UNC669

Catalog No.S7373

For research use only.

UNC669 is a potent and selective MBT (malignant brain tumor) inhibitor with IC50 of 6 μM for L3MBTL1, 5- and 11-fold selective over L3MBTL3 and L3MBTL4.

UNC669 Chemical Structure

CAS No. 1314241-44-5

Selleck's UNC669 has been cited by 3 Publications

Purity & Quality Control

Choose Selective Epigenetic Reader Domain Inhibitors

Biological Activity

Description UNC669 is a potent and selective MBT (malignant brain tumor) inhibitor with IC50 of 6 μM for L3MBTL1, 5- and 11-fold selective over L3MBTL3 and L3MBTL4.
Features MBT-selective chemical probe.
Targets
L3MBTL1 [1] L3MBTL3 [1] L3MBTL4 [1]
6 μM 35 μM 69 μM
In vitro

UNC669, as a low μM binder of L3MBTL1, provides new directions for optimization of MBT inhibitors to improve potency and selectivity. [1]

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 338.24
Formula

C15H20BrN3O

CAS No. 1314241-44-5
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1CCN(C1)C2CCN(CC2)C(=O)C3=CC(=CN=C3)Br

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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