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Formula | C19H16N2O5 |
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Molecular Weight | 352.34 | CAS No. | 808118-40-3 | ||||
Solubility (25°C)* | In vitro | DMSO | 70 mg/mL (198.67 mM) | ||||
Ethanol | 4 mg/mL (11.35 mM) | ||||||
Water | Insoluble | ||||||
In vivo (Add solvents to the product individually and in order) |
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
Description | Roxadustat (FG-4592) is an HIF-α prolyl hydroxylase inhibitor in a cell-free assay, stabilizes HIF-2 and induces EPO production. Roxadustat potentiates RSL3 induced ferroptosis. Phase 3. |
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In vitro | FG-4592 is an oral inhibitor of hypoxia inducible factor (HIF) prolyl hydroxylase currently in clinical development for the treatment of anemia. FG-4592 stabilizes the activities of HIF, a cytosolic transcription factor, leading to activation of the genes associated with erythropoiesis, including erythropoietin and enzymes involved in iron metabolism. [1] |
In vivo | Roxadustat (50 mg/kg; i.p.; daily for 7 days) protects the survival of motor neurons and improves recovery from spinal cord injury.[2] |
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Animal Study: |
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Data from [Data independently produced by , , Chem Sci, 2017, doi: 10.1039/C7SC02103H]
Data from [Data independently produced by , , Cell Physiol Biochem, 2018, 46(6):2460-2470]
Data from [Data independently produced by , , Clin Sci, 2018, 132(7):825-838]
Data from [Data independently produced by , , J Pharmacol Exp Ther, 2018, 364(1):87-96]
Single-embryo transcriptomic atlas of oxygen response reveals the critical role of HIF-1α in prompting embryonic zygotic genome activation [ Redox Biol, 2024, 72:103147] | PubMed: 38593632 |
Factor inhibiting HIF negatively regulates antiviral innate immunity via hydroxylation of IKKϵ [ Cell Rep, 2024, 43(1):113606.] | PubMed: 38127621 |
Inhibition of OGFOD1 by FG4592 confers neuroprotection by activating unfolded protein response and autophagy after ischemic stroke [ J Transl Med, 2024, 22(1):248] | PubMed: 38454480 |
The N6-methyladenosine demethylase ALKBH5 regulates the hypoxic HBV transcriptome [ PLoS Pathog, 2024, 20(1):e1011917] | PubMed: 38227578 |
Mitophagy mediated by HIF-1α/FUNDC1 signaling in tubular cells protects against renal ischemia/reperfusion injury [ Ren Fail, 2024, 46(1):2332492] | PubMed: 38584135 |
Hypoxia-inducible factor upregulation by roxadustat attenuates drug reward by altering brain iron homoeostasis [ Signal Transduct Target Ther, 2023, 10.1038/s41392-023-01578-2] | PubMed: 37718358 |
Hypoxia-inducible factor upregulation by roxadustat attenuates drug reward by altering brain iron homoeostasis [ Signal Transduct Target Ther, 2023, 8(1):355] | PubMed: 37718358 |
Hypoxia stabilizes SETDB1 to maintain genome stability [ Nucleic Acids Res, 2023, gkad796] | PubMed: 37850636 |
Osteocyte Egln1/Phd2 links oxygen sensing and biomineralization via FGF23 [ Bone Res, 2023, 11(1):7] | PubMed: 36650133 |
Selective induction of human renal interstitial progenitor-like cell lineages from iPSCs reveals development of mesangial and EPO-producing cells [ Cell Rep, 2023, S2211-1247(23)01614-5] | PubMed: 38237600 |
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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
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