Danofloxacin Mesylate

For research use only. Not for use in humans.

Catalog No.S3058 Synonyms: CP-76136-27

Danofloxacin Mesylate Chemical Structure

Molecular Weight(MW): 453.48

Danofloxacin is a fluoroquinolone antibacterial for veterinary use, with MIC90 of 0.28 μM.

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Biological Activity

Description Danofloxacin is a fluoroquinolone antibacterial for veterinary use, with MIC90 of 0.28 μM.
In vitro

Danofloxacin is a synthetic antibacterial agent of the fluoroquinolone class, acts principally by the inhibition of bacterial DNA-gyrase, which is necessary for supercoiling of DNA to provide a suitable spatial arrangement of DNA within the bacterial cell. The minimum inhibitory concentration of danofloxacin against 90% (MIC90) of contemporary European and North American field isolates of Pasteurella haemolytica, Pasteurella multocida and Haemophilus somnus, the most important bacterial respiratory pathogens of cattle, is 0.125 μg/ml. [1]

In vivo Danofloxacin shows protective dose (PD50) of 0.38, 0.8, 2.42 mg/kg for P. multocida, E. coli and S. choleraesuis in in vivo mouse protection assay. [2]

Protocol

Animal Research:[2]
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  • Animal Models: mice
  • Formulation: 2.5% or 5% water solution
  • Dosages: 0-10 mg/kg
  • Administration: p. o or s. c.
    (Only for Reference)

Solubility (25°C)

In vitro Water 91 mg/mL (200.67 mM)
DMSO Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
Saline
For best results, use promptly after mixing.
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 453.48
Formula

C19H20FN3O3.CH4O3S

CAS No. 119478-55-6
Storage powder
in solvent
Synonyms CP-76136-27
Smiles CN1CC2CC1CN2C3=CC4=C(C=C3F)C(=O)C(=CN4C5CC5)C(O)=O.C[S](O)(=O)=O

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID