Dactolisib (BEZ235, NVP-BEZ235)

Catalog No.S1009

Dactolisib (BEZ235, NVP-BEZ235) Chemical Structure

Molecular Weight(MW): 469.55

Dactolisib (BEZ235, NVP-BEZ235) is a dual ATP-competitive PI3K and mTOR inhibitor for p110α/γ/δ/β and mTOR(p70S6K) with IC50 of 4 nM /5 nM /7 nM /75 nM /6 nM in cell-free assays, respectively. Inhibits ATR with IC50 of 21 nM in 3T3TopBP1-ER cell.

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Cited by 82 Publications

11 Customer Reviews

  • Level of phospho-proteins in RTK and PI3K–Akt–mTOR pathways in treated tumours, detected with western blot.

    Nature, 2017, 728-732. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

    Relative kinase activities of p110α mutants and the inhibitory effect of PI3K inhibitors against hotspot mutants of p110α. A, recombinant FLAG-tagged PI3K p110α/p85α protein complex produced in 293T cells was immunoprecipitated , and the immunoprecipitates were used for the quantitative PI3K-HTRF assay (32).

    B, effect of three PI3K inhibitors (ZSTK474, LY294002, and NVP-BEZ235) on the enzymatic activity of two hotspot mutants (E545K and H1047R) p110α compared with the wild-type. No striking difference was observed in the IC50 concentrations of these inhibitors between wild-type and mutant p110α.
     

     

    Cancer Res 2010 70, 4982-4994. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

  • A, ANOVA of IC50 values of the dual PI3K/mTOR inhibitor NVP-BEZ235 in 23 melanoma cell lines showing no significant difference in sensitivity to this compound in B-Raf mutant and Braf wild-type cells. B, decreases in pAkt and pP70S6K in a dose and time-dependent fashion in 2 melanoma cell lines treated with NVP-BEZ235. pP70S6K levels are undetectable at all concentrations and time points studied, whereas levels of pAkt start rising again after 4 hours of drug exposure in a dose-dependent fashion. C, clonogenic assays in 2 melanoma cell lines (YUVON and YUSIK) treated with NVP-BEZ235 at different concentrations. NVPBEZ235 was effective in inhibiting colony formation at low nanomolar concentrations.

    Clin Cancer Res 2010 16, 6029-6039. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

    Three-dimensional responses of MCF7/IGF-1R cells to TAM (1 μM), E2 and IGF-1. Compared to parental MCF7 cells (a), MCF7/IGF-1R cells (b) in three-dimensional (3D) culture formed bigger acini in response to IGF-1 stimulation and displayed significant TAM resistance when treated with TAM (1 μM) + E2 + IGF-1, which was removable by kinase inhibitors BMS-536924, U0126 and BEZ235 (c). Cells (10,000/well) were seeded in 96-well plates. Acini were formed on 100% Matrigel and cultured for 14 days in starving medium containing 2% Matrigel and 5% charcoal/dextran-stripped fetal bovine serum with the treatments as indicated. Concentrations used: TAM (1 μM), E2 (1 nM) and IGF-1 (100 ng/mL). Confocal image original magnification, × 20. Red, rhodamine phalloidin (actin). Blue, Hoechst blue stain. Results are representative of two individual experiments.

    Breast Cancer Res 2011 13, R52. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

  • TAM (10 nM) agonistic behavior in MCF7/IGF-1R cells is not inhibited by phosphatidylinositol 3-kinase/Akt inhibitor BEZ235. (a) Inhibitory effects of kinase inhibitors BMS-536924, U0126 and BEZ235 on agonistic effect of TAM (10 nM) in the presence of IGF-1 (100 ng/mL). **P < 0.01. (b) Inhibitory effects of phosphatidylinositol 3-kinase (PI3K)/Akt inhibitor BEZ235 at various dose ranges on IGF-1R signaling. (c) Agonistic behavior of TAM (10 nM) in response to BEZ235 kinase inhibitor. (-), no BEZ235. Results are representative of three independent experiments. Data are expressed as means ± SD.

    Breast Cancer Res 2011 13:R52. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

    ZSTK474 and GDC-0941 selectively inhibit class I PI3K over mTOR. (A) Inhibition profiles of the selected five PI3K inhibitors for mTOR. Data shown are mean±SD (n = 3), representative of 2 or 3 independent experiments. (B) IC50 values of the PI3K inhibitors for mTOR. (C) Selectivity of each PI3K inhibitor for PI3Ka over mTOR. The selectivity index is expressed as the ratio of the IC50 value for mTOR over that for PI3Ka. The IC50 values of ZSTK474, NVP-BEZ235 and LY294002 for PI3Ka are 0.016, 0.007 and 0.6 μM, respectively, as reported previously by us.

     

     

    Eur J Cancer 2010 46, 1111-1121. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

  • (B) The effects of AZD2014, BEZ235, lapatinib, LEE011, pazopanib on PI3K/AKT signaling in sarcoma PDC line were determined by immunoblotting analysis. Cells were treated with 1 μM of the indicated drugs for 72 h.

    Transl Oncol, 2016, 9(3):197-202. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

    The effects of LY294002, rapamycin and NVP-BEZ235 on activation of PI3K-Akt-mTOR pathway in hepatocytes. (a) The mRNA expression (PI3K, Akt, mTOR, raptor) by Real-Time PCR, (b) protein expression (PI3K, Akt, mTOR, S6K) by ELISA kits; (c) protein expression of S6K and P-S6K by western blotting. The different letters indicated significant differences (P <0.05). LY = LY294002; rapa = rapamycin; NVP = NVP-BEZ235.

    Animal, 2016, 10(8):1319-27. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

  •  After starved in serum-free medium for 24h,breast cancer cells incubated with the indicated concentrations of BEZ235 for 3h,followed by 20-minute  stimulation of 100ng/ml EGF.

     

     

     

    Dr. Zhang of Tianjin Medical University. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

    After starved in serum-free medium for 24h,breast cancer cells incubated with the indicated concentrations of BEZ235 for 3h,followed by 20-minute  stimulation of 100ng/ml EGF.

     

     

    Dr. Zhang of Tianjin Medical University. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

  •  

    FIG. 4. Phospholipase A2 group 4A (PLA2G4A) expression was increased after BEZ235 treatment in basal-like xenografts. The bar graph shows the quantification of the immunoblots (mean±SD). PLA2G4A, Ethanolamine kinase 1 and 2 (ETNK1/2), Choline kinase alpha/beta (ChoKA/B), and β-actin protein expression were examined by immunoblotting of tissue samples after MRS experiments [control group (n= 5) and BEZ235-treated group (n=7)]. This demonstrated a higher expression of PLA2G4A protein ( P=0.005), but no changes in ETNK1 and ChoKA/B in samples from basal-like xenografts treated with BEZ235.

    Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

Purity & Quality Control

Choose Selective PI3K Inhibitors

Biological Activity

Description Dactolisib (BEZ235, NVP-BEZ235) is a dual ATP-competitive PI3K and mTOR inhibitor for p110α/γ/δ/β and mTOR(p70S6K) with IC50 of 4 nM /5 nM /7 nM /75 nM /6 nM in cell-free assays, respectively. Inhibits ATR with IC50 of 21 nM in 3T3TopBP1-ER cell.
Targets
p110α [1]
(Cell-free assay)
p110γ [1]
(Cell-free assay)
mTOR (p70S6K) [1]
(Cell-free assay)
