Dactolisib (BEZ235, NVP-BEZ235)

Catalog No.S1009

Dactolisib (BEZ235, NVP-BEZ235) Chemical Structure

Molecular Weight(MW): 469.55

Dactolisib (BEZ235, NVP-BEZ235) is a dual ATP-competitive PI3K and mTOR inhibitor for p110α/γ/δ/β and mTOR(p70S6K) with IC50 of 4 nM /5 nM /7 nM /75 nM /6 nM in cell-free assays, respectively. Inhibits ATR with IC50 of 21 nM in 3T3TopBP1-ER cell.

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Cited by 82 Publications

11 Customer Reviews

  • Level of phospho-proteins in RTK and PI3K–Akt–mTOR pathways in treated tumours, detected with western blot.

    Nature, 2017, 728-732. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

    Relative kinase activities of p110α mutants and the inhibitory effect of PI3K inhibitors against hotspot mutants of p110α. A, recombinant FLAG-tagged PI3K p110α/p85α protein complex produced in 293T cells was immunoprecipitated , and the immunoprecipitates were used for the quantitative PI3K-HTRF assay (32).

    B, effect of three PI3K inhibitors (ZSTK474, LY294002, and NVP-BEZ235) on the enzymatic activity of two hotspot mutants (E545K and H1047R) p110α compared with the wild-type. No striking difference was observed in the IC50 concentrations of these inhibitors between wild-type and mutant p110α.
     

     

    Cancer Res 2010 70, 4982-4994. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

  • A, ANOVA of IC50 values of the dual PI3K/mTOR inhibitor NVP-BEZ235 in 23 melanoma cell lines showing no significant difference in sensitivity to this compound in B-Raf mutant and Braf wild-type cells. B, decreases in pAkt and pP70S6K in a dose and time-dependent fashion in 2 melanoma cell lines treated with NVP-BEZ235. pP70S6K levels are undetectable at all concentrations and time points studied, whereas levels of pAkt start rising again after 4 hours of drug exposure in a dose-dependent fashion. C, clonogenic assays in 2 melanoma cell lines (YUVON and YUSIK) treated with NVP-BEZ235 at different concentrations. NVPBEZ235 was effective in inhibiting colony formation at low nanomolar concentrations.

    Clin Cancer Res 2010 16, 6029-6039. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

    Three-dimensional responses of MCF7/IGF-1R cells to TAM (1 μM), E2 and IGF-1. Compared to parental MCF7 cells (a), MCF7/IGF-1R cells (b) in three-dimensional (3D) culture formed bigger acini in response to IGF-1 stimulation and displayed significant TAM resistance when treated with TAM (1 μM) + E2 + IGF-1, which was removable by kinase inhibitors BMS-536924, U0126 and BEZ235 (c). Cells (10,000/well) were seeded in 96-well plates. Acini were formed on 100% Matrigel and cultured for 14 days in starving medium containing 2% Matrigel and 5% charcoal/dextran-stripped fetal bovine serum with the treatments as indicated. Concentrations used: TAM (1 μM), E2 (1 nM) and IGF-1 (100 ng/mL). Confocal image original magnification, × 20. Red, rhodamine phalloidin (actin). Blue, Hoechst blue stain. Results are representative of two individual experiments.

    Breast Cancer Res 2011 13, R52. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

  • TAM (10 nM) agonistic behavior in MCF7/IGF-1R cells is not inhibited by phosphatidylinositol 3-kinase/Akt inhibitor BEZ235. (a) Inhibitory effects of kinase inhibitors BMS-536924, U0126 and BEZ235 on agonistic effect of TAM (10 nM) in the presence of IGF-1 (100 ng/mL). **P < 0.01. (b) Inhibitory effects of phosphatidylinositol 3-kinase (PI3K)/Akt inhibitor BEZ235 at various dose ranges on IGF-1R signaling. (c) Agonistic behavior of TAM (10 nM) in response to BEZ235 kinase inhibitor. (-), no BEZ235. Results are representative of three independent experiments. Data are expressed as means ± SD.

    Breast Cancer Res 2011 13:R52. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

    ZSTK474 and GDC-0941 selectively inhibit class I PI3K over mTOR. (A) Inhibition profiles of the selected five PI3K inhibitors for mTOR. Data shown are mean±SD (n = 3), representative of 2 or 3 independent experiments. (B) IC50 values of the PI3K inhibitors for mTOR. (C) Selectivity of each PI3K inhibitor for PI3Ka over mTOR. The selectivity index is expressed as the ratio of the IC50 value for mTOR over that for PI3Ka. The IC50 values of ZSTK474, NVP-BEZ235 and LY294002 for PI3Ka are 0.016, 0.007 and 0.6 μM, respectively, as reported previously by us.

     

     

    Eur J Cancer 2010 46, 1111-1121. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

  • (B) The effects of AZD2014, BEZ235, lapatinib, LEE011, pazopanib on PI3K/AKT signaling in sarcoma PDC line were determined by immunoblotting analysis. Cells were treated with 1 μM of the indicated drugs for 72 h.

    Transl Oncol, 2016, 9(3):197-202. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

    The effects of LY294002, rapamycin and NVP-BEZ235 on activation of PI3K-Akt-mTOR pathway in hepatocytes. (a) The mRNA expression (PI3K, Akt, mTOR, raptor) by Real-Time PCR, (b) protein expression (PI3K, Akt, mTOR, S6K) by ELISA kits; (c) protein expression of S6K and P-S6K by western blotting. The different letters indicated significant differences (P <0.05). LY = LY294002; rapa = rapamycin; NVP = NVP-BEZ235.

    Animal, 2016, 10(8):1319-27. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

  •  After starved in serum-free medium for 24h,breast cancer cells incubated with the indicated concentrations of BEZ235 for 3h,followed by 20-minute  stimulation of 100ng/ml EGF.

     

     

     

    Dr. Zhang of Tianjin Medical University. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

    After starved in serum-free medium for 24h,breast cancer cells incubated with the indicated concentrations of BEZ235 for 3h,followed by 20-minute  stimulation of 100ng/ml EGF.

     

     

    Dr. Zhang of Tianjin Medical University. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

  •  

    FIG. 4. Phospholipase A2 group 4A (PLA2G4A) expression was increased after BEZ235 treatment in basal-like xenografts. The bar graph shows the quantification of the immunoblots (mean±SD). PLA2G4A, Ethanolamine kinase 1 and 2 (ETNK1/2), Choline kinase alpha/beta (ChoKA/B), and β-actin protein expression were examined by immunoblotting of tissue samples after MRS experiments [control group (n= 5) and BEZ235-treated group (n=7)]. This demonstrated a higher expression of PLA2G4A protein ( P=0.005), but no changes in ETNK1 and ChoKA/B in samples from basal-like xenografts treated with BEZ235.

    Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

Purity & Quality Control

Choose Selective PI3K Inhibitors

Biological Activity

Description Dactolisib (BEZ235, NVP-BEZ235) is a dual ATP-competitive PI3K and mTOR inhibitor for p110α/γ/δ/β and mTOR(p70S6K) with IC50 of 4 nM /5 nM /7 nM /75 nM /6 nM in cell-free assays, respectively. Inhibits ATR with IC50 of 21 nM in 3T3TopBP1-ER cell.
Targets
p110α [1]
(Cell-free assay)
p110γ [1]
(Cell-free assay)
mTOR (p70S6K) [1]
(Cell-free assay)
p110δ [1]
(Cell-free assay)
ATR [8]
(3T3TopBP1-ER cells)
4 nM 5 nM 6 nM 7 nM 21 nM
In vitro

BEZ235 significantly reduces the phosphorylation levels of the mTOR activated kinase p70S6K. BEZ235 results in a reduction of S235/S236P-RPS6 levels with IC50 of 6.5 nM. The activity of BEZ235 against mTOR is determined using a biochemical mTOR K-LISA assay with IC50 of 20.7 nM. BEZ235 shows slightly lower activity against its β paralogue with IC50 of 75 nM. The PI3K/Akt/mTOR pathway is often constitutively activated in human tumor cells. BEZ235 blocks PI3K and mTOR kinase activity by binding to the ATP-binding cleft of these enzymes. Both PTEN-null cell lines PC3M and U87MG show a dose-dependent reduction in cell proliferation when treated with increasing concentrations of BEZ235 with an average GI50 of 10-12 nM. [1] BEZ235 is an mTORC1/2 catalytic inhibitor. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Trypanosoma brucei brucei MlvlRY51cW2rY4LvZolidCCDc4PhfS=> MXyxPEBp MnPnSG1UVw>? M3T0eWFvfGm2conwZY5we2:vYXygZYN1cX[rdImge4l1cCCHQ{WwJI9nKDBwMECyOUDPxE1? MofjNlQ5ODV7NE[=
MCF7 M4PtN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWWwMlAyNTFyMDFOwG0> NWH2NZM5PDhiaB?= MULEUXNQ MWjJR|UxRTBwN{Og{txO MkXvNlM5PzF7MES=
HCT116 MmfDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3;Yd|AvODFvMUCwJO69VQ>? MkDUOFghcA>? NV3tOHlwTE2VTx?= MUnJR|UxRTFwMU[g{txO NGj6c5ozOzh5MUmwOC=>
U87MG NW\UdFk4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYGwMlAyNTFyMDFOwG0> NYL0fnJ3PDhiaB?= M3;hWGROW09? NGnpfFdKSzVyPUGuN|Ih|ryP MXuyN|g4OTlyNB?=
HBC4 NFjtfGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV6wMlAyNTFyMDFOwG0> M3O2[lQ5KGh? NFXvRnFNd2diR1m1NF0uQC54MTDN M3HqN|IzOzN4MkS2
BSY1 NU\DdYJET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHLFU2IxNjBzLUGwNEDPxE1? M2PofFQ5KGh? MWTMc4chT0l3ME2tPE41QCCP M4jVc|IzOzN4MkS2
HBC5 MmfyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmfBNE4xOS1zMECg{txO M4\relQ5KGh? MXXMc4chT0l3ME2tO{45PyCP M3vUO|IzOzN4MkS2
MCF7 NEjwVJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmfINE4xOS1zMECg{txO MkTEOFghcA>? M4TjWGxw\yCJSUWwQU05NjF4IF2= NXPKOnlwOjJ|M{[yOFY>
MDA-MB-231 NGr2XmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkP5NE4xOS1zMECg{txO MlXuOFghcA>? MV7Mc4chT0l3ME2tPE4xQSCP MVyyNlM{PjJ2Nh?=
U251 NX24Z4lPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUewMlAyNTFyMDFOwG0> MVW0PEBp Mn35UI9oKEeLNUC9MVcvPjZiTR?= MoXhNlI{OzZ{NE[=
SF268 Mo\uS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkXKNE4xOS1zMECg{txO NYTtO45kPDhiaB?= NVG3S5VXVG:pIFfJOVA:NTdwOUKgUS=> M33H[FIzOzN4MkS2
SF295 NHPGS4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGPHOlMxNjBzLUGwNEDPxE1? Ml7BOFghcA>? MVnMc4chT0l3ME2tPE4{OSCP NVXmTIJoOjJ|M{[yOFY>
SF539 MlfxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV6wMlAyNTFyMDFOwG0> MljxOFghcA>? NYLUUohmVG:pIFfJOVA:NThwNUmgUS=> NW\6[pk2OjJ|M{[yOFY>
SNB75 M3TzeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NE[1eXoxNjBzLUGwNEDPxE1? NHXNZWM1QCCq NXXobYZ[VG:pIFfJOVA:NThwNUigUS=> M1i3d|IzOzN4MkS2
SNB78 NH7ZZWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWKwMlAyNTFyMDFOwG0> MXG0PEBp M1ra[Gxw\yCJSUWwQU05NjZ3IF2= Mkj1NlI{OzZ{NE[=
HCC2998 M2Ds[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWGwMlAyNTFyMDFOwG0> NXLlSI5SPDhiaB?= NGrWWGRNd2diR1m1NF0uQC5yNTDN NYHWXZFkOjJ|M{[yOFY>
KM12 MmTvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mo\LNE4xOS1zMECg{txO M1fHVlQ5KGh? M4fC[Wxw\yCJSUWwQU04NjV2IF2= MmG2NlI{OzZ{NE[=
HT-29 NHP5cphIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEPLRmMxNjBzLUGwNEDPxE1? NF;kW5I1QCCq NWfvZ2w{VG:pIFfJOVA:NTdwN{WgUS=> Ml7vNlI{OzZ{NE[=
HCT15 NFvJW49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmDFNE4xOS1zMECg{txO M3TUXlQ5KGh? NGjUNGtNd2diR1m1NF0uQC5yMzDN Ml7INlI{OzZ{NE[=
HCT116 M1vPSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2niW|AvODFvMUCwJO69VQ>? NEDJPFE1QCCq M3HhUGxw\yCJSUWwQU04NjZzIF2= NX7PcoZCOjJ|M{[yOFY>
NCI-H23 MlXyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlfRNE4xOS1zMECg{txO NXTqeYc2PDhiaB?= M3LLN2xw\yCJSUWwQU04NjZ2IF2= MXiyNlM{PjJ2Nh?=
NCI-H226 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MonxNE4xOS1zMECg{txO NHH0Olk1QCCq NIDIcnhNd2diR1m1NF0uQC52NDDN M2XE[|IzOzN4MkS2
NCI-H522 NFTKV2RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYmwMlAyNTFyMDFOwG0> NFvlfGQ1QCCq M1nMN2xw\yCJSUWwQU05NjR3IF2= MVSyNlM{PjJ2Nh?=
NCI-H438 NUjkWmkyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml64NE4xOS1zMECg{txO MlLEOFghcA>? MXjMc4chT0l3ME2tPE4yOSCP NFX0OGgzOjN|NkK0Oi=>
A549 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M33ZZ|AvODFvMUCwJO69VQ>? NGTvV2k1QCCq MnSyUI9oKEeLNUC9MVgvODdiTR?= M33u[lIzOzN4MkS2
DMS273 NUnHRWdNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1HpfFAvODFvMUCwJO69VQ>? MYi0PEBp NEL6WJVNd2diR1m1NF0uPy56MDDN NG[wfmUzOjN|NkK0Oi=>
DMS114 M{nZfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYiwMlAyNTFyMDFOwG0> NIfCfnY1QCCq NXnxUWF3VG:pIFfJOVA:NThwM{mgUS=> NI\rOWczOjN|NkK0Oi=>
LOXIMVI MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1fXR|AvODFvMUCwJO69VQ>? NILLPGw1QCCq NH\Q[3JNd2diR1m1NF0uQC54NjDN MVOyNlM{PjJ2Nh?=
OVCAR3 NX\k[pBbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1HP[lAvODFvMUCwJO69VQ>? MWO0PEBp MlyzUI9oKEeLNUC9MVgvOTdiTR?= MWKyNlM{PjJ2Nh?=
OVCAR4 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIfqcJUxNjBzLUGwNEDPxE1? MYq0PEBp NF7l[ItNd2diR1m1NF0uQC53ODDN NEnGbZMzOjN|NkK0Oi=>
OVCAR5 MkDIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUCwMlAyNTFyMDFOwG0> NYnMbVlyPDhiaB?= NEX2PWNNd2diR1m1NF0uPy53NzDN M2PhcFIzOzN4MkS2
OVCAR8 NWrIUZVqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1z0UlAvODFvMUCwJO69VQ>? NIHqVGQ1QCCq M4qwUGxw\yCJSUWwQU04Njh2IF2= MXOyNlM{PjJ2Nh?=
SKOV3 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVWwMlAyNTFyMDFOwG0> MUe0PEBp NXezfYtNVG:pIFfJOVA:NThwNEGgUS=> MonYNlI{OzZ{NE[=
RXF631L MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2jZUFAvODFvMUCwJO69VQ>? MYm0PEBp NF;wVW5Nd2diR1m1NF0uQC5{MTDN NH\DcFIzOjN|NkK0Oi=>
ACHN Ml[5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHjSPZoxNjBzLUGwNEDPxE1? MX:0PEBp NEKzbI5Nd2diR1m1NF0uPy57NTDN NWroeHBUOjJ|M{[yOFY>
St-4 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXvWN3hYOC5yMT2xNFAh|ryP M{jkXFQ5KGh? MmXUUI9oKEeLNUC9MVcvPDdiTR?= MVyyNlM{PjJ2Nh?=
MKN1 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVL5T5RlOC5yMT2xNFAh|ryP Ml\lOFghcA>? NVntXnJmVG:pIFfJOVA:NThwNEGgUS=> NESxV3ozOjN|NkK0Oi=>
MKN7 NX7kSYQzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkfzNE4xOS1zMECg{txO M1P3VFQ5KGh? Mn3uUI9oKEeLNUC9MVcvPjhiTR?= Ml7MNlI{OzZ{NE[=
MKN28 MmTjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXLRdHZyOC5yMT2xNFAh|ryP MlfMOFghcA>? Ml7CUI9oKEeLNUC9MVcvODdiTR?= MVuyNlM{PjJ2Nh?=
MKN45 NUnBXYkyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1LIRlAvODFvMUCwJO69VQ>? MnvVOFghcA>? MYTMc4chT0l3ME2tPE4{PCCP MlX2NlI{OzZ{NE[=
MKN74 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEHQfHoxNjBzLUGwNEDPxE1? MlXmOFghcA>? NX7hSGd1VG:pIFfJOVA:NTdwNEKgUS=> NWPTe3N2OjJ|M{[yOFY>
DU145 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYHBXYkyOC5yMT2xNFAh|ryP M3vWbFQ5KGh? Ml3ZUI9oKEeLNUC9MVgvOTZiTR?= MXyyNlM{PjJ2Nh?=
PC3 NHmxWFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEDRboUxNjBzLUGwNEDPxE1? NVr1UWc3PDhiaB?= MnzqUI9oKEeLNUC9MVgvPjZiTR?= M2jVWlIzOzN4MkS2
Trypanosoma brucei brucei MULGeY5kfGmxbjDBd5NigQ>? M2\ldVIxOCCwTR?= MX[xNkBp NGL4NoxFVVOR M{LQPWRm[3KnYYPlJIlvKHCqb4PwbI91cWS7bDDpco9{cXSxbDDwbI9{eGijdHWgcIV3\Wx? MXWyOFgxPTl2Nh?=
Trypanosoma brucei brucei MkX5SpVv[3Srb36gRZN{[Xl? MXqxPEBp MmLlSG1UVw>? NVrnOYZwUW6qaXLpeIlwdiCxZjDy[YNmeHSxcj3t[YRq[XSnZDDlcoRw[3m2b4Ppd{Bie3Onc4Pl[EBieyCmZXPy[YF{\SCrbjD0doFve2[ncoLpckB2eHSja3W= NUXCd5l1OjR6MEW5OFY>
Trypanosoma brucei brucei M1XaXmZ2dmO2aX;uJGF{e2G7 M2jublIxOCCwTR?= MX6xNkBp NEfPVpFFVVOR M1[5[GVn\mWldDDvckB{eGirbnfvcZlt\WmwIHzleoVt NUHGPFV3OjR6MEW5OFY>
Trypanosoma brucei brucei NX7vOpo3TnWwY4Tpc44hSXO|YYm= MYeyNFAhdk1? M{DkV|EzKGh? M2XjPWROW09? MXzF[oZm[3Rib36gdIhwe3CqYYTp[Jlt[2ixbHnu[UBt\X[nbB?= MoHINlQ5ODV7NE[=
UM-UC-3 M3jEPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NG[4bY9KSzVyPUOxOUBxVQ>? MlzvV2FPT0WU
SBC-1 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1;MUGlEPTB;N{SyJJBO M1\LUXNCVkeHUh?=
MKN1 NFrqN3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2m5XGlEPTB;Mj64JI5O NUnMUJVyW0GQR1XS
NCI-H720 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXzJR|UxRTNwNUegcm0> MWPTRW5ITVJ?
BFTC-909 M4\pXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVvTXnBnUUN3ME2zMlcyKG6P M{LhSHNCVkeHUh?=
BPH-1 NVvqeY1{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEPs[plKSzVyPUSuO|Yhdk1? NHHyeVdUSU6JRWK=
PC-3 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MknETWM2OD13LkC5JI5O MojUV2FPT0WU
AN3-CA NGLCXGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHn2W49KSzVyPUWuOVYhdk1? MkTCV2FPT0WU
HN M4LSOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3fvcGlEPTB;NT65OkBvVQ>? NGXufnNUSU6JRWK=
HCC2218 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYDldZkzUUN3ME22MlYyKG6P MnvUV2FPT0WU
KP-4 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX;VZmpuUUN3ME23JI5O NX33d4VVW0GQR1XS
LU-139 MoDUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIfKNppKSzVyPUeuO|chdk1? NHfoN|VUSU6JRWK=
ETK-1 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIH3NWVKSzVyPUeuPFghdk1? M{PpSXNCVkeHUh?=
Ramos-2G6-4C10 M{S3O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mm\GTWM2OD16LkS5JI5O M4roU3NCVkeHUh?=
MHH-PREB-1 NXO0OXd{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnPmTWM2OD17LkGyJI5O NWLxS4UyW0GQR1XS
DU-4475 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4f5ZWlEPTB;OT60OEBvVQ>? MWnTRW5ITVJ?
NCI-H1666 NX3aO403T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml20TWM2OD17LkexJI5O NFLmNFNUSU6JRWK=
CAMA-1 NUO5[YViT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2nIfmlEPTB;OT64JI5O M{Pvb3NCVkeHUh?=
TYK-nu NYfTbHFoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NW\oNZc6UUN3ME25Mlk1KG6P M3;4[nNCVkeHUh?=
MFE-280 NEizVoJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEHiSm1KSzVyPUmuPVkhdk1? MnXVV2FPT0WU
A549 MmfhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVrJR|UxRTFyLkG0JI5O NIi0TpdUSU6JRWK=
769-P MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1PzRWlEPTB;MUCuOFQhdk1? NFruVY1USU6JRWK=
L-363 NVLoUG5CT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUHtSFN5UUN3ME2xNE43QSCwTR?= NGnpd4hUSU6JRWK=
ES8 NXjlPZRXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4LY[mlEPTB;MUCuPUBvVQ>? NF\kWFVUSU6JRWK=
PA-1 NGnMO4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4qzbmlEPTB;MUGuPFIhdk1? MorwV2FPT0WU
Mewo NIf0dIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXLJR|UxRTFzLkm5JI5O MmjYV2FPT0WU
HSC-3 M2Sxc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M362UWlEPTB;MUKuNlEhdk1? M4nld3NCVkeHUh?=
H4 MnnBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn3LTWM2OD1zMj62O{BvVQ>? M1:w[3NCVkeHUh?=
BB65-RCC M2Txfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYfJR|UxRTF{LkeyJI5O NYntUG41W0GQR1XS
NCI-H1793 NELPWWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NInxRYpKSzVyPUGyMlgzKG6P NYO4bJJWW0GQR1XS
KARPAS-45 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX;3[YVzUUN3ME2xN{42OSCwTR?= NVH4U41nW0GQR1XS
GCT NXTQd|h6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFzxNZhKSzVyPUGzMlY5KG6P MVrTRW5ITVJ?
EoL-1 NGjzSI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX:z[ow5UUN3ME2xN{46OyCwTR?= MojIV2FPT0WU
LB2241-RCC MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn\sTWM2OD1zND6wNUBvVQ>? MWrTRW5ITVJ?
ES5 NVn0VnZWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEP2S3NKSzVyPUG0Mlc1KG6P MkHBV2FPT0WU
LOXIMVI M1PEcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoqwTWM2OD1zND65PUBvVQ>? NYe0WGY{W0GQR1XS
COR-L105 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1XhXGlEPTB;MUWuNFQhdk1? Ml\yV2FPT0WU
P12-ICHIKAWA NFLKc2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2TiWmlEPTB;MUWuNUBvVQ>? MX7TRW5ITVJ?
CHL-1 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYrJR|UxRTF3LkS1JI5O M2rnVnNCVkeHUh?=
VMRC-RCZ NYPTPW1OT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHntRlNKSzVyPUG1MlY{KG6P M{\uN3NCVkeHUh?=
HH MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYTJR|UxRTF3Lkegcm0> NV3DTWl{W0GQR1XS
NUGC-3 MmPFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml7NTWM2OD1zNj6zOEBvVQ>? MkHaV2FPT0WU
EGI-1 NGr5RlBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHL1VFBKSzVyPUG2MlQ{KG6P NHTaSW1USU6JRWK=
OS-RC-2 M1PCTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkP4TWM2OD1zNj60O{BvVQ>? NIXKWohUSU6JRWK=
MOLT-16 M13oWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXTJR|UxRTF5LkG1JI5O M4DkOHNCVkeHUh?=
NCI-H209 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFrGcItKSzVyPUG3MlI6KG6P M2HiVnNCVkeHUh?=
697 NUj6PZNpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFrQUHdKSzVyPUG3MlQ{KG6P NGnscmhUSU6JRWK=
