Catalog No.S8792

For research use only.

UAMC-3203 is an improved ferroptosis inhibitor with an IC50 value of 10 nM in IMR-32 neuroblastoma cells.

UAMC-3203 Chemical Structure

CAS No. 2271358-64-4

Selleck's UAMC-3203 has been cited by 2 Publications

Purity & Quality Control

Choose Selective Ferroptosis Inhibitors

Biological Activity

Description UAMC-3203 is an improved ferroptosis inhibitor with an IC50 value of 10 nM in IMR-32 neuroblastoma cells.
Ferroptosis [1]
(IMR-32 neuroblastoma cells)
10 nM
In vitro

UAMC-3203 has an impressive t1/2 when incubated with both human and rat microsomes (t1/2 = 20.5 h and t1/2 = 16.5 h respectively) but is found to be relatively less stable when incubated with murine microsomes (t1/2 = 3.46 h)[1].

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
IMR32 M1[yNWZ2dmO2aX;uJIF{e2G7 MYGxJIhz NYm2O2JqUW6qaXLpeIlwdiCxZjDldoF{fGmwLXnu[JVk\WRiZnXydo9xfG:|aYOgbY4hcHWvYX6gTW1TOzJiY3XscJMheHKnaX7jeYJifGWmIH\vdkAyKGi{IH\vcIxwf2WmIHL5JIVz[XO2aX6gd5RqdXWuYYTpc44h[W6mIH3lZZN2emWmIHHmeIVzKDF|IHjyd{BjgSC|eYTvfEBoemWnbj3iZZNm\CCobIXvdoV{[2WwY3WgZZN{[XluIFnDOVAhRSByLkCxJO69VS5? NVLoWFBMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CzOVQyODFpPkOwN|U1OTBzPD;hQi=>
IMR32 M2jYWWZ2dmO2aX;uJIF{e2G7 NGjyXGUyKGi{ NIH3[VFKdmirYnn0bY9vKG:oIH\ldpJwfXNiYX3tc45qfW1ic4XsdIhifGVvaX7keYNm\CCoZYLyc5B1d3OrczDpckBpfW2jbjDJUXI{OiClZXzsd{BxemWrbnP1ZoF1\WRiZn;yJFEhcHJiZn;scI94\WRiYomg[ZJie3SrbjDzeIlufWyjdHnvckBidmRibXXhd5Vz\WRiYX\0[ZIhOTNiaILzJIJ6KHO7dH;4JIdz\WWwLXLhd4VlKG[udX;y[ZNk\W6lZTDhd5NigcLi MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODN3NEGwNUc,OzB|NUSxNFE9N2F-
In vivo

UAMC-3203 significantly lowers the plasma levels of lactate dehydrogenase (LDH) in mice. It is rapidly removed from the bloodstream and redistributed into various tissues, as can be expected for lipophilic basic compounds. Significant concentrations of UAMC-3203 are found in all analyzed tissues (liver, kidney, and lungs)[1].

Protocol (from reference)

Animal Research:


  • Animal Models: wild-type mice derived from a Gpx4 fl/fl breeding
  • Dosages: 20 μmol/kg
  • Administration: IV

Solubility (25°C)

In vitro

DMSO 94 mg/mL
(199.29 mM)
Ethanol 94 mg/mL
(199.29 mM)
Water Insoluble

Chemical Information

Molecular Weight 471.66


CAS No. 2271358-64-4
Storage 3 years -20°C powder
2 years -80°C in solvent

In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Molarity Calculator

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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