Catalog No.S1007 Synonyms: ASP1517
Molecular Weight(MW): 352.34
Roxadustat (FG-4592) is an HIF-α prolyl hydroxylase inhibitor in a cell-free assay, stabilizes HIF-2 and induces EPO production. Phase 3.
Cited by 23 Publications
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|Description||Roxadustat (FG-4592) is an HIF-α prolyl hydroxylase inhibitor in a cell-free assay, stabilizes HIF-2 and induces EPO production. Phase 3.|
FG-4592 is an oral inhibitor of hypoxia inducible factor (HIF) prolyl hydroxylase currently in clinical development for the treatment of anemia. FG-4592 stabilizes the activities of HIF, a cytosolic transcription factor, leading to activation of the genes associated with erythropoiesis, including erythropoietin and enzymes involved in iron metabolism. 
|In vitro||DMSO||70 mg/mL (198.67 mM)|
|In vivo||Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
5% DMSO+50% PEG 300+ddH2O
For best results, use promptly after mixing.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
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Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT03303066||Recruiting||Drug: FG-4592|Drug: Placebo||Primary MDS Classified as Very Low Low or Intermediate Risk With <5% Blasts||FibroGen|AstraZeneca||June 6 2018||Phase 2|Phase 3|
|NCT03263091||Recruiting||Drug: FG-4592|Drug: Placebo||Primary MDS (Very Low Low or Intermediate IPSS-R With <5% Blasts)||FibroGen|AstraZeneca||September 7 2017||Phase 3|
|NCT02988973||Active not recruiting||Drug: roxadustat|Drug: DA||Chronic Kidney Disease||Astellas Pharma Inc|FibroGen||January 12 2017||Phase 3|
|NCT02964936||Completed||Drug: roxadustat||Chronic Kidney Disease||Astellas Pharma Inc|FibroGen||January 11 2017||Phase 3|
|NCT02952040||Completed||Drug: ASP1517|Drug: Lanthanum carbonate hydrate||Healthy Subjects||Astellas Pharma Inc|FibroGen||November 2016||Phase 1|
|NCT02952092||Completed||Drug: roxadustat|Drug: Darbepoetin alfa||Hemodialysis Chronic Kidney Disease Patients With Anemia||Astellas Pharma Inc|FibroGen||November 30 2016||Phase 3|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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Frequently Asked Questions
Can you tell me what the half-life of the product is, please?
The half-life of S1007 Roxadustat is around 12 hours. Please the reference below: https://www.ncbi.nlm.nih.gov/pubmed/26846333