D-56MG MnTTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoLTTWM2OD1zNz62PUBvVQ>? NIjoe29USU6JRWK=
VA-ES-BJ NUjmTmoxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1LZb2lEPTB;MUeuPFMhdk1? NFLuXlZUSU6JRWK=
EW-16 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUDJR|UxRTF6LkC0JI5O NULOSJkyW0GQR1XS
HGC-27 MmnvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NE\QTYZKSzVyPUG4MlA3KG6P Mly2V2FPT0WU
ES7 NXPp[nhsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYLId4dMUUN3ME2xPE4xQSCwTR?= NH7HdZRUSU6JRWK=
HuH-7 M4\yfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1zxO2lEPTB;MUiuOEBvVQ>? MlnhV2FPT0WU
BCPAP M{HQb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRTF6Lk[1JI5O MmDNV2FPT0WU
SW1710 NFvLc5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYHTXZd5UUN3ME2xPE44OiCwTR?= Mmj2V2FPT0WU
IST-MEL1 NXzPWm5MT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4\IVmlEPTB;MUiuO|chdk1? NYPyRmZbW0GQR1XS
SF295 NYfyWIlDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmD0TWM2OD1zOD65N{BvVQ>? MojHV2FPT0WU
RPMI-7951 NIXPfFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXvJR|UxRTF7LkK4JI5O MWLTRW5ITVJ?
SF126 MlXVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIPWOW1KSzVyPUG5MlQyKG6P NHLKWGFUSU6JRWK=
GAMG NGHK[5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1[5O2lEPTB;MUmuOFghdk1? M4DuXXNCVkeHUh?=
KNS-81-FD NX63bm53T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1HMcmlEPTB;MUmuOVQhdk1? NFHUeFVUSU6JRWK=
RT-112 NXSxU|d7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnfITWM2OD1zOT62OkBvVQ>? NXXYfZVQW0GQR1XS
DEL MmC2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFLKUpVKSzVyPUKwMlQ6KG6P NGnlS2JUSU6JRWK=
CGTH-W-1 MlmyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4rZT2lEPTB;MkCuOlMhdk1? MXXTRW5ITVJ?
HOS NHvDXVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUjESJBDUUN3ME2yNU4xPiCwTR?= MXfTRW5ITVJ?
ES4 NYPRcJpST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEO1N2dKSzVyPUKxMlA5KG6P NULyZ2w6W0GQR1XS
RXF393 MljkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXPJR|UxRTJzLkS1JI5O M3jjUXNCVkeHUh?=
NCI-H2030 NHfoXlZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGnJPVBKSzVyPUKxMlUzKG6P NYH3Spd{W0GQR1XS
YH-13 NH3LdnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkLVTWM2OD1{MT64PEBvVQ>? NYrQTJd2W0GQR1XS
HT-1080 NI[zbINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlvyTWM2OD1{MT65N{BvVQ>? NYr3N4ZCW0GQR1XS
NCI-SNU-1 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYLJR|UxRTJzLkm1JI5O NXHLdlhvW0GQR1XS
G-402 NHz1U4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGe0NnJKSzVyPUKyMlE3KG6P NUPkRmcyW0GQR1XS
786-0 M1Lxemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkjvTWM2OD1{Mj6yPUBvVQ>? NFewO2JUSU6JRWK=
ME-180 MlLmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXHlbVNRUUN3ME2yNk41OyCwTR?= NXfL[2FVW0GQR1XS
NB69 MmL1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1q1SmlEPTB;MkKuOVMhdk1? MlvzV2FPT0WU
J-RT3-T3-5 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUfTUllxUUN3ME2yNk46PiCwTR?= MlfFV2FPT0WU
TGBC1TKB NY\wRnhqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV\JR|UxRTJ|LkC1JI5O MXfTRW5ITVJ?
SW780 NYjX[ItoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXjJR|UxRTJ|LkGzJI5O NYTWVlBIW0GQR1XS
MG-63 NVvsUFdbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3PabGlEPTB;MkOuOFUhdk1? NFHvdm1USU6JRWK=
BV-173 MlHDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFm0XldKSzVyPUKzMlg4KG6P MVHTRW5ITVJ?
CAL-51 NW\LPHFRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFTIRVFKSzVyPUKzMlg6KG6P M3LvbnNCVkeHUh?=
A375 NWTjWZZPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkXhTWM2OD1{Mz65N{BvVQ>? NE\JcVNUSU6JRWK=
MEL-HO NWHXZ4ZHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX;rU4JKUUN3ME2yOE4xPCCwTR?= MYTTRW5ITVJ?
EFO-27 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWjlZVdbUUN3ME2yOE4{OyCwTR?= Ml6yV2FPT0WU
Hs-578-T NUDnU|UzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXfDVI9wUUN3ME2yOE42QCCwTR?= MVrTRW5ITVJ?
NBsusSR NGHQXHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1fRUWlEPTB;MkSuOkBvVQ>? MnT4V2FPT0WU
CTB-1 M{\qO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXnJR|UxRTJ2Lk[3JI5O NHv6WYtUSU6JRWK=
FTC-133 MnzQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV\JR|UxRTJ3LkGgcm0> MYXTRW5ITVJ?
MOLT-4 M{\acGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVzN[4RLUUN3ME2yOU4yOiCwTR?= NIHDOYRUSU6JRWK=
HO-1-N-1 Ml\TS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1PLWWlEPTB;MkWuNVUhdk1? NIDvcJVUSU6JRWK=
ES3 Mm[3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXXJR|UxRTJ3LkKyJI5O NGTv[nZUSU6JRWK=
TI-73 M3y0Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIfJN49KSzVyPUK1MlI5KG6P MnjlV2FPT0WU
MPP-89 NVvwXFFGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4nINWlEPTB;MkWuN|Ihdk1? NXfhVVR[W0GQR1XS
KYSE-150 MnrOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUDHOlZIUUN3ME2yOU45QSCwTR?= MUDTRW5ITVJ?
LXF-289 MmmzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2PE[mlEPTB;Mk[uNFQhdk1? NUHLRpZnW0GQR1XS
SK-LU-1 NUPvZVFjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoTyTWM2OD1{Nj6xO{BvVQ>? MXnTRW5ITVJ?
HOP-92 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NITBOIhKSzVyPUK2MlQ5KG6P NV3EPGh[W0GQR1XS
HuO9 NHLVUVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVzJR|UxRTJ4Lke2JI5O M2qwcHNCVkeHUh?=
SW962 MnnxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M175VWlEPTB;Mk[uO|Yhdk1? MVLTRW5ITVJ?
RS4-11 M2rVNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnyzTWM2OD1{Nj65NUBvVQ>? MlS5V2FPT0WU
NCI-H292 NIW5NYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUTybZdtUUN3ME2yO{BvVQ>? M2D5cHNCVkeHUh?=
DB MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYrJR|UxRTJ5LkO2JI5O NGWwNIVUSU6JRWK=
SW1088 MmHUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3T6[WlEPTB;MkiuNlkhdk1? MUPTRW5ITVJ?
A204 MlftS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGDEd2NKSzVyPUK4MlQ4KG6P M3P1enNCVkeHUh?=
A3-KAW Mo\pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVLJR|UxRTJ6Lk[0JI5O MmTFV2FPT0WU
MV-4-11 NGfTXmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFTXSJNKSzVyPUK4Mlchdk1? NIS3T|FUSU6JRWK=
ES1 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWP4NlVHUUN3ME2yPE45PCCwTR?= MWDTRW5ITVJ?
ONS-76 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGC1W2pKSzVyPUK5MlA2KG6P Mm\DV2FPT0WU
D-263MG NVHwbo9bT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M170RmlEPTB;MkmuN|Uhdk1? NXvidJhuW0GQR1XS
U-2-OS Mm\YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2LCVGlEPTB;MkmuOUBvVQ>? MnLyV2FPT0WU
T98G NXGycXJHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlW4TWM2OD1{OT64PEBvVQ>? NFiyeJZUSU6JRWK=
GI-ME-N Ml\2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX7JR|UxRTJ7LkmxJI5O NIPCN3lUSU6JRWK=
BHT-101 MmfQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYHJR|UxRTNyLkC1JI5O MVXTRW5ITVJ?
NOS-1 M2\jZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX\jS4p3UUN3ME2zNE4yOiCwTR?= MkfXV2FPT0WU
AsPC-1 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIHUe2xKSzVyPUOwMlIhdk1? MmXzV2FPT0WU
QIMR-WIL NHP2b5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF\CTGVKSzVyPUOwMlYhdk1? MVrTRW5ITVJ?
JVM-3 NXLCUmlvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIPCUmxKSzVyPUOwMlg{KG6P MYXTRW5ITVJ?
KU-19-19 MkX2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHT5WoRKSzVyPUOxMlE{KG6P MYXTRW5ITVJ?
OVCAR-8 NHnDSpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmjETWM2OD1|MT6yOkBvVQ>? NWTyZlFDW0GQR1XS
BEN NHjJN3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEPsOHpKSzVyPUOxMlY{KG6P Mm[1V2FPT0WU
BE-13 NFe1dHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4\hT2lEPTB;M{GuPFIhdk1? NE\ZSJZUSU6JRWK=
EW-18 NHm3c3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVvJR|UxRTNzLki2JI5O Moe4V2FPT0WU
ECC10 MlzsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXXJR|UxRTNzLkm1JI5O MY\TRW5ITVJ?
CTV-1 MknmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUfqS29yUUN3ME2zNk45OiCwTR?= NXOxOHozW0GQR1XS
COLO-800 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFXhW2VKSzVyPUOyMlkzKG6P NGDjWoxUSU6JRWK=
A2058 MnG0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGriVFVKSzVyPUOzMlI2KG6P NY\UW4Y{W0GQR1XS
VM-CUB-1 M4\mPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFfP[I1KSzVyPUOzMlQ{KG6P NXnaXZlWW0GQR1XS
Ca9-22 M{[zb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUDJR|UxRTN|LkW1JI5O MWHTRW5ITVJ?
COLO-684 NYTpWXA3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{TOVWlEPTB;M{OuOVghdk1? MVjTRW5ITVJ?
RPMI-8226 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnXMTWM2OD1|Mz64NkBvVQ>? MUTTRW5ITVJ?
SK-NEP-1 NXzDe4p5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3O0ZmlEPTB;M{SuNVUhdk1? NFqwSlNUSU6JRWK=
Becker M2XFSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWnOU413UUN3ME2zOE4zOSCwTR?= MkK0V2FPT0WU
NCI-H28 MljRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3nzW2lEPTB;M{SuOFQhdk1? M133VnNCVkeHUh?=
CAL-120 NUfVTJRUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1npTmlEPTB;M{SuO|Ihdk1? MlnzV2FPT0WU
MDA-MB-157 NGfLXFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1zycWlEPTB;M{WuOFEhdk1? NIXkXI9USU6JRWK=
OVCAR-5 NVPhPZV[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4XYN2lEPTB;M{WuOFchdk1? MYPTRW5ITVJ?
LAMA-84 NH21OYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmL1TWM2OD1|NT64O{BvVQ>? MoG5V2FPT0WU
CAKI-1 NUHPb2JJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVPJR|UxRTN4LkSzJI5O MoPUV2FPT0WU
Daoy MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mlq4TWM2OD1|Nj63JI5O NIe4ZYFUSU6JRWK=
CAL-62 NHPBS3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUfJR|UxRTN4Lki2JI5O M3;0U3NCVkeHUh?=
8-MG-BA MkexS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml7NTWM2OD1|Nz6yOUBvVQ>? M3\nXnNCVkeHUh?=
8505C Mnv0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGnr[o5KSzVyPUO3MlUyKG6P NGj2TnJUSU6JRWK=
LNCaP-Clone-FGC NVXjUWlzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2HHeGlEPTB;M{euOVkhdk1? NV3tfFdiW0GQR1XS
CAL-39 M3zqSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXzJR|UxRTN5Lkmgcm0> NYHteXFtW0GQR1XS
MN-60 NHLX[4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3L5ZmlEPTB;M{euPVYhdk1? Mn3kV2FPT0WU
RKO M2rMNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmDnTWM2OD1|OD6zN{BvVQ>? MUPTRW5ITVJ?
U251 NFLEc5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mm\wTWM2OD1|OD60N{BvVQ>? NH;p[nZUSU6JRWK=
SJSA-1 NGriZnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXS4ZnJUUUN3ME2zPE42PCCwTR?= MXfTRW5ITVJ?
CAL-12T MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1nt[WlEPTB;M{iuOkBvVQ>? NUnoWWtzW0GQR1XS
HCC1419 NInNN2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUjibHB[UUN3ME2zPE44OSCwTR?= MVLTRW5ITVJ?
CO-314 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoX4TWM2OD1|OD63OEBvVQ>? M1TH[nNCVkeHUh?=
LB1047-RCC M3PCNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWjJR|UxRTN6LkixJI5O M{\ESHNCVkeHUh?=
A101D MnPqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYnJR|UxRTN6Lkm3JI5O M{\TfXNCVkeHUh?=
MDA-MB-175-VII Ml\hS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYXaXJZ6UUN3ME2zPU42OSCwTR?= M1fnS3NCVkeHUh?=
MZ2-MEL MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWPJR|UxRTN7Lk[2JI5O M3;PVHNCVkeHUh?=
NB5 MmLXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1\Z[2lEPTB;NECuOlQhdk1? NWSwc4l6W0GQR1XS
G-401 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnzqTWM2OD12MD64NkBvVQ>? NF\IV3RUSU6JRWK=
HT M3TPPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIH1d2dKSzVyPUSxMlAzKG6P NYTLe5ZGW0GQR1XS
8305C MkK3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmLITWM2OD12MT64O{BvVQ>? NF;KNJVUSU6JRWK=
BHY NUe1cmQ{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX3pPVM{UUN3ME20Nk44OiCwTR?= MUXTRW5ITVJ?
NTERA-S-cl-D1 NFHZeI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{POb2lEPTB;NEOgcm0> NWPNZZpxW0GQR1XS
T-24 MmXOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIDoOmxKSzVyPUSzMlg{KG6P NEe1Z2VUSU6JRWK=
EPLC-272H M1jCb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1;VTGlEPTB;NESuN|khdk1? Mn;6V2FPT0WU
PSN1 M3XhSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2PBVmlEPTB;NESuOEBvVQ>? NWK2dI9kW0GQR1XS
NCI-H2452 NEn2clJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUnJR|UxRTR2LkW4JI5O M3XVSHNCVkeHUh?=
KS-1 M3f5R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEWzbHNKSzVyPUS0MlY3KG6P M2XqdHNCVkeHUh?=
HD-MY-Z NVXVXG9FT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUKyNZlIUUN3ME20OE46OiCwTR?= M{\Ue3NCVkeHUh?=
KNS-62 NF\IU2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnSwTWM2OD12NT6zPEBvVQ>? NGfqSItUSU6JRWK=
NOMO-1 NYfrRXNVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2nabGlEPTB;NEWuPFchdk1? NYPGOJV4W0GQR1XS
SK-HEP-1 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYXCbGxYUUN3ME20Ok4xPCCwTR?= MoTnV2FPT0WU
IGR-1 M{jSOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGP1O4tKSzVyPUS2MlE{KG6P MmGxV2FPT0WU
KYSE-180 M1PnSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXTJR|UxRTR4LkG3JI5O MXHTRW5ITVJ?
EW-22 M1PWZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWjkXHJSUUN3ME20Ok4zKG6P NWDxWXZmW0GQR1XS
NCI-H1355 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmPzTWM2OD12Nj6zOEBvVQ>? NIroOnNUSU6JRWK=
DOHH-2 NIrOWINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUGzWW94UUN3ME20Ok4{PyCwTR?= MlHUV2FPT0WU
A4-Fuk NIPTS4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEPlVlBKSzVyPUS2MlUzKG6P NH;XWGxUSU6JRWK=
PC-14 NH\se4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoqzTWM2OD12Nj61O{BvVQ>? MnXOV2FPT0WU
TE-5 Mn3kS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYDJR|UxRTR4Lki0JI5O M2jNb3NCVkeHUh?=
LB996-RCC M2ToZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1TrUmlEPTB;NEeuNVkhdk1? MlfMV2FPT0WU
NCI-H1623 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXrJR|UxRTR5Lke2JI5O NGHPXnNUSU6JRWK=
NCI-H1155 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUDGV4U6UUN3ME20PE4{OiCwTR?= NFXXcJdUSU6JRWK=
LoVo M33rVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1jPd2lEPTB;NEiuOEBvVQ>? MnvaV2FPT0WU
MCF7 Ml:4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYLobllxUUN3ME20PE42QCCwTR?= MnnKV2FPT0WU
AGS M37VUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWnJR|UxRTR6Lke3JI5O NFz1[plUSU6JRWK=
PFSK-1 NYPuOFdLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXTJR|UxRTR7LkC2JI5O NWLyXFJrW0GQR1XS
22RV1 NIHWfYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3\wOmlEPTB;NEmuNFkhdk1? MYHTRW5ITVJ?
COR-L23 NI\OVW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVHJR|UxRTR7LkG2JI5O M3q3V3NCVkeHUh?=
D-283MED MljqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVrJR|UxRTR7Lk[xJI5O MYHTRW5ITVJ?
SW982 M2e2T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEPpV4ZKSzVyPUS5MlkyKG6P Mn20V2FPT0WU
SW620 NYLnb4pbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHXxfJZKSzVyPUWwMlM3KG6P MmP6V2FPT0WU
KYSE-140 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWTRWoRjUUN3ME21NE42PSCwTR?= M1rsVXNCVkeHUh?=
GCIY NX;hbXd2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVTMO4xNUUN3ME21NE43PyCwTR?= MoC0V2FPT0WU
MHH-ESS-1 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV7JR|UxRTVzLkm1JI5O M3;rUnNCVkeHUh?=
D-423MG NW\HcWY5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3XaPGlEPTB;NUKuNFghdk1? MXvTRW5ITVJ?
SF539 NHPxdFlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoLuTWM2OD13Mj6zOUBvVQ>? Mn7vV2FPT0WU
RPMI-2650 M4jBeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkjrTWM2OD13Mj62PUBvVQ>? MUTTRW5ITVJ?
GR-ST NIn0TlZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M33ZdWlEPTB;NUKuPFchdk1? MUDTRW5ITVJ?
YKG-1 M3zx[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWPIe4hCUUN3ME21N{BvVQ>? MnXKV2FPT0WU
SK-MES-1 NXfSc3hyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoDwTWM2OD13Mz6yOkBvVQ>? MkTuV2FPT0WU
HLE NH71UVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGLBWo9KSzVyPUWzMlQ4KG6P MVLTRW5ITVJ?
RVH-421 M{fnemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFrmcVVKSzVyPUWzMlY4KG6P NFjhSmdUSU6JRWK=
C32 NH7S[lNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWTSSIdtUUN3ME21N{45OyCwTR?= MWLTRW5ITVJ?
GB-1 NHHMd41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3;ZR2lEPTB;NUSuNkBvVQ>? NX\rRnFMW0GQR1XS
SNB75 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUnJR|UxRTV2LkK2JI5O MVfTRW5ITVJ?
EM-2 MoD4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoHOTWM2OD13ND60JI5O MYXTRW5ITVJ?
RH-1 NV;RPINJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYjuU3NOUUN3ME21OE44KG6P MWTTRW5ITVJ?
NKM-1 NF;zdG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1jlRWlEPTB;NUSuPFEhdk1? MV3TRW5ITVJ?
NCI-H2405 MmHmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MY\JR|UxRTV2Lki4JI5O M3zVSHNCVkeHUh?=
KYSE-450 M2W1ZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWrJR|UxRTV3LkG2JI5O M{TE[XNCVkeHUh?=
A704 NXfYRVhDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1TSVGlEPTB;NUWuOVkhdk1? MnLnV2FPT0WU
HAL-01 NHS1NnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1vsOGlEPTB;NUWuPFMhdk1? NEnhO5RUSU6JRWK=
TE-11 MkjaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV3JR|UxRTV3Lkm5JI5O MlWyV2FPT0WU
DOK MmW5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHT6UmVKSzVyPUW2MlAzKG6P M3HTOnNCVkeHUh?=
KY821 M3L2[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYS0PJAzUUN3ME21Ok4zKG6P M1jiPHNCVkeHUh?=
KGN M{npcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHiwSWJKSzVyPUW2MlMzKG6P MlvHV2FPT0WU
MC116 M{[5cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmC5TWM2OD13Nz64JI5O NHrz[WpUSU6JRWK=
PANC-08-13 NXLzTIpCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn\1TWM2OD13OD6wNUBvVQ>? NHvmV|ZUSU6JRWK=
KE-37 NUPjZZZDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH;TZpRKSzVyPUW4Mlc4KG6P M1m5cHNCVkeHUh?=
KYSE-410 NX7QcYFCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUHJR|UxRTV7LkS3JI5O MYnTRW5ITVJ?
RO82-W-1 NXnxSYV5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWrJR|UxRTV7Lkmgcm0> NGPhVo5USU6JRWK=
M14 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF3MZm9KSzVyPU[wMlA1KG6P M2nGcHNCVkeHUh?=
GI-1 NY\3eXBsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoX4TWM2OD14MD6zJI5O M2fZbXNCVkeHUh?=
ML-2 MlrsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWjobnNDUUN3ME22NE43OiCwTR?= NXPtOYlXW0GQR1XS
BFTC-905 M2XRZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGfPZXJKSzVyPU[wMlY2KG6P MonjV2FPT0WU
DMS-273 M32xd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn3zTWM2OD14MD64O{BvVQ>? NVTjSolYW0GQR1XS
MDA-MB-361 M2rKZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHPZbHdKSzVyPU[xJI5O M{XhT3NCVkeHUh?=
MSTO-211H MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGHyW2hKSzVyPU[zMlUyKG6P NWj3[pNDW0GQR1XS
MEG-01 NHzVUJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1;RSWlEPTB;NkOuOVIhdk1? MkewV2FPT0WU
M059J MlXpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYrJR|UxRTZ|LkW4JI5O MnrsV2FPT0WU
LN-405 NVSxWIh[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUTJR|UxRTZ|Lki1JI5O NEK1cVFUSU6JRWK=
NCI-H1581 M3e0RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2jEO2lEPTB;NkSuNFMhdk1? M1fJcXNCVkeHUh?=
TCCSUP MnvyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX3hPXZ6UUN3ME22OE42OyCwTR?= NH:yT3VUSU6JRWK=
SW872 M3v6fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFLmVXhKSzVyPU[0MlU4KG6P M1PofXNCVkeHUh?=
KYSE-510 NHe0XmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVPJR|UxRTZ3Lke1JI5O M{\IVHNCVkeHUh?=
NCI-H1792 NV\BTVI3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4XKeWlEPTB;Nk[uNVUhdk1? M4\OcnNCVkeHUh?=
SW13 NEe0flVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1TlNGlEPTB;Nk[uOUBvVQ>? M1PhRnNCVkeHUh?=
TE-8 NUHM[XRQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoDTTWM2OD14Nj61NkBvVQ>? NEj5bXJUSU6JRWK=
SCH MofXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mmq4TWM2OD14Nz6xJI5O NXHLR5ZPW0GQR1XS
NEC8 M3;6UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnvpTWM2OD14Nz6yOEBvVQ>? NEjic4pUSU6JRWK=
HuO-3N1 NITzPFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NInieGlKSzVyPU[3MlMyKG6P NV7oVGVpW0GQR1XS
EFM-19 M1;UT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYqxcpN6UUN3ME22O{42KG6P MWTTRW5ITVJ?
HEC-1 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3PiSWlEPTB;NkeuOVIhdk1? M4f0THNCVkeHUh?=
T47D NIDW[|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mli4TWM2OD14Nz64O{BvVQ>? NFjLN2xUSU6JRWK=
SNU-423 MoXnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4WySmlEPTB;NkeuPVghdk1? NVfuNIxxW0GQR1XS
WM-115 Mof0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVjwRVNbUUN3ME22PE4yPCCwTR?= NVXQc3J6W0GQR1XS
CaR-1 MlfSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWXJR|UxRTZ6LkK1JI5O NHL5XG1USU6JRWK=
KU812 MkD6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlOwTWM2OD14OD62PUBvVQ>? M1[3OXNCVkeHUh?=
AM-38 M4PLWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIDJW41KSzVyPU[5MlMyKG6P M3\JR3NCVkeHUh?=
KOSC-2 NEHpdGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnfVTWM2OD14OT65O{BvVQ>? M1LMVXNCVkeHUh?=
MC-IXC NYi5ZZhIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEjwNGdKSzVyPUewMlA5KG6P NVrrO|VQW0GQR1XS
SCC-4 NYnJNHZ2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGTtcoNKSzVyPUexMlM5KG6P MYTTRW5ITVJ?
Calu-3 MmPkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWjFcoF7UUN3ME23NU46QCCwTR?= Mn;2V2FPT0WU
RPMI-8866 NF[4SodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmXhTWM2OD15Mj64NkBvVQ>? MmTpV2FPT0WU
OVCAR-4 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUjWcVZyUUN3ME23N{4{PiCwTR?= M1q5[3NCVkeHUh?=
OAW-42 M1juSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWnJR|UxRTd|LkO5JI5O M1XyUHNCVkeHUh?=
ATN-1 NGq2XXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEn5NIdKSzVyPUezMlg4KG6P MkDNV2FPT0WU
CHP-212 MoTlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYLJR|UxRTd2Lkm1JI5O MoT4V2FPT0WU
C2BBe1 NWLJWYN1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MY\JR|UxRTd3LkCzJI5O MoflV2FPT0WU
A498 MnG5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHv1Z49KSzVyPUe1MlE2KG6P M3HtZnNCVkeHUh?=
SH-4 NYPSXnVmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEXtboJKSzVyPUe1MlIyKG6P MXrTRW5ITVJ?
SNU-449 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn;GTWM2OD15NT63PUBvVQ>? NUXx[pRFW0GQR1XS
RD NH2w[ZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M13leWlEPTB;N{WuPFYhdk1? M{DlVnNCVkeHUh?=
PANC-03-27 NYjET5Y1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1fDZmlEPTB;N{[uNlUhdk1? NHzNRVRUSU6JRWK=
S-117 M1zGWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2SwU2lEPTB;N{[uNlchdk1? NXvWTll6W0GQR1XS
SK-MEL-2 M170Rmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHLaUYNKSzVyPUe2Mlc2KG6P NIXNZm9USU6JRWK=
LK-2 NU\I[ndsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVTJR|UxRTd5LkC1JI5O MX;TRW5ITVJ?
CP50-MEL-B MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkL4TWM2OD15Nz60JI5O M{DsdnNCVkeHUh?=
647-V M4G4SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkHPTWM2OD15OD6wO{BvVQ>? NEjFOppUSU6JRWK=
LU-134-A NE\4bWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnTCTWM2OD15OT6wN{BvVQ>? M1rL[3NCVkeHUh?=
5637 NFHybXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1ToeGlEPTB;N{muNlMhdk1? MUHTRW5ITVJ?
NCI-H1437 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkHwTWM2OD16MD61JI5O NGfONINUSU6JRWK=
NCI-H460 Mk\nS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M130RmlEPTB;OEGuNlMhdk1? NGrEbWRUSU6JRWK=
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OAW-28 M4m4[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYTFSZh7UUN3ME2yMlA3QTF7IN88US=> MofBV2FPT0WU
C8166 NUXPN2VVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MULJR|UxRTJwNkOzPVIh|ryP M1r4VXNCVkeHUh?=
COLO-678 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NInjd|JKSzVyPUKuPFM4PjhizszN NVjoS5JYW0GQR1XS
SK-N-DZ Mn\BS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV;5NnhMUUN3ME2yMlg3OzhzIN88US=> M3T4XXNCVkeHUh?=
NCI-H82 NVPnW2h3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4O3eGlEPTB;Mj65NFM3QSEQvF2= M4nofnNCVkeHUh?=
JVM-2 Mlz2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH3YdnRKSzVyPUOuNFMyQDhizszN MWPTRW5ITVJ?
SW1116 MnrTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFroRnZKSzVyPUOuNFU1OTFizszN NG\5enFUSU6JRWK=
MDA-MB-453 NHTRWGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUHJR|UxRTNwMUC0N|kh|ryP M4nieXNCVkeHUh?=
Calu-6 NWjOO4hFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkT5TWM2OD1|LkG5PVch|ryP NWrrfGp4W0GQR1XS
SHP-77 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVjqTZdSUUN3ME2zMlUzQCEQvF2= NG\ne45USU6JRWK=
Capan-2 NHH3RlJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1HJcGlEPTB;ND6zNlU5OSEQvF2= MWDTRW5ITVJ?
SW948 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4PDcGlEPTB;ND63OFc4QSEQvF2= NFrFPIpUSU6JRWK=
HDLM-2 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYXJR|UxRTVwMEe3NlUh|ryP M2PUcXNCVkeHUh?=
LAN-6 NH\Q[mhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1j3OmlEPTB;Nj6yNVQ6PSEQvF2= MV\TRW5ITVJ?
LU-135 NILkNXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYLwRlhPUUN3ME22MlQ{ODd5IN88US=> NYjWbmJRW0GQR1XS
T84 NH\OboJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTZwOUi2OEDPxE1? Mm\0V2FPT0WU
CAPAN-1 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUnMTos3UUN3ME23MlYzOjN|IN88US=> NHLsSHNUSU6JRWK=
SW1417 MmPKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3fKfGlEPTB;Nz65NVc{OSEQvF2= Ml\OV2FPT0WU
BALL-1 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWDMcWNmUUN3ME24MlUxPDB7IN88US=> MUXTRW5ITVJ?
HT-29 M{jTRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGPkXZhKSzVyPUmuNFc2QTlizszN MWjTRW5ITVJ?
C3A MmDJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3\Oc2lEPTB;OT64PFM6PCEQvF2= NETTfIJUSU6JRWK=
NCI-H1993 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3LFe2lEPTB;MUCuOVA5OSEQvF2= NXn0b5A4W0GQR1XS
SK-MEL-1 NILr[mJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX3JR|UxRTFzLk[yPFkh|ryP NHfubXpUSU6JRWK=
DU-145 NGryTpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH3WSnFKSzVyPUG0MlUxPTJizszN MmnSV2FPT0WU
KP-N-YN MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFf2eZVKSzVyPUG0MlUyODNizszN NHzo[YFUSU6JRWK=
CCRF-CEM NVziTGszT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NE\sO5VKSzVyPUG0Mlc5ODlizszN MnmyV2FPT0WU
ZR-75-30 M3TOeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXWwcWp[UUN3ME2xOk4{OzB|IN88US=> NU\GSHVFW0GQR1XS
A673 NH\3cnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mkn0TWM2OD1{MD61OVA4KM7:TR?= M4e0SXNCVkeHUh?=
K-562 NVXGeGxkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4nROGlEPTB;MkiuOFE5OyEQvF2= NXj6OXRVW0GQR1XS

... Click to View More Cell Line Experimental Data

In vivo BEZ235 induces regression of the tumors (69%) without statistically significant effect on body weight gain. Altogether, these preliminary in vivo efficacy results show that BEZ235 causes disease stasis when administered orally as a single agent and can enhance the efficacy of other anticancer agents when used in combination studies. [1]

Protocol

Kinase Assay:

[1]

+ Expand

In vitro Protein Kinase, PI3K, and mTOR Assays:

PI3Kα, β, and δ proteins are composed of the iSH2 domain of p85 NH2-terminally fused to the full-length protein p110 protein, with the exception of α that also does not contain the last 20 amino acids. PI3Kγ is produced as full-length protein deleted for its first 144 amino acids. All constructs are fused to a COOH-terminal His tag for convenient purification and then cloned into the pBlue-Bac4.5 (for α, β, and δ isoforms) or pVL1393 (for γ isoform) plasmids. The different vectors are then cotransfected with BaculoGold WT genomic DNA using methods recommended by the vendor for production of the respective recombinant baculoviruses and proteins. BEZ235 are tested for their activity against PI3K using a Kinase-Glo assay. The kinase reaction is done in 384-well black plate. Each well is loaded with 50 μL of test items (in 90% DMSO) and 5 μL reaction buffer containing 10 μg/mL PI substrate (l-α-phosphatidylinositol; Avanti Polar Lipids; prepared in 3% octyl-glucoside) and the PI3K proteins (10, 25, 10, and 150 nM of p110α, p110β, p110δ, and p110γ, respectively) are then added to it. The reaction is started by the addition of 5 μL of 1 μM ATP prepared in the reaction buffer and is incubated for either 60 (for p110α, p110β, and p110δ) or 120 min (for p110γ). It is terminated by the addition of 10 μL Kinase-Glo buffer. The plates are then read in a Synergy 2 reader for luminescence detection.
Cell Research:

[2]

+ Expand
  • Cell lines: HCT116, DLD-1 and SW480 cells
  • Concentrations: 0-1 μM
  • Incubation Time: 48 hours
  • Method:

    The human CRC cell lines, HCT116 (PIK3CA mutant; kinase domain at H1047R), DLD-1 (PIK3CA mutant; helical domain at E545K), and SW480 (PIK3CA wild-type) and isogenic DLD-1 PIK3CA mutant as well as wild-type cells are maintained in DMEM with 10% FBS and 1 × Penicillin/Streptomycin. Cells are plated at different initial densities (HCT116: 3 × 103 cells/well, DLD-1: 5.5 × 103 cells/well, SW480: 4.5 × 103 cells/well, DLD-1 PIK3CA mutant: 7 × 103 cells/well, and DLD-1 PIK3CA wild-type: 9 × 103 cells/well) to account for differential growth kinetics. After 16 hours, cells are incubated with increasing concentrations of BEZ235, and the drug-containing growth medium is changed every 24 hours. Cell viability is assessed 16 hours after the initial plating and 48 hours after initiation of drug treatment using the colorimetric MTS assay CellTiter 96® AQueous One Solution Cell Proliferation Assay, as per the manufacturer's instructions. Cell viability after drug treatment is normalized to that of untreated cells also grown for 48 hours. For western blot analysis, cells are plated with zero or maximum inhibitory dose (500 nM) BEZ235 for 2, 6, 24, or 48 hours.


    (Only for Reference)
Animal Research:

[1]

+ Expand
  • Animal Models: Female Harlan athymic nude mice
  • Formulation: NMP/polyethylene glycol 300 (10/90, v/v)
  • Dosages: 45 mg/kg
  • Administration: p.o.
    (Only for Reference)

Solubility (25°C)

In vitro DMF 18 mg/mL warmed (38.33 mM)
DMSO 0.01 mg/mL (0.02 mM)
Water Insoluble
In vivo Add solvents individually and in order:
NMP+polyethylene glycol 300 (10+90, v+v)
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 469.55
Formula

C30H23N5O

CAS No. 915019-65-7
Storage powder
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

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Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

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Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00620594 Completed Breast Cancer|Advanced Solid Tumors|Cowden Syndrome Novartis Pharmaceuticals|Novartis December 21, 2006 Phase 1
NCT01856101 Terminated Carcinoma Transitional Cell Cliniques universitaires Saint-Luc- Université Catholique de Louvain|Novartis February 2013 Phase 2
NCT01717898 Terminated Castrate-resistant Prostate Cancer Patients. Charles Ryan|Novartis Pharmaceuticals|University of California, San Francisco January 2013 Phase 1|Phase 2
NCT01658436 Completed Pancreatic Neuroendocrine Tumors (pNET) Novartis Pharmaceuticals|Novartis November 2012 Phase 2
NCT01628913 Terminated Pancreatic Neuroendocrine Tumors (pNET) Novartis Pharmaceuticals|Novartis October 2012 Phase 2
NCT01690871 Withdrawn Malignant PEComa (Perivascular Epithelioid Cell Tumors) Novartis Pharmaceuticals|Novartis September 2012 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    With difficulties in dissolving BEZ235, How can I improve its solubility?

  • Answer:

    For in vivo study, we suggest the vehicle solution NMP/polyethylene glycol 300 (10/90, v/v). Please dissolve BEZ235 in NMP as more as possible. You can sonicate and warm it in water bath for a while. Then dilute with PEG 300.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID