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Glucosamine HIF inhibitor

Cat.No.S6400

Glucosamine (2-amino-2-deoxy-D-glucose) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids. It is commonly used as a treatment for osteoarthritis. This compound treatment selectively downregulates HIF-1α at the protein level in YD-8 cells via interference of production of the citric acid cycle metabolites.
Glucosamine HIF inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 179.17

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Quality Control

Batch: Purity: >97%
97

Solubility

In vitro
Batch:

DMSO : 36 mg/mL (200.92 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : 36 mg/mL

Ethanol : Insoluble

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In vivo
Batch:

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
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Chemical Information, Storage & Stability

Molecular Weight 179.17 Formula

C6H13NO5

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 3416-24-8 -- Storage of Stock Solutions

Synonyms 2-amino-2-deoxy-D-glucose Smiles NC(C=O)C(O)C(O)C(O)CO

Mechanism of Action

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06200415 Completed
Periodontal Pocket
Ain Shams University
 November 8 2022 Phase 2
NCT05305937 Not yet recruiting
Malignant Tumor of Breast|Benign Breast Lumps|High-Risk Breast Cancer
Meir Medical Center|Tel Aviv University
 May 2022 Not Applicable
NCT05038436 Completed
Cholesterol Lowering
Certmedica International GmbH|University Hospital Bonn
 September 16 2021 Not Applicable
NCT03827161 Completed
Healthy Subject|Overweight
Fred Hutchinson Cancer Center
 August 1 2017 Phase 1
NCT03743896 Completed
Osteoarthritis Knee
Lynk Biotechnologies Pte Ltd|T&T Family Health Clinic and Surgery Singapore|Temasek Polytechnic School of Applied Science Singapore
 May 18 2016 Phase 4

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