• HIF1
  • HIF2
  • PHD1
  • PHD2
  • PHD3

HIF2 Selective Inhibitors | Antagonists

Catalog No. Product Name Information Selective / Pan IC50 / Ki
S8886 Belzutifan (PT2977) Belzutifan (PT2977), an orally active and selective HIF-2α inhibitor, increases potency and improves pharmacokinetic profile, providing a potential treatment for clear cell renal cell carcinoma (ccRCC). Selective HIF-2α, IC50: 9 nM
S8352 PT2385 PT2385 is a HIF-2α antagonist with luciferase EC50 of 27 nM and no significant off-target activity. Selective HIF-2α, EC50: 27 nM
S8351 PT2399 PT2399 is a potent and orally available antagonist of HIF-2 that selectively disrupts the heterodimerization of HIF-2α with HIF-1β. Pan
S1233 2-Methoxyestradiol (2-MeOE2) 2-Methoxyestradiol (2-MeOE2, NSC 659853, 2-ME2) depolymerizes microtubules and blocks HIF-1α nuclear accumulation and HIF-transcriptional activity. 2-Methoxyestradiol induces both autophagy and apoptosis in various carcinogenic cell lines. Pan
S6684 IOX4 IOX4 is a potent and selective HIF prolyl-hydroxylase 2 (PHD2) inhibitor with IC50 of 1.6 nM. IOX4 induces HIFα in various mouse tissues and human cell lines. Pan