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Thalidomide-O-COOH (Cereblon ligand 3)

Synonyms: E3 ligase Ligand 3

Thalidomide-O-COOH (Cereblon ligand 3, E3 ligase Ligand 3), a Thalidomide-based Cereblon (CRBN) ligand, is used in the recruitment of CRBN protein. Thalidomide-O-COOH (Cereblon ligand 3) can be connected to the ligand for protein by a linker to form PROTACs (Proteolysis Targeting Chimera).

Thalidomide-O-COOH (Cereblon ligand 3) Chemical Structure

Thalidomide-O-COOH (Cereblon ligand 3) Chemical Structure

CAS: 1061605-21-7

Purity & Quality Control

Batch: S679401 DMSO] 66 mg/mL] false] Water] Insoluble] false] Ethanol] Insoluble] false Purity: 99.87%
99.87

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Biological Activity

Description Thalidomide-O-COOH (Cereblon ligand 3, E3 ligase Ligand 3), a Thalidomide-based Cereblon (CRBN) ligand, is used in the recruitment of CRBN protein. Thalidomide-O-COOH (Cereblon ligand 3) can be connected to the ligand for protein by a linker to form PROTACs (Proteolysis Targeting Chimera).
Targets
CRBN [1]

Chemical Information & Solubility

Molecular Weight 332.27 Formula

C15H12N2O7
CAS No. 1061605-21-7 SDF --
Smiles C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)OCC(=O)O
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 66 mg/mL ( (198.63 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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