GSK 5959
Catalog No.S5916

Molecular Weight(MW): 394.47
GSK5959 is a potent and selective BRPF1 bromodomain inhibitor with an IC50 of 80 nM and exhibits >100-fold selectivity for BRPF1 over a panel of 35 other bromodomains, including BRPF2/3 and BET family bromodomains.
Purity & Quality Control
Choose Selective Epigenetic Reader Domain Inhibitors
Biological Activity
Description | GSK5959 is a potent and selective BRPF1 bromodomain inhibitor with an IC50 of 80 nM and exhibits >100-fold selectivity for BRPF1 over a panel of 35 other bromodomains, including BRPF2/3 and BET family bromodomains. | ||||||
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Targets |
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In vitro |
In the BROMOscan panel of 34 bromodomain binding assays, GSK5959 shows 10 nM BRPF1 inhibition, 90-fold selectivity over BRPF2, and over 500-fold selectivity over all members of the BET family[1]. |
Protocol
Solubility (25°C)
In vitro | DMSO | 6 mg/mL (15.21 mM) |
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Ethanol | 3 mg/mL (7.6 mM) | |
Water | Insoluble |
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Information
Molecular Weight | 394.47 |
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Formula | C22H26N4O3 |
CAS No. | 901245-65-6 |
Storage | powder |
in solvent | |
Synonyms | N/A |
Bio Calculators
Molarity Calculator
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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).
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Molarity Calculator
Tech Support
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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