For research use only.
Catalog No.S4004 Synonyms: CL40881
CAS No. 1070-11-7
Ethambutol 2HCl (CL40881) is a bacteriostatic antimycobacterial agent, which obstructs the formation of cell wall by inhibiting arabinosyl transferases.
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|Description||Ethambutol 2HCl (CL40881) is a bacteriostatic antimycobacterial agent, which obstructs the formation of cell wall by inhibiting arabinosyl transferases.|
Ethambutol directly affects two polymers, arabinogalactan (AG) and lipoarabinomannan (LAM) in Mycobacterium smegmatis. In M. smegmatis, Ethambutol inhibits synthesis of arabinan completely and inhibits AG synthesis most likely as a consequence of this; more than 50% of the cell arabinan is released from the bacteria following Ethambutol treatment, whereas no galactan is released. Ethambutol main targets against embB gene product in M. avium. Ethambutol induces 60% changes in the embB gene in M. tuberculosis resistant mutants.  Ethambutol is effective against actively growing microorganisms of the genus Mycobacterium, including M. tuberculosis. Nearly all strains of M. tuberculosis and M. kansasii as well as a number of strains of the M. aviumcomplex (MAC) are sensitive to Ethambutol.  Ethambutol is potency against M. tuberculosis (H37Rv) with MIC of 0.5 μg/mL in vitro.  Ethambutol is efficient on treatment of mycobacterial-infected macrophages. When M. tuberculosis infected macrophages are treated with 6 μg/mL Ethambutol, the log CFUs following treatment for 3 days is 4.17, while value in control group is 4.8. The MICs for M. avium (MTCC 1723) and M. smegmatis (MTCC 6) are 15 μg/mL and 0.18 μg/mL, respectively. 
|In vivo||Ethambutol is efficient in animal model. 100 mg/kg Ethambutol given orally 15 days post i.v. infection 1 ×/week for 5 weeks, induces a lower log CFU compared with untreatment (4.59 vs 5.07). |
|In vitro||DMSO||56 mg/mL (201.99 mM)|
|Water||56 mg/mL (201.99 mM)|
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Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT04972903||Not yet recruiting||--||Tuberculosis|Pulmonary||Institut National de la Santé Et de la Recherche Médicale France|National Agency for Research on AIDS and Viral Hepatitis (ANRS)||August 2021||--|
|NCT02114684||Completed||Drug: moxifloxacin||Recurrent Tuberculosis||Centre for the AIDS Programme of Research in South Africa||November 2013||Phase 1|Phase 2|
|NCT02496572||Unknown status||Drug: Short course MDR-TB treatment regimen||Multidrug Resistant Tuberculosis||Medecins Sans Frontieres Netherlands|Ministry of Health Republic of Uzbekistan|Imperial College London||September 2013||--|
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