Molecular Weight(MW): 3147.61
Pituitary adenylate cyclase activating polypeptide (PACAP 1-27) is a potent PACAP receptor antagonist.
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|Description||Pituitary adenylate cyclase activating polypeptide (PACAP 1-27) is a potent PACAP receptor antagonist.|
PACAP27(100 nM) inhibits all Tat-mediated toxic effects including DNA DSBs, and it prevents the induction of neuronal loss induced by Tat(transactivator of transcription). PACAP27, through CCL5, mitigates the effects of Tat-induced neuronal dysfunction exerting its neuroprotective effect. PACAP-27 (EC50=10nM) stimulates glibenclamide-sensitive and DIDS-insensitive iodide efflux in Calu-3 cells.
|In vivo||PACAP-27 is potent VIP-like vasodilators of the femoral arterial bed in dogs. In the cardiovascular system, PACAP27 has vasodepressor actions similar to VIP in anesthetized rats. Intra-arterial infusion of PACAP27 induces dose-related increases in peak femoral arterial flow.|
|In vitro||Water||100 mg/mL (31.77 mM)|
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