Dactolisib (BEZ235, NVP-BEZ235)

Catalog No.S1009

Dactolisib (BEZ235, NVP-BEZ235) Chemical Structure

Molecular Weight(MW): 469.55

Dactolisib (BEZ235, NVP-BEZ235) is a dual ATP-competitive PI3K and mTOR inhibitor for p110α/γ/δ/β and mTOR(p70S6K) with IC50 of 4 nM /5 nM /7 nM /75 nM /6 nM in cell-free assays, respectively. Inhibits ATR with IC50 of 21 nM in 3T3TopBP1-ER cell.

Size Price Stock Quantity  
USD 110 In stock
USD 170 In stock

Free Overnight Delivery on orders over $ 500
Next day delivery by 10:00 a.m. Order now.

Cited by 78 Publications

8 Customer Reviews

  • Relative kinase activities of p110α mutants and the inhibitory effect of PI3K inhibitors against hotspot mutants of p110α. A, recombinant FLAG-tagged PI3K p110α/p85α protein complex produced in 293T cells was immunoprecipitated , and the immunoprecipitates were used for the quantitative PI3K-HTRF assay (32).

    B, effect of three PI3K inhibitors (ZSTK474, LY294002, and NVP-BEZ235) on the enzymatic activity of two hotspot mutants (E545K and H1047R) p110α compared with the wild-type. No striking difference was observed in the IC50 concentrations of these inhibitors between wild-type and mutant p110α.
     

     

    Cancer Res 2010 70, 4982-4994. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

    A, ANOVA of IC50 values of the dual PI3K/mTOR inhibitor NVP-BEZ235 in 23 melanoma cell lines showing no significant difference in sensitivity to this compound in B-Raf mutant and Braf wild-type cells. B, decreases in pAkt and pP70S6K in a dose and time-dependent fashion in 2 melanoma cell lines treated with NVP-BEZ235. pP70S6K levels are undetectable at all concentrations and time points studied, whereas levels of pAkt start rising again after 4 hours of drug exposure in a dose-dependent fashion. C, clonogenic assays in 2 melanoma cell lines (YUVON and YUSIK) treated with NVP-BEZ235 at different concentrations. NVPBEZ235 was effective in inhibiting colony formation at low nanomolar concentrations.

    Clin Cancer Res 2010 16, 6029-6039. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

  • Three-dimensional responses of MCF7/IGF-1R cells to TAM (1 μM), E2 and IGF-1. Compared to parental MCF7 cells (a), MCF7/IGF-1R cells (b) in three-dimensional (3D) culture formed bigger acini in response to IGF-1 stimulation and displayed significant TAM resistance when treated with TAM (1 μM) + E2 + IGF-1, which was removable by kinase inhibitors BMS-536924, U0126 and BEZ235 (c). Cells (10,000/well) were seeded in 96-well plates. Acini were formed on 100% Matrigel and cultured for 14 days in starving medium containing 2% Matrigel and 5% charcoal/dextran-stripped fetal bovine serum with the treatments as indicated. Concentrations used: TAM (1 μM), E2 (1 nM) and IGF-1 (100 ng/mL). Confocal image original magnification, × 20. Red, rhodamine phalloidin (actin). Blue, Hoechst blue stain. Results are representative of two individual experiments.

    Breast Cancer Res 2011 13, R52. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

    TAM (10 nM) agonistic behavior in MCF7/IGF-1R cells is not inhibited by phosphatidylinositol 3-kinase/Akt inhibitor BEZ235. (a) Inhibitory effects of kinase inhibitors BMS-536924, U0126 and BEZ235 on agonistic effect of TAM (10 nM) in the presence of IGF-1 (100 ng/mL). **P < 0.01. (b) Inhibitory effects of phosphatidylinositol 3-kinase (PI3K)/Akt inhibitor BEZ235 at various dose ranges on IGF-1R signaling. (c) Agonistic behavior of TAM (10 nM) in response to BEZ235 kinase inhibitor. (-), no BEZ235. Results are representative of three independent experiments. Data are expressed as means ± SD.

    Breast Cancer Res 2011 13:R52. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

  • ZSTK474 and GDC-0941 selectively inhibit class I PI3K over mTOR. (A) Inhibition profiles of the selected five PI3K inhibitors for mTOR. Data shown are mean±SD (n = 3), representative of 2 or 3 independent experiments. (B) IC50 values of the PI3K inhibitors for mTOR. (C) Selectivity of each PI3K inhibitor for PI3Ka over mTOR. The selectivity index is expressed as the ratio of the IC50 value for mTOR over that for PI3Ka. The IC50 values of ZSTK474, NVP-BEZ235 and LY294002 for PI3Ka are 0.016, 0.007 and 0.6 μM, respectively, as reported previously by us.

     

     

    Eur J Cancer 2010 46, 1111-1121. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

     After starved in serum-free medium for 24h,breast cancer cells incubated with the indicated concentrations of BEZ235 for 3h,followed by 20-minute  stimulation of 100ng/ml EGF.

     

     

     

    Dr. Zhang of Tianjin Medical University. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

  • After starved in serum-free medium for 24h,breast cancer cells incubated with the indicated concentrations of BEZ235 for 3h,followed by 20-minute  stimulation of 100ng/ml EGF.

     

     

    Dr. Zhang of Tianjin Medical University. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

     

    FIG. 4. Phospholipase A2 group 4A (PLA2G4A) expression was increased after BEZ235 treatment in basal-like xenografts. The bar graph shows the quantification of the immunoblots (mean±SD). PLA2G4A, Ethanolamine kinase 1 and 2 (ETNK1/2), Choline kinase alpha/beta (ChoKA/B), and β-actin protein expression were examined by immunoblotting of tissue samples after MRS experiments [control group (n= 5) and BEZ235-treated group (n=7)]. This demonstrated a higher expression of PLA2G4A protein ( P=0.005), but no changes in ETNK1 and ChoKA/B in samples from basal-like xenografts treated with BEZ235.

    Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

Purity & Quality Control

Choose Selective PI3K Inhibitors

Click to view more

Notes:

2. For more details, such as half maximal inhibitory concentrations (IC50s) and working concentrations of each inhibitor, please click on the link of the inhibitor of interest.
3. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation.
4. Orange "√" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

Biological Activity

Description Dactolisib (BEZ235, NVP-BEZ235) is a dual ATP-competitive PI3K and mTOR inhibitor for p110α/γ/δ/β and mTOR(p70S6K) with IC50 of 4 nM /5 nM /7 nM /75 nM /6 nM in cell-free assays, respectively. Inhibits ATR with IC50 of 21 nM in 3T3TopBP1-ER cell.
Targets
p110α [1]
(Cell-free assay)
p110γ [1]
(Cell-free assay)
mTOR (p70S6K) [1]
(Cell-free assay)
p110δ [1]
(Cell-free assay)
ATR [8]
(3T3TopBP1-ER cells)
4 nM 5 nM 6 nM 7 nM 21 nM
In vitro

BEZ235 significantly reduces the phosphorylation levels of the mTOR activated kinase p70S6K. BEZ235 results in a reduction of S235/S236P-RPS6 levels with IC50 of 6.5 nM. The activity of BEZ235 against mTOR is determined using a biochemical mTOR K-LISA assay with IC50 of 20.7 nM. BEZ235 shows slightly lower activity against its β paralogue with IC50 of 75 nM. The PI3K/Akt/mTOR pathway is often constitutively activated in human tumor cells. BEZ235 blocks PI3K and mTOR kinase activity by binding to the ATP-binding cleft of these enzymes. Both PTEN-null cell lines PC3M and U87MG show a dose-dependent reduction in cell proliferation when treated with increasing concentrations of BEZ235 with an average GI50 of 10-12 nM. [1] BEZ235 is an mTORC1/2 catalytic inhibitor. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Trypanosoma brucei brucei MmPkRY51cW2rY4LvZolidCCDc4PhfS=> MoTlNVghcA>? NVHGcmpKTE2VTx?= MorvRY51cXS{eYDhco9{d22jbDDhZ5Rqfmm2eTD3bZRpKEWFNUCgc4YhOC5yMEK1JO69VQ>? MlH5NlQ5ODV7NE[=
MCF7 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NULucJhJOC5yMT2xNFAh|ryP M4r1eFQ5KGh? MWXEUXNQ NF30PVhKSzVyPUCuO|Mh|ryP MXuyN|g4OTlyNB?=
HCT116 MlnRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVywMlAyNTFyMDFOwG0> M3z3VVQ5KGh? Ml\kSG1UVw>? MV7JR|UxRTFwMU[g{txO NUf5Nm5wOjN6N{G5NFQ>
U87MG MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYWwMlAyNTFyMDFOwG0> M3rscFQ5KGh? MVHEUXNQ MWXJR|UxRTFwM{Kg{txO NIj0dHIzOzh5MUmwOC=>
HBC4 M1Sw[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXGwRnQ4OC5yMT2xNFAh|ryP Mm\4OFghcA>? NE\DeHFNd2diR1m1NF0uQC54MTDN NVfQWZk3OjJ|M{[yOFY>
BSY1 NHTIOIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4HuV|AvODFvMUCwJO69VQ>? MnnWOFghcA>? M33YTGxw\yCJSUWwQU05NjR6IF2= M1L5b|IzOzN4MkS2
HBC5 MnHYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4jXfVAvODFvMUCwJO69VQ>? M{O2U|Q5KGh? MUHMc4chT0l3ME2tO{45PyCP M4j1NFIzOzN4MkS2
MCF7 NFXxclBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEjxbpMxNjBzLUGwNEDPxE1? NULwPW1IPDhiaB?= MkTaUI9oKEeLNUC9MVgvOTZiTR?= MYmyNlM{PjJ2Nh?=
MDA-MB-231 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXOwMlAyNTFyMDFOwG0> NUe1XGh6PDhiaB?= NWf1dIROVG:pIFfJOVA:NThwMEmgUS=> MnX3NlI{OzZ{NE[=
U251 NIP5dmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEfTWo0xNjBzLUGwNEDPxE1? NYn0RlBLPDhiaB?= NGLINZJNd2diR1m1NF0uPy54NjDN NGjiZYQzOjN|NkK0Oi=>
SF268 NWD4ZpV7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVSwMlAyNTFyMDFOwG0> NV;h[WJTPDhiaB?= M2DaV2xw\yCJSUWwQU04Njl{IF2= MWiyNlM{PjJ2Nh?=
SF295 NYTQOoxjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2n4U|AvODFvMUCwJO69VQ>? NYrNRXNpPDhiaB?= M1XQUmxw\yCJSUWwQU05NjNzIF2= MXWyNlM{PjJ2Nh?=
SF539 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUSwMlAyNTFyMDFOwG0> NI\YW4M1QCCq NU[0W5JEVG:pIFfJOVA:NThwNUmgUS=> NEXCcnUzOjN|NkK0Oi=>
SNB75 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXWwMlAyNTFyMDFOwG0> M1;xVlQ5KGh? NWLhO5lQVG:pIFfJOVA:NThwNUigUS=> NFy1e4YzOjN|NkK0Oi=>
SNB78 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVzrfIR3OC5yMT2xNFAh|ryP M4freVQ5KGh? MXTMc4chT0l3ME2tPE43PSCP MnzRNlI{OzZ{NE[=
HCC2998 M3r5U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUDuPYdWOC5yMT2xNFAh|ryP NXPVSlhbPDhiaB?= MmjKUI9oKEeLNUC9MVgvODViTR?= M{O0NlIzOzN4MkS2
KM12 NF3LW|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M362d|AvODFvMUCwJO69VQ>? NGXub5U1QCCq MV\Mc4chT0l3ME2tO{42PCCP NV;sbXVnOjJ|M{[yOFY>
HT-29 NUHmOJg2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUOwMlAyNTFyMDFOwG0> MYG0PEBp M{O0UWxw\yCJSUWwQU04Njd3IF2= M2DyNVIzOzN4MkS2
HCT15 M1[wfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVGwMlAyNTFyMDFOwG0> NHPGZ3I1QCCq M{n5S2xw\yCJSUWwQU05NjB|IF2= M1r2OFIzOzN4MkS2
HCT116 NV3YSXFoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnHUNE4xOS1zMECg{txO M3npelQ5KGh? MYLMc4chT0l3ME2tO{43OSCP NX;ENY92OjJ|M{[yOFY>
NCI-H23 M4HsZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXX0[XoyOC5yMT2xNFAh|ryP NI\4O5c1QCCq Mlz3UI9oKEeLNUC9MVcvPjRiTR?= M2j6ZlIzOzN4MkS2
NCI-H226 MoPTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX6ySlFmOC5yMT2xNFAh|ryP MlTROFghcA>? NYD3UJJ7VG:pIFfJOVA:NThwNESgUS=> MmL2NlI{OzZ{NE[=
NCI-H522 NFLZU5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWPzUWhIOC5yMT2xNFAh|ryP Ml7tOFghcA>? NWXjfId7VG:pIFfJOVA:NThwNEWgUS=> M33ZdFIzOzN4MkS2
NCI-H438 M2fLbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVuyW3FUOC5yMT2xNFAh|ryP NFLtdFk1QCCq NED1UGxNd2diR1m1NF0uQC5zMTDN NUHHZWF5OjJ|M{[yOFY>
A549 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{nGcVAvODFvMUCwJO69VQ>? NW\vVoZPPDhiaB?= NIrjbodNd2diR1m1NF0uQC5yNzDN NF3DdlEzOjN|NkK0Oi=>
DMS273 MoC1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX2wMlAyNTFyMDFOwG0> MXi0PEBp M{PJ[2xw\yCJSUWwQU04NjhyIF2= MVmyNlM{PjJ2Nh?=
DMS114 MlXGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmDrNE4xOS1zMECg{txO NHu4UYs1QCCq MkTiUI9oKEeLNUC9MVgvOzliTR?= NUGzWm5XOjJ|M{[yOFY>
LOXIMVI Mmi4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFzPV3UxNjBzLUGwNEDPxE1? MnS3OFghcA>? MYjMc4chT0l3ME2tPE43PiCP M{flN|IzOzN4MkS2
OVCAR3 NU\FcXV6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{XyTFAvODFvMUCwJO69VQ>? MljYOFghcA>? NEDUdXZNd2diR1m1NF0uQC5zNzDN Mn;rNlI{OzZ{NE[=
OVCAR4 NVq5UFR6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFfUem4xNjBzLUGwNEDPxE1? MmjwOFghcA>? M2HmXWxw\yCJSUWwQU05NjV6IF2= NIrU[XgzOjN|NkK0Oi=>
OVCAR5 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlHTNE4xOS1zMECg{txO MnnJOFghcA>? MlHEUI9oKEeLNUC9MVcvPTdiTR?= MWGyNlM{PjJ2Nh?=
OVCAR8 M2nWcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWWwMlAyNTFyMDFOwG0> NHr3eVc1QCCq NWTmRYVzVG:pIFfJOVA:NTdwOESgUS=> MmjZNlI{OzZ{NE[=
SKOV3 MlLiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH\ydpcxNjBzLUGwNEDPxE1? M1fHSVQ5KGh? MWXMc4chT0l3ME2tPE41OSCP NEfxfYQzOjN|NkK0Oi=>
RXF631L MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MknlNE4xOS1zMECg{txO NW\KboZrPDhiaB?= NUTZOXI5VG:pIFfJOVA:NThwMkGgUS=> MUeyNlM{PjJ2Nh?=
ACHN NYnvRll7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYmwMlAyNTFyMDFOwG0> MUC0PEBp NYrCc45lVG:pIFfJOVA:NTdwOUWgUS=> NHXZco8zOjN|NkK0Oi=>
St-4 M3T6[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVOwMlAyNTFyMDFOwG0> M4rON|Q5KGh? NGDR[5lNd2diR1m1NF0uPy52NzDN MkGzNlI{OzZ{NE[=
MKN1 NWfhenhwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGn5TGcxNjBzLUGwNEDPxE1? NEnFUGQ1QCCq MVLMc4chT0l3ME2tPE41OSCP NWjY[4plOjJ|M{[yOFY>
MKN7 MoroS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFLPblMxNjBzLUGwNEDPxE1? NFfNU4k1QCCq MUPMc4chT0l3ME2tO{43QCCP NHzVdIszOjN|NkK0Oi=>
MKN28 M{jxfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NILQPWMxNjBzLUGwNEDPxE1? NYLpRWRmPDhiaB?= M2nEVGxw\yCJSUWwQU04NjB5IF2= NUjWS41XOjJ|M{[yOFY>
MKN45 NIfoZZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4jweFAvODFvMUCwJO69VQ>? MX20PEBp NYTEOY9NVG:pIFfJOVA:NThwM{SgUS=> NXHSRoQ5OjJ|M{[yOFY>
MKN74 M4\LUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2\EfVAvODFvMUCwJO69VQ>? NWLHdo1sPDhiaB?= NIfLeZBNd2diR1m1NF0uPy52MjDN NG\UNnMzOjN|NkK0Oi=>
DU145 NYW5N4ZDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnrmNE4xOS1zMECg{txO M1;WRlQ5KGh? MWTMc4chT0l3ME2tPE4yPiCP NVXyfHI6OjJ|M{[yOFY>
PC3 NX3aeXJQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEL0[pUxNjBzLUGwNEDPxE1? M2nWVVQ5KGh? NVexW|JUVG:pIFfJOVA:NThwNk[gUS=> NHHtZ5ozOjN|NkK0Oi=>
Trypanosoma brucei brucei NIrzXGdHfW6ldHnvckBCe3OjeR?= NWSwfXdOOjByIH7N M1LUPVEzKGh? MUfEUXNQ M3n6[GRm[3KnYYPlJIlvKHCqb4PwbI91cWS7bDDpco9{cXSxbDDwbI9{eGijdHWgcIV3\Wx? MofwNlQ5ODV7NE[=
Trypanosoma brucei brucei MUPGeY5kfGmxbjDBd5NigQ>? NH\MWpMyQCCq MUnEUXNQ NX7iNIV2UW6qaXLpeIlwdiCxZjDy[YNmeHSxcj3t[YRq[XSnZDDlcoRw[3m2b4Ppd{Bie3Onc4Pl[EBieyCmZXPy[YF{\SCrbjD0doFve2[ncoLpckB2eHSja3W= MV[yOFgxPTl2Nh?=
Trypanosoma brucei brucei NFjIZmVHfW6ldHnvckBCe3OjeR?= MUeyNFAhdk1? NGLsfGMyOiCq MVrEUXNQ NIjrfG9G\m[nY4Sgc44he3CqaX7nc416dGWrbjDs[ZZmdA>? MVyyOFgxPTl2Nh?=
Trypanosoma brucei brucei NI[xS|hHfW6ldHnvckBCe3OjeR?= NUfsdXRzOjByIH7N M2WzW|EzKGh? NH;lRpVFVVOR NILj[Y9G\m[nY4Sgc44heGixc4DoZZRq\HmuY3jvcIlv\SCuZY\lcC=> MnrrNlQ5ODV7NE[=
UM-UC-3 NUD3NYlJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVfJR|UxRTNzNTDwUS=> NXnRUoVLW0GQR1XS
SBC-1 NFzJblBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml;rTWM2OD15NEKgdG0> M1vIZXNCVkeHUh?=
MKN1 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFfZdFNKSzVyPUKuPEBvVQ>? MW\TRW5ITVJ?
NCI-H720 M1H6Nmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIrL[GdKSzVyPUOuOVchdk1? MWLTRW5ITVJ?
BFTC-909 NX7Ldmx1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYO0TXAyUUN3ME2zMlcyKG6P MkK2V2FPT0WU
BPH-1 M3LDcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWHDbJk6UUN3ME20Mlc3KG6P NYXLXnE1W0GQR1XS
PC-3 Ml;tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoLrTWM2OD13LkC5JI5O M4TLenNCVkeHUh?=
AN3-CA MmH0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkKxTWM2OD13LkW2JI5O MU\TRW5ITVJ?
HN NWewdpJjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVLqO5pLUUN3ME21Mlk3KG6P NFHYOZFUSU6JRWK=
HCC2218 NVL1V4tVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkjETWM2OD14Lk[xJI5O MUHTRW5ITVJ?
KP-4 M3y5R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXHIcJNUUUN3ME23JI5O MnTDV2FPT0WU
LU-139 Mmn1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYjJR|UxRTdwN{egcm0> MlzNV2FPT0WU
ETK-1 NYni[YE3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEHkeoFKSzVyPUeuPFghdk1? NV;JR5ppW0GQR1XS
Ramos-2G6-4C10 NISwRlRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWHGVpFsUUN3ME24MlQ6KG6P NWHRVpRPW0GQR1XS
MHH-PREB-1 MmfNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWSzUGdsUUN3ME25MlEzKG6P NG[4[IdUSU6JRWK=
DU-4475 MkX6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1SxNmlEPTB;OT60OEBvVQ>? MnPyV2FPT0WU
NCI-H1666 MofUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX7JR|UxRTlwN{Ggcm0> MYrTRW5ITVJ?
CAMA-1 MmH4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVvJR|UxRTlwODDuUS=> NYfxWIUyW0GQR1XS
TYK-nu MmHmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1njTmlEPTB;OT65OEBvVQ>? MVHTRW5ITVJ?
MFE-280 NWDFPJZHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUmyWlBKUUN3ME25Mlk6KG6P M{CzXnNCVkeHUh?=
A549 NFzUflBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlzrTWM2OD1zMD6xOEBvVQ>? Mn\NV2FPT0WU
769-P Ml\VS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlP5TWM2OD1zMD60OEBvVQ>? NUHNUFFuW0GQR1XS
L-363 MkHjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXvJR|UxRTFyLk[5JI5O MYPTRW5ITVJ?
ES8 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml3hTWM2OD1zMD65JI5O MX;TRW5ITVJ?
PA-1 NH;m[lBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3KxOmlEPTB;MUGuPFIhdk1? NVuxXXpuW0GQR1XS
Mewo MonSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn\JTWM2OD1zMT65PUBvVQ>? MmfhV2FPT0WU
HSC-3 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWf3dlFGUUN3ME2xNk4zOSCwTR?= NVr6SVVPW0GQR1XS
H4 NWHWcoV7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX7JR|UxRTF{Lk[3JI5O MmjNV2FPT0WU
BB65-RCC NVvPd2lmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWHJR|UxRTF{LkeyJI5O NUK5WJo{W0GQR1XS
NCI-H1793 M2HsNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml;ITWM2OD1zMj64NkBvVQ>? Mkn1V2FPT0WU
KARPAS-45 NUnYTXVvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFjmWGZKSzVyPUGzMlUyKG6P MXnTRW5ITVJ?
GCT NVvvdXI3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHrnOGNKSzVyPUGzMlY5KG6P MXPTRW5ITVJ?
EoL-1 NGflTnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NW[3dFMxUUN3ME2xN{46OyCwTR?= NHf2V4NUSU6JRWK=
LB2241-RCC NXLhZoFZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3LyNGlEPTB;MUSuNFEhdk1? MWfTRW5ITVJ?
ES5 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVXJR|UxRTF2Lke0JI5O MkXyV2FPT0WU
LOXIMVI MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{nWfGlEPTB;MUSuPVkhdk1? MV\TRW5ITVJ?
COR-L105 NF;HdJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWTJR|UxRTF3LkC0JI5O MlHqV2FPT0WU
P12-ICHIKAWA NIm2PZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTF3LkGgcm0> MmPYV2FPT0WU
CHL-1 NXPobHJJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3LRV2lEPTB;MUWuOFUhdk1? NE\CPXhUSU6JRWK=
VMRC-RCZ M2q1fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIfGTmxKSzVyPUG1MlY{KG6P M1LocnNCVkeHUh?=
HH Moj0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NInJUXNKSzVyPUG1Mlchdk1? NXvtZ49CW0GQR1XS
NUGC-3 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVvrS20{UUN3ME2xOk4{PCCwTR?= NYi1Z41RW0GQR1XS
EGI-1 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4HlOWlEPTB;MU[uOFMhdk1? NHzpU2RUSU6JRWK=
OS-RC-2 NF7IdpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUDJR|UxRTF4LkS3JI5O NXPUcoF[W0GQR1XS
MOLT-16 M13hcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWWz[3A4UUN3ME2xO{4yPSCwTR?= MmXjV2FPT0WU
NCI-H209 M4W5Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NViybmRyUUN3ME2xO{4zQSCwTR?= NXvkc|ZVW0GQR1XS
697 M{Dl[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn\WTWM2OD1zNz60N{BvVQ>? MUjTRW5ITVJ?
D-56MG NHnE[lVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXLzbVZ7UUN3ME2xO{43QSCwTR?= NWjnVYdHW0GQR1XS
VA-ES-BJ M1\kZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MorkTWM2OD1zNz64N{BvVQ>? NU\SXZdIW0GQR1XS
EW-16 NIPyWmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYrJR|UxRTF6LkC0JI5O NIXIbJBUSU6JRWK=
HGC-27 NHH1e5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmCxTWM2OD1zOD6wOkBvVQ>? MlnYV2FPT0WU
ES7 NWG3OIxyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2T4SGlEPTB;MUiuNFkhdk1? NXmzU|VIW0GQR1XS
HuH-7 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXLJR|UxRTF6LkSgcm0> MmLyV2FPT0WU
BCPAP MoDES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGK2enFKSzVyPUG4MlY2KG6P MnLxV2FPT0WU
SW1710 NFKyemJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUTJR|UxRTF6LkeyJI5O NXPJfVkzW0GQR1XS
IST-MEL1 M3T1cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFXKSo5KSzVyPUG4Mlc4KG6P NIHhc4NUSU6JRWK=
SF295 NUfQdppiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWXWcph{UUN3ME2xPE46OyCwTR?= NF7TO4JUSU6JRWK=
RPMI-7951 M1fU[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXXJR|UxRTF7LkK4JI5O MmrVV2FPT0WU
SF126 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1r6VmlEPTB;MUmuOFEhdk1? NFnVV3hUSU6JRWK=
GAMG MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn;UTWM2OD1zOT60PEBvVQ>? NWL2dlVJW0GQR1XS
KNS-81-FD NI[5fVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2DncmlEPTB;MUmuOVQhdk1? MkPlV2FPT0WU
RT-112 M1nZOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUXJR|UxRTF7Lk[2JI5O MYHTRW5ITVJ?
DEL NIHVRlBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2LSOmlEPTB;MkCuOFkhdk1? MVLTRW5ITVJ?
CGTH-W-1 NUGyT3VoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M37mV2lEPTB;MkCuOlMhdk1? NV21PYhnW0GQR1XS
HOS MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NW\1dI9QUUN3ME2yNU4xPiCwTR?= M1jE[HNCVkeHUh?=
ES4 Mme2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mon6TWM2OD1{MT6wPEBvVQ>? M3XnXnNCVkeHUh?=
RXF393 M3fDVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFvZXHlKSzVyPUKxMlQ2KG6P NITnT5VUSU6JRWK=
NCI-H2030 NYLHTG5mT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYfRNGl5UUN3ME2yNU42OiCwTR?= NF73[|NUSU6JRWK=
YH-13 NELVVVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NG\2UVZKSzVyPUKxMlg5KG6P NVjvXGsxW0GQR1XS
HT-1080 NX7rb2VRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MljjTWM2OD1{MT65N{BvVQ>? MYDTRW5ITVJ?
NCI-SNU-1 NXnWS5ozT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3vXS2lEPTB;MkGuPVUhdk1? M3PubnNCVkeHUh?=
G-402 NFvvSJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnPsTWM2OD1{Mj6xOkBvVQ>? NYX2UmhJW0GQR1XS
786-0 NHn5T49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXzJR|UxRTJ{LkK5JI5O MXTTRW5ITVJ?
ME-180 MmfPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnrxTWM2OD1{Mj60N{BvVQ>? MlO5V2FPT0WU
NB69 NIe1OIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnPCTWM2OD1{Mj61N{BvVQ>? NV3PSlNoW0GQR1XS
J-RT3-T3-5 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M332bWlEPTB;MkKuPVYhdk1? MmDkV2FPT0WU
TGBC1TKB MmO0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml;PTWM2OD1{Mz6wOUBvVQ>? M2PTUXNCVkeHUh?=
SW780 NHT1O5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYTJR|UxRTJ|LkGzJI5O NXXPbYNvW0GQR1XS
MG-63 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3[4UWlEPTB;MkOuOFUhdk1? NWD1VWpzW0GQR1XS
BV-173 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFrvNVJKSzVyPUKzMlg4KG6P NXK5bJA1W0GQR1XS
CAL-51 M3jvfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mnf1TWM2OD1{Mz64PUBvVQ>? MnXNV2FPT0WU
A375 NF:4UmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWT1S5NRUUN3ME2yN{46OyCwTR?= NHXKNYdUSU6JRWK=
MEL-HO MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NE\5[XFKSzVyPUK0MlA1KG6P MYXTRW5ITVJ?
EFO-27 MlT2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVrJR|UxRTJ2LkOzJI5O NYPMWY4xW0GQR1XS
Hs-578-T MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXjJR|UxRTJ2LkW4JI5O NHPiWohUSU6JRWK=
NBsusSR MnToS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGDyV|dKSzVyPUK0MlYhdk1? MVTTRW5ITVJ?
CTB-1 M2Lh[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYjJR|UxRTJ2Lk[3JI5O M4n4d3NCVkeHUh?=
FTC-133 NXHCN|BVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYrU[5YzUUN3ME2yOU4yKG6P MULTRW5ITVJ?
MOLT-4 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlnmTWM2OD1{NT6xNkBvVQ>? M2DGZnNCVkeHUh?=
HO-1-N-1 M{fOXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH;4R5JKSzVyPUK1MlE2KG6P NYW0TXNXW0GQR1XS
ES3 NVrnXGZZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{O0bmlEPTB;MkWuNlIhdk1? NE[wTWhUSU6JRWK=
TI-73 NXv4Z5AxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnHQTWM2OD1{NT6yPEBvVQ>? M1vaNXNCVkeHUh?=
MPP-89 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2[wVWlEPTB;MkWuN|Ihdk1? M2ruT3NCVkeHUh?=
KYSE-150 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2PZbmlEPTB;MkWuPFkhdk1? M2XqZXNCVkeHUh?=
LXF-289 Mn;4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn\NTWM2OD1{Nj6wOEBvVQ>? MUjTRW5ITVJ?
SK-LU-1 M4\GO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVvJR|UxRTJ4LkG3JI5O M2D4NHNCVkeHUh?=
HOP-92 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mo\5TWM2OD1{Nj60PEBvVQ>? MljmV2FPT0WU
HuO9 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2fJNWlEPTB;Mk[uO|Yhdk1? M2\5SnNCVkeHUh?=
SW962 M3LBdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlmxTWM2OD1{Nj63OkBvVQ>? NI[3PWRUSU6JRWK=
RS4-11 M4\t[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGHEWXNKSzVyPUK2MlkyKG6P NFq4TZNUSU6JRWK=
NCI-H292 NVHzXZBsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1jhe2lEPTB;Mkegcm0> NEXCSZpUSU6JRWK=
DB NV;a[pE4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIXod5FKSzVyPUK3MlM3KG6P MVTTRW5ITVJ?
SW1088 Ml\WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{nzWWlEPTB;MkiuNlkhdk1? MoL6V2FPT0WU
A204 NITIUIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2jYcGlEPTB;MkiuOFchdk1? MUHTRW5ITVJ?
A3-KAW M{PUPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUTncIxbUUN3ME2yPE43PCCwTR?= M1q0d3NCVkeHUh?=
MV-4-11 M2DJRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnjFTWM2OD1{OD63JI5O NVXNT3NnW0GQR1XS
ES1 NGT3THJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2fJd2lEPTB;MkiuPFQhdk1? M1nqd3NCVkeHUh?=
ONS-76 NUDkeYpqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUXJR|UxRTJ7LkC1JI5O NVrJUmlnW0GQR1XS
D-263MG NGPPVHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH;VTnRKSzVyPUK5MlM2KG6P NEK5NGpUSU6JRWK=
U-2-OS NXHj[GdnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXHJR|UxRTJ7LkWgcm0> NEHSTG1USU6JRWK=
T98G MmnnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnLlTWM2OD1{OT64PEBvVQ>? M125bXNCVkeHUh?=
GI-ME-N MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYntbWlyUUN3ME2yPU46OSCwTR?= M4LPbnNCVkeHUh?=
BHT-101 NHHFVFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVrJR|UxRTNyLkC1JI5O NE\sVZdUSU6JRWK=
NOS-1 MnjsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2ni[2lEPTB;M{CuNVIhdk1? NEn1UIpUSU6JRWK=
AsPC-1 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEjoXm1KSzVyPUOwMlIhdk1? NX74XYFLW0GQR1XS
QIMR-WIL NIDZN2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEnibFVKSzVyPUOwMlYhdk1? NHy2[ZlUSU6JRWK=
JVM-3 M2XDZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnP3TWM2OD1|MD64N{BvVQ>? NIf2W5BUSU6JRWK=
KU-19-19 MnXNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV;JR|UxRTNzLkGzJI5O NGXoeI9USU6JRWK=
OVCAR-8 MmXTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1PGb2lEPTB;M{GuNlYhdk1? M{fDOXNCVkeHUh?=
BEN MoTOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWTqPYRnUUN3ME2zNU43OyCwTR?= MX3TRW5ITVJ?
BE-13 NFjUSoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH;1e4NKSzVyPUOxMlgzKG6P MlT6V2FPT0WU
EW-18 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mme3TWM2OD1|MT64OkBvVQ>? NU\iS5FHW0GQR1XS
ECC10 NWG1cWpqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWraWmNTUUN3ME2zNU46PSCwTR?= NUT1dYFnW0GQR1XS
CTV-1 NWW2ToV3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1\FPWlEPTB;M{KuPFIhdk1? M3;JSXNCVkeHUh?=
COLO-800 NEjwO25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NET4UplKSzVyPUOyMlkzKG6P NWLDcJhyW0GQR1XS
A2058 MoD5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlvhTWM2OD1|Mz6yOUBvVQ>? NEniOHhUSU6JRWK=
VM-CUB-1 NHO4c3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3rOSmlEPTB;M{OuOFMhdk1? M{G3VHNCVkeHUh?=
Ca9-22 NF30R2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV3JR|UxRTN|LkW1JI5O MUXTRW5ITVJ?
COLO-684 NHf0eWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MULJR|UxRTN|LkW4JI5O MkjSV2FPT0WU
RPMI-8226 MmH5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkXOTWM2OD1|Mz64NkBvVQ>? M3:4VXNCVkeHUh?=
SK-NEP-1 NYrpTJNOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MW\JR|UxRTN2LkG1JI5O MX\TRW5ITVJ?
Becker NHyxU41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTN2LkKxJI5O MXHTRW5ITVJ?
NCI-H28 M13Fe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVL6b3FsUUN3ME2zOE41PCCwTR?= M3j6T3NCVkeHUh?=
CAL-120 NYH2NYtKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoniTWM2OD1|ND63NkBvVQ>? MnnnV2FPT0WU
MDA-MB-157 M4PHcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXT6VlZUUUN3ME2zOU41OSCwTR?= NITCXJVUSU6JRWK=
OVCAR-5 MlXqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MY\JR|UxRTN3LkS3JI5O NWXUTG9VW0GQR1XS
LAMA-84 MlL3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4XGSmlEPTB;M{WuPFchdk1? M3jWcXNCVkeHUh?=
CAKI-1 NY[wRYxrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVjkcWFXUUN3ME2zOk41OyCwTR?= MoWyV2FPT0WU
Daoy NUW3VpJGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIHH[XhKSzVyPUO2Mlchdk1? NFTKfXZUSU6JRWK=
CAL-62 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWLJR|UxRTN4Lki2JI5O MVPTRW5ITVJ?
8-MG-BA M4O1cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NU\wXlhWUUN3ME2zO{4zPSCwTR?= Mn\LV2FPT0WU
8505C MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnS4TWM2OD1|Nz61NUBvVQ>? MYDTRW5ITVJ?
LNCaP-Clone-FGC NVnCeWtUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVfpbI1QUUN3ME2zO{42QSCwTR?= MYfTRW5ITVJ?
CAL-39 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXfJR|UxRTN5Lkmgcm0> NG\hfJpUSU6JRWK=
MN-60 NFzXNnZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NY\vSHJ1UUN3ME2zO{46PiCwTR?= NULaPZhtW0GQR1XS
RKO NILqRoZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWPMW2NlUUN3ME2zPE4{OyCwTR?= MXXTRW5ITVJ?
U251 MoXtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3nWc2lEPTB;M{iuOFMhdk1? NY\4W25tW0GQR1XS
SJSA-1 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXPJR|UxRTN6LkW0JI5O M1O3eHNCVkeHUh?=
CAL-12T M3rGcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4TWUmlEPTB;M{iuOkBvVQ>? NHzMTZNUSU6JRWK=
HCC1419 M4iwNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVHJR|UxRTN6LkexJI5O NXzUNnFWW0GQR1XS
CO-314 NX3tWWRbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXLoPZd6UUN3ME2zPE44PCCwTR?= NVXrSXd2W0GQR1XS
LB1047-RCC MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWTQPFJYUUN3ME2zPE45OSCwTR?= MWHTRW5ITVJ?
A101D Mn:xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWPJR|UxRTN6Lkm3JI5O NGH6S|hUSU6JRWK=
MDA-MB-175-VII NGDXcllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXLoNVlWUUN3ME2zPU42OSCwTR?= MmXzV2FPT0WU
MZ2-MEL MmTuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYrteIN2UUN3ME2zPU43PiCwTR?= MUTTRW5ITVJ?
NB5 M3fFcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1u1NGlEPTB;NECuOlQhdk1? NF;1bHlUSU6JRWK=
G-401 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1nqSmlEPTB;NECuPFIhdk1? NIm4cI1USU6JRWK=
HT M2nENmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnvrTWM2OD12MT6wNkBvVQ>? MmPrV2FPT0WU
8305C MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{\ySmlEPTB;NEGuPFchdk1? MYTTRW5ITVJ?
BHY NEfLWIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV3JR|UxRTR{LkeyJI5O M2rEZ3NCVkeHUh?=
NTERA-S-cl-D1 NYfERm9pT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml3GTWM2OD12MzDuUS=> NHW3[npUSU6JRWK=
T-24 MmOzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF7ZeJRKSzVyPUSzMlg{KG6P Mlf2V2FPT0WU
EPLC-272H NXy4[XBiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{nrRmlEPTB;NESuN|khdk1? M4nWUHNCVkeHUh?=
PSN1 M37V[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mk\CTWM2OD12ND60JI5O NXHq[2xyW0GQR1XS
NCI-H2452 NWXKNG1OT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX;JR|UxRTR2LkW4JI5O MXXTRW5ITVJ?
KS-1 M2\UWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXvGUXdlUUN3ME20OE43PiCwTR?= NHzpO|lUSU6JRWK=
HD-MY-Z MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUPZOGlyUUN3ME20OE46OiCwTR?= M2e0UXNCVkeHUh?=
KNS-62 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWLJR|UxRTR3LkO4JI5O NV;tUpJ2W0GQR1XS
NOMO-1 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIH3SIJKSzVyPUS1Mlg4KG6P M1vVRXNCVkeHUh?=
SK-HEP-1 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NILlXXhKSzVyPUS2MlA1KG6P MYXTRW5ITVJ?
IGR-1 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX7mXoVIUUN3ME20Ok4yOyCwTR?= M2X1dXNCVkeHUh?=
KYSE-180 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NILpXGpKSzVyPUS2MlE4KG6P MUTTRW5ITVJ?
EW-22 MkLDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnLwTWM2OD12Nj6yJI5O MUnTRW5ITVJ?
NCI-H1355 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{XCNGlEPTB;NE[uN|Qhdk1? MWLTRW5ITVJ?
DOHH-2 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWnJR|UxRTR4LkO3JI5O M4DOZ3NCVkeHUh?=
A4-Fuk Mn;IS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mm\TTWM2OD12Nj61NkBvVQ>? MUXTRW5ITVJ?
PC-14 MoPtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1nLbWlEPTB;NE[uOVchdk1? MmnjV2FPT0WU
TE-5 Ml3jS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVjENmU1UUN3ME20Ok45PCCwTR?= NY\Vc|ZsW0GQR1XS
LB996-RCC NVz4fY9RT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX3JR|UxRTR5LkG5JI5O NU\jTFVtW0GQR1XS
NCI-H1623 MkXJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYrJR|UxRTR5Lke2JI5O M4XWOXNCVkeHUh?=
NCI-H1155 NGS2OZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3W5fGlEPTB;NEiuN|Ihdk1? NV3SPI56W0GQR1XS
LoVo MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF22U5JKSzVyPUS4MlQhdk1? MWfTRW5ITVJ?
MCF7 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmfZTWM2OD12OD61PEBvVQ>? NV\xPGQ{W0GQR1XS
AGS MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NILTeXhKSzVyPUS4Mlc4KG6P NXvwephtW0GQR1XS
PFSK-1 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4\MbWlEPTB;NEmuNFYhdk1? M3mxUXNCVkeHUh?=
22RV1 M13nWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml;xTWM2OD12OT6wPUBvVQ>? MX7TRW5ITVJ?
COR-L23 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWjJR|UxRTR7LkG2JI5O NEfuSpVUSU6JRWK=
D-283MED NYPOUWlPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWTJR|UxRTR7Lk[xJI5O MWLTRW5ITVJ?
SW982 MlnLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NE\YUWRKSzVyPUS5MlkyKG6P NHvPUJNUSU6JRWK=
SW620 NWDNOopUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXzJR|UxRTVyLkO2JI5O MmiyV2FPT0WU
KYSE-140 NHHuVFlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4nKNGlEPTB;NUCuOVUhdk1? MkXKV2FPT0WU
GCIY M2q0fGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{PLWWlEPTB;NUCuOlchdk1? MofaV2FPT0WU
MHH-ESS-1 M4rN[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1PueGlEPTB;NUGuPVUhdk1? Mn7sV2FPT0WU
D-423MG MlvxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYTJR|UxRTV{LkC4JI5O NVrNcopTW0GQR1XS
SF539 M3\1XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4\WT2lEPTB;NUKuN|Uhdk1? NEHDdIdUSU6JRWK=
RPMI-2650 NEXrfo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV7QVY02UUN3ME21Nk43QSCwTR?= NFy5SotUSU6JRWK=
GR-ST NEX0cFlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVTJR|UxRTV{Lki3JI5O M37ITHNCVkeHUh?=
YKG-1 NVLPOGt7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3jGT2lEPTB;NUOgcm0> MoCzV2FPT0WU
SK-MES-1 NXnqXWh[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmXOTWM2OD13Mz6yOkBvVQ>? NF6yeWVUSU6JRWK=
HLE NUnUU3FQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{fBeWlEPTB;NUOuOFchdk1? M37qcXNCVkeHUh?=
RVH-421 NE\T[ldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVLJR|UxRTV|Lk[3JI5O NHLlRolUSU6JRWK=
C32 NHjLWolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUfDPGprUUN3ME21N{45OyCwTR?= MXrTRW5ITVJ?
GB-1 MkTKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH;h[JFKSzVyPUW0MlIhdk1? MYfTRW5ITVJ?
SNB75 M1nwUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MofuTWM2OD13ND6yOkBvVQ>? MlPzV2FPT0WU
EM-2 NWjlRoNiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWrJR|UxRTV2LkSgcm0> M33jWnNCVkeHUh?=
RH-1 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mlz4TWM2OD13ND63JI5O MoTQV2FPT0WU
NKM-1 M1npbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVTwcWd[UUN3ME21OE45OSCwTR?= NV3OfHR6W0GQR1XS
NCI-H2405 NXW2R|I{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHLIdYJKSzVyPUW0Mlg5KG6P M1Hke3NCVkeHUh?=
KYSE-450 NVTxOYF{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHPnUnhKSzVyPUW1MlE3KG6P NXzZPXZpW0GQR1XS
A704 M1vrTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYXj[3AzUUN3ME21OU42QSCwTR?= M{\QcnNCVkeHUh?=
HAL-01 NVHoVGNwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWHJR|UxRTV3LkizJI5O MXLTRW5ITVJ?
TE-11 M4nvXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUfJR|UxRTV3Lkm5JI5O M2XiOHNCVkeHUh?=
DOK Mn\KS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYXzRWt5UUN3ME21Ok4xOiCwTR?= M4TGTXNCVkeHUh?=
KY821 NHnRWodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NI\repRKSzVyPUW2MlIhdk1? MYTTRW5ITVJ?
KGN NXLQbpZLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFPhTndKSzVyPUW2MlMzKG6P M{TCSXNCVkeHUh?=
MC116 NWnpRmExT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MULJR|UxRTV5Lkigcm0> NWjpZ5N2W0GQR1XS
PANC-08-13 MnHnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmfMTWM2OD13OD6wNUBvVQ>? MUjTRW5ITVJ?
KE-37 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUHjclVHUUN3ME21PE44PyCwTR?= M1PJe3NCVkeHUh?=
KYSE-410 NED6b|JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVfJR|UxRTV7LkS3JI5O NHP5SoRUSU6JRWK=
RO82-W-1 Mk\6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlznTWM2OD13OT65JI5O M2DSbHNCVkeHUh?=
M14 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1z5cmlEPTB;NkCuNFQhdk1? Mk\iV2FPT0WU
GI-1 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NU\Vc4duUUN3ME22NE4{KG6P MWLTRW5ITVJ?
ML-2 M4\wWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUfnTZRRUUN3ME22NE43OiCwTR?= MXfTRW5ITVJ?
BFTC-905 MnnLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NETO[2JKSzVyPU[wMlY2KG6P MlzEV2FPT0WU
DMS-273 Mnu5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYLJR|UxRTZyLki3JI5O MmLsV2FPT0WU
MDA-MB-361 NFrD[ZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVnJR|UxRTZzIH7N Ml;lV2FPT0WU
MSTO-211H NI\vbJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYHJR|UxRTZ|LkWxJI5O M36ycXNCVkeHUh?=
MEG-01 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mk\5TWM2OD14Mz61NkBvVQ>? Mm\1V2FPT0WU
M059J NHPDWY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXvRN3VvUUN3ME22N{42QCCwTR?= MXrTRW5ITVJ?
LN-405 MknRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnfXTWM2OD14Mz64OUBvVQ>? NEnJcVVUSU6JRWK=
NCI-H1581 NGO3bY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2fXe2lEPTB;NkSuNFMhdk1? MmTYV2FPT0WU
TCCSUP Ml\ZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmTnTWM2OD14ND61N{BvVQ>? MUPTRW5ITVJ?
SW872 NVzrUGRST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF\CT|lKSzVyPU[0MlU4KG6P NIDBeXRUSU6JRWK=
KYSE-510 M3nsWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWfJR|UxRTZ3Lke1JI5O NIr4U2FUSU6JRWK=
NCI-H1792 M3nrTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoT3TWM2OD14Nj6xOUBvVQ>? M3z1VXNCVkeHUh?=
SW13 NHvmdJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV\QcoRJUUN3ME22Ok42KG6P NWfJfJZ1W0GQR1XS
TE-8 M{PUTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoPUTWM2OD14Nj61NkBvVQ>? M{Tm[3NCVkeHUh?=
SCH M2Ltdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWHJR|UxRTZ5LkGgcm0> M3\PW3NCVkeHUh?=
NEC8 NYDUT4NIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWXJR|UxRTZ5LkK0JI5O MWDTRW5ITVJ?
HuO-3N1 M4HaUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUfJR|UxRTZ5LkOxJI5O NXK2dI5vW0GQR1XS
EFM-19 MmLES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVrJR|UxRTZ5LkWgcm0> M2HjXnNCVkeHUh?=
HEC-1 M2rHZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHjmeHJKSzVyPU[3MlUzKG6P M{nvfHNCVkeHUh?=
T47D MoL4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4e1[2lEPTB;NkeuPFchdk1? NW[2OZI2W0GQR1XS
SNU-423 MmLCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVTTNFExUUN3ME22O{46QCCwTR?= MlTtV2FPT0WU
WM-115 NUm0XJQ{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2jHcWlEPTB;NkiuNVQhdk1? NWrlbJZjW0GQR1XS
CaR-1 M{m0[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUDMPGVuUUN3ME22PE4zPSCwTR?= M3rle3NCVkeHUh?=
KU812 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXi0VmZWUUN3ME22PE43QSCwTR?= M{HKR3NCVkeHUh?=
AM-38 M2\CS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV3IR5RZUUN3ME22PU4{OSCwTR?= MYrTRW5ITVJ?
KOSC-2 MoLaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml2wTWM2OD14OT65O{BvVQ>? NX73cIJxW0GQR1XS
MC-IXC Mk[0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHjPb4ZKSzVyPUewMlA5KG6P MlHzV2FPT0WU
SCC-4 NUHLeVF5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlnDTWM2OD15MT6zPEBvVQ>? NWLjeJNvW0GQR1XS
Calu-3 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX3JR|UxRTdzLkm4JI5O NV64eGY2W0GQR1XS
RPMI-8866 Mo[yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnLQTWM2OD15Mj64NkBvVQ>? NELBb5BUSU6JRWK=
OVCAR-4 NVPVe2c3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX;JR|UxRTd|LkO2JI5O MkX3V2FPT0WU
OAW-42 NGXyUopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M13C[2lEPTB;N{OuN|khdk1? NX3tZolEW0GQR1XS
ATN-1 M1jKWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYrxNlUyUUN3ME23N{45PyCwTR?= MXPTRW5ITVJ?
CHP-212 MnHDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIPjZY1KSzVyPUe0Mlk2KG6P NYnUUYR3W0GQR1XS
C2BBe1 M{TEN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWnPXWJoUUN3ME23OU4xOyCwTR?= MlXWV2FPT0WU
A498 NIX5[m5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1HueGlEPTB;N{WuNVUhdk1? MWjTRW5ITVJ?
SH-4 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MU\JR|UxRTd3LkKxJI5O MmrEV2FPT0WU
SNU-449 Mn76S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH\pSJBKSzVyPUe1Mlc6KG6P NVXuXFllW0GQR1XS
RD NFq3RYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXjJR|UxRTd3Lki2JI5O M3y1UXNCVkeHUh?=
PANC-03-27 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWPFPGZSUUN3ME23Ok4zPSCwTR?= MWrTRW5ITVJ?
S-117 NX\ST21CT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2LLRmlEPTB;N{[uNlchdk1? NWHSWotiW0GQR1XS
SK-MEL-2 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NE\1VmRKSzVyPUe2Mlc2KG6P NYPPWHRmW0GQR1XS
LK-2 NVjDVlRIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmK5TWM2OD15Nz6wOUBvVQ>? MnLoV2FPT0WU
CP50-MEL-B NWD6[4N3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2fuZmlEPTB;N{euOEBvVQ>? NUTnOXl{W0GQR1XS
647-V M1rPRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX;adZRkUUN3ME23PE4xPyCwTR?= M{L0VHNCVkeHUh?=
LU-134-A M3;aSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXHHXlRRUUN3ME23PU4xOyCwTR?= MoXGV2FPT0WU
5637 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXvJR|UxRTd7LkKzJI5O Mn3hV2FPT0WU
NCI-H1437 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVzWc3NnUUN3ME24NE42KG6P MX;TRW5ITVJ?
NCI-H460 MmK0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIrJU25KSzVyPUixMlI{KG6P MXjTRW5ITVJ?
BxPC-3 M4qxVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVHNOpFIUUN3ME24NU41PiCwTR?= NYHpSJN6W0GQR1XS
CAN NV24Wlc2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn32TWM2OD16MT64OEBvVQ>? NXO4cXFTW0GQR1XS
KINGS-1 NH\yc2RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYPJR|UxRTh{LkOyJI5O MUfTRW5ITVJ?
OCUB-M MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MknxTWM2OD16Mj60NUBvVQ>? MUfTRW5ITVJ?
KALS-1 NXjrVHFFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX3pUINTUUN3ME24Nk42PCCwTR?= MVvTRW5ITVJ?
OCI-AML2 NGLOZlJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF7UTpNKSzVyPUiyMlYyKG6P MoXrV2FPT0WU
A253 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYLD[Y1oUUN3ME24Nk43PSCwTR?= NGrtfZVUSU6JRWK=
LCLC-97TM1 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWPFW3lyUUN3ME24Nk45PiCwTR?= M2HreHNCVkeHUh?=
NCI-H520 NWC0fHRyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF\3XotKSzVyPUizMlA3KG6P NWDVcJZ1W0GQR1XS
P30-OHK M3jBVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mkn6TWM2OD16Mz61JI5O NFXQNnhUSU6JRWK=
SBC-5 NFLqO5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3TZV2lEPTB;OEOuOVIhdk1? MYrTRW5ITVJ?
HCE-T NH32XmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXHJR|UxRTh|Lke0JI5O NUjVOJM4W0GQR1XS
JEG-3 NWqwTG5tT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M17KXWlEPTB;OESuNUBvVQ>? M1HrSHNCVkeHUh?=
KG-1 M1zhS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2PaNGlEPTB;OESuNlQhdk1? MlfZV2FPT0WU
MIA-PaCa-2 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoL1TWM2OD16ND61OEBvVQ>? MXjTRW5ITVJ?
CAL-33 MmGxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXLjUGxlUUN3ME24OU4xQCCwTR?= MXLTRW5ITVJ?
639-V MmL3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4PSXmlEPTB;OEWuOFIhdk1? MkfCV2FPT0WU
NCI-H1048 M3O4S2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVTVZXBwUUN3ME24Ok4{OSCwTR?= MYTTRW5ITVJ?
NCI-H1573 Mn2zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnTtTWM2OD16Nz60PEBvVQ>? MkO3V2FPT0WU
NCI-H2228 NGHEbZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYLJR|UxRTh6LkK2JI5O NWnNSmt2W0GQR1XS
NB14 M33LWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml3yTWM2OD16OD6zJI5O MlPaV2FPT0WU
SCC-25 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWDJR|UxRTh7LkiyJI5O NYXERnhyW0GQR1XS
A431 NWnwWJV7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHTkdmRKSzVyPUi5Mlk4KG6P M1rZS3NCVkeHUh?=
SN12C MkPpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVvJR|UxRTlyLk[yJI5O NX\VXXpsW0GQR1XS
HuCCT1 MlHlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX;JR|UxRTlyLke2JI5O MWTTRW5ITVJ?
LS-123 NWXFdmE6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVPPUZhIUUN3ME25Nk4yQCCwTR?= NFzhZXVUSU6JRWK=
CAL-85-1 NVrRRYFmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mm\JTWM2OD17Mj60PEBvVQ>? MWrTRW5ITVJ?
ES6 NYD6VndpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1vEbmlEPTB;OUKuPFMhdk1? MWDTRW5ITVJ?
NCI-H650 NVvLfWJuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEfYe3VKSzVyPUm0MlA6KG6P NHr0TXFUSU6JRWK=
NCI-H446 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHS4eGFKSzVyPUm1MlEzKG6P MmrLV2FPT0WU
EW-13 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NW\4bYFWUUN3ME25OU44PSCwTR?= M4\ZcHNCVkeHUh?=
HSC-2 NYjmSXdYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkjZTWM2OD17NT64PUBvVQ>? NULvOYhRW0GQR1XS
U031 NH\mTWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVLJR|UxRTl4LkezJI5O MV;TRW5ITVJ?
EW-11 NYjvRXFpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXrJR|UxRTl4Lki4JI5O M{HUN3NCVkeHUh?=
GAK M3ntZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn:xTWM2OD17OD65N{BvVQ>? NVHOVGhWW0GQR1XS
SK-OV-3 M3n1cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoK3TWM2OD1zMECuNFchdk1? MmnwV2FPT0WU
OMC-1 M{XFdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYK1PYxxUUN3ME2xNFAvOThibl2= M17GOXNCVkeHUh?=
TK10 M{PMUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlW1TWM2OD1zMECuNlEhdk1? MWLTRW5ITVJ?
EKVX MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkHzTWM2OD1zMECuOkBvVQ>? NWe0WoRmW0GQR1XS
Detroit562 NGPNcnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1TuXGlEPTB;MUCyMlE4KG6P Mn;6V2FPT0WU
SF268 M1TiSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3jFU2lEPTB;MUCyMlM1KG6P M{iyTXNCVkeHUh?=
SNU-387 MoTwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlPqTWM2OD1zMESuNVchdk1? NFfyd2dUSU6JRWK=
MDA-MB-231 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnjXTWM2OD1zMEWuNFYhdk1? M4WwXnNCVkeHUh?=
NCI-H1563 NILmU4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHTXZmZKSzVyPUGwOU4yQCCwTR?= NYrafXA3W0GQR1XS
D-502MG M{TRWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWLV[2ZtUUN3ME2xNFUvPyCwTR?= NGjjN4VUSU6JRWK=
A2780 NIKzUY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWm2[WRqUUN3ME2xNFYvPDdibl2= NGX4RW9USU6JRWK=
IA-LM NHOwT|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn;PTWM2OD1zMEeuOVEhdk1? M2foOnNCVkeHUh?=
D-392MG NYKzb4E{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3n3OWlEPTB;MUC3MlU1KG6P M1P4[XNCVkeHUh?=
MS-1 MnPPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2fFeGlEPTB;MUC3MlcyKG6P NULN[5A1W0GQR1XS
SW1990 MlfQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYPOR5NCUUN3ME2xNFgvPTRibl2= Mnn2V2FPT0WU
HEL NFTye4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXPJR|UxRTFyOT6yPUBvVQ>? NYq3e2NxW0GQR1XS
SW1573 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3z1c2lEPTB;MUC5MlMyKG6P NHnQPYJUSU6JRWK=
SW1783 NXTsUppET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFHvUpJKSzVyPUGxNE4zOiCwTR?= Mli2V2FPT0WU
COLO-680N NWfvOoNCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF3LR5ZKSzVyPUGxNE44PiCwTR?= MU\TRW5ITVJ?
NCI-N87 M2Xm[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHrSO|JKSzVyPUGxNU4xPCCwTR?= NXTZNZY5W0GQR1XS
SK-MEL-28 MoDoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIrYZYlKSzVyPUGxNU42PSCwTR?= Ml\GV2FPT0WU
BT-20 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2HR[GlEPTB;MUGyMlAyKG6P NXHGOGtCW0GQR1XS
NCI-H1648 MnrVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV6yeZg5UUN3ME2xNVMhdk1? Ml3KV2FPT0WU
no-11 NI\WbYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmfvTWM2OD1zMUOuNlghdk1? NIizbXFUSU6JRWK=
MOLT-13 M{fmTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWXJR|UxRTFzMz60OEBvVQ>? M2KwcHNCVkeHUh?=
NCI-H2170 NX3hcYFRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1P6VGlEPTB;MUG0MlUyKG6P M2\mO3NCVkeHUh?=
HTC-C3 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkTWTWM2OD1zMU[uPFUhdk1? MWPTRW5ITVJ?
LU-99A NHuyemZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1fleWlEPTB;MUG3MlIyKG6P NFzmTY1USU6JRWK=
HCC2998 Mnv2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnPsTWM2OD1zMUeuPVIhdk1? M3vC[HNCVkeHUh?=
NB13 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXLJR|UxRTFzNz65PUBvVQ>? MV3TRW5ITVJ?
GT3TKB MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXTJR|UxRTFzOD6wPEBvVQ>? M3eyVHNCVkeHUh?=
BT-549 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWnJR|UxRTFzOD65OUBvVQ>? NFfuNo1USU6JRWK=
NCI-H747 M2LMemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmPKTWM2OD1zMUmuN|Qhdk1? MXrTRW5ITVJ?
EW-1 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVnJR|UxRTF{MD6yJI5O Mnj5V2FPT0WU
LB831-BLC NHexPIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml2xTWM2OD1zMkCuOlMhdk1? M3rNUXNCVkeHUh?=
NMC-G1 M1[3Xmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFPBZoNKSzVyPUGyNU4yOSCwTR?= Ml3BV2FPT0WU
COLO-679 MlT0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFn1SW9KSzVyPUGyNk4yPSCwTR?= MU\TRW5ITVJ?
HL-60 MmKzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVP6T45zUUN3ME2xNlMvOSCwTR?= NUnjVVR1W0GQR1XS
MKN7 NWXpUVRsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH33ZmdKSzVyPUGyN{45OyCwTR?= MorDV2FPT0WU
RERF-LC-MS MnKzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3;5WGlEPTB;MUK0MlMyKG6P NF\rNpJUSU6JRWK=
DMS-114 NYDpeFlQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlPSTWM2OD1zMkWuNFkhdk1? MYrTRW5ITVJ?
HuP-T4 NYXxR2NzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX7JR|UxRTF{Nj65O{BvVQ>? NFr5T41USU6JRWK=
HCC2157 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFr3TldKSzVyPUGyO{42KG6P NEm3RmlUSU6JRWK=
SKG-IIIa MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2XoWGlEPTB;MUK4Mlghdk1? M3rrZnNCVkeHUh?=
HCT-116 Ml\2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGCzcXBKSzVyPUGzNE43PCCwTR?= NWC4[FB4W0GQR1XS
BB30-HNC NXmyT5k{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWTJR|UxRTF|MD63PEBvVQ>? M{XMcHNCVkeHUh?=
KYSE-270 NH\HV5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWrJR|UxRTF|MD64PEBvVQ>? NFfURXlUSU6JRWK=
MFM-223 Mmj6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXfJR|UxRTF|MT61NUBvVQ>? NED3[VBUSU6JRWK=
NH-12 MoXVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHu0RmJKSzVyPUGzNk46QSCwTR?= M{XZfnNCVkeHUh?=
U-118-MG M4\3PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkXFTWM2OD1zM{OuOlIhdk1? Mk[yV2FPT0WU
ESS-1 Mmi2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX;JR|UxRTF|NT6xPEBvVQ>? NH3jW25USU6JRWK=
D-247MG Mn7OS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF\P[GRKSzVyPUGzOU4zOSCwTR?= M{\tcHNCVkeHUh?=
IGROV-1 MljVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYOxNYQ3UUN3ME2xN|UvPzZibl2= MX3TRW5ITVJ?
C-33-A MlPES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWHFOYh3UUN3ME2xN|UvQTdibl2= M1Tte3NCVkeHUh?=
NCI-H1693 MlPoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYDJR|UxRTF|Nj6xNkBvVQ>? NX3wUIJ1W0GQR1XS
MLMA NXHzdZRWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEHPXVFKSzVyPUGzOk42QCCwTR?= NInlNpRUSU6JRWK=
SK-N-AS MmHDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3zlVmlEPTB;MUO3MlE4KG6P M4\jW3NCVkeHUh?=
NCI-H1755 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH\tVZpKSzVyPUGzPE45PSCwTR?= MmPHV2FPT0WU
CHP-134 MmHNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX\lfJZrUUN3ME2xN|kvPTVibl2= M{DzTnNCVkeHUh?=
LS-513 NY[1VY5RT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIW2cIRKSzVyPUG0NE46OSCyTR?= MYXTRW5ITVJ?
TE-12 NHPV[49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3jCcWlEPTB;MUSwMlk{KG6P MVHTRW5ITVJ?
KNS-42 MlPuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MorJTWM2OD1zNESuN{BvVQ>? MVfTRW5ITVJ?
SJRH30 M2PMRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH\UVW1KSzVyPUG0OE41PCCwTR?= NWXWR5JyW0GQR1XS
NCI-H1092 Moj0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MULJR|UxRTF2ND61NkBvVQ>? M2j5N3NCVkeHUh?=
H-EMC-SS NIiwWXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NG\xSJVKSzVyPUG0Ok45OSCwTR?= MYHTRW5ITVJ?
SK-MEL-3 M2\Zb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIGwdXBKSzVyPUG0O{42PSCwTR?= M4jTWXNCVkeHUh?=
SK-N-FI NHz6fYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M36x[GlEPTB;MUS3MlU6KG6P MYTTRW5ITVJ?
NCI-H2126 NVfsSldZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkfqTWM2OD1zNEiuNVUhdk1? MUjTRW5ITVJ?
NCI-H1299 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVjJR|UxRTF3MD6yNkBvVQ>? NYPw[JBzW0GQR1XS
CFPAC-1 NVvPZ41qT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MULJR|UxRTF3MD62OkBvVQ>? M4rUWHNCVkeHUh?=
NCI-H661 NF\TfGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVT0eYdvUUN3ME2xOVEvOjZibl2= NFK4eoNUSU6JRWK=
KYSE-70 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGLQTJdKSzVyPUG1NU44QSCwTR?= MY\TRW5ITVJ?
SW900 NUfHUm1sT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2fNNmlEPTB;MUW0MlY2KG6P NHK0U2lUSU6JRWK=
Ca-Ski M4nDd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M13pc2lEPTB;MUW2MlM6KG6P Mm\5V2FPT0WU
HPAF-II M2f2VGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4X1XWlEPTB;MUW2MlQ4KG6P MUXTRW5ITVJ?
LB2518-MEL M1rwO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4C5XWlEPTB;MUW3MlEhdk1? NWq1TIZzW0GQR1XS
LC-2-ad MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYn2TXlXUUN3ME2xOVgvPjJibl2= NXnhbXViW0GQR1XS
HCC1806 NG\LT|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2jrcWlEPTB;MU[3Mlg5KG6P NETpU4VUSU6JRWK=
UACC-62 NEPnO5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWja[XFEUUN3ME2xOlgvODlibl2= NVzC[Y5YW0GQR1XS
KM-H2 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV;Kd5BnUUN3ME2xO|AvPThibl2= M2LpfHNCVkeHUh?=
NCI-H2347 NYP4T3piT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYXJR|UxRTF5Mj63NkBvVQ>? Mo\RV2FPT0WU
SCC-15 M{HXOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1XLemlEPTB;MUezMlY3KG6P M32wO3NCVkeHUh?=
BB49-HNC M3TBdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2Gzd2lEPTB;MUezMlgyKG6P NYeyVIpQW0GQR1XS
GMS-10 NXzOVGdTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVrBR3dkUUN3ME2xO|MvQTRibl2= MkPyV2FPT0WU
NCI-H2052 NYnFZnM1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF\IUoxKSzVyPUG3OE46KG6P NHWxUFVUSU6JRWK=
SW626 Mnz1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkP1TWM2OD1zN{[uNFYhdk1? NXK2c5o4W0GQR1XS
MDA-MB-415 M{mxcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFvpO5ZKSzVyPUG3Ok43OSCwTR?= NGTaU3hUSU6JRWK=
Saos-2 NVLFXGFQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEnDcHdKSzVyPUG3PU4{PSCwTR?= NXjLfFNJW0GQR1XS
DK-MG MnHkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkPsTWM2OD1zOECuN{BvVQ>? NGXNZ4xUSU6JRWK=
SNU-C2B M13WNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlnoTWM2OD1zOECuO|Mhdk1? NX;pfIpPW0GQR1XS
A427 NF76boVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3nJSmlEPTB;MUiyMlU4KG6P M4XtUnNCVkeHUh?=
KP-N-YS NXK4OoJ7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NY\BenBbUUN3ME2xPFUhdk1? NIq2O2VUSU6JRWK=
J82 NWjlTGV[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1\PdWlEPTB;MUi1MlE5KG6P Mmi2V2FPT0WU
LS-411N NF[wRXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXvxb5BCUUN3ME2xPFcvOjhibl2= MnTGV2FPT0WU
HCC1937 M3naUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUTmO3dGUUN3ME2xPFcvPDlibl2= NGT1bVhUSU6JRWK=
OE33 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX7JR|UxRTF6OD65O{BvVQ>? M37IN3NCVkeHUh?=
NB7 M1jFZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn7VTWM2OD1zOEmuPFkhdk1? NETqbYhUSU6JRWK=
SW684 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX7FbnV3UUN3ME2xPVYvOTNibl2= NUKz[XQ6W0GQR1XS
HT-144 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnvUTWM2OD1zOU[uNVUhdk1? MUDTRW5ITVJ?
SK-MEL-30 NXzJTVByT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVLzb281UUN3ME2xPVYvOiCwTR?= NXfGcox2W0GQR1XS
DBTRG-05MG MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn7jTWM2OD1zOUiuOFchdk1? NVu3UoU5W0GQR1XS
NCI-H1395 MmP5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFWzcmZKSzVyPUG5PE45PSCwTR?= M3z0[nNCVkeHUh?=
NCI-H2122 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3jDRWlEPTB;MkCwMlU6KG6P NIXBOVBUSU6JRWK=
no-10 M2Dne2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVzJR|UxRTJyMT6wOEBvVQ>? M4TRVXNCVkeHUh?=
SW48 NXXaPGFXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml\OTWM2OD1{MEGuN|Ehdk1? NH\YbFJUSU6JRWK=
NCI-H1650 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mk\uTWM2OD1{MESuNFEhdk1? NETlTnBUSU6JRWK=
MZ1-PC Mnv4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoTzTWM2OD1{MEWuOVghdk1? NXjUcGRjW0GQR1XS
U-266 NE\qdXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFLKVFZKSzVyPUKwOU44QSCwTR?= NXPWdZNxW0GQR1XS
CAS-1 M1nTUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXzJR|UxRTJyNz60OEBvVQ>? NVX3c5FyW0GQR1XS
AU565 Mn\vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVjJR|UxRTJzMj64NkBvVQ>? MV;TRW5ITVJ?
UACC-257 NYfB[|Y2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX3JR|UxRTJzMz65PUBvVQ>? NYK5N|E1W0GQR1XS
CAL-27 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV;yd|FiUUN3ME2yNVcvODVibl2= MoTaV2FPT0WU
NCI-H23 M3HVO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{m5R2lEPTB;MkG5MlM{KG6P NGXUd4VUSU6JRWK=
TE-6 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYfJR|UxRTJzOT62PEBvVQ>? NEjHcWZUSU6JRWK=
TGBC24TKB NFrWeHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVXRW4FKUUN3ME2yNlIvOTdibl2= MXzTRW5ITVJ?
TE-1 NFHXTHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEjrVGdKSzVyPUKyNk45QCCwTR?= MV3TRW5ITVJ?
RCC10RGB NHToSnZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVezN3RZUUN3ME2yNlQvOTlibl2= MUHTRW5ITVJ?
NCI-H596 NXXJZWdTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYfJR|UxRTJ{OD6yNkBvVQ>? NWfYO2RrW0GQR1XS
SW954 NYLmVG1pT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWX6OHdpUUN3ME2yN|MvQDNibl2= NYTCbWx4W0GQR1XS
NCI-H2087 NX7FN5RsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXzxdG1zUUN3ME2yN|QvPTFibl2= NGHEZVNUSU6JRWK=
SK-PN-DW MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFPGPHZKSzVyPUKzOU4yQSCwTR?= NW\1XmVkW0GQR1XS
KM12 Mnm1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnLBTWM2OD1{M{WuO{BvVQ>? NWnNSmtwW0GQR1XS
BT-474 MmnuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnfUTWM2OD1{M{WuO|Mhdk1? MlKyV2FPT0WU
IST-MES1 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEG0fJJKSzVyPUKzOk42PyCwTR?= MnriV2FPT0WU
HT-1197 MmLDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlzQTWM2OD1{M{iuNFkhdk1? NH6zXYhUSU6JRWK=
CAL-54 NHPzZmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVzJR|UxRTJ|OD60PUBvVQ>? MW\TRW5ITVJ?
NB10 M{jrPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWPBPIoyUUN3ME2yOFAvODZibl2= MX7TRW5ITVJ?
PANC-10-05 NUfhSFNzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3fBZmlEPTB;MkS1MlU3KG6P Mon4V2FPT0WU
NCI-H522 M3THdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWfJR|UxRTJ2OD6zNUBvVQ>? NF;RO3pUSU6JRWK=
A388 NUT2ZXJ5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYnJR|UxRTJ2OT64NkBvVQ>? MWHTRW5ITVJ?
GOTO NVmwRoZST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2K3cWlEPTB;MkWwMlI6KG6P NIr4[oZUSU6JRWK=
KLE NFnjdpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1XJdWlEPTB;MkWxMlg4KG6P Ml2zV2FPT0WU
KYSE-520 MlLnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXHJR|UxRTJ3Mj64OkBvVQ>? MWrTRW5ITVJ?
HCE-4 MlzES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXXJR|UxRTJ4Mj61JI5O Mn:1V2FPT0WU
KURAMOCHI M3fkeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NETU[olKSzVyPUK2OU46KG6P NVG0dIJvW0GQR1XS
HCC38 M1XlcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWTJR|UxRTJ4Nj60PEBvVQ>? NXGxfYRuW0GQR1XS
FADU MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXrJR|UxRTJ4Nj62N{BvVQ>? Mmm0V2FPT0WU
CW-2 NVe5[ll1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2nyVmlEPTB;Mk[5Mlk3KG6P MX;TRW5ITVJ?
L-428 Ml\0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{nHdWlEPTB;Mke1MlE2KG6P MonuV2FPT0WU
HCC1569 NGq3OWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVLX[|dEUUN3ME2yO|UvQDRibl2= M1K1eXNCVkeHUh?=
NCI-H810 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4nCOGlEPTB;Mke4MlMyKG6P MnvZV2FPT0WU
LB771-HNC NFPKPYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFvpe5lKSzVyPUK4OU45PCCwTR?= MVjTRW5ITVJ?
LCLC-103H M36zTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnjhTWM2OD1{OEWuPVkhdk1? NIT3O2dUSU6JRWK=
EFO-21 M1XnRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mm\uTWM2OD1{OEeuOlghdk1? MWDTRW5ITVJ?
CAL-72 M13YUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY\JR|UxRTJ7Mz6xPUBvVQ>? MoraV2FPT0WU
SCC-9 MnLyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXPrT|VCUUN3ME2yPVMvOjJibl2= M3TNeHNCVkeHUh?=
COLO-829 NVnCXFM1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUDJR|UxRTJ7Nj61JI5O MmW4V2FPT0WU
U-87-MG M1L5bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{\BXWlEPTB;M{CwMlc{KG6P MnXOV2FPT0WU
MZ7-mel MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXnSNIRTUUN3ME2zNlMvPzZibl2= MWHTRW5ITVJ?
NCI-H1770 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGDMV|hKSzVyPUOyOk44PCCwTR?= M{\2Z3NCVkeHUh?=
ChaGo-K-1 NIXId41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX\JR|UxRTN{OD6xJI5O NY\NfpVNW0GQR1XS
SiHa NIryW|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVPJR|UxRTN{OT6yOEBvVQ>? NYLL[Hl{W0GQR1XS
NCI-SNU-5 NFLlZWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3\MOmlEPTB;M{O2Mlc4KG6P MUPTRW5ITVJ?
DJM-1 MlLpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUHJR|UxRTN2MD6zN{BvVQ>? MYfTRW5ITVJ?
OE19 NI\idW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTN2MD61N{BvVQ>? NWr5eIZzW0GQR1XS
NCI-H1651 NWPJOIw6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoW2TWM2OD1|NESuNVghdk1? MXzTRW5ITVJ?
COLO-792 NYXrNG9pT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXvJR|UxRTN3ND60NkBvVQ>? NV3KbWp7W0GQR1XS
ACHN M1rydGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3WwNmlEPTB;M{W2MlcyKG6P M1e2c3NCVkeHUh?=
TH-3 NUeyN3U5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUXJR|UxRTN5OT65OUBvVQ>? MVLTRW5ITVJ?
HT-1376 MmPBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHvBZ4hKSzVyPUO4OE45QCCwTR?= Mn:zV2FPT0WU
RH-18 M3zzW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHnrOnZKSzVyPUO5OE44PCCwTR?= NYTCboh{W0GQR1XS
NB6 NFHmXWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFmx[4xKSzVyPUO5Ok43PiCwTR?= M1PPNnNCVkeHUh?=
COLO-320-HSR M{OwZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnH4TWM2OD12MEOuN|chdk1? MoG5V2FPT0WU
UACC-893 NV;IVoRuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NY\QeW5SUUN3ME20NFYvPDdibl2= MV3TRW5ITVJ?
DSH1 M{jnNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlnoTWM2OD12ME[uPVEhdk1? M{WwSXNCVkeHUh?=
TE-10 NXLoXnl4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn72TWM2OD12MEeuNFEhdk1? MnHNV2FPT0WU
HCC70 NXL3[IhnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkXXTWM2OD12MEmuNlEhdk1? M2LN[nNCVkeHUh?=
TGBC11TKB MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVGwVZE2UUN3ME20NVAvOzNibl2= MWfTRW5ITVJ?
NCI-H727 NI\6em9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVXJR|UxRTRzMj6xNUBvVQ>? NHS5fIpUSU6JRWK=
ALL-PO MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVjJR|UxRTRzNT62PUBvVQ>? NFW3RolUSU6JRWK=
ABC-1 M3TaZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWXLNnZZUUN3ME20NlAvPDVibl2= NIrEVI1USU6JRWK=
NCI-H69 M3u1XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NInwNm5KSzVyPUSyOk44PiCwTR?= NUDHSnJ2W0GQR1XS
GP5d NYHoSlR5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEnJeWRKSzVyPUSzOE41OSCwTR?= M4XxdnNCVkeHUh?=
UMC-11 M4\ieWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUPJR|UxRTR3OD6zOkBvVQ>? MYnTRW5ITVJ?
RMG-I NVz0SoU4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlrWTWM2OD12NkeuOVYhdk1? M4rQbXNCVkeHUh?=
YAPC NEniUYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWrwTZo2UUN3ME20PVAvPiCwTR?= NUfCPGtuW0GQR1XS
LS-1034 MkLHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUTK[3c3UUN3ME20PVEvODZibl2= NH3xenBUSU6JRWK=
RCM-1 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlfDTWM2OD12OU[uOlghdk1? NWX3boFMW0GQR1XS
HCC1954 M2fKW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUnQZnU{UUN3ME21NVIvPSCwTR?= MXLTRW5ITVJ?
SK-MEL-24 NVvSXpQ3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVrBPI9pUUN3ME21NVYvPTFibl2= MnjUV2FPT0WU
NB12 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXLzdYtsUUN3ME21NlgvPDJibl2= M{DjUXNCVkeHUh?=
SW756 MkPrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHzXR2tKSzVyPUW1OE46PiCwTR?= M{Tz[nNCVkeHUh?=
HCC1187 NWXFVmx1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUPJR|UxRTV5NT64N{BvVQ>? NXnCW2xYW0GQR1XS
NCI-H2342 Ml\JS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NU\0c2p[UUN3ME21PVAvOzlibl2= NIqwN2tUSU6JRWK=
NCI-H2291 NXXq[ppjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYqy[FJ5UUN3ME21PVgvOzFibl2= NFPWWFJUSU6JRWK=
OVCAR-3 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3GxR2lEPTB;NUm4Mlk3KG6P M3zuSXNCVkeHUh?=
MHH-NB-11 NIni[GlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlW2TWM2OD14MkmuNFEhdk1? MVnTRW5ITVJ?
SAS NWPzRoU2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF25NINKSzVyPU[1Nk43PyCwTR?= NH3BRY5USU6JRWK=
COLO-824 NY\mTIZpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{DvfmlEPTB;Nki5MlM4KG6P NHj4OW5USU6JRWK=
HCC1395 MljVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoX5TWM2OD14OUiuOUBvVQ>? NUfRRYk1W0GQR1XS
COLO-668 M1;PeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUXJR|UxRTdyNj6xJI5O NV7FUZNFW0GQR1XS
NCI-H226 NGLYe3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MULJR|UxRTdyNz64JI5O NGjjeIdUSU6JRWK=
NB17 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEW5PHFKSzVyPUeyNU44PSCwTR?= M3\VWXNCVkeHUh?=
SW1463 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFzhOIhKSzVyPUezPU4yQSCwTR?= NVHscoNUW0GQR1XS
TGW MlO1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2C1e2lEPTB;N{[wMlE2KG6P M1rGSHNCVkeHUh?=
NCI-H526 NVz0XYl[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{LOPWlEPTB;OEKzMlU{KG6P NVLYfXNUW0GQR1XS
COR-L88 MmDNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVu0bG9uUUN3ME24OFgvOTJibl2= MV7TRW5ITVJ?
NCI-H441 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{fyWGlEPTB;OEm1MlIzKG6P NH7OZZhUSU6JRWK=
NCI-H630 NF;5cZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkXKTWM2OD17MUKuPVYhdk1? M2[xRnNCVkeHUh?=
Mo-T NXK5TYhKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYjJR|UxRTl2Nz64PEBvVQ>? MYPTRW5ITVJ?
JAR MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnXPTWM2OD17NU[uNlQhdk1? NHrrW2pUSU6JRWK=
NCI-H1838 M3nDR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUOw[FZJUUN3ME2xMlAzOzh6IN88US=> NXnGXXQ5W0GQR1XS
DoTc2-4510 NW\2dWQ4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXfJR|UxRTFwMEezO|Yh|ryP NW\0TZEyW0GQR1XS
MKN28 M3T4UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXnmN3lvUUN3ME2xMlA6ODJ2IN88US=> NFjFc|NUSU6JRWK=
HuP-T3 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH;OXIJKSzVyPUGuNVE6ODVizszN MmHnV2FPT0WU
TE-9 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M16zU2lEPTB;MT6xNlk4OyEQvF2= NEnU[oRUSU6JRWK=
NY NHrxTW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlzxTWM2OD1zLkG2O|kzKM7:TR?= NUH5WG1XW0GQR1XS
HT55 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoPXTWM2OD1zLkOxN|Q1KM7:TR?= Moj0V2FPT0WU
SW837 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWq5VpZDUUN3ME2xMlMzQTd6IN88US=> MV\TRW5ITVJ?
NCI-H2029 NFLiTXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnjSTWM2OD1zLkSxO|kyKM7:TR?= MmPMV2FPT0WU
IST-SL1 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIrpdFZKSzVyPUGuOFQzPCEQvF2= Mn\HV2FPT0WU
COLO-741 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NG\WW|hKSzVyPUGuOFk4PzFizszN M2npWXNCVkeHUh?=
LU-65 M{joUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmLKTWM2OD1zLk[yNlQ6KM7:TR?= NFHLfllUSU6JRWK=
NCI-H1304 NV73TGpFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYnn[|RKUUN3ME2xMlY2PDl6IN88US=> M2nXW3NCVkeHUh?=
KARPAS-299 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{fPXmlEPTB;MT63PVQ4QSEQvF2= MmOzV2FPT0WU
NCI-H358 Ml;5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF3Yc2hKSzVyPUGuPVU2ODNizszN M3X6[nNCVkeHUh?=
OAW-28 MlHtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFfpbG5KSzVyPUKuNFY6OTlizszN M1nq[nNCVkeHUh?=
C8166 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MljpTWM2OD1{Lk[zN|kzKM7:TR?= M{TWXXNCVkeHUh?=
COLO-678 NF7MZ41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVHJR|UxRTJwOEO3Olgh|ryP MXfTRW5ITVJ?
SK-N-DZ NYrJd4dzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlzWTWM2OD1{Lki2N|gyKM7:TR?= M3nTfHNCVkeHUh?=
NCI-H82 NFzpSGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHPkNGJKSzVyPUKuPVA{PjlizszN NUK0bWQ{W0GQR1XS
JVM-2 MlTnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{nibGlEPTB;Mz6wN|E5QCEQvF2= NVLFWmdyW0GQR1XS
SW1116 M1zZSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3LGUmlEPTB;Mz6wOVQyOSEQvF2= M322R3NCVkeHUh?=
MDA-MB-453 NEnZcmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnGxTWM2OD1|LkGwOFM6KM7:TR?= M2fVe3NCVkeHUh?=
Calu-6 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkDQTWM2OD1|LkG5PVch|ryP NUG2[XppW0GQR1XS
SHP-77 NV[yZZBDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkHuTWM2OD1|LkWyPEDPxE1? NXr5[lg{W0GQR1XS
Capan-2 MlLDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFPiS2xKSzVyPUSuN|I2QDFizszN NIroSFVUSU6JRWK=
SW948 NVLmSFRCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV;JR|UxRTRwN{S3O|kh|ryP MoH1V2FPT0WU
HDLM-2 NIL3UFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFHmO|hKSzVyPUWuNFc4OjVizszN NYO1ZmltW0GQR1XS
LAN-6 MomxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVrEV2U4UUN3ME22MlIyPDl3IN88US=> Mo\YV2FPT0WU
LU-135 NFPQOmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX70cHY3UUN3ME22MlQ{ODd5IN88US=> M{LmdnNCVkeHUh?=
T84 NVHJOFJjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX3JR|UxRTZwOUi2OEDPxE1? MmjqV2FPT0WU
CAPAN-1 NHLPV3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFjQTXlKSzVyPUeuOlIzOzNizszN MmKzV2FPT0WU
SW1417 NWPYWHhbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEf3TnNKSzVyPUeuPVE4OzFizszN NELiVXFUSU6JRWK=
BALL-1 MkL5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWf6PGlwUUN3ME24MlUxPDB7IN88US=> MVHTRW5ITVJ?
HT-29 M1fNcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmfjTWM2OD17LkC3OVk6KM7:TR?= M1jKSnNCVkeHUh?=
C3A MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2W3TGlEPTB;OT64PFM6PCEQvF2= MnrjV2FPT0WU
NCI-H1993 M{DkXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmfWTWM2OD1zMD61NFgyKM7:TR?= MVHTRW5ITVJ?
SK-MEL-1 Mn7QS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXPJR|UxRTFzLk[yPFkh|ryP MWHTRW5ITVJ?
DU-145 M3u1[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEHycGhKSzVyPUG0MlUxPTJizszN NUTJXlNYW0GQR1XS
KP-N-YN MlPKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{LTcWlEPTB;MUSuOVExOyEQvF2= MUPTRW5ITVJ?
CCRF-CEM MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXrJR|UxRTF2Lke4NFkh|ryP MVTTRW5ITVJ?
ZR-75-30 NWrSZYFNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV\DRopoUUN3ME2xOk4{OzB|IN88US=> M3LrUHNCVkeHUh?=
A673 NE\JS5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXPIUGw{UUN3ME2yNE42PTB5IN88US=> M2XNb3NCVkeHUh?=
K-562 NFjWWFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3v3ZmlEPTB;MkiuOFE5OyEQvF2= MlTtV2FPT0WU

... Click to View More Cell Line Experimental Data

In vivo BEZ235 induces regression of the tumors (69%) without statistically significant effect on body weight gain. Altogether, these preliminary in vivo efficacy results show that BEZ235 causes disease stasis when administered orally as a single agent and can enhance the efficacy of other anticancer agents when used in combination studies. [1]

Protocol

Kinase Assay:

[1]

+ Expand

In vitro Protein Kinase, PI3K, and mTOR Assays:

PI3Kα, β, and δ proteins are composed of the iSH2 domain of p85 NH2-terminally fused to the full-length protein p110 protein, with the exception of α that also does not contain the last 20 amino acids. PI3Kγ is produced as full-length protein deleted for its first 144 amino acids. All constructs are fused to a COOH-terminal His tag for convenient purification and then cloned into the pBlue-Bac4.5 (for α, β, and δ isoforms) or pVL1393 (for γ isoform) plasmids. The different vectors are then cotransfected with BaculoGold WT genomic DNA using methods recommended by the vendor for production of the respective recombinant baculoviruses and proteins. BEZ235 are tested for their activity against PI3K using a Kinase-Glo assay. The kinase reaction is done in 384-well black plate. Each well is loaded with 50 μL of test items (in 90% DMSO) and 5 μL reaction buffer containing 10 μg/mL PI substrate (l-α-phosphatidylinositol; Avanti Polar Lipids; prepared in 3% octyl-glucoside) and the PI3K proteins (10, 25, 10, and 150 nM of p110α, p110β, p110δ, and p110γ, respectively) are then added to it. The reaction is started by the addition of 5 μL of 1 μM ATP prepared in the reaction buffer and is incubated for either 60 (for p110α, p110β, and p110δ) or 120 min (for p110γ). It is terminated by the addition of 10 μL Kinase-Glo buffer. The plates are then read in a Synergy 2 reader for luminescence detection.
Cell Research:

[2]

+ Expand
  • Cell lines: HCT116, DLD-1 and SW480 cells
  • Concentrations: 0-1 μM
  • Incubation Time: 48 hours
  • Method:

    The human CRC cell lines, HCT116 (PIK3CA mutant; kinase domain at H1047R), DLD-1 (PIK3CA mutant; helical domain at E545K), and SW480 (PIK3CA wild-type) and isogenic DLD-1 PIK3CA mutant as well as wild-type cells are maintained in DMEM with 10% FBS and 1 × Penicillin/Streptomycin. Cells are plated at different initial densities (HCT116: 3 × 103 cells/well, DLD-1: 5.5 × 103 cells/well, SW480: 4.5 × 103 cells/well, DLD-1 PIK3CA mutant: 7 × 103 cells/well, and DLD-1 PIK3CA wild-type: 9 × 103 cells/well) to account for differential growth kinetics. After 16 hours, cells are incubated with increasing concentrations of BEZ235, and the drug-containing growth medium is changed every 24 hours. Cell viability is assessed 16 hours after the initial plating and 48 hours after initiation of drug treatment using the colorimetric MTS assay CellTiter 96® AQueous One Solution Cell Proliferation Assay, as per the manufacturer's instructions. Cell viability after drug treatment is normalized to that of untreated cells also grown for 48 hours. For western blot analysis, cells are plated with zero or maximum inhibitory dose (500 nM) BEZ235 for 2, 6, 24, or 48 hours.


    (Only for Reference)
Animal Research:

[1]

+ Expand
  • Animal Models: Female Harlan athymic nude mice
  • Formulation: NMP/polyethylene glycol 300 (10/90, v/v)
  • Dosages: 45 mg/kg
  • Administration: p.o.
    (Only for Reference)

Solubility (25°C)

In vitro DMF 18 mg/mL (38.33 mM) warming
DMSO 0.01 mg/mL (0.02 mM)
Water <1 mg/mL
In vivo NMP+polyethylene glycol 300 (10+90, v+v) 30 mg/mL

* 1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 469.55
Formula

C30H23N5O

CAS No. 915019-65-7
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00620594 Completed Breast Cancer|Advanced Solid Tumors|Cowden Syndrome Novartis Pharmaceuticals|Novartis December 21, 2006 Phase 1
NCT01856101 Terminated Carcinoma Transitional Cell Cliniques universitaires Saint-Luc- Université Catholique de Louvain|Novartis February 2013 Phase 2
NCT01717898 Terminated Castrate-resistant Prostate Cancer Patients. Charles Ryan|Novartis Pharmaceuticals|University of California, San Francisco January 2013 Phase 1|Phase 2
NCT01658436 Completed Pancreatic Neuroendocrine Tumors (pNET) Novartis Pharmaceuticals|Novartis November 2012 Phase 2
NCT01628913 Terminated Pancreatic Neuroendocrine Tumors (pNET) Novartis Pharmaceuticals|Novartis October 2012 Phase 2
NCT01690871 Withdrawn Malignant PEComa (Perivascular Epithelioid Cell Tumors) Novartis Pharmaceuticals|Novartis September 2012 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

PI3K Signaling Pathway Map

PI3K Inhibitors with Unique Features

Related PI3K Products

Tags: buy Dactolisib (BEZ235, NVP-BEZ235) | Dactolisib (BEZ235, NVP-BEZ235) supplier | purchase Dactolisib (BEZ235, NVP-BEZ235) | Dactolisib (BEZ235, NVP-BEZ235) cost | Dactolisib (BEZ235, NVP-BEZ235) manufacturer | order Dactolisib (BEZ235, NVP-BEZ235) | Dactolisib (BEZ235, NVP-BEZ235) distributor
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID