Ethambutol 2HCl

For research use only.

Catalog No.S4004 Synonyms: CL40881

1 publication

Ethambutol 2HCl Chemical Structure

CAS No. 1070-11-7

Ethambutol 2HCl (CL40881) is a bacteriostatic antimycobacterial agent, which obstructs the formation of cell wall by inhibiting arabinosyl transferases.

Selleck's Ethambutol 2HCl has been cited by 1 publication

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Biological Activity

Description Ethambutol 2HCl (CL40881) is a bacteriostatic antimycobacterial agent, which obstructs the formation of cell wall by inhibiting arabinosyl transferases.
In vitro

Ethambutol directly affects two polymers, arabinogalactan (AG) and lipoarabinomannan (LAM) in Mycobacterium smegmatis. In M. smegmatis, Ethambutol inhibits synthesis of arabinan completely and inhibits AG synthesis most likely as a consequence of this; more than 50% of the cell arabinan is released from the bacteria following Ethambutol treatment, whereas no galactan is released. Ethambutol main targets against embB gene product in M. avium. Ethambutol induces 60% changes in the embB gene in M. tuberculosis resistant mutants. [1] Ethambutol is effective against actively growing microorganisms of the genus Mycobacterium, including M. tuberculosis. Nearly all strains of M. tuberculosis and M. kansasii as well as a number of strains of the M. aviumcomplex (MAC) are sensitive to Ethambutol. [1] Ethambutol is potency against M. tuberculosis (H37Rv) with MIC of 0.5 μg/mL in vitro. [2] Ethambutol is efficient on treatment of mycobacterial-infected macrophages. When M. tuberculosis infected macrophages are treated with 6 μg/mL Ethambutol, the log CFUs following treatment for 3 days is 4.17, while value in control group is 4.8. The MICs for M. avium (MTCC 1723) and M. smegmatis (MTCC 6) are 15 μg/mL and 0.18 μg/mL, respectively. [3]

In vivo Ethambutol is efficient in animal model. 100 mg/kg Ethambutol given orally 15 days post i.v. infection 1 ×/week for 5 weeks, induces a lower log CFU compared with untreatment (4.59 vs 5.07). [3]


Solubility (25°C)

In vitro DMSO 56 mg/mL (201.99 mM)
Water 56 mg/mL (201.99 mM)
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 277.23


CAS No. 1070-11-7
Storage powder
in solvent
Synonyms CL40881

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04972903 Not yet recruiting -- Tuberculosis|Pulmonary Institut National de la Santé Et de la Recherche Médicale France|National Agency for Research on AIDS and Viral Hepatitis (ANRS) August 2021 --
NCT02114684 Completed Drug: moxifloxacin Recurrent Tuberculosis Centre for the AIDS Programme of Research in South Africa November 2013 Phase 1|Phase 2
NCT02496572 Unknown status Drug: Short course MDR-TB treatment regimen Multidrug Resistant Tuberculosis Medecins Sans Frontieres Netherlands|Ministry of Health Republic of Uzbekistan|Imperial College London September 2013 --

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID