Dactolisib (BEZ235, NVP-BEZ235)

Catalog No.S1009

Dactolisib (BEZ235, NVP-BEZ235) Chemical Structure

Molecular Weight(MW): 469.55

Dactolisib (BEZ235, NVP-BEZ235) is a dual ATP-competitive PI3K and mTOR inhibitor for p110α/γ/δ/β and mTOR(p70S6K) with IC50 of 4 nM /5 nM /7 nM /75 nM /6 nM in cell-free assays, respectively. Inhibits ATR with IC50 of 21 nM in 3T3TopBP1-ER cell.

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Cited by 82 Publications

11 Customer Reviews

  • Level of phospho-proteins in RTK and PI3K–Akt–mTOR pathways in treated tumours, detected with western blot.

    Nature, 2017, 728-732. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

    Relative kinase activities of p110α mutants and the inhibitory effect of PI3K inhibitors against hotspot mutants of p110α. A, recombinant FLAG-tagged PI3K p110α/p85α protein complex produced in 293T cells was immunoprecipitated , and the immunoprecipitates were used for the quantitative PI3K-HTRF assay (32).

    B, effect of three PI3K inhibitors (ZSTK474, LY294002, and NVP-BEZ235) on the enzymatic activity of two hotspot mutants (E545K and H1047R) p110α compared with the wild-type. No striking difference was observed in the IC50 concentrations of these inhibitors between wild-type and mutant p110α.
     

     

    Cancer Res 2010 70, 4982-4994. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

  • A, ANOVA of IC50 values of the dual PI3K/mTOR inhibitor NVP-BEZ235 in 23 melanoma cell lines showing no significant difference in sensitivity to this compound in B-Raf mutant and Braf wild-type cells. B, decreases in pAkt and pP70S6K in a dose and time-dependent fashion in 2 melanoma cell lines treated with NVP-BEZ235. pP70S6K levels are undetectable at all concentrations and time points studied, whereas levels of pAkt start rising again after 4 hours of drug exposure in a dose-dependent fashion. C, clonogenic assays in 2 melanoma cell lines (YUVON and YUSIK) treated with NVP-BEZ235 at different concentrations. NVPBEZ235 was effective in inhibiting colony formation at low nanomolar concentrations.

    Clin Cancer Res 2010 16, 6029-6039. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

    Three-dimensional responses of MCF7/IGF-1R cells to TAM (1 μM), E2 and IGF-1. Compared to parental MCF7 cells (a), MCF7/IGF-1R cells (b) in three-dimensional (3D) culture formed bigger acini in response to IGF-1 stimulation and displayed significant TAM resistance when treated with TAM (1 μM) + E2 + IGF-1, which was removable by kinase inhibitors BMS-536924, U0126 and BEZ235 (c). Cells (10,000/well) were seeded in 96-well plates. Acini were formed on 100% Matrigel and cultured for 14 days in starving medium containing 2% Matrigel and 5% charcoal/dextran-stripped fetal bovine serum with the treatments as indicated. Concentrations used: TAM (1 μM), E2 (1 nM) and IGF-1 (100 ng/mL). Confocal image original magnification, × 20. Red, rhodamine phalloidin (actin). Blue, Hoechst blue stain. Results are representative of two individual experiments.

    Breast Cancer Res 2011 13, R52. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

  • TAM (10 nM) agonistic behavior in MCF7/IGF-1R cells is not inhibited by phosphatidylinositol 3-kinase/Akt inhibitor BEZ235. (a) Inhibitory effects of kinase inhibitors BMS-536924, U0126 and BEZ235 on agonistic effect of TAM (10 nM) in the presence of IGF-1 (100 ng/mL). **P < 0.01. (b) Inhibitory effects of phosphatidylinositol 3-kinase (PI3K)/Akt inhibitor BEZ235 at various dose ranges on IGF-1R signaling. (c) Agonistic behavior of TAM (10 nM) in response to BEZ235 kinase inhibitor. (-), no BEZ235. Results are representative of three independent experiments. Data are expressed as means ± SD.

    Breast Cancer Res 2011 13:R52. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

    ZSTK474 and GDC-0941 selectively inhibit class I PI3K over mTOR. (A) Inhibition profiles of the selected five PI3K inhibitors for mTOR. Data shown are mean±SD (n = 3), representative of 2 or 3 independent experiments. (B) IC50 values of the PI3K inhibitors for mTOR. (C) Selectivity of each PI3K inhibitor for PI3Ka over mTOR. The selectivity index is expressed as the ratio of the IC50 value for mTOR over that for PI3Ka. The IC50 values of ZSTK474, NVP-BEZ235 and LY294002 for PI3Ka are 0.016, 0.007 and 0.6 μM, respectively, as reported previously by us.

     

     

    Eur J Cancer 2010 46, 1111-1121. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

  • (B) The effects of AZD2014, BEZ235, lapatinib, LEE011, pazopanib on PI3K/AKT signaling in sarcoma PDC line were determined by immunoblotting analysis. Cells were treated with 1 μM of the indicated drugs for 72 h.

    Transl Oncol, 2016, 9(3):197-202. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

    The effects of LY294002, rapamycin and NVP-BEZ235 on activation of PI3K-Akt-mTOR pathway in hepatocytes. (a) The mRNA expression (PI3K, Akt, mTOR, raptor) by Real-Time PCR, (b) protein expression (PI3K, Akt, mTOR, S6K) by ELISA kits; (c) protein expression of S6K and P-S6K by western blotting. The different letters indicated significant differences (P <0.05). LY = LY294002; rapa = rapamycin; NVP = NVP-BEZ235.

    Animal, 2016, 10(8):1319-27. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

  •  After starved in serum-free medium for 24h,breast cancer cells incubated with the indicated concentrations of BEZ235 for 3h,followed by 20-minute  stimulation of 100ng/ml EGF.

     

     

     

    Dr. Zhang of Tianjin Medical University. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

    After starved in serum-free medium for 24h,breast cancer cells incubated with the indicated concentrations of BEZ235 for 3h,followed by 20-minute  stimulation of 100ng/ml EGF.

     

     

    Dr. Zhang of Tianjin Medical University. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

  •  

    FIG. 4. Phospholipase A2 group 4A (PLA2G4A) expression was increased after BEZ235 treatment in basal-like xenografts. The bar graph shows the quantification of the immunoblots (mean±SD). PLA2G4A, Ethanolamine kinase 1 and 2 (ETNK1/2), Choline kinase alpha/beta (ChoKA/B), and β-actin protein expression were examined by immunoblotting of tissue samples after MRS experiments [control group (n= 5) and BEZ235-treated group (n=7)]. This demonstrated a higher expression of PLA2G4A protein ( P=0.005), but no changes in ETNK1 and ChoKA/B in samples from basal-like xenografts treated with BEZ235.

    Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

Purity & Quality Control

Choose Selective PI3K Inhibitors

Biological Activity

Description Dactolisib (BEZ235, NVP-BEZ235) is a dual ATP-competitive PI3K and mTOR inhibitor for p110α/γ/δ/β and mTOR(p70S6K) with IC50 of 4 nM /5 nM /7 nM /75 nM /6 nM in cell-free assays, respectively. Inhibits ATR with IC50 of 21 nM in 3T3TopBP1-ER cell.
Targets
p110α [1]
(Cell-free assay)
p110γ [1]
(Cell-free assay)
mTOR (p70S6K) [1]
(Cell-free assay)
p110δ [1]
(Cell-free assay)
ATR [8]
(3T3TopBP1-ER cells)
4 nM 5 nM 6 nM 7 nM 21 nM
In vitro

BEZ235 significantly reduces the phosphorylation levels of the mTOR activated kinase p70S6K. BEZ235 results in a reduction of S235/S236P-RPS6 levels with IC50 of 6.5 nM. The activity of BEZ235 against mTOR is determined using a biochemical mTOR K-LISA assay with IC50 of 20.7 nM. BEZ235 shows slightly lower activity against its β paralogue with IC50 of 75 nM. The PI3K/Akt/mTOR pathway is often constitutively activated in human tumor cells. BEZ235 blocks PI3K and mTOR kinase activity by binding to the ATP-binding cleft of these enzymes. Both PTEN-null cell lines PC3M and U87MG show a dose-dependent reduction in cell proliferation when treated with increasing concentrations of BEZ235 with an average GI50 of 10-12 nM. [1] BEZ235 is an mTORC1/2 catalytic inhibitor. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Trypanosoma brucei brucei NW\xZW5GSW62aX3pZ5Jw[mmjbDDBd5NigQ>? MUKxPEBp M4DRN2ROW09? NWXTeXB[SW62aYTyfZBidm:|b33hcEBi[3Srdnn0fUB4cXSqIFXDOVAhd2ZiMD6wNFI2KM7:TR?= NGrxO5IzPDhyNUm0Oi=>
MCF7 NXyzOplVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUSwMlAyNTFyMDFOwG0> NYfLfHp{PDhiaB?= MlrISG1UVw>? M4CzN2lEPTB;MD63N{DPxE1? NV7De|JNOjN6N{G5NFQ>
HCT116 NYXDSZU5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1HKclAvODFvMUCwJO69VQ>? M4\mR|Q5KGh? MXvEUXNQ MkPxTWM2OD1zLkG2JO69VQ>? NXjsU5NZOjN6N{G5NFQ>
U87MG MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYWwMlAyNTFyMDFOwG0> M1;EXlQ5KGh? M{HQOWROW09? NGriZXlKSzVyPUGuN|Ih|ryP Moq2NlM5PzF7MES=
HBC4 NWm1ZpJGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVSwMlAyNTFyMDFOwG0> NUTLPZZFPDhiaB?= MnrIUI9oKEeLNUC9MVgvPjFiTR?= MknQNlI{OzZ{NE[=
BSY1 M3XNOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVSwMlAyNTFyMDFOwG0> MX20PEBp NWHkc4VmVG:pIFfJOVA:NThwNEigUS=> NYnmdmtiOjJ|M{[yOFY>
HBC5 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1i3elAvODFvMUCwJO69VQ>? MmTLOFghcA>? MlHxUI9oKEeLNUC9MVcvQDdiTR?= M1PaZVIzOzN4MkS2
MCF7 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnPMNE4xOS1zMECg{txO M1u4clQ5KGh? MV7Mc4chT0l3ME2tPE4yPiCP MnPCNlI{OzZ{NE[=
MDA-MB-231 MljqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmLqNE4xOS1zMECg{txO MVy0PEBp M4j1WWxw\yCJSUWwQU05NjB7IF2= NWDKO4l[OjJ|M{[yOFY>
U251 NFPCbndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGf2Z28xNjBzLUGwNEDPxE1? NILmT5M1QCCq NGLjeZZNd2diR1m1NF0uPy54NjDN MXKyNlM{PjJ2Nh?=
SF268 NV3nNVAzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEP4ZXYxNjBzLUGwNEDPxE1? MYO0PEBp MUfMc4chT0l3ME2tO{46OiCP NF;INpYzOjN|NkK0Oi=>
SF295 NH7kVIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoLCNE4xOS1zMECg{txO M2HOc|Q5KGh? NWG2bYY6VG:pIFfJOVA:NThwM{GgUS=> NUP2Ool2OjJ|M{[yOFY>
SF539 Ml3IS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{[3TVAvODFvMUCwJO69VQ>? MWW0PEBp NWHZO4h1VG:pIFfJOVA:NThwNUmgUS=> M3TaW|IzOzN4MkS2
SNB75 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUW4NZNQOC5yMT2xNFAh|ryP MXW0PEBp NU[zWVU1VG:pIFfJOVA:NThwNUigUS=> MlS3NlI{OzZ{NE[=
SNB78 NGP2WYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NW\WS2V[OC5yMT2xNFAh|ryP Moj2OFghcA>? MXrMc4chT0l3ME2tPE43PSCP NX\3c5JpOjJ|M{[yOFY>
HCC2998 NXH0SIF4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUfQc|R3OC5yMT2xNFAh|ryP NXvO[HA1PDhiaB?= MXrMc4chT0l3ME2tPE4xPSCP MnfyNlI{OzZ{NE[=
KM12 NHnQRnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVrSSmpuOC5yMT2xNFAh|ryP MnjOOFghcA>? M1vNZ2xw\yCJSUWwQU04NjV2IF2= NIDsWmkzOjN|NkK0Oi=>
HT-29 NIfMPVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH7hVnAxNjBzLUGwNEDPxE1? Mn7KOFghcA>? M4fWNmxw\yCJSUWwQU04Njd3IF2= MorFNlI{OzZ{NE[=
HCT15 MlT6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MojMNE4xOS1zMECg{txO NXq0[5ljPDhiaB?= MoHsUI9oKEeLNUC9MVgvODNiTR?= NInqWmszOjN|NkK0Oi=>
HCT116 MoD2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYGwMlAyNTFyMDFOwG0> Moe1OFghcA>? NIG0dHdNd2diR1m1NF0uPy54MTDN MlrrNlI{OzZ{NE[=
NCI-H23 M4jYdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVPifZZiOC5yMT2xNFAh|ryP NVvFcpI{PDhiaB?= M4\0Rmxw\yCJSUWwQU04NjZ2IF2= MYWyNlM{PjJ2Nh?=
NCI-H226 Mne3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWWwMlAyNTFyMDFOwG0> MWe0PEBp NYnQWGpCVG:pIFfJOVA:NThwNESgUS=> NHXXdFEzOjN|NkK0Oi=>
NCI-H522 M2riS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGDKPHMxNjBzLUGwNEDPxE1? NV\ON2pvPDhiaB?= NIG5T5JNd2diR1m1NF0uQC52NTDN MkCwNlI{OzZ{NE[=
NCI-H438 NXnQcI96T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGno[osxNjBzLUGwNEDPxE1? MXi0PEBp M3jYSmxw\yCJSUWwQU05NjFzIF2= NUDMTlBjOjJ|M{[yOFY>
A549 NVO1WXBkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2K5fFAvODFvMUCwJO69VQ>? NX;FbYN2PDhiaB?= MVHMc4chT0l3ME2tPE4xPyCP MXqyNlM{PjJ2Nh?=
DMS273 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoX3NE4xOS1zMECg{txO MUm0PEBp MV;Mc4chT0l3ME2tO{45OCCP NGXoSHUzOjN|NkK0Oi=>
DMS114 NInheVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYrLT|MxOC5yMT2xNFAh|ryP NGTtSmk1QCCq MlrSUI9oKEeLNUC9MVgvOzliTR?= NHq3Z3ozOjN|NkK0Oi=>
LOXIMVI MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXywMlAyNTFyMDFOwG0> M1TvbVQ5KGh? M3S4XWxw\yCJSUWwQU05NjZ4IF2= NIS3UYwzOjN|NkK0Oi=>
OVCAR3 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWiwMlAyNTFyMDFOwG0> M{nPVFQ5KGh? NIXaZoJNd2diR1m1NF0uQC5zNzDN M4rJSFIzOzN4MkS2
OVCAR4 MnXTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1zLOlAvODFvMUCwJO69VQ>? NWfYNYliPDhiaB?= NVewfY1VVG:pIFfJOVA:NThwNUigUS=> NFXKWZozOjN|NkK0Oi=>
OVCAR5 M4XEWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2TYWlAvODFvMUCwJO69VQ>? M3jBNFQ5KGh? M1HB[Wxw\yCJSUWwQU04NjV5IF2= MXeyNlM{PjJ2Nh?=
OVCAR8 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NE\KW|AxNjBzLUGwNEDPxE1? MXO0PEBp MoLzUI9oKEeLNUC9MVcvQDRiTR?= MWWyNlM{PjJ2Nh?=
SKOV3 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVqwMlAyNTFyMDFOwG0> MoPWOFghcA>? NHfIZYJNd2diR1m1NF0uQC52MTDN NV75WYVCOjJ|M{[yOFY>
RXF631L NHX2S5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHTRSZkxNjBzLUGwNEDPxE1? NHLZ[Wc1QCCq MlPQUI9oKEeLNUC9MVgvOjFiTR?= NIH5T5YzOjN|NkK0Oi=>
ACHN NXvLTo56T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF[x[IwxNjBzLUGwNEDPxE1? NVXpbXdIPDhiaB?= MYPMc4chT0l3ME2tO{46PSCP MVSyNlM{PjJ2Nh?=
St-4 MmfBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYP2NYIyOC5yMT2xNFAh|ryP NXfEToQ1PDhiaB?= NWfvfoRrVG:pIFfJOVA:NTdwNEegUS=> MWeyNlM{PjJ2Nh?=
MKN1 MoLJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUO5XIw3OC5yMT2xNFAh|ryP M{HQUVQ5KGh? NV;ufZdpVG:pIFfJOVA:NThwNEGgUS=> MkHHNlI{OzZ{NE[=
MKN7 NU\jUoQ2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3LHVlAvODFvMUCwJO69VQ>? NYftbZNpPDhiaB?= MVrMc4chT0l3ME2tO{43QCCP MnjINlI{OzZ{NE[=
MKN28 NYG5Tpk6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHSyPGsxNjBzLUGwNEDPxE1? NGC3OWM1QCCq NIDuOZVNd2diR1m1NF0uPy5yNzDN Mn7tNlI{OzZ{NE[=
MKN45 M{DEPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUOwMlAyNTFyMDFOwG0> MornOFghcA>? NVXjfmw4VG:pIFfJOVA:NThwM{SgUS=> M13wSlIzOzN4MkS2
MKN74 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3nFNFAvODFvMUCwJO69VQ>? MVe0PEBp NFGwZ2dNd2diR1m1NF0uPy52MjDN MoPXNlI{OzZ{NE[=
DU145 NF\Zc|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M37zO|AvODFvMUCwJO69VQ>? MX[0PEBp MY\Mc4chT0l3ME2tPE4yPiCP NVz4XmhSOjJ|M{[yOFY>
PC3 MnTPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4\HfVAvODFvMUCwJO69VQ>? M{fXbVQ5KGh? NF:1cYxNd2diR1m1NF0uQC54NjDN MXyyNlM{PjJ2Nh?=
Trypanosoma brucei brucei M3nqZ2Z2dmO2aX;uJGF{e2G7 MVWyNFAhdk1? NGD6fGUyOiCq MlTZSG1UVw>? M{i1fGRm[3KnYYPlJIlvKHCqb4PwbI91cWS7bDDpco9{cXSxbDDwbI9{eGijdHWgcIV3\Wx? Mo\ONlQ5ODV7NE[=
Trypanosoma brucei brucei MnnrSpVv[3Srb36gRZN{[Xl? M1XreFE5KGh? NFPDZm5FVVOR NVHubYZsUW6qaXLpeIlwdiCxZjDy[YNmeHSxcj3t[YRq[XSnZDDlcoRw[3m2b4Ppd{Bie3Onc4Pl[EBieyCmZXPy[YF{\SCrbjD0doFve2[ncoLpckB2eHSja3W= NYf6b2I5OjR6MEW5OFY>
Trypanosoma brucei brucei M4rjRmZ2dmO2aX;uJGF{e2G7 M1jUOVIxOCCwTR?= NXzNfplDOTJiaB?= NUP0XW5lTE2VTx?= NF3WTnFG\m[nY4Sgc44he3CqaX7nc416dGWrbjDs[ZZmdA>? NH[zdnYzPDhyNUm0Oi=>
Trypanosoma brucei brucei Ml\DSpVv[3Srb36gRZN{[Xl? MYWyNFAhdk1? M4nBWlEzKGh? MWrEUXNQ NXTr[G5oTW[oZXP0JI9vKHCqb4PwbIF1cWS7bHPoc4xqdmVibHX2[Yw> Mo\4NlQ5ODV7NE[=
UM-UC-3 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWjJR|UxRTNzNTDwUS=> M1vNeHNCVkeHUh?=
SBC-1 M3u0[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkTHTWM2OD15NEKgdG0> NUL1R3FmW0GQR1XS
MKN1 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXPJR|UxRTJwODDuUS=> MVTTRW5ITVJ?
NCI-H720 M{HvVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUCxcm1uUUN3ME2zMlU4KG6P NFjYVpZUSU6JRWK=
BFTC-909 NUfpeHNOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmjGTWM2OD1|LkexJI5O NGG1eW1USU6JRWK=
BPH-1 NGntcG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWPqNHdNUUN3ME20Mlc3KG6P NXyx[3ZiW0GQR1XS
PC-3 M3W2SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXvJR|UxRTVwMEmgcm0> M2TB[3NCVkeHUh?=
AN3-CA NVnCSG5[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWTBXHBYUUN3ME21MlU3KG6P M4XUPHNCVkeHUh?=
HN M{TLd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYK5N|A{UUN3ME21Mlk3KG6P NHzEZ5pUSU6JRWK=
HCC2218 M{jzc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlzwTWM2OD14Lk[xJI5O NIDQOJBUSU6JRWK=
KP-4 MkHOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NInEfppKSzVyPUegcm0> MkX3V2FPT0WU
LU-139 MmDVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUXJR|UxRTdwN{egcm0> NIjzcmFUSU6JRWK=
ETK-1 M2D0Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWLJR|UxRTdwOEigcm0> NELlfXBUSU6JRWK=
Ramos-2G6-4C10 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoTHTWM2OD16LkS5JI5O MlHyV2FPT0WU
MHH-PREB-1 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2\uRmlEPTB;OT6xNkBvVQ>? M2jvcHNCVkeHUh?=
DU-4475 M3O0T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIT3WY5KSzVyPUmuOFQhdk1? NYe2WVVVW0GQR1XS
NCI-H1666 M4nJemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYDJR|UxRTlwN{Ggcm0> Mnv5V2FPT0WU
CAMA-1 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEXvToJKSzVyPUmuPEBvVQ>? NFXwbpRUSU6JRWK=
TYK-nu MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlzxTWM2OD17Lkm0JI5O M{T3bXNCVkeHUh?=
MFE-280 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3nNZWlEPTB;OT65PUBvVQ>? NF6xbVBUSU6JRWK=
A549 M4rEZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH\qdpRKSzVyPUGwMlE1KG6P MWnTRW5ITVJ?
769-P NHzvSWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3T5OWlEPTB;MUCuOFQhdk1? MYLTRW5ITVJ?
L-363 NYrrPWp3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF;RfWVKSzVyPUGwMlY6KG6P Mn;LV2FPT0WU
ES8 NH[xNFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1PFbWlEPTB;MUCuPUBvVQ>? MWjTRW5ITVJ?
PA-1 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYj0[Wh7UUN3ME2xNU45OiCwTR?= MYDTRW5ITVJ?
Mewo MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIfVU|NKSzVyPUGxMlk6KG6P M1HocnNCVkeHUh?=
HSC-3 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF7tVGZKSzVyPUGyMlIyKG6P NULvT3I3W0GQR1XS
H4 NEL0OYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVPJR|UxRTF{Lk[3JI5O NYPQTZRDW0GQR1XS
BB65-RCC M1zEOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHHmVIhKSzVyPUGyMlczKG6P MUnTRW5ITVJ?
NCI-H1793 MlzPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEnIcFZKSzVyPUGyMlgzKG6P NGD0[WtUSU6JRWK=
KARPAS-45 NIf3ToRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVrJR|UxRTF|LkWxJI5O MnHRV2FPT0WU
GCT MoTPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkfkTWM2OD1zMz62PEBvVQ>? MmDCV2FPT0WU
EoL-1 M3z4TWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4f5Z2lEPTB;MUOuPVMhdk1? MnLOV2FPT0WU
LB2241-RCC NYDjOIxkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYjF[WR1UUN3ME2xOE4xOSCwTR?= MV7TRW5ITVJ?
ES5 M1v2WWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVzJR|UxRTF2Lke0JI5O NEDo[mxUSU6JRWK=
LOXIMVI MnnlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmG1TWM2OD1zND65PUBvVQ>? NYT3Z2JTW0GQR1XS
COR-L105 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVW4UZREUUN3ME2xOU4xPCCwTR?= NEj4cmZUSU6JRWK=
P12-ICHIKAWA M1;wOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlnlTWM2OD1zNT6xJI5O NXXUbGM1W0GQR1XS
CHL-1 M1vnSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NI\PPW9KSzVyPUG1MlQ2KG6P M1T3dHNCVkeHUh?=
VMRC-RCZ MlywS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXHJR|UxRTF3Lk[zJI5O NEnxZ4lUSU6JRWK=
HH MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1f0Z2lEPTB;MUWuO{BvVQ>? M2G0eXNCVkeHUh?=
NUGC-3 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mm[2TWM2OD1zNj6zOEBvVQ>? MYfTRW5ITVJ?
EGI-1 NUnQNXZ2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4\KNWlEPTB;MU[uOFMhdk1? MnLBV2FPT0WU
OS-RC-2 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXrs[ldDUUN3ME2xOk41PyCwTR?= NH\jZoZUSU6JRWK=
MOLT-16 MkTzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXrJR|UxRTF5LkG1JI5O NUj3cIhUW0GQR1XS
NCI-H209 MmTES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml3ITWM2OD1zNz6yPUBvVQ>? NGCwb3JUSU6JRWK=
697 NIW0RoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NY\yPIoyUUN3ME2xO{41OyCwTR?= MkfYV2FPT0WU
D-56MG MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MknjTWM2OD1zNz62PUBvVQ>? NFTwZ3JUSU6JRWK=
VA-ES-BJ MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4fBR2lEPTB;MUeuPFMhdk1? NELoSYRUSU6JRWK=
EW-16 NW\FVGVlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWTJR|UxRTF6LkC0JI5O MYnTRW5ITVJ?
HGC-27 M3j4XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{i1TGlEPTB;MUiuNFYhdk1? MVXTRW5ITVJ?
ES7 M3rkN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX;KbXE3UUN3ME2xPE4xQSCwTR?= Mo\lV2FPT0WU
HuH-7 NHTZSoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVL2RXMxUUN3ME2xPE41KG6P Mn\DV2FPT0WU
BCPAP NHPncHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFW5cIhKSzVyPUG4MlY2KG6P MnTNV2FPT0WU
SW1710 NUDhUYZkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1uwXWlEPTB;MUiuO|Ihdk1? NGnwTmRUSU6JRWK=
IST-MEL1 NWjQfYh{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml3pTWM2OD1zOD63O{BvVQ>? MojFV2FPT0WU
SF295 M37iOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoTmTWM2OD1zOD65N{BvVQ>? M{W4VHNCVkeHUh?=
RPMI-7951 NHTqRYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mmn3TWM2OD1zOT6yPEBvVQ>? MVrTRW5ITVJ?
SF126 NGPFSWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnGwTWM2OD1zOT60NUBvVQ>? MoHxV2FPT0WU
GAMG NILw[ZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWfJR|UxRTF7LkS4JI5O M1HPfHNCVkeHUh?=
KNS-81-FD MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4rBdWlEPTB;MUmuOVQhdk1? MlrsV2FPT0WU
RT-112 NH;Ed2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHvxTXZKSzVyPUG5MlY3KG6P NHLwe|hUSU6JRWK=
DEL NYSyZoNKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVrme4JGUUN3ME2yNE41QSCwTR?= Mn3YV2FPT0WU
CGTH-W-1 NVjTV5RPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkfmTWM2OD1{MD62N{BvVQ>? NGDmUGFUSU6JRWK=
HOS NFv0UnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYS4[YFtUUN3ME2yNU4xPiCwTR?= NYWycVI2W0GQR1XS
ES4 M3zxOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mnm5TWM2OD1{MT6wPEBvVQ>? NHXjNndUSU6JRWK=
RXF393 NYXJWFk3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3rlNGlEPTB;MkGuOFUhdk1? NYnVUpRlW0GQR1XS
NCI-H2030 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mmn4TWM2OD1{MT61NkBvVQ>? NUewXXBxW0GQR1XS
YH-13 MkO4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUfUXVRqUUN3ME2yNU45QCCwTR?= NYH4co9YW0GQR1XS
HT-1080 NYTMb48zT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV;JR|UxRTJzLkmzJI5O M2nRWnNCVkeHUh?=
NCI-SNU-1 NWLmTpNvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mlz4TWM2OD1{MT65OUBvVQ>? Ml\zV2FPT0WU
G-402 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHnlSIZKSzVyPUKyMlE3KG6P M4Du[XNCVkeHUh?=
786-0 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWDJR|UxRTJ{LkK5JI5O NXHuW4pOW0GQR1XS
ME-180 M3v4cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXrBUGJlUUN3ME2yNk41OyCwTR?= NGmyVXFUSU6JRWK=
NB69 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVTJR|UxRTJ{LkWzJI5O MmTxV2FPT0WU
J-RT3-T3-5 MkHaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXv1[Yk{UUN3ME2yNk46PiCwTR?= NX\nSZVGW0GQR1XS
TGBC1TKB NX72[JJkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXfJR|UxRTJ|LkC1JI5O NEf6T|lUSU6JRWK=
SW780 M3PFbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnThTWM2OD1{Mz6xN{BvVQ>? NEHyOnFUSU6JRWK=
MG-63 M1T6[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mo\VTWM2OD1{Mz60OUBvVQ>? MX3TRW5ITVJ?
BV-173 NV3VeIFOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV\JR|UxRTJ|Lki3JI5O M3PFe3NCVkeHUh?=
CAL-51 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M37t[GlEPTB;MkOuPFkhdk1? MVTTRW5ITVJ?
A375 NYfXeZhUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3jWe2lEPTB;MkOuPVMhdk1? NGXRZ3hUSU6JRWK=
MEL-HO MmL0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEH0foVKSzVyPUK0MlA1KG6P MlXNV2FPT0WU
EFO-27 MkjnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3XzOGlEPTB;MkSuN|Mhdk1? NF7LTXhUSU6JRWK=
Hs-578-T NUP6N2RxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIjZ[m1KSzVyPUK0MlU5KG6P NGD5b41USU6JRWK=
NBsusSR MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml;YTWM2OD1{ND62JI5O NWDPSJVtW0GQR1XS
CTB-1 MmDKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYXJR|UxRTJ2Lk[3JI5O NXjWeG9lW0GQR1XS
FTC-133 M1PIWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIHIXI5KSzVyPUK1MlEhdk1? MnfNV2FPT0WU
MOLT-4 M3Pu[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXn5SmpJUUN3ME2yOU4yOiCwTR?= NF3RT|NUSU6JRWK=
HO-1-N-1 NWnEN2dHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2rR[mlEPTB;MkWuNVUhdk1? NF7tPJpUSU6JRWK=
ES3 M3HSRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn;mTWM2OD1{NT6yNkBvVQ>? NWXiRW9[W0GQR1XS
TI-73 NVLI[YY{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkHMTWM2OD1{NT6yPEBvVQ>? NFnsW5NUSU6JRWK=
MPP-89 NGf0VWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF\p[|FKSzVyPUK1MlMzKG6P M3rGb3NCVkeHUh?=
KYSE-150 NILVTXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2PicWlEPTB;MkWuPFkhdk1? M2qyfnNCVkeHUh?=
LXF-289 M{DXNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn\FTWM2OD1{Nj6wOEBvVQ>? MoLhV2FPT0WU
SK-LU-1 M1zETWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIPLbnBKSzVyPUK2MlE4KG6P MoSwV2FPT0WU
HOP-92 NEO2S3dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV;kdWY1UUN3ME2yOk41QCCwTR?= MX\TRW5ITVJ?
HuO9 MmPkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MY\JR|UxRTJ4Lke2JI5O MXHTRW5ITVJ?
SW962 M3:0WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWLJR|UxRTJ4Lke2JI5O NWTIWI1HW0GQR1XS
RS4-11 NWrm[5ZRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFrtfXVKSzVyPUK2MlkyKG6P NHjwTZlUSU6JRWK=
NCI-H292 NIHxU|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnfsTWM2OD1{NzDuUS=> NEX5SnVUSU6JRWK=
DB NVfoV4djT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkTMTWM2OD1{Nz6zOkBvVQ>? M3myTHNCVkeHUh?=
SW1088 MmjaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXzBOldvUUN3ME2yPE4zQSCwTR?= NGTaOYZUSU6JRWK=
A204 M2myUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3vkPGlEPTB;MkiuOFchdk1? NF7DcFNUSU6JRWK=
A3-KAW NHXESohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4TlNmlEPTB;MkiuOlQhdk1? NEnIVHFUSU6JRWK=
MV-4-11 NVXtN|RUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWLJR|UxRTJ6Lkegcm0> NHrzVoZUSU6JRWK=
ES1 MlnwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mk\tTWM2OD1{OD64OEBvVQ>? Mni1V2FPT0WU
ONS-76 M2fFcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVvJR|UxRTJ7LkC1JI5O M3fZOHNCVkeHUh?=
D-263MG MkjRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXzkb3B3UUN3ME2yPU4{PSCwTR?= NFv4RVBUSU6JRWK=
U-2-OS MlnLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1rJN2lEPTB;MkmuOUBvVQ>? NY\6c|BbW0GQR1XS
T98G NYPX[ox{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWXjc2wxUUN3ME2yPU45QCCwTR?= NXvqO|M6W0GQR1XS
GI-ME-N MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX7JR|UxRTJ7LkmxJI5O MXLTRW5ITVJ?
BHT-101 NX7O[GVCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXrJR|UxRTNyLkC1JI5O MV;TRW5ITVJ?
NOS-1 NInqSYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF;OUYlKSzVyPUOwMlEzKG6P MYHTRW5ITVJ?
AsPC-1 M{CzZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIXsOmRKSzVyPUOwMlIhdk1? NH7U[XVUSU6JRWK=
QIMR-WIL MnXCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFHoUY1KSzVyPUOwMlYhdk1? NY\jXYxsW0GQR1XS
JVM-3 NFLiSGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWDNd2VbUUN3ME2zNE45OyCwTR?= Mln5V2FPT0WU
KU-19-19 NFS5ZYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYPJR|UxRTNzLkGzJI5O M{\HW3NCVkeHUh?=
OVCAR-8 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml;3TWM2OD1|MT6yOkBvVQ>? MV;TRW5ITVJ?
BEN MmDWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXPJR|UxRTNzLk[zJI5O MXPTRW5ITVJ?
BE-13 Ml3BS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2KzfWlEPTB;M{GuPFIhdk1? MlXoV2FPT0WU
EW-18 NUCyUZlLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlXsTWM2OD1|MT64OkBvVQ>? NXribW52W0GQR1XS
ECC10 Mkj5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGDsbnpKSzVyPUOxMlk2KG6P MVLTRW5ITVJ?
CTV-1 NVnlOoRTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGP3d3FKSzVyPUOyMlgzKG6P MUHTRW5ITVJ?
COLO-800 MmrVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV3JR|UxRTN{LkmyJI5O NUHRZmVxW0GQR1XS
A2058 NV25SY82T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoPQTWM2OD1|Mz6yOUBvVQ>? MnP0V2FPT0WU
VM-CUB-1 NELhRXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV;FbZNYUUN3ME2zN{41OyCwTR?= NXLienRVW0GQR1XS
Ca9-22 NULNdoZ3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MonhTWM2OD1|Mz61OUBvVQ>? NVTqfZJ7W0GQR1XS
COLO-684 NELHNohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{XSXWlEPTB;M{OuOVghdk1? MWHTRW5ITVJ?
RPMI-8226 Mo[3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV\JT4VuUUN3ME2zN{45OiCwTR?= M4PUWnNCVkeHUh?=
SK-NEP-1 M1vyVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4K2TmlEPTB;M{SuNVUhdk1? MlPrV2FPT0WU
Becker MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M37pemlEPTB;M{SuNlEhdk1? M17iU3NCVkeHUh?=
NCI-H28 NUfvSVVMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{TjVWlEPTB;M{SuOFQhdk1? M2O5eHNCVkeHUh?=
CAL-120 MknyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3vWbWlEPTB;M{SuO|Ihdk1? MYLTRW5ITVJ?
MDA-MB-157 MnjMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4nHb2lEPTB;M{WuOFEhdk1? NWH3c3dDW0GQR1XS
OVCAR-5 M1vVd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkDjTWM2OD1|NT60O{BvVQ>? NXLEfJFJW0GQR1XS
LAMA-84 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlW4TWM2OD1|NT64O{BvVQ>? NF\3NGtUSU6JRWK=
CAKI-1 MljhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml;4TWM2OD1|Nj60N{BvVQ>? NW\2fYViW0GQR1XS
Daoy NXvtRYx2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmfuTWM2OD1|Nj63JI5O MkT3V2FPT0WU
CAL-62 Ml3tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnX2TWM2OD1|Nj64OkBvVQ>? M3S1dXNCVkeHUh?=
8-MG-BA Mn\PS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX3vUJBGUUN3ME2zO{4zPSCwTR?= Mn3EV2FPT0WU
8505C MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVTJR|UxRTN5LkWxJI5O NELHeXpUSU6JRWK=
LNCaP-Clone-FGC Mor4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUXJR|UxRTN5LkW5JI5O MnTMV2FPT0WU
CAL-39 M2LFVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1nMeGlEPTB;M{euPUBvVQ>? NHzS[lRUSU6JRWK=
MN-60 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3zKXmlEPTB;M{euPVYhdk1? Mnu4V2FPT0WU
RKO M3ewOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUjJR|UxRTN6LkOzJI5O NFXOWVlUSU6JRWK=
U251 NX21RolyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX7JR|UxRTN6LkSzJI5O MlXKV2FPT0WU
SJSA-1 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4LBfmlEPTB;M{iuOVQhdk1? MXPTRW5ITVJ?
CAL-12T NETl[2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUPJR|UxRTN6Lk[gcm0> M{fiOXNCVkeHUh?=
HCC1419 NXqySHBPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVLYdoUzUUN3ME2zPE44OSCwTR?= NWTqWlVoW0GQR1XS
CO-314 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHj1UFJKSzVyPUO4Mlc1KG6P MmrOV2FPT0WU
LB1047-RCC M3rYT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1;1T2lEPTB;M{iuPFEhdk1? M4XTT3NCVkeHUh?=
A101D NVnndI85T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYLMd297UUN3ME2zPE46PyCwTR?= NYPV[FBFW0GQR1XS
MDA-MB-175-VII M4fHZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1v5fmlEPTB;M{muOVEhdk1? NYqyb4JZW0GQR1XS
MZ2-MEL NYTJco1TT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1\5cmlEPTB;M{muOlYhdk1? MlrBV2FPT0WU
NB5 MlXzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2XPSGlEPTB;NECuOlQhdk1? M4jCTXNCVkeHUh?=
G-401 MlznS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1LqXmlEPTB;NECuPFIhdk1? MoCwV2FPT0WU
HT NF;XZWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4mzN2lEPTB;NEGuNFIhdk1? NILkblhUSU6JRWK=
8305C NWrvcG1qT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Moj6TWM2OD12MT64O{BvVQ>? NXXPXZJWW0GQR1XS
BHY NH\tVWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXLJR|UxRTR{LkeyJI5O NFfndJVUSU6JRWK=
NTERA-S-cl-D1 M33SZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnLsTWM2OD12MzDuUS=> MVrTRW5ITVJ?
T-24 NFK0SGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWnOblkyUUN3ME20N{45OyCwTR?= NFnNXlVUSU6JRWK=
EPLC-272H M3f2Rmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1ThbmlEPTB;NESuN|khdk1? M{Xte3NCVkeHUh?=
PSN1 NF;Y[|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoXqTWM2OD12ND60JI5O MYjTRW5ITVJ?
NCI-H2452 NV24SWtjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGLDTW9KSzVyPUS0MlU5KG6P NHjBRY1USU6JRWK=
KS-1 M4D1b2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXvoNFVmUUN3ME20OE43PiCwTR?= MVjTRW5ITVJ?
HD-MY-Z NEnjXohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mmn5TWM2OD12ND65NkBvVQ>? NXriOZp{W0GQR1XS
KNS-62 M1Xaemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEnpSm5KSzVyPUS1MlM5KG6P MkC1V2FPT0WU
NOMO-1 Ml32S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX3JR|UxRTR3Lki3JI5O MVXTRW5ITVJ?
SK-HEP-1 Mlj1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFvHeG5KSzVyPUS2MlA1KG6P NYLxeHN7W0GQR1XS
IGR-1 NF[2U4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH7XO2RKSzVyPUS2MlE{KG6P M3rMW3NCVkeHUh?=
KYSE-180 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MU\JR|UxRTR4LkG3JI5O Mn3SV2FPT0WU
EW-22 M2LwV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnXSTWM2OD12Nj6yJI5O M4PCTXNCVkeHUh?=
NCI-H1355 MmnZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV;JR|UxRTR4LkO0JI5O MkizV2FPT0WU
DOHH-2 MofxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGPUSW1KSzVyPUS2MlM4KG6P MUTTRW5ITVJ?
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PC-14 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmHqTWM2OD12Nj61O{BvVQ>? MYrTRW5ITVJ?
TE-5 NW\uXno5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn;rTWM2OD12Nj64OEBvVQ>? NHrmVpZUSU6JRWK=
LB996-RCC MlfxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkLGTWM2OD12Nz6xPUBvVQ>? NHP3fYRUSU6JRWK=
NCI-H1623 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1jYRWlEPTB;NEeuO|Yhdk1? NEPmU4hUSU6JRWK=
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LoVo Mm\6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1nxU2lEPTB;NEiuOEBvVQ>? MlzHV2FPT0WU
MCF7 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4\E[mlEPTB;NEiuOVghdk1? NGPMWHZUSU6JRWK=
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PFSK-1 NIHMOWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4n1[GlEPTB;NEmuNFYhdk1? NG[2blVUSU6JRWK=
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COR-L23 MorvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3zIO2lEPTB;NEmuNVYhdk1? MV\TRW5ITVJ?
D-283MED NFWxOnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnnRTWM2OD12OT62NUBvVQ>? Mof3V2FPT0WU
SW982 M2\VNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3LQOmlEPTB;NEmuPVEhdk1? NH:4fZNUSU6JRWK=
SW620 NF7zWVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYHrZ2pRUUN3ME21NE4{PiCwTR?= NIG1XIlUSU6JRWK=
KYSE-140 NWD5PJhyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkP3TWM2OD13MD61OUBvVQ>? NHm4OHZUSU6JRWK=
GCIY M4rsUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVzJR|UxRTVyLk[3JI5O M1GxZXNCVkeHUh?=
MHH-ESS-1 MnjqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mln0TWM2OD13MT65OUBvVQ>? NV63WpBWW0GQR1XS
D-423MG NILmR4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1XicWlEPTB;NUKuNFghdk1? NV3EXVFqW0GQR1XS
SF539 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFTP[GVKSzVyPUWyMlM2KG6P NH\CV5NUSU6JRWK=
RPMI-2650 NV7WW2FqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXz5T|YxUUN3ME21Nk43QSCwTR?= NWLPOYVCW0GQR1XS
GR-ST MnfHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4PNSWlEPTB;NUKuPFchdk1? MnvvV2FPT0WU
YKG-1 M1PEbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXnJR|UxRTV|IH7N NV\ZU25TW0GQR1XS
SK-MES-1 MmPoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWPJR|UxRTV|LkK2JI5O MoPSV2FPT0WU
HLE NWDBNoFlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkfsTWM2OD13Mz60O{BvVQ>? MYnTRW5ITVJ?
RVH-421 NVL0U2pUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkjPTWM2OD13Mz62O{BvVQ>? NELzRoRUSU6JRWK=
C32 M4CycWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWHJR|UxRTV|LkizJI5O MkDVV2FPT0WU
GB-1 NVvEU4dQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWPWUFFiUUN3ME21OE4zKG6P NVfKXpdiW0GQR1XS
SNB75 NIC4PZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mo\tTWM2OD13ND6yOkBvVQ>? NHvhSWZUSU6JRWK=
EM-2 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVvJR|UxRTV2LkSgcm0> NVHPcFdvW0GQR1XS
RH-1 NFG1W49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWLJR|UxRTV2Lkegcm0> NW\tZ293W0GQR1XS
NKM-1 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mlj4TWM2OD13ND64NUBvVQ>? NHHI[WdUSU6JRWK=
NCI-H2405 M2rhfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUXJR|UxRTV2Lki4JI5O M2XWW3NCVkeHUh?=
KYSE-450 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmTJTWM2OD13NT6xOkBvVQ>? M3rlRnNCVkeHUh?=
A704 NF\hV2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVHJR|UxRTV3LkW5JI5O NFvOVVBUSU6JRWK=
HAL-01 NFHMZZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH72[3lKSzVyPUW1Mlg{KG6P MVLTRW5ITVJ?
TE-11 MkiyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXrZdGJwUUN3ME21OU46QSCwTR?= M4myPHNCVkeHUh?=
DOK MmL3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVnJR|UxRTV4LkCyJI5O MmL1V2FPT0WU
KY821 MofkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVvJR|UxRTV4LkKgcm0> M1vjWnNCVkeHUh?=
KGN NWfo[JR2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX\JR|UxRTV4LkOyJI5O M3vEcnNCVkeHUh?=
MC116 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2X1TWlEPTB;NUeuPEBvVQ>? M3jJdXNCVkeHUh?=
PANC-08-13 NV;zc2JyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml3TTWM2OD13OD6wNUBvVQ>? M{G0OXNCVkeHUh?=
KE-37 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlLDTWM2OD13OD63O{BvVQ>? MYnTRW5ITVJ?
KYSE-410 M3HSeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVzJR|UxRTV7LkS3JI5O MYjTRW5ITVJ?
RO82-W-1 MmLyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIK5Uo9KSzVyPUW5Mlkhdk1? MnPlV2FPT0WU
M14 M3vocGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTZyLkC0JI5O MXrTRW5ITVJ?
GI-1 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{\qfGlEPTB;NkCuN{BvVQ>? M3vGc3NCVkeHUh?=
ML-2 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkP1TWM2OD14MD62NkBvVQ>? NH20UW1USU6JRWK=
BFTC-905 Mli1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV3BVoF[UUN3ME22NE43PSCwTR?= NYjmOoRRW0GQR1XS
DMS-273 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn7tTWM2OD14MD64O{BvVQ>? NX\WW4pKW0GQR1XS
MDA-MB-361 Ml3GS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYrJR|UxRTZzIH7N Mnq5V2FPT0WU
MSTO-211H MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml;TTWM2OD14Mz61NUBvVQ>? Mo\DV2FPT0WU
MEG-01 NXe3OmhJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFHVOZZKSzVyPU[zMlUzKG6P M2PNS3NCVkeHUh?=
M059J M{ftWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4roRmlEPTB;NkOuOVghdk1? NVnjW41HW0GQR1XS
LN-405 NV;KfY1TT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mni3TWM2OD14Mz64OUBvVQ>? NHrndpJUSU6JRWK=
NCI-H1581 NFnP[5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NELEfo1KSzVyPU[0MlA{KG6P NWfhbZVnW0GQR1XS
TCCSUP NGm0dJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2f0[2lEPTB;NkSuOVMhdk1? M1fBTnNCVkeHUh?=
SW872 NVH3O5VYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVyyenM4UUN3ME22OE42PyCwTR?= MYrTRW5ITVJ?
KYSE-510 M3Psdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml3OTWM2OD14NT63OUBvVQ>? NHjncHNUSU6JRWK=
NCI-H1792 M3;PSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYnJR|UxRTZ4LkG1JI5O MmHrV2FPT0WU
SW13 M{PaOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MonNTWM2OD14Nj61JI5O MkHRV2FPT0WU
TE-8 NVi0W|ZUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUm4blNSUUN3ME22Ok42OiCwTR?= NUnoU3FEW0GQR1XS
SCH NETFRmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlfvTWM2OD14Nz6xJI5O NUHLUHVvW0GQR1XS
NEC8 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIPPXmFKSzVyPU[3MlI1KG6P NELjR5JUSU6JRWK=
HuO-3N1 NV33e5hIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn\6TWM2OD14Nz6zNUBvVQ>? M4PjeXNCVkeHUh?=
EFM-19 NEi5Z21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH;zfW1KSzVyPU[3MlUhdk1? NVzpUHVCW0GQR1XS
HEC-1 MlfsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4jFcmlEPTB;NkeuOVIhdk1? MUnTRW5ITVJ?
T47D MnzES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmXGTWM2OD14Nz64O{BvVQ>? MlTpV2FPT0WU
SNU-423 MnrWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHficFRKSzVyPU[3Mlk5KG6P NH3hT|lUSU6JRWK=
WM-115 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmnqTWM2OD14OD6xOEBvVQ>? M13NfnNCVkeHUh?=
CaR-1 M37zTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHHMTHpKSzVyPU[4MlI2KG6P Mkj4V2FPT0WU
KU812 NF7QTmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUXJR|UxRTZ6Lk[5JI5O M174SXNCVkeHUh?=
AM-38 NWPkcIR[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1;qdWlEPTB;NkmuN|Ehdk1? Mn22V2FPT0WU
KOSC-2 NV3V[HdxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVTJR|UxRTZ7Lkm3JI5O NVPzN5A3W0GQR1XS
MC-IXC M3XK[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXe0RZBsUUN3ME23NE4xQCCwTR?= Moi4V2FPT0WU
SCC-4 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NED5S29KSzVyPUexMlM5KG6P M1fXWHNCVkeHUh?=
Calu-3 NV3HUFVoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnfuTWM2OD15MT65PEBvVQ>? NHztO2VUSU6JRWK=
RPMI-8866 M3L6b2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHTEbZdKSzVyPUeyMlgzKG6P M2fDT3NCVkeHUh?=
OVCAR-4 MoHoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUDJR|UxRTd|LkO2JI5O MmLKV2FPT0WU
OAW-42 NXvaeYg3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX\MVm9wUUN3ME23N{4{QSCwTR?= Mlr1V2FPT0WU
ATN-1 Mn7ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnS4TWM2OD15Mz64O{BvVQ>? MWPTRW5ITVJ?
CHP-212 NXrm[IFTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M33JO2lEPTB;N{SuPVUhdk1? NXnld5BnW0GQR1XS
C2BBe1 MmLwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGHEV2FKSzVyPUe1MlA{KG6P NFLTRW5USU6JRWK=
A498 NWfjOG12T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYDJR|UxRTd3LkG1JI5O NH3hdodUSU6JRWK=
SH-4 NFryVYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGXITWdKSzVyPUe1MlIyKG6P M2[wUnNCVkeHUh?=
SNU-449 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NELoSmxKSzVyPUe1Mlc6KG6P NHKyZYRUSU6JRWK=
RD M4fz[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV;JR|UxRTd3Lki2JI5O MYPTRW5ITVJ?
PANC-03-27 NXnDTXhuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkDPTWM2OD15Nj6yOUBvVQ>? NXnOflNTW0GQR1XS
S-117 M1TCOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY\JR|UxRTd4LkK3JI5O NULuU21WW0GQR1XS
SK-MEL-2 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1TPbGlEPTB;N{[uO|Uhdk1? M3zoWXNCVkeHUh?=
LK-2 M1yx[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3:zbWlEPTB;N{euNFUhdk1? MlzuV2FPT0WU
CP50-MEL-B MmO1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWm4cYxbUUN3ME23O{41KG6P M4HobXNCVkeHUh?=
647-V MlL0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGHkVnZKSzVyPUe4MlA4KG6P NVrwV4tnW0GQR1XS
LU-134-A NUGw[ZJRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlLmTWM2OD15OT6wN{BvVQ>? MlH0V2FPT0WU
5637 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXXTPXk5UUN3ME23PU4zOyCwTR?= NVjRdZhkW0GQR1XS
NCI-H1437 MmLSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{CzWmlEPTB;OECuOUBvVQ>? NHPudItUSU6JRWK=
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COLO-678 NFfWNnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXX3co4{UUN3ME2yMlg{PzZ6IN88US=> MXjTRW5ITVJ?
SK-N-DZ NY\pVJRDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2nGbmlEPTB;Mj64OlM5OSEQvF2= MWXTRW5ITVJ?
NCI-H82 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVnJR|UxRTJwOUCzOlkh|ryP M1TXNHNCVkeHUh?=
JVM-2 M3HHfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MljaTWM2OD1|LkCzNVg5KM7:TR?= Ml3hV2FPT0WU
SW1116 Mn3DS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXLJR|UxRTNwMEW0NVEh|ryP NIf0PYZUSU6JRWK=
MDA-MB-453 M{S2UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NE\jbGhKSzVyPUOuNVA1OzlizszN NHzxNmxUSU6JRWK=
Calu-6 M4\VRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYLJR|UxRTNwMUm5O{DPxE1? MU\TRW5ITVJ?
SHP-77 MnPjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYf6VGN[UUN3ME2zMlUzQCEQvF2= M2jpVnNCVkeHUh?=
Capan-2 MmfVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXjJR|UxRTRwM{K1PFEh|ryP Mlm4V2FPT0WU
SW948 M3\Qbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIDJZYlKSzVyPUSuO|Q4PzlizszN MkC2V2FPT0WU
HDLM-2 M3zT[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFS3TYpKSzVyPUWuNFc4OjVizszN NI[4ToRUSU6JRWK=
LAN-6 NUDPRYw1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHP2dHBKSzVyPU[uNlE1QTVizszN NGrwfXFUSU6JRWK=
LU-135 NGPRSo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn\5TWM2OD14LkSzNFc4KM7:TR?= NVzuUXI1W0GQR1XS
T84 MljjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV7JR|UxRTZwOUi2OEDPxE1? M3j5U3NCVkeHUh?=
CAPAN-1 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmXrTWM2OD15Lk[yNlM{KM7:TR?= NHm5SWVUSU6JRWK=
SW1417 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHWzflFKSzVyPUeuPVE4OzFizszN MXXTRW5ITVJ?
BALL-1 M2PtTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVPJR|UxRThwNUC0NFkh|ryP Mn;iV2FPT0WU
HT-29 M{C1fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV\JR|UxRTlwMEe1PVkh|ryP NWG2O3I4W0GQR1XS
C3A NEDM[mhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXfxUG9vUUN3ME25Mlg5Ozl2IN88US=> MWTTRW5ITVJ?
NCI-H1993 M{HENmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXHJR|UxRTFyLkWwPFEh|ryP MoP0V2FPT0WU
SK-MEL-1 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4TYXGlEPTB;MUGuOlI5QSEQvF2= NX;yUIl1W0GQR1XS
DU-145 M2jJcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NG\TWmFKSzVyPUG0MlUxPTJizszN M{i3cXNCVkeHUh?=
KP-N-YN M2\Z[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoK3TWM2OD1zND61NVA{KM7:TR?= NGnMS4NUSU6JRWK=
CCRF-CEM NGna[YFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlKzTWM2OD1zND63PFA6KM7:TR?= M2qxR3NCVkeHUh?=
ZR-75-30 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH3aeZNKSzVyPUG2MlM{ODNizszN NV\BPWx1W0GQR1XS
A673 NF:wXGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIfLdmJKSzVyPUKwMlU2ODdizszN NGC1T2lUSU6JRWK=
K-562 MlToS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoqxTWM2OD1{OD60NVg{KM7:TR?= M4PTTnNCVkeHUh?=

... Click to View More Cell Line Experimental Data

In vivo BEZ235 induces regression of the tumors (69%) without statistically significant effect on body weight gain. Altogether, these preliminary in vivo efficacy results show that BEZ235 causes disease stasis when administered orally as a single agent and can enhance the efficacy of other anticancer agents when used in combination studies. [1]

Protocol

Kinase Assay:

[1]

+ Expand

In vitro Protein Kinase, PI3K, and mTOR Assays:

PI3Kα, β, and δ proteins are composed of the iSH2 domain of p85 NH2-terminally fused to the full-length protein p110 protein, with the exception of α that also does not contain the last 20 amino acids. PI3Kγ is produced as full-length protein deleted for its first 144 amino acids. All constructs are fused to a COOH-terminal His tag for convenient purification and then cloned into the pBlue-Bac4.5 (for α, β, and δ isoforms) or pVL1393 (for γ isoform) plasmids. The different vectors are then cotransfected with BaculoGold WT genomic DNA using methods recommended by the vendor for production of the respective recombinant baculoviruses and proteins. BEZ235 are tested for their activity against PI3K using a Kinase-Glo assay. The kinase reaction is done in 384-well black plate. Each well is loaded with 50 μL of test items (in 90% DMSO) and 5 μL reaction buffer containing 10 μg/mL PI substrate (l-α-phosphatidylinositol; Avanti Polar Lipids; prepared in 3% octyl-glucoside) and the PI3K proteins (10, 25, 10, and 150 nM of p110α, p110β, p110δ, and p110γ, respectively) are then added to it. The reaction is started by the addition of 5 μL of 1 μM ATP prepared in the reaction buffer and is incubated for either 60 (for p110α, p110β, and p110δ) or 120 min (for p110γ). It is terminated by the addition of 10 μL Kinase-Glo buffer. The plates are then read in a Synergy 2 reader for luminescence detection.
Cell Research:

[2]

+ Expand
  • Cell lines: HCT116, DLD-1 and SW480 cells
  • Concentrations: 0-1 μM
  • Incubation Time: 48 hours
  • Method:

    The human CRC cell lines, HCT116 (PIK3CA mutant; kinase domain at H1047R), DLD-1 (PIK3CA mutant; helical domain at E545K), and SW480 (PIK3CA wild-type) and isogenic DLD-1 PIK3CA mutant as well as wild-type cells are maintained in DMEM with 10% FBS and 1 × Penicillin/Streptomycin. Cells are plated at different initial densities (HCT116: 3 × 103 cells/well, DLD-1: 5.5 × 103 cells/well, SW480: 4.5 × 103 cells/well, DLD-1 PIK3CA mutant: 7 × 103 cells/well, and DLD-1 PIK3CA wild-type: 9 × 103 cells/well) to account for differential growth kinetics. After 16 hours, cells are incubated with increasing concentrations of BEZ235, and the drug-containing growth medium is changed every 24 hours. Cell viability is assessed 16 hours after the initial plating and 48 hours after initiation of drug treatment using the colorimetric MTS assay CellTiter 96® AQueous One Solution Cell Proliferation Assay, as per the manufacturer's instructions. Cell viability after drug treatment is normalized to that of untreated cells also grown for 48 hours. For western blot analysis, cells are plated with zero or maximum inhibitory dose (500 nM) BEZ235 for 2, 6, 24, or 48 hours.


    (Only for Reference)
Animal Research:

[1]

+ Expand
  • Animal Models: Female Harlan athymic nude mice
  • Formulation: NMP/polyethylene glycol 300 (10/90, v/v)
  • Dosages: 45 mg/kg
  • Administration: p.o.
    (Only for Reference)

Solubility (25°C)

In vitro DMF 18 mg/mL warmed (38.33 mM)
DMSO 0.01 mg/mL (0.02 mM)
Water Insoluble
In vivo Add solvents individually and in order:
NMP+polyethylene glycol 300 (10+90, v+v)
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 469.55
Formula

C30H23N5O

CAS No. 915019-65-7
Storage powder
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

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  • Computed Result

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Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

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Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00620594 Completed Breast Cancer|Advanced Solid Tumors|Cowden Syndrome Novartis Pharmaceuticals|Novartis December 21, 2006 Phase 1
NCT01856101 Terminated Carcinoma Transitional Cell Cliniques universitaires Saint-Luc- Université Catholique de Louvain|Novartis February 2013 Phase 2
NCT01717898 Terminated Castrate-resistant Prostate Cancer Patients. Charles Ryan|Novartis Pharmaceuticals|University of California, San Francisco January 2013 Phase 1|Phase 2
NCT01658436 Completed Pancreatic Neuroendocrine Tumors (pNET) Novartis Pharmaceuticals|Novartis November 2012 Phase 2
NCT01628913 Terminated Pancreatic Neuroendocrine Tumors (pNET) Novartis Pharmaceuticals|Novartis October 2012 Phase 2
NCT01690871 Withdrawn Malignant PEComa (Perivascular Epithelioid Cell Tumors) Novartis Pharmaceuticals|Novartis September 2012 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    With difficulties in dissolving BEZ235, How can I improve its solubility?

  • Answer:

    For in vivo study, we suggest the vehicle solution NMP/polyethylene glycol 300 (10/90, v/v). Please dissolve BEZ235 in NMP as more as possible. You can sonicate and warm it in water bath for a while. Then dilute with PEG 300.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID