Daprodustat (GSK1278863)

Daprodustat (GSK1278863) is an orally administered hypoxia-inducible factor-prolyl hydroxylase (HIF-PH) inhibitor. Phase 2.

Daprodustat (GSK1278863) Chemical Structure

Daprodustat (GSK1278863) Chemical Structure

CAS No. 960539-70-2

Purity & Quality Control

Daprodustat (GSK1278863) Related Products

Signaling Pathway

Biological Activity

Description Daprodustat (GSK1278863) is an orally administered hypoxia-inducible factor-prolyl hydroxylase (HIF-PH) inhibitor. Phase 2.
Targets
HIF-PH [1]
In vitro
In vitro GSK1278863 induces an effective EPO response and stimulates non-EPO mechanisms for erythropoiesis. [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05682326 Recruiting
Anaemia
GlaxoSmithKline
September 6 2023 Phase 3
NCT05951192 Active not recruiting
Anemia|Renal Insufficiency Chronic|Renal Anemia
USRC Kidney Research|GlaxoSmithKline
July 1 2023 Phase 4
NCT04640311 Completed
Anaemia
GlaxoSmithKline
December 18 2020 Phase 1

Chemical Information & Solubility

Molecular Weight 393.43 Formula

C19H27N3O6

CAS No. 960539-70-2 SDF Download Daprodustat (GSK1278863) SDF
Smiles C1CCC(CC1)N2C(=O)C(C(=O)N(C2=O)C3CCCCC3)C(=O)NCC(=O)O
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 5 mg/mL ( (12.7 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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