PACAP 1-27

For research use only.

Catalog No.S8414

PACAP 1-27 Chemical Structure

CAS No. 127317-03-7

Pituitary adenylate cyclase activating polypeptide (PACAP 1-27) is a potent PACAP receptor antagonist.

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Biological Activity

Description Pituitary adenylate cyclase activating polypeptide (PACAP 1-27) is a potent PACAP receptor antagonist.
PACAP receptor [1]
In vitro

PACAP27(100 nM) inhibits all Tat-mediated toxic effects including DNA DSBs, and it prevents the induction of neuronal loss induced by Tat(transactivator of transcription). PACAP27, through CCL5, mitigates the effects of Tat-induced neuronal dysfunction exerting its neuroprotective effect[4]. PACAP-27 (EC50=10nM) stimulates glibenclamide-sensitive and DIDS-insensitive iodide efflux in Calu-3 cells[5].

In vivo PACAP-27 is potent VIP-like vasodilators of the femoral arterial bed in dogs. In the cardiovascular system, PACAP27 has vasodepressor actions similar to VIP in anesthetized rats. Intra-arterial infusion of PACAP27 induces dose-related increases in peak femoral arterial flow[3].


Cell Research:[2]
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  • Cell lines: The pulmonary carcinoma cell line CALU-6
  • Concentrations: 10 pmol/L to 1 μmol/L
  • Incubation Time: 20 h
  • Method: Cells are incubated with PACAP (1-27) (10 pmol/L to 1 μmol/L) or forskolin (5 μmol/L) for 20 h. Thereafter, cells are harvested, and isolation of total RNA, reverse transcriptase-PCR, and subsequent determination of renin mRNA and β-actin mRNA expression using real-time PCR.
    (Only for Reference)
Animal Research:[3]
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  • Animal Models: beagle dogs
  • Dosages: 0.25, 0.5, 1, 2.5, 5, 10, and 25 pmol/kg
  • Administration: Intra-arterial infusion
    (Only for Reference)

Solubility (25°C)

In vitro Water 100 mg/mL (31.77 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 3147.61


CAS No. 127317-03-7
Storage powder
in solvent
Synonyms N/A
Smiles CCC(C)C(C(=O)NC(CC1=CC=CC=C1)C(=O)NC(C(C)O)C(=O)NC(CC(=O)O)C(=O)NC(CO)C(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC(CO)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC3=CC=C(C=C3)O)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCCN)C(=O)NC(CCC(=O)N)C(=O)NC(CCSC)C(=O)NC(C)C(=O)NC(C(C)C)C(=O)NC(CCCCN)C(=O)N䲧瘆Ỵ瘇㧀瘅膉疴睥⪈-ី'-Ā㺣疲帉疲Ѐ瑖猗﫜돸ቬ-Ā鄸ቬ彿猘奋猘巫猘쟜ቬ쫀ቬ彿猘쪴ቬ塚猘쫀ቬꍈ猝돸ቬ學猘漸猝圔猘돸ቬ圞猘圭猘﫜玚Wី' ី'戤睕$ଐ঵䐺疲暼睥ଐ঵

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cAMP Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID