click the link to review the publication )

Leukemia, 2017, 31(3):614-624

PubMed: 27538487 ( click the link to review the publication )

J Hematol Oncol, 2017, 10(1):80

PubMed: 28359287 ( click the link to review the publication )

Oncogene, 2017,

PubMed: 27748757 ( click the link to review the publication )

Oncogene, 2017, 36(32):4653-4661

PubMed: 28368423 ( click the link to review the publication )

J Exp Clin Cancer Res, 2017, 36(1):96

PubMed: 28716053 ( click the link to review the publication )

EBioMedicine, 2017, 15:24-35

PubMed: 27932296 ( click the link to review the publication )
Arch Toxicol, 2017, 91(8):2921-2938

PubMed: 28032146 ( click the link to review the publication )

Mol Cancer Ther, 2017,

PubMed: 28615297 ( click the link to review the publication )

Mol Cancer Ther, 2017, 16(11):2586-2597

PubMed: 28835384 ( click the link to review the publication )

Am J Hematol, 2017, 92(8):E138-E145

PubMed: 28474779 ( click the link to review the publication )

Eur J Med Chem, 2017, 140:421-434

PubMed: 28987604 ( click the link to review the publication )

Mol Cancer Res, 2017, 15(12):1692-1703

PubMed: 28835371 ( click the link to review the publication )

Mol Pharm, 2017, 14(11):4042-4051

PubMed: 28933554 ( click the link to review the publication )

Toxicol Sci, 2017, 158(1):213-226

PubMed: 28453775 ( click the link to review the publication )

J Pharmacol Exp Ther, 2017, 361(1):140-150

PubMed: 28174211 ( click the link to review the publication )

Clin Immunol, 2017, 178:64-73

PubMed: 28163195 ( click the link to review the publication )

Virology, 2017, 500:96-102

PubMed: 27792904 ( click the link to review the publication )

PLoS One, 2017, 12(2):e0171427

PubMed: 28166283 ( click the link to review the publication )

Int J Hematol, 2017, 106(5):666-674

PubMed: 28795321 ( click the link to review the publication )

SLAS Discov, 2017, 22(5):494-506

PubMed: 28346091 ( click the link to review the publication )

SLAS Discov, 2017, 22(7):915-922

PubMed: 28346107 ( click the link to review the publication )

Cancer Genet, 2017, 216-217:128-141

PubMed: 29025587 ( click the link to review the publication )

Anticancer Res, 2017, 37(11):6203-6209

PubMed: 29061802 ( click the link to review the publication )

Oncotarget, 2017,

PubMed: 29113297 ( click the link to review the publication )

Blood Adv, 2017, 1(26):2610-2623

PubMed: 29296914 ( click the link to review the publication )

Oncotarget, 2017, 8(35):59235-59245

PubMed: 28938632 ( click the link to review the publication )

Oncotarget, 2017, 8(67):111386-111395

PubMed: 29340061 ( click the link to review the publication )

JCI Insight, 2017, 2(6):e90196

PubMed: 28352655 ( click the link to review the publication )

Oncotarget, 2017, 8(8):12953-12967

PubMed: 28088788 ( click the link to review the publication )

Leukemia, 2017, 31(3):614-624

PubMed: 27538487 ( click the link to review the publication )
Oncotarget, 2017, 8(8):12764-12774

PubMed: 28061447 ( click the link to review the publication )

Oncotarget, 2017, 8(3):5361-5370

PubMed: 28036258 ( click the link to review the publication )

Oncotarget, 2017, 8(68):112917-112927

PubMed: 29348877 ( click the link to review the publication )

Oncotarget, 2017, 8(67):111495-111507

PubMed: 29340070 ( click the link to review the publication )

Proc Natl Acad Sci U S A, 2017, 114(36):E7554-E7563

PubMed: 28784769 ( click the link to review the publication )

Oncotarget, 2017, 8(69):114156-114172

PubMed: 29371976 ( click the link to review the publication )

Oncotarget, 2017, 8(8):12953-12967

PubMed: 28088788 ( click the link to review the publication )

Blood Adv, 2017, 1(26):2610-2623

PubMed: 29296914 ( click the link to review the publication )

JCI Insight, 2017, 2(6):e90196

PubMed: 28352655 ( click the link to review the publication )

Oncotarget, 2017, 8(67):111386-111395

PubMed: 29340061 ( click the link to review the publication )

Oncotarget, 2017, 8(1):742-756

PubMed: 27888629 ( click the link to review the publication )

Oncotarget, 2017, 8(46):80223-80234

PubMed: 29113297 ( click the link to review the publication )

Oncotarget, 2017, 8(52):90013-90027

PubMed: 29163807 ( click the link to review the publication )

Oncotarget, 2017, 8(10):16259-16274

PubMed: 28187444 ( click the link to review the publication )

Oncotarget, 2017, 8(22):35508-35522

PubMed: 28418900 ( click the link to review the publication )

Oncotarget, 2017, 8(47):81794-81802

PubMed: 29137222 ( click the link to review the publication )

Oncotarget, 2017, 8(25):40318-40326

PubMed: 28454099 ( click the link to review the publication )

Oncotarget, 2017, 8(52):90013-90027

PubMed: 29163807 ( click the link to review the publication )

Oncotarget, 2017, 8(45):78480-78495

PubMed: 29108243 ( click the link to review the publication )

Nature, 2017, 544(7651):493-497

PubMed: 28424516 ( click the link to review the publication )

Oncotarget, 2017, 8(8):12764-12774

PubMed: 28061447 ( click the link to review the publication )

J Hematol Oncol, 2017, 10(1):80

PubMed: 28359287 ( click the link to review the publication )

Oncotarget, 2017,

PubMed: 28036258 ( click the link to review the publication )

Oncotarget, 2017, 8(1):742-756

PubMed: 27888629 ( click the link to review the publication )
Oncotarget, 2017, 8(68):112917-112927

PubMed: 29348877 ( click the link to review the publication )

Blood, 2016, 127(4):449-57

PubMed: 26491071 ( click the link to review the publication )

Blood, 2016, 127(4):436-48

PubMed: 26508782 ( click the link to review the publication )

Blood, 2016, 128(1):82-92

PubMed: 27127301 ( click the link to review the publication )

Ann Oncol, 2016, 27(6):1123-8

PubMed: 26961147 ( click the link to review the publication )

J Allergy Clin Immunol, 2016, 137(3):889-98

PubMed: 26478008 ( click the link to review the publication )

Nat Commun, 2016, 7:11589

PubMed: 27199251 ( click the link to review the publication )

Nat Commun, 2016, 7:11889

PubMed: 27297662 ( click the link to review the publication )

Clin Cancer Res, 2016, 22(1):86-95

PubMed: 26283682 ( click the link to review the publication )

Clin Cancer Res, 2016, 22(7):1572-82

PubMed: 26660519 ( click the link to review the publication )

Clin Cancer Res, 2016, 22(24):6099-6109

PubMed: 27287071 ( click the link to review the publication )

Clin Cancer Res, 2016, 22(11):2684-96

PubMed: 26819453 ( click the link to review the publication )

Clin Cancer Res, 2016, 22(3):746-56

PubMed: 26408402 ( click the link to review the publication )

Clin Cancer Res, 2016, 22(16):4197-205

PubMed: 27022065 ( click the link to review the publication )

Leukemia, 2016, 10.1038/leu.2016.153

PubMed: 27282255 ( click the link to review the publication )

Semin Cancer Biol, 2016, 39:40-8

PubMed: 27491692 ( click the link to review the publication )

Blood Cancer J, 2016, 10;6(6):e434

PubMed: 27284738 ( click the link to review the publication )

Cell Death Differ, 2016, 23(2):303-12

PubMed: 26184912 ( click the link to review the publication )

Cell Death Differ, 2016, 23(4):628-39

PubMed: 26450454 ( click the link to review the publication )

Sci Signal, 2016, 9(415):ra17

PubMed: 26884599 ( click the link to review the publication )

Bioinformatics, 2016, 32(12):i253-i261

PubMed: 27307624 ( click the link to review the publication )

Mol Cancer Ther, 2016, 15(12):2835-2844

PubMed: 27678331 ( click the link to review the publication )

Mol Cancer Ther, 2016, 15(6):1248-60

PubMed: 27197306 ( click the link to review the publication )

Front Cell Dev Biol, 2016, 0.20138888889

PubMed: 27303665 ( click the link to review the publication )
Cancer Sci, 2016,

PubMed: 27348272 ( click the link to review the publication )

J Immunol, 2016, 196(8):3385-97

PubMed: 26983789 ( click the link to review the publication )

Ann Hematol, 2016, 95(12):1979-1988

PubMed: 27542958 ( click the link to review the publication )

PLoS One, 2016, 11(1):e0146955

PubMed: 26785352 ( click the link to review the publication )

PLoS One, 2016, 11(8):e0161415

PubMed: 27556570 ( click the link to review the publication )

Leuk Lymphoma, 2016, 57(6):1413-22

PubMed: 26699656 ( click the link to review the publication )

Exp Hematol, 2016, 44(1):38-49

PubMed: 26325331 ( click the link to review the publication )

Leuk Res, 2016, 47:1-7

PubMed: 27235717 ( click the link to review the publication )

Clin Lymphoma Myeloma Leuk, 2016, 16(11):593-606

PubMed: 27601002 ( click the link to review the publication )

Cancer Genet, 2016, 209(4):119-29

PubMed: 26880400 ( click the link to review the publication )

Mol Med Rep, 2016, 13(6):4934-8

PubMed: 27082823 ( click the link to review the publication )

Oncotarget, 2016,

PubMed: 26701728 ( click the link to review the publication )

Oncotarget, 2016, 7(25):38180-38190

PubMed: 27224912 ( click the link to review the publication )

Oncotarget, 2016, 7(43):69961-69975

PubMed: 27564106 ( click the link to review the publication )

J Immunol Res, 2016, 2016:5281823

PubMed: 28116319 ( click the link to review the publication )

Oncotarget, 2016, 7(43):70623-70638

PubMed: 27661115 ( click the link to review the publication )

Oncotarget, 2016, 7(45):72608-72621

PubMed: 27579615 ( click the link to review the publication )

Oncotarget, 2016, 7(26):39784-39795

PubMed: 27174919 ( click the link to review the publication )

Oncotarget, 2016, 7(25):38523-38538

PubMed: 27229530 ( click the link to review the publication )

Oncotarget, 2016, 7(23):34785-99

PubMed: 27166183 ( click the link to review the publication )

Oncotarget, 2016, 7(40):65968-65981

PubMed: 27602755 ( click the link to review the publication )

Oncotarget, 2016, 7(4):4598-610

PubMed: 26717038 ( click the link to review the publication )

Oncotarget, 2016, 7(43):69961-69975

PubMed: 27564106 ( click the link to review the publication )

Oncotarget, 2016, 7(3):2765-79

PubMed: 26624983 ( click the link to review the publication )
Oncotarget, 2016, 7(46):74807-74819

PubMed: 27579538 ( click the link to review the publication )

Oncotarget, 2016, 7(48):79637-79653

PubMed: 27793034 ( click the link to review the publication )

Oncotarget, 2016, 8(32):52225-52236

PubMed: 28881725 ( click the link to review the publication )

Oncotarget, 2016, 7(46):74807-74819

PubMed: 27579538 ( click the link to review the publication )

Oncotarget, 2016, 7(4):4598-610

PubMed: 26717038 ( click the link to review the publication )

Oncotarget, 2016, 7(45):72608-72621

PubMed: 27579615 ( click the link to review the publication )

Oncotarget, 2016,

PubMed: 27602755 ( click the link to review the publication )

Blood, 2015, 125(2):407-10

PubMed: 25573971 ( click the link to review the publication )

Blood, 2015, 14;125(20):3128-32

PubMed: 25838351 ( click the link to review the publication )

Blood, 2015, 24;126(13):1565-74

PubMed: 26254443 ( click the link to review the publication )

Blood, 2015, 10.1182/blood-2014-12-618470

PubMed: 25833959 ( click the link to review the publication )

Blood, 2015, 125(20):3128-32

PubMed: 25838351 ( click the link to review the publication )

J Clin Invest, 2015, 125(12):4559-71

PubMed: 26529251 ( click the link to review the publication )

Nat Commun, 2015, 4.5673611111

PubMed: 25692415 ( click the link to review the publication )

Nat Commun, 2015, 6.1395833333

PubMed: 26412466 ( click the link to review the publication )

Lancet Haematol, 2015, 2(5):e204-11

PubMed: 26688095 ( click the link to review the publication )

J Exp Med, 2015, 10.1084/jem.20141957

PubMed: 25847947 ( click the link to review the publication )

J Exp Med, 2015, 212(6):833-43

PubMed: 25987724 ( click the link to review the publication )

Clin Cancer Res, 2015, 21(9):2115-26

PubMed: 25673699 ( click the link to review the publication )

Clin Cancer Res, 2015, 21(16):3705-15

PubMed: 25829398 ( click the link to review the publication )

Clin Cancer Res, 2015, 21(7):1628-38

PubMed: 25623213 ( click the link to review the publication )

Leukemia, 2015, 29(2):356-68

PubMed: 24990614 ( click the link to review the publication )

Proc Natl Acad Sci U S A, 2015, 112(52):E7230-8

PubMed: 26668357 ( click the link to review the publication )

Haematologica, 2015, 100(1):77-86

PubMed: 25344523 ( click the link to review the publication )
Haematologica, 2015, 100(8):e302-6

PubMed: 25957396 ( click the link to review the publication )

Clin Cancer Res, 2015, 21(7):1628-38

PubMed: 25623213 ( click the link to review the publication )

Int J Cancer, 2015, 136(12):2761-74

PubMed: 25388373 ( click the link to review the publication )

J Med Chem, 2015, 58(16):6589-606

PubMed: 26258521 ( click the link to review the publication )

J Med Chem, 2015, 58(23):9228-37

PubMed: 26562217 ( click the link to review the publication )

Arterioscler Thromb Vasc Biol, 2015, 35(11):2326-35

PubMed: 26359510 ( click the link to review the publication )

ACS Chem Biol, 2015, 10(12):2687-96

PubMed: 26390252 ( click the link to review the publication )

J Immunol, 2015, 195(8):3890-900

PubMed: 26371254 ( click the link to review the publication )

J Cell Sci, 2015, 128(2):251-65

PubMed: 25413351 ( click the link to review the publication )

Sci Rep, 2015, 5:12949

PubMed: 26292723 ( click the link to review the publication )

Apoptosis, 2015, 20(7):975-85

PubMed: 25835755 ( click the link to review the publication )

J Biol Chem, 2015, 10.1074/jbc.M114.629527

PubMed: 25767114 ( click the link to review the publication )

Drug Metab Dispos, 2015, 43(3):375-84

PubMed: 25504185 ( click the link to review the publication )

Drug Metab Dispos, 2015, 43(12):1934-7

PubMed: 26443648 ( click the link to review the publication )

J Neurovirol, 2015, 10.1007/s13365-015-0323-5

PubMed: 25672887 ( click the link to review the publication )

J Pharm Biomed Anal, 2015, 107:151-8

PubMed: 25594893 ( click the link to review the publication )

PLoS ONE, 2015,

PubMed: 26110819 ( click the link to review the publication )

PLoS One, 2015, 10(11):e0143685

PubMed: 26606677 ( click the link to review the publication )

Exp Hematol, 2015,

PubMed: 25641047 ( click the link to review the publication )

J Anal Methods Chem, 2015, 2015:215128

PubMed: 26101692 ( click the link to review the publication )

Oncotarget, 2015, 6(11):8750-9

PubMed: 25797245 ( click the link to review the publication )

Oncotarget, 2015, 6(29):27388-402

PubMed: 26317541 ( click the link to review the publication )

Ann N Y Acad Sci, 2015, 1362:239-249

PubMed: 26096907 ( click the link to review the publication )

Drug Metab Dispos, 2015, 43(12):1934-7

PubMed: 26443648 ( click the link to review the publication )
Lancet Haematol, 2015, 2(5):e204-11

PubMed: 26688095 ( click the link to review the publication )

J Exp Med, 2015, 212(6):833-43

PubMed: 25987724 ( click the link to review the publication )

Oncotarget, 2015, 6(26):22734-49

PubMed: 26068951 ( click the link to review the publication )

Oncotarget, 2015, 6(39):42130-49

PubMed: 26517523 ( click the link to review the publication )

Oncotarget, 2015, 6(39):42232-42

PubMed: 26540570 ( click the link to review the publication )

Oncotarget, 2015, 6(11):8750-9

PubMed: 25797245 ( click the link to review the publication )

Oncotarget, 2015, 6(29):27388-402

PubMed: 26317541 ( click the link to review the publication )

Oncotarget, 2015,

PubMed: 26540570 ( click the link to review the publication )

Oncotarget, 2015, 6(16):14632-45

PubMed: 25999352 ( click the link to review the publication )

Sci Rep, 2015, 5:13891

PubMed: 26403635 ( click the link to review the publication )

Oncotarget, 2015, 6(34):35247-62

PubMed: 26497213 ( click the link to review the publication )

Ann N Y Acad Sci, 2015, 1362:239-249

PubMed: 26096907 ( click the link to review the publication )

Proc Natl Acad Sci U S A, 2015, 112(52):E7230-8

PubMed: 26668357 ( click the link to review the publication )

Oncotarget, 2015, 6(26):22734-49

PubMed: 26068951 ( click the link to review the publication )

Expert Opin Drug Metab Toxicol, 2015, 11(9):1371-91

PubMed: 26156752 ( click the link to review the publication )

Oncotarget, 2015,

PubMed: 25999352 ( click the link to review the publication )

Blood, 2014, 123(8):1229-38

PubMed: 24307721 ( click the link to review the publication )

Blood, 2014, 124(26):3991-5

PubMed: 25305202 ( click the link to review the publication )

Blood, 2014, 123(26):4120-31

PubMed: 24711662 ( click the link to review the publication )

Blood, 2014, 123(6):884-93

PubMed: 24352880 ( click the link to review the publication )

J Allergy Clin Immunol, 2014, 134(2):420-428

PubMed: 24679343 ( click the link to review the publication )

J Allergy Clin Immunol, 2014, 133(6):1644-50

PubMed: 24612681 ( click the link to review the publication )

Nat Commun, 2014, 3.4791666667

PubMed: 25134989 ( click the link to review the publication )

J Natl Cancer Inst, 2014, 106(9)

PubMed: 25214559 ( click the link to review the publication )
Clin Cancer Res, 2014, 20(6):1576-89

PubMed: 24634471 ( click the link to review the publication )

Leukemia, 2014, 28(6):1289-98

PubMed: 24280868 ( click the link to review the publication )

Leukemia, 2014, 28(12):2376-87

PubMed: 24811343 ( click the link to review the publication )

Semin Cancer Biol, 2014, 24:43-8

PubMed: 23831274 ( click the link to review the publication )

Blood Cancer J, 2014, 4:e181

PubMed: 24531445 ( click the link to review the publication )

Mol Cancer, 2014, 13(1):265

PubMed: 25496233 ( click the link to review the publication )

Mol Cancer, 2014, 13(1):159

PubMed: 24972933 ( click the link to review the publication )

Cancer Lett, 2014, 352(1):4-14

PubMed: 23879961 ( click the link to review the publication )

PLoS Pathog, 2014, 10(12):e1004525

PubMed: 25474208 ( click the link to review the publication )

Cell Death Dis, 2014, 5:e1528

PubMed: 25412306 ( click the link to review the publication )

Br J Haematol, 2014, 166(6):849-61

PubMed: 24957109 ( click the link to review the publication )

Gastric Cancer, 2014, 10.1007/s10120-014-0444-1

PubMed: 25407459 ( click the link to review the publication )

Neoplasia, 2014, 16(2):147-57

PubMed: 24709422 ( click the link to review the publication )

Eur J Med Chem, 2014, 86C:664-675

PubMed: 25222877 ( click the link to review the publication )

J Immunol, 2014, 193(2):909-20

PubMed: 24929000 ( click the link to review the publication )

Cancer Cell Int, 2014, 14(1):32

PubMed: 24693884 ( click the link to review the publication )

J Pharm Biomed Anal, 2014, 61:70-7

PubMed: 22196804 ( click the link to review the publication )

PLoS One, 2014, 9(6):e98818

PubMed: 24901342 ( click the link to review the publication )

Leuk Lymphoma, 2014, 10.3109/10428194.2014.898760

PubMed: 24597981 ( click the link to review the publication )

J Bone Miner Metab, 2014, 10.1007/s00774-014-0612-8

PubMed: 25230818 ( click the link to review the publication )

Evodevo, 2014, 5(1):46

PubMed: 25598963 ( click the link to review the publication )

Drug Metab Lett, 2014, 8(1):19-30

PubMed: 24628405 ( click the link to review the publication )

Oncotarget, 2014, 5(20):9930-8

PubMed: 25294819 ( click the link to review the publication )

Assay Drug Dev Technol, 2014, 12(9-10):514-26

PubMed: 25506801 ( click the link to review the publication )
Trends Microbiol, 2013, 21(6):286-95

PubMed: 23608036 ( click the link to review the publication )

J Exp Med, 2013, 210(13):2887-902

PubMed: 24323359 ( click the link to review the publication )

Leukemia, 2013, 27(10):2096-100

PubMed: 23545990 ( click the link to review the publication )

Leukemia, 2013, 27(10):2094-6

PubMed: 23900138 ( click the link to review the publication )

J Med Chem, 2013, 56(3):1262-75

PubMed: 23320547 ( click the link to review the publication )

Cell Signal, 2013, 25(1):106-12

PubMed: 22975686 ( click the link to review the publication )

PLoS One, 2013, 8(8): e74103

PubMed: 23967355 ( click the link to review the publication )

PLoS One, 2013, 8(8):e69126

PubMed: 23936317 ( click the link to review the publication )

Leuk Res, 2013, 37(10):1271-7

PubMed: 23962569 ( click the link to review the publication )

Oncotarget, 2013, 4(12):2550-66

PubMed: 24334291 ( click the link to review the publication )

Blood, 2012, 120(19):3978-85

PubMed: 22927247 ( click the link to review the publication )

Methods Mol Biol, 2011, 685:91-109

PubMed: 20981520 ( click the link to review the publication )

Thyroid, 2010, 20(7):689-95

PubMed: 20578898 ( click the link to review the publication )

Purity & Quality Control

Choose Selective Target Protein Ligand Inhibitors

Biological Activity

Description

Targets

BTK ^[1] (Cell-free assay)	BLK ^[1] (Cell-free assay)	Bmx ^[1] (Cell-free assay)	CSK ^[1] (Cell-free assay)	FGR ^[1] (Cell-free assay)	View More
0.5 nM	0.5 nM	0.8 nM	2.3 nM	2.3 nM	View More

In vitro

Ibrutinib shows the potent and irreversible inhibitory effect and selectivity for Btk enzymatic activity. In BCR pathway-activated DOHH2 cell line, Ibrutinib inhibits autophosphorylation of Btk, phosphorylation of Btk's physiological substrate PLCγ, and phosphorylation of further downstream kinase, ERK with IC50 of 11 nM, 29 nM and 13 nM, respectively. ^[1] Ibrutinib exhibits a significant dose-dependent and time-dependent induction of cytotoxicity in chronic lymphocytic leukemia (CLL) cells. In addition, Ibrutinib induces cell death depending on caspase pathway activation and antagonizes the ability of CLL cells to proliferate after TLR signaling. ^[2] A recent study shows that Ibrutinib inhibits BCR-activated primary B cell proliferation with IC50 of 8 nM and results in inhibition of TNFα, IL-1β and IL-6 production in primary monocytes with IC50 of 2.6 nM, 0.5 nM and 3.9 nM, respectively. ^[3]

Cell Data

Cell Lines	Assay Type	Concentration	Incubation Time	Activity Description	PMID
human Rec1 cells	MomwSpVv[3Srb36gZZN{[Xl?	NGnTcHczNjVizszN	MlTXOkBp	NWfYbIdbUW6qaXLpeIlwdiCxZjDMfY4heGixc4Doc5J6dGG2aX;uJIlvKGi3bXHuJHJm[zFiY3XscJMh[XRiMj61JJVOKGmwY4XiZZRm\CCob4KgOkBpenNiYomgW4V{fGW{bjDicI91fGmwZzDt[ZRpd2R?	NHLxeGY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUKyNlg4Pyd-MkWyNlI5Pzd:L3G+
human WSU-NHL cells	NUPLTXg1S3m2b4TvfIlkyqCjc4PhfS=>		NY\VPXNsPzJiaB?=	Moe4R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gW3NWNU6KTDDj[YxteyCjc4Pld5Nm\CCjczDndo94fGhiaX7obYJqfGmxbjDh[pRmeiB5MjDodpMh[nliQ3XscHRqfGW{LVfsc{BtfW2rbnXzZ4VvfCClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zLkC5JO69VQ>?	NFT0dXg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEmxOVI6OSd-MkS5NVUzQTF:L3G+
human SU-DHL6 cells	MUnDfZRwfG:6aXRCpIF{e2G7		M2\E[FczKGh?	M4jUeWN6fG:2b4jpZ4l1gSCjZ3HpcpN1KGi3bXHuJHNWNUSKTE[gZ4VtdHNiYYPz[ZN{\WRiYYOg[5Jwf3SqIHnubIljcXSrb36gZYZ1\XJiN{KgbJJ{KGK7IFPlcIxVcXSncj3HcI8hdHWvaX7ld4NmdnRiY3XscEB3cWGkaXzpeJkh[XO\|YYmsJGlEPTB;MD61PEDPxE1w	NITMT5I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEmxOVI6OSd-MkS5NVUzQTF:L3G+
human DOHH2 cells	Mkf4R5l1d3SxeHnjxsBie3OjeR?=		MXu3NkBp	Ml3HR5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gSG9JUDJiY3XscJMh[XO\|ZYPz[YQh[XNiZ4Lve5RpKGmwaHnibZRqd25iYX\0[ZIhPzJiaILzJIJ6KEOnbHzUbZRmei2JbH:gcJVucW6nc3PlcpQh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OC52MTFOwG0v	MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDlzNUK5NUc,OjR7MUWyPVE9N2F-
Sf9 cells	MX7GeY5kfGmxbjDhd5NigQ>?		NXn0cXFXOSCq	NX30eGVuUW6qaXLpeIlwdiCxZjDMXW4uSSCneIDy[ZN{\WRiaX6gV4Y6KGOnbHzzJIFnfGW{IE[wJI1qdnNiYomgWHIuTlKHVDDBd5NigSxiSVO1NF0xNjJizszNMi=>	NFnlRWs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUm1PFU1Pyd-MkG5OVg2PDd:L3G+
human Ramos cells	Mn;pSpVv[3Srb36gZZN{[Xl?		M1HmclEhcA>?	M2TyWGlvcGmkaYTpc44hd2ZiQoTrJIlvKGi3bXHuJHJidW:\|IHPlcIx{KGG\|c3Xzd4VlKGG\|IHnubIljcXSrb36gc4YhWEyFLXfhcY1iOiCyaH;zdIhwenmuYYTpc44h[XRiVInyNVIyPyCjZoTldkAyKGi{IHL5JHdme3Sncn6gZoxwfCCjbnHsfZNqeyxiSVO1NF0yPCCwTT6=	MoHxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR7MUWyPVEoRjJ2OUG1NlkyRC:jPh?=
human Pfeiffer cells	MlP6SpVv[3Srb36gZZN{[Xl?		MVO3NkBp	MYLDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDQ[oVq\m[ncjDj[YxteyCjc4Pld5Nm\CCjczDndo94fGhiaX7obYJqfGmxbjDh[pRmeiB5MjDodpMh[nliQ3XscHRqfGW{LVfsc{BtfW2rbnXzZ4VvfCClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{IH7NMi=>	NEL4dlc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEmxOVI6OSd-MkS5NVUzQTF:L3G+
Sf9 cells	M3f0RmZ2dmO2aX;uJIF{e2G7		MmPSNUBp	MYPJcohq[mm2aX;uJI9nKGi3bXHuJIZ2dGxvbHXu[5RpKEKWSzDlfJBz\XO\|ZXSgbY4hW2Z7IHPlcIx{KHW\|aX7nJGZCVS2VcnP0bYRmKHCncITp[IUh[XNic4Xid5Rz[XSnIHHmeIVzKDZyIH3pcpMh[nliVGKtSnJGXCCDc4Phfg+9lCCLQ{WwQVAvPSCwTT6=	NVGwOlhbRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG5OVg2PDdpPkKxPVU5PTR5PD;hQi=>
Sf9 insect cells	M3jNfmZ2dmO2aX;uJIF{e2G7		MofVOlAhdWmwcx?=	MV7JR\|UxKD1iMD6wNFA{KM7:TR?=	NHfwcIY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUG0OlE{Pid-MkmxOFYyOzZ:L3G+
sf9 cells	MnfhSpVv[3Srb36gZZN{[Xl?			M4nBT2lEPTBiPTCwMlAxODNizszN	NUju[4RtRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke5PVQ4OzZpPkK3PVk1PzN4PD;hQi=>
Sf9 insect cells	MVnGeY5kfGmxbjDhd5NigQ>?		MUC2NEBucW6\|	NFfXV4FKSzVyIE2gNE4xODB\|NDFOwG0>	MnmwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd7MUKxO\|UoRjJ5OUGyNVc2RC:jPh?=
Sf9 insect cells	MkXUSpVv[3Srb36gZZN{[Xl?		NF;hco43OCCvaX7z	MmO3TWM2OCB;IECuNFAxOzRizszN	NVfYb49kRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki0N\|I6PDZpPkK4OFMzQTR4PD;hQi=>
Sf9 insect cells	MmSySpVv[3Srb36gZZN{[Xl?		Mn[4OlAhdWmwcx?=	MWXJR\|UxKD1iMD6wNFA{PCEQvF2=	MljzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd7NU[wN\|coRjJ5OUW2NFM4RC:jPh?=
Sf9 cells	MnfESpVv[3Srb36gZZN{[Xl?		MYq2NEBucW6\|	M3TXO2lEPTBiPTCwMlAxODRizszN	NWq1XpF{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CwNFYyPDNpPkOwNFA3OTR\|PD;hQi=>
Sf9 cells	M3uyXmZ2dmO2aX;uJIF{e2G7		NFLGbY43OCCvaX7z	M1rtNmlEPTBiPTCwMlAxODVizszN	NV7oTpdDRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG5OVg2PDdpPkKxPVU5PTR5PD;hQi=>
Ramos cells	NITZZ3hHfW6ldHnvckBie3OjeR?=		NHq1WXYyKGh?	M1jBWGlEPTBiPTCwMlAxODVizszN	NULiZYlHRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiyPFAzPjFpPkK4NlgxOjZzPD;hQi=>
Sf9 cells	NEHUV3BHfW6ldHnvckBie3OjeR?=		MlK3OlAhdWmwcx?=	M1fxNGlEPTBiPTCwMlAxOSEQvF2=	NYr1W5Q3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CwO\|c3ODhpPkOwNFc4PjB6PD;hQi=>
Pfeiffer cells	MnLjR5l1d3SxeHnjbZR6KGG\|c3H5		MWS3NkBp	NUCwV3BoT0l3MDC9JFAvODB{IN88US=>	M2jN[\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OUG1NlkyLz5{NEmxOVI6OTxxYU6=
B cells	NV\UcHV5TnWwY4Tpc44h[XO\|YYm=		NH:zfHgyKGh?	MWDJR\|UxKD1iMD6wNFQ3KM7:TR?=	MXu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODJ7MEm4PEc,OzB{OUC5PFg9N2F-
Sf9 insect cells	NHzh[2dHfW6ldHnvckBie3OjeR?=		NHXDNoEzKHSxIE[wJI1qdnN?	MXnLbUA:KDBwMEC0PEDPxE1?	Ml3CQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh\|MUW1PVcoRjJ6M{G1OVk4RC:jPh?=
Ramos cells	NE\6UldHfW6ldHnvckBie3OjeR?=		NYjqRYl[OSCq	NID2WIdKSzVyIE2gNE4xODd3IN88US=>	NXTBVI5zRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS5NVUzQTFpPkK0PVE2OjlzPD;hQi=>
Sf9 insect cells	NG\IflVHfW6ldHnvckBie3OjeR?=		MX[2NEBucW6\|	NV3nZ5o2UUN3MDC9JFAvODB6IN88US=>	M3Pmd\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6M{G1OVk4Lz5{OEOxOVU6PzxxYU6=
TMD8 cells	NHL0WoJCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?=		NHXoTYo4OiCq	MYPJR\|UxKD1iMD6wNUDPxE1?	M{ntWlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7N{G1NFI{Lz5{OUexOVAzOzxxYU6=
CD19+ B cells	MmfwSpVv[3Srb36gZZN{[Xl?		NH;yPHAyKGh?	MYfJR\|UxKD1iMD6wNVIh\|ryP	MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTR3N{m4Nkc,Ojl2NUe5PFI9N2F-
Sf9 insect cells	M1[zPWZ2dmO2aX;uJIF{e2G7		NIK0dZc3OCCvaX7z	MmqwTWM2OCB;IECuNFEzKM7:TR?=	MkG0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh\|MUW1PVcoRjJ6M{G1OVk4RC:jPh?=
Ramos cells	NFn6dFJHfW6ldHnvckBie3OjeR?=		MmTMNUBp	NV\pRZlsUUN3MDC9JFAvODF2IN88US=>	NW\2dGQ4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS5NVUzQTFpPkK0PVE2OjlzPD;hQi=>
Sf9 insect cells	MWTGeY5kfGmxbjDhd5NigQ>?		NVfVZ5dkOSCq	M4rJWmlEPTBiPTCwMlAyPDRizszN	M3XodVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7N{G1NFI{Lz5{OUexOVAzOzxxYU6=
Sf9 insect cells	M3fRcGZ2dmO2aX;uJIF{e2G7		MoiyOlAhdWmwcx?=	MoPRTWM2OCB;IECuNFE3OSEQvF2=	NX25WGh5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkmxOFYyOzZpPkK5NVQ3OTN4PD;hQi=>
HCC827 cells	Mmm5RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl?		MlSzO\|IhcA>?	M3vTOmlEPTBiPTCwMlA{QSEQvF2=	NULVOYlmRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki3N\|Q2QDFpPkK4O\|M1PThzPD;hQi=>
PC9 cells	NWXneJhmTnWwY4Tpc44h[XO\|YYm=		Mm\6O\|IhcA>?	MV7HTVUxKD1iMD6wOUDPxE1?	M1z3RVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MkiyNVIzLz5{OEK4NlEzOjxxYU6=
Sf9 cells	M3zkTmZ2dmO2aX;uJIF{e2G7		Mn3kOlAhdWmwcx?=	MnrHTWM2OCB;IECuNUDPxE1?	MYO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODByNkG0N{c,OzByME[xOFM9N2F-
H3255 cells	MoPiSpVv[3Srb36gZZN{[Xl?		M2HIVlczKGh?	M3v0O2dKPTBiPTCwMlEyKM7:TR?=	NVW1Z4pDRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiyPFIyOjJpPkK4NlgzOTJ{PD;hQi=>
BaF3 cells	MYDGeY5kfGmxbjDhd5NigQ>?		Mn7yO\|IhcA>?	MV;HTVUxKD1iMD6xNkDPxE1?	M17kdFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4NkOwOVU{Lz5{Nk[zNFU2OzxxYU6=
BAF3 cells	NVnkZm5bSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO\|YYm=		M4jr[lczKGh?	MVXHTVUxKD1iMD6xNkDPxE1?	NEjNOZU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEm1OlkzOyd-Mki5OVY6OjN:L3G+
Sf9 insect cells	NGnodXhHfW6ldHnvckBie3OjeR?=		MkTqOlAhdWmwcx?=	NV7WbZBQUUN3MDC9JFAvOTJ\|IN88US=>	Mk\0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh\|MUW1PVcoRjJ6M{G1OVk4RC:jPh?=
Sf9 insect cells	MVjGeY5kfGmxbjDhd5NigQ>?		M3vvfFYxKG2rboO=	MWTJR\|UxKD1iMD6xOFYh\|ryP	NWTmNJZjRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkizNVU2QTdpPkK4N\|E2PTl5PD;hQi=>
BAF3 cells	MmrnSpVv[3Srb36gZZN{[Xl?		MXS3NkBp	M{f5XmdKPTBiPTCwMlE3KM7:TR?=	M3O0RVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6MkiyNVIzLz5{OEK4NlEzOjxxYU6=
Sf9 cells	NVq0WGg{TnWwY4Tpc44h[XO\|YYm=		MXG2NEBucW6\|	M17vc2lEPTBiPTCwMlIh\|ryP	NG[wNpc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUm1PFU1Pyd-MkG5OVg2PDd:L3G+
MV411 cells	NETLfpZIem:5dHigbY5pcWKrdHnvckBie3OjeR?=			MmnwS2k2OCB;IECuNlUh\|ryP	NXvZRpppRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkizNVU2QTdpPkK4N\|E2PTl5PD;hQi=>
MV4-11 cells	NHTPR4pCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?=		MlPOO\|IhcA>?	NVGwVVNNT0l3MDC9JFAvOzNizszN	M3;YelxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4NkOwOVU{Lz5{Nk[zNFU2OzxxYU6=
MV4-11 cells	NYCwdmx1SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO\|YYm=		Mo\nO\|IhcA>?	NFH4WVJIUTVyIE2gNE4{OyEQvF2=	M13tT\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6OUW2PVI{Lz5{OEm1OlkzOzxxYU6=
DOHH2 cells	NH;VVHlEgXSxdH;4bYNqfHliYYPzZZk>		MYG3NkBp	MXvHTVUxKD1iMD60NUDPxE1?	MVm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDlzNUK5NUc,OjR7MUWyPVE9N2F-
HCC827 cells	NVnY[mtFSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO\|YYm=		NGTHVYE6PiCq	NHzRb2pGSzVyIE2gNE41PSEQvF2=	MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDh3M{W3OUc,Ojh6NUO1O\|U9N2F-
SU-DHL6 cells	MlHPR5l1d3SxeHnjbZR6KGG\|c3H5		MXS3NkBp	NWDWVHZlT0l3MDC9JFAvPThizszN	NITrd4I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEmxOVI6OSd-MkS5NVUzQTF:L3G+
M07e cells	NHv5bYhIem:5dHigbY5pcWKrdHnvckBie3OjeR?=			NGH5NJpIUTVyIE2gNE42QSEQvF2=	NVTZOINuRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkizNVU2QTdpPkK4N\|E2PTl5PD;hQi=>
NCI-H1975 cells	NH\pdJNCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?=		MkG5PVYhcA>?	MmnYSWM2OCB;IECuOlQh\|ryP	NUD3OlNyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki4OVM2PzVpPkK4PFU{PTd3PD;hQi=>
SU-DHL-2 cells	NIrJdnhIem:5dHigbY5pcWKrdHnvckBie3OjeR?=			MofXS2k2OCB;IECuOlQh\|ryP	NGHQVmU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEOxOVU6Pyd-MkizNVU2QTd:L3G+
HEK293T cells	NYHyfFk{TnWwY4Tpc44h[XO\|YYm=		NX3mT4dOOSCq	M37mVWlEPTBiPTCwMlkh\|ryP	NUjMR2g1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiyPFAzPjFpPkK4NlgxOjZzPD;hQi=>
Ramos cells	MmfERY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl?		M3LSe\|czKGh?	NYDrZpFYUUN3MDC9JFAvQTJizszN	NEPyVYo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUexOVAzOyd-Mkm3NVUxOjN:L3G+
BA/F3 cells	NFzxfmFCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?=		MX[3NkBp	NWT0dVFrUUN3MDC9JFEh\|ryP	NGTKbG89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkK1PFUzOSd-Mk[yOVg2OjF:L3G+
WSU-NHL cells	NIKxSHpEgXSxdH;4bYNqfHliYYPzZZk>		M1;1e\|czKGh?	MVjHTVUxKD1iMT6wPUDPxE1?	M{f0SFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2OUG1NlkyLz5{NEmxOVI6OTxxYU6=
NCI-H1975 cells	M13vUmZ2dmO2aX;uJIF{e2G7		NYTIVIVrPzJiaB?=	NFe2SpNIUTVyIE2gNU4zKM7:TR?=	Ml3CQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh{OEKxNlIoRjJ6MkiyNVIzRC:jPh?=
NCI-H1975 cells	M1OxWmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7		MXS3NkBp	MmPzTWM2OCB;IEGuNlch\|ryP	Mnm2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh5M{S1PFEoRjJ6N{O0OVgyRC:jPh?=
Raji cells	NITMeZhCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?=		MoHYOFghcA>?	NGnnNWRKSzVyIE2gNU41QSEQvF2=	MlLSQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl3NkeyPVUoRjJ7NU[3Nlk2RC:jPh?=
Pfeiffer cells	MlfJS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?			NX7Z[3cxT0l3MDC9JFEvPiEQvF2=	NX20RWV6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkizNVU2QTdpPkK4N\|E2PTl5PD;hQi=>
A431 cells	MVzBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>?		NHy3T5o6PiCq	MWjFR\|UxKD1iMj6zPEDPxE1?	NW\QeHlNRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki4OVM2PzVpPkK4PFU{PTd3PD;hQi=>
BAF3 cells	NXT2VnM3SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO\|YYm=		NIr1RVk4OiCq	M13XS2dKPTBiPTCyMlUh\|ryP	M3z5NFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6OUW2PVI{Lz5{OEm1OlkzOzxxYU6=
U937 cells	NYLZTIl7T3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=			NF7IbYNIUTVyIE2gNk46KM7:TR?=	M4DPfVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6M{G1OVk4Lz5{OEOxOVU6PzxxYU6=
NB4 cells	M4CxNWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7			MoOxS2k2OCB;IEOg{txO	NXnubGV2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkizNVU2QTdpPkK4N\|E2PTl5PD;hQi=>
Ramos cells	NUjqTHdbT3Kxd4ToJIlvcGmkaYTpc44h[XO\|YYm=			M4XJeWdKPTBiPTCzMlQh\|ryP	MojwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh\|MUW1PVcoRjJ6M{G1OVk4RC:jPh?=
SKM1 cells	NEP0bWFIem:5dHigbY5pcWKrdHnvckBie3OjeR?=			NVLFbIFJT0l3MDC9JFMvPiEQvF2=	NXfIXWY1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkizNVU2QTdpPkK4N\|E2PTl5PD;hQi=>
U2932 cells	M361fGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7			MlnXS2k2OCB;IESuOEDPxE1?	MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDNzNUW5O{c,Ojh\|MUW1PVc9N2F-
Ramos cells	MYrBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>?		MVO3NkBp	NFHEcmtKSzVyIE2gOU4yPCEQvF2=	MVW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODByNkG0N{c,OzByME[xOFM9N2F-
Ramos cells	MXPBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>?		MojCOFghcA>?	M4PQOWlEPTBiPTC1MlE1KM7:TR?=	MnHDQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd7NU[wN\|coRjJ5OUW2NFM4RC:jPh?=
Ramos cells	MonjRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl?		NGTDWm41QCCq	NF3ON\|JKSzVyIE2gOU45QCEQvF2=	MWK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDR\|Mkm0Okc,Ojh2M{K5OFY9N2F-
Ramos cells	NYnHSGp{SW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO\|YYm=		MVq3NkBp	M1\kWWlEPTBiPTC2MlYzKM7:TR?=	NInxTWo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUG0OlE{Pid-MkmxOFYyOzZ:L3G+
K562 cells	M{jNemFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7		MnnzOFghcA>?	MkPCTWM2OCB;IEeuOUDPxE1?	NUPiXY9oRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CwO\|c3ODhpPkOwNFc4PjB6PD;hQi=>
HL60 cells	M1\xTWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7		MmXkOFghcA>?	M2nX[WlEPTBiPTC4JO69VQ>?	NFrvemE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9\|MEC3O\|YxQCd-M{CwO\|c3ODh:L3G+
Ramos cells	MoL5RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl?		MXq0PEBp	MXrJR\|UxKD1iOD6xNUDPxE1?	NVvkPXc{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMke5PVQ4OzZpPkK3PVk1PzN4PD;hQi=>
Ramos cells	MUTBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>?		MVK0PEBp	M1e5O2lEPTBiPTC4MlI3KM7:TR?=	NUO3Rox1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm1OlczQTVpPkK5OVY4Ojl3PD;hQi=>
OCI-AML3 cells	Ml7pS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl?			M4T5OWdKPTBiPTC5MlIh\|ryP	NI\ZeIY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEOxOVU6Pyd-MkizNVU2QTd:L3G+
BAF3 cells	MnzoR5l1d3SxeHnjbZR6KGG\|c3H5		NXu1ToJZPzJiaB?=	M4D3XWdKPTBiPTCxNEDPxE1?	MV:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjZ\|MEW1N{c,OjZ4M{C1OVM9N2F-
BAF3 cells	M3nnW2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7		NYXQS5gzPzJiaB?=	MlewS2k2OCB;IEGwJO69VQ>?	MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDl3NkmyN{c,Ojh7NU[5NlM9N2F-
BAF3 cells	M1XGSWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7		NYruPZlbPzJiaB?=	MmjiS2k2OCB;IEGwJO69VQ>?	NEPYSHk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OEK4NlEzOid-MkiyPFIyOjJ:L3G+
NAMALWA cells	Mo\IRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl?		NEfaSWY4OiCq	MkHGTWM2OCB;IEGwMlQ2KM7:TR?=	NXrSXGFLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkmxOFYyOzZpPkK5NVQ3OTN4PD;hQi=>
Ramos cells	NHTaXHVCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?=		Mn\JOFghcA>?	MkLOTWM2OCB;IEGyMlYh\|ryP	Ml\YQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd7MUKxO\|UoRjJ5OUGyNVc2RC:jPh?=
Raji cells	NFqyUotCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?=		M3zTVlQ5KGh?	NGjqUmZKSzVyIE2gNVQvOiEQvF2=	MnvaQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzByN{e2NFgoRjNyMEe3OlA5RC:jPh?=
Raji cells	MYfBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>?		MV[0PEBp	M3;BZmlEPTBiPTCxOU4zKM7:TR?=	M2nBblxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ5OUm0O\|M3Lz5{N{m5OFc{PjxxYU6=
MIAPaCa2 cells	M1HNSmN6fG:2b4jpZ4l1gSCjc4PhfS=>		NXjQd4Y1OyCmYYnz	NYHLeJFiUUN3MDC9JFE3NjZizszN	NFXTNog9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{C3O\|IzQCd-MkewO\|czOjh:L3G+
HeLa cells	MYDDfZRwfG:6aXPpeJkh[XO\|YYm=		M3j6cVMh\GG7cx?=	NWW0TnBtUUN3MDC9JFE3NjhizszN	MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPzB5N{KyPEc,OjdyN{eyNlg9N2F-
Raji cells	M4HhbGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7		NYTjdIpFPDhiaB?=	NFrzPWFKSzVyIE2gNVkvOyEQvF2=	MkS0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjd7MUKxO\|UoRjJ5OUGyNVc2RC:jPh?=
Raji cells	M2fuOGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIF{e2G7		MmfEOFghcA>?	NULY[GdKUUN3MDC9JFE6NjNizszN	MknrQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjh2M{K5OFYoRjJ6NEOyPVQ3RC:jPh?=
Raji cells	NHL5OndCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?=		NEPHeWE4OiCq	M3rxbGlEPTBiPTCxPU42KM7:TR?=	NV36PGZJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CwNFYyPDNpPkOwNFA3OTR\|PD;hQi=>
Raji cells	MmHKRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{[Xl?		MkmzOFghcA>?	M3HvNGlEPTBiPTCxPU42KM7:TR?=	NH3KPWU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{m1OlA{Pyd-Mke5OVYxOzd:L3G+
NAMALWA cells	NILNSFJCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3OjeR?=		NVPxNVJqPzJiaB?=	MYPJR\|UxKD1iMUmuOkDPxE1?	M1vOeVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMEC2NVQ{Lz5\|MECwOlE1OzxxYU6=
A2780 cells	Mn;wR5l1d3SxeHnjbZR6KGG\|c3H5		NYTBWFVbOyCmYYnz	M4q1SWVEPTBiPTCyNE4yKM7:TR?=	NVraRVQ3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewO\|czOjhpPkK3NFc4OjJ6PD;hQi=>
Raji cells	NXLmbWZWSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO\|YYm=		M2X5O\|czKGh?	M3v6N2lEPTBiPTCyNE45QCEQvF2=	MVS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTF2NkGzOkc,OjlzNE[xN\|Y9N2F-
A549 cells	MY\BcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDhd5NigQ>?		MorBO\|IhcA>?	MnjJTWM2OCB;IEKxMlc6KM7:TR?=	M1j1Z\|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ6N{O0OVgyLz5{OEezOFU5OTxxYU6=
SW480 cells	NGrCPYhEgXSxdH;4bYNqfHliYYPzZZk>		NGe4T4s{KGSjeYO=	MoLsTWM2OCB;IEK1MlYh\|ryP	NWL6RYRvRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkewO\|czOjhpPkK3NFc4OjJ6PD;hQi=>
Ramos cells	MVvDfZRwfG:6aXPpeJkh[XO\|YYm=		MXSyOEBp	M{LNd2lEPTBiPTCyPE44KM7:TR?=	NWrQcZFNRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC\|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkiyO\|Q3PzVpPkK4Nlc1Pjd3PD;hQi=>

... Click to View More Cell Line Experimental Data

Assay

Methods	Test Index	PMID
Western blot	pEGFR(Tyr1068) / EGFR; PubMed: 28061447 Oncotarget Ibrutinib inhibitory effects on EGFRY1068 auto-phosphorylation in the HCC827 cell line at different time points by removal of drug after 4 h pretreatment. pBTK / pPLCγ2 / pAKT / pERK / pJNK; PubMed: 23940282 Blood Mino (left panel) or Jeko1 (right panel) cells pretreated with vehicle or ibrutinib 10, 100, or 1000 nM were either stimulated with anti-IgM, CXCL12, or CXCL13 or treated with medium (Med) for 15 minutes and then immunoblotted for pBTK, pPLCγ2, pAKT, pERK, and pJNK.	28061447 23940282
Immunofluorescence	CD11b; PubMed: 30231870 J Neuroinflammation BV2 microglial cells were pretreated with ibrutinib (1 μM) or vehicle (1% DMSO) for 30 min, followed by treatment with LPS (1 μg/ml) or PBS for 5.5 h and immunostaining with an anti-CD11b antibody. Scale bar = 20 μm. COX-2; PubMed: 30231870 J Neuroinflammation BV2 microglial cells were treated with vehicle (1% DMSO) or ibrutinib (1 μM) for 30 min, followed by PBS or LPS (1 μg/ml) for 5.5 h, and immunocytochemistry was conducted with anti-CD11b and anti-COX-2 antibodies.	30231870
ELISA	hTNFα; PubMed: 26627823 J Biol Chem PBMs were isolated and pretreated with 1, 5, or 10 μm ibrutinib (IB) or left untreated (UT, −). Pretreated PBMs were incubated for 24 h in 96-well plates precoated without (PBS) or with 10 μg/ml whole human IgG. Cleared supernatants were collected and analyzed by ELISA for TNFα (n = 3). IL-10; PubMed: 27792904 Virology LMP2A-negative (vector.1/.2) and -positive (express LMP2A) B cell lines were incubated in the absence or presence of increasing concentrations of Ibrutinib for 24 hours and supernatants were isolated for analysis using an IL-10 ELISA.	26627823 27792904

In vivo

In a collagen-induced arthritis model, Ibrutinib significantly reduces clinical arthritis scores reflecting paw swelling and joint inflammation by inhibiting B-cell activation. In a MRL-Fas(lpr) lupus model, Ibrutinib reduces renal disease and autoantibody production. ^[1] In an adoptive transfer TCL1 mouse model of CLL, Ibrutinib (25 mg/kg/day) causes a transient early lymphocytosis, and delays CLL disease progression. ^[4]

Protocol

Kinase Assay: ^[1]	- Collapse Kinase Assays : In vitro kinase IC50 values are measured using ³³P filtration binding assay after 1 hour incubation of kinase, ³³P-ATP, Ibrutinib, and substrate [0.2 mg/mL poly(EY)(4:1]. Assays are performed at Reaction Biology.
Cell Research: ^[2]	- Collapse Cell lines: Chronic lymphocytic leukemia (CLL) cells Concentrations: 0.01-100 μM Incubation Time: 48 hours Method: MTT (3'[4,5-dimethylthiazol-2-yl]-2,5-diphenyl-tetrazolium bromide) assays are performed to determine cytotoxicity. Briefly, cells (CLL B cells or healthy volunteer T cells or NK cells) are incubated for 48 hours with different concentrations of Ibrutinib, or vehicle control. MTT reagent is then added, and plates are incubated for an additional 20 hours before washing with protamine sulfate in phosphate-buffered saline. Dimethyl sulfoxide is added, and absorbance is measured by spectrophotometry at 540 nm in a Labsystems plate reader. Cell viability is also measured at various time points with the use of annexin/PI flow cytometry. Data are analyzed with Expo-ADC32 software package. Results are expressed as the percentage of total positive cells over untreated control. Experiments examining caspase-dependent apoptosis includes the addition of 100μM Z-VAD. (Only for Reference)
Animal Research: ^[1]	- Collapse Animal Models: MRL-Fas(lpr) lupus model and collagen-induced arthritis model. Dosages: ≤50 mg/kg Administration: Administered via p.o. (Only for Reference)

References

[4] Ponader S, et al. Blood. 2012, 119(5), 1182-1189.

- Collapse

Solubility (25°C)

In vitro	DMSO	88 mg/mL (199.77 mM)
	Ethanol	45 mg/mL (102.15 mM)
	Water	Insoluble
In vivo	Add solvents to the product individually and in order(Data is from Selleck tests instead of citations): 5% DMSO+30% PEG 300+5% Tween 80+ddH2O For best results, use promptly after mixing.	10mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information Download Ibrutinib (PCI-32765) SDF

Molecular Weight	440.5
Formula	C₂₅H₂₄N₆O₂
CAS No.	936563-96-1
Storage	3 years-20°C powder 2 years-80°C in solvent
Synonyms	N/A
Smiles	C=CC(=O)N1CCCC(C1)N2C3=NC=NC(=C3C(=N2)C4=CC=C(C=C4)OC5=CC=CC=C5)N

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage

mg/kg

Average weight of animals

Dosing volume per animal

Number of animals

Step 2: Enter the in vivo formulation (Different batches have different solubility ratios, please contact Selleck to provide you with the correct ratio)

% DMSO+ % + % Tween 80+ % ddH₂O

Calculate Reset

Calculation results:

Working concentration： mg/ml；

Method for preparing DMSO master liquid: ： mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL， Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation：Take μL DMSO master liquid, next addμL PEG300， mix and clarify, next addμL Tween 80，mix and clarify, next add μL ddH₂O，mix and clarify.

Note：1.Please make sure the liquid is clear before adding the next solvent.
2.Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

Bio Calculators

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration _(start) x Volume _(start) = Concentration _(final) x Volume _(final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

Serial Dilutions
Concertration (start):
Dilution-folds:

Computed Result

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2021-01-06)

NCT Number	Recruitment	interventions	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT04294641	Recruiting	Drug: Ibrutinib	Chronic GVHD	National Cancer Institute (NCI)\|National Institutes of Health Clinical Center (CC)	January 5 2021	Phase 2
NCT04665115	Not yet recruiting	Drug: Ibrutinib\|Other: Quality-of-Life Assessment	Asymptomatic COVID-19 Infection Laboratory-Confirmed\|B-Cell Neoplasm\|Chronic Lymphocytic Leukemia\|Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma\|Mantle Cell Lymphoma\|Marginal Zone Lymphoma\|Small Lymphocytic Lymphoma\|Symptomatic COVID-19 Infection Laboratory-Confirmed\|Waldenstrom Macroglobulinemia	Academic and Community Cancer Research United\|National Cancer Institute (NCI)	December 31 2020	Phase 2
NCT04514393	Not yet recruiting	Drug: Methotrexate\|Drug: Ibrutinib\|Drug: Temozolomide	Primary Central Nervous System Lymphoma\|PCNSL\|Non Hodgkin Lymphoma	Huiqiang Huang\|Guangdong 999 Brain Hospital\|Nanfang Hospital of Southern Medical University\|Xian-Janssen Pharmaceutical Ltd.\|Sun Yat-sen University	December 1 2020	Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

Frequently Asked Questions

Question 1:
How to reconstitute the compound S2680 for in vivo studies?
Answer:
For in vivo study, we suggest to use 5% DMSO+30% PEG 300+5% Tween 80+ddH2O up to 10mg/ml.

Choose Your Country or Region

By Signaling Pathways

By product type

Ibrutinib (PCI-32765)