Name: Vadadustat
Brand: Selleck Chemicals
SKU: S6490
Availability: InStock
Rating: 5 (2 reviews)

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Quality Control

Batch: S649001 DMSO]61 mg/mL]false]Ethanol]9 mg/mL]false]Water]Insoluble]false Purity: 99.56%

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COA
NMR
SDS/MSDS
Datasheet

99.56

Related Targets	EGFR VEGFR JAK FGFR PDGFR Src FLT3 HER2 FLT Bcr-Abl
Other HIF Inhibitors	PT2399 PX-478 Dihydrochloride BAY 87-2243 KC7F2 Molidustat (BAY 85-3934) IOX2 CAY10585 (LW 6) PT2385 IDF-11774 Daprodustat (GSK1278863)

Solubility

In vitro
Batch:

DMSO : 61 mg/mL (198.89 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 9 mg/mL

Water : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	3mg/ml (9.78mM)	Taking the 1 mL working solution as an example, add 50 μL of 60 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Clear solution	5% DMSO 1 95% Corn oil Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	3mg/ml (9.78mM)	Taking the 1 mL working solution as an example, add 50 μL of 60 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

%

% Tween 80

% ddH₂O

% DMSO

+

%

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	306.70	Formula	C₁₄H₁₁ClN₂O₄	Storage (From the date of receipt)	3 years -20°C powder
CAS No.	1000025-07-9	--		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	AKB-6548, B-506, PG-1016548			SMILES	C1=CC(=CC(=C1)Cl)C2=CC(=C(N=C2)C(=O)NCC(=O)O)O

Read more about storage stability stock solution CAS number SMILES

Mechanism of Action

Targets/IC₅₀/Ki	PH2 0.029 μM FIH(factor inhibiting HIF) 29 μM
In vitro	Vadadustat works by active site iron chelating mechanisms in terms of inhibiting isolated PHD2.
References	[1] https://pubmed.ncbi.nlm.nih.gov/29435217/

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2026-08-10)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT07086755	RECRUITING	Nonintubated Acute Respiratory Distress Syndrome (ARDS); Pathogen-associated Lung Injury	Paul Potnuru	2025-10-23	PHASE2; PHASE3
NCT07565701	NOT_YET_RECRUITING	Anemia Associated With Chronic Kidney Disease	Geoff Block	2026-04	PHASE3
NCT07537816	NOT_YET_RECRUITING	Renal Anemia	Mackay Memorial Hospital	2026-04-15	PHASE4
NCT06901505	COMPLETED	Anemia of Chronic Kidney Disease	Akebia Therapeutics	2025-07-24	PHASE3
NCT05082571	WITHDRAWN	Anemia of Chronic Kidney Disease	Akebia Therapeutics	2025-01	PHASE3
NCT05082584	WITHDRAWN	Anemia of Chronic Kidney Disease	Akebia Therapeutics	2025-01	PHASE3

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Handling Instructions

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Vadadustat HIF modulator

Chemical Structure

Molecular Weight: 306.70