Liproxstatin-1
Catalog No.S7699
Molecular Weight(MW): 340.85
Liproxstatin-1 is a potent ferroptosis inhibitor with an IC50 of 22 nM.
7 Customer Reviews
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(a-d) Liproxstatin-1 treatment, given immediately after reperfusion, attenuated motor function decline measured by rotarod (a), progressive neurological deficits (b), n =8, final infarct volumes (c, right) and cognitive function decline (d). Representative TTC-stained serial brain sections 24 h after MCAO/reperfusion are shown in (c, left), scale bar=1 cm.
Mol Psychiatry, 2017, 22(11):1520-1530. Liproxstatin-1 purchased from Selleck.
(D) Indicated NRF2 knockdown HCC cells were treated with erastin (10 μM) and sorafenib (5 μM) with or without indicated inhibitors (ferrostatin-1, 1 μM; liproxstatin-1, 100 nM; ZVAD-FMK, 10 μM; necrostatin-1, 10 μM; necrosulfonamide, 0.5 μM) for 24 hours, and cell viability was assayed (n 5 3, *P < 0.05). Abbreviation: GAPDH, glyceraldehyde 3-phosphate dehydrogenase.
Liproxstatin-1 purchased from Selleck.
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Nude mice were injected subcutaneously with PANC1 cells (2 × 106 cells/mouse) and treated with GEM (20 mg/kg/i.p., once every other day), SAS (100 mg/kg/i.p., once every other day), GEM+SAS, or GEM+SAS+liproxstatin-1 (10 mg/kg/i.p., once every other day) at day seven for two weeks (n=5 mice/group). Protein levels of HSPA5 and GPX4 (F) in isolated tumor at day 28 were assayed (* p < 0.05).
Cancer Res, 2017, 77(8):2064-2077. Liproxstatin-1 purchased from Selleck.
Western blots showing attenuated neurodegeneration (NeuN, Synaptophysin, SNAP25) and neuroinflammation (GFAP) in HC of Gpx4BIKO-VED mice treated with the ferroptosis inhibitor liproxstatin-1 compared to Gpx4BIKO-VED mice treated with vehicle (DMSO) at 1 week post TAM treatment (n=5 for all groups). * p<0.05 versus Con-VED; #p<0.05 versus Gpx4BIKO-VED treated with DMSO.
Redox Biol, 2017, 12:8-17. Liproxstatin-1 purchased from Selleck.
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Liproxstatin-1 improves cardiomyocytes functional properties after etoposide treatment. The hiPSC-CMs were co-treated with ETP and 200 nM Liproxstatin-1 (ferroptosis inhibitor) for 48 h. Real-time data of hPSC-CMs cell index, beating rate, and beating amplitude were obtained using xCELLigence RTCA system. Representative graphs display % beating rate values, showing even though Liproxstatin-1 had no significant effect in preventing ETP-induced cytotoxicity; it significantly improved hPSC-CMs ability to recover from ETP-induced alterations in beating rate and beating amplitude (n = 3, error bars represent ± SEM) (t test, *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001)
Arch Toxicol, 2018, 92(4):1507-1524. Liproxstatin-1 purchased from Selleck.
RSL3 promotes ferroptosis-associated LIP increase and ROS accumulation. (A) The cellular LIP was analyzed with a flow cytometer. (B) Representative results of using an oxidation-sensitive fluorescent probe, DCFH-DA. (C) Values are mean ± SD of three independent experiments; ∗∗p < 0.01.
Front Pharmacol, 2018, 9:1371. Liproxstatin-1 purchased from Selleck.
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(C) Baicalein is a strong inhibitor of ferroptosis, but not apoptosis. PANC1 cells were treated with the ferroptosis inducer (erastin, 20 μM) or the apoptosis inducer staurosporine (0.5 μM) in the absence or presence of baicalein and indicated inhibitors for 24 h. Cell viability was assayed using the CCK-8 kit.
Biochem Biophys Res Commun, 2016, 473(4):775-80.. Liproxstatin-1 purchased from Selleck.
Purity & Quality Control
Choose Selective Ferroptosis Inhibitors
Biological Activity
| Description | Liproxstatin-1 is a potent ferroptosis inhibitor with an IC50 of 22 nM. | ||
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| Targets |
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| In vitro |
Liproxstatin-1 is able to inhibit ferroptosis in the low nanomolar range and inhibit the growth of Gpx4−/−cells with IC50 of 22 nM. Liproxstatin-1 (50 nM) completely prevents lipid peroxidation in Gpx4−/−cells. Liproxstatin-1 (200 nM) protects against FINs, such as BSO (10 µM), erastin (1 µM) and RSL3 (0.5 µM), in a dose dependent manner, whereas it fails to rescue cell death induced by staurosporine (0.2 µM) and H2O2 (200 µM).[1] |
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| In vivo | Liproxstatin-1 remarkably extends survival compared with the vehicle-treated group, delays ferroptosis in tubular cells, and mitigates tissue injury in ischaemia/reperfusion-induced liver injury. [1] |
Protocol
| Cell Research: |
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| Animal Research: |
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Solubility (25°C)
| In vitro | DMSO | 68 mg/mL (199.5 mM) |
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| Ethanol | 21 mg/mL warmed (61.61 mM) | |
| Water | Insoluble | |
| In vivo | Add solvents to the product individually and in order(Data is from Selleck tests instead of citations): 2% DMSO+40% PEG 300+2% Tween 80+ddH2O For best results, use promptly after mixing. |
3mg/mL |
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Information
| Molecular Weight | 340.85 |
|---|---|
| Formula | C19H21ClN4 |
| CAS No. | 950455-15-9 |
| Storage | powder |
| in solvent | |
| Synonyms | N/A |
Bio Calculators
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Tech Support
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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