For research use only.

Catalog No.S7699

67 publications

Liproxstatin-1 Chemical Structure

CAS No. 950455-15-9

Liproxstatin-1 is a potent ferroptosis inhibitor with an IC50 of 22 nM.

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10mM (1mL in DMSO) EUR 144 In stock
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Selleck's Liproxstatin-1 has been cited by 67 publications

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Choose Selective Ferroptosis Inhibitors

Biological Activity

Description Liproxstatin-1 is a potent ferroptosis inhibitor with an IC50 of 22 nM.
ferroptosis [1]
(Cell-free assay)
22 nM
In vitro

Liproxstatin-1 is able to inhibit ferroptosis in the low nanomolar range and inhibit the growth of Gpx4−/−cells with IC50 of 22 nM. Liproxstatin-1 (50 nM) completely prevents lipid peroxidation in Gpx4−/−cells. Liproxstatin-1 (200 nM) protects against FINs, such as BSO (10 µM), erastin (1 µM) and RSL3 (0.5 µM), in a dose dependent manner, whereas it fails to rescue cell death induced by staurosporine (0.2 µM) and H2O2 (200 µM).[1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MRC-5 lung fibroblast cells NIXSdWlFVkSLOjDDfZRwfG:6aXPpeJkh[WejaX7zeEBpfW2jbjDNVmMuPSCudX7nJIZq[nKxYnzhd5Qh[2WubIOsJGlEPTBiPTC5MlE1KM7:TR?= MXq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:5d4eu[YJqNmGlLoXrM4Np\W2kbD;jc41xd3WwZG;y[ZBwenShY3Hy[E9EUEWPQlyyNFk1PzVyLze+R4hGVUKOPD;hQi=>

... Click to View More Cell Line Experimental Data

In vivo Liproxstatin-1 remarkably extends survival compared with the vehicle-treated group, delays ferroptosis in tubular cells, and mitigates tissue injury in ischaemia/reperfusion-induced liver injury. [1]


Cell Research:


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  • Cell lines: Gpx4−/−cells
  • Concentrations: ~200 nM
  • Incubation Time: ~72 h
  • Method:

    Cell viability is assessed at different time points after treatment using AquaBluer according to the manufacturer’s recommendations. Alternatively, cell death is also quantified by measuring released lactate dehydrogenase activity using the cytotoxicity detection kit (LDH).

    (Only for Reference)
Animal Research:


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  • Animal Models: GreERT2; Gpx4fI/fI mice
  • Dosages: 10 mg/kg
  • Administration: i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 68 mg/mL (199.5 mM)
Ethanol 21 mg/mL warmed (61.61 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+40% PEG 300+2% Tween 80+ddH2O
For best results, use promptly after mixing.

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 340.85


CAS No. 950455-15-9
Storage powder
in solvent
Synonyms N/A
Smiles C1CNCCC12C(=NCC3=CC(=CC=C3)Cl)NC4=CC=CC=C4N2

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Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
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% DMSO % % Tween 80 % ddH2O

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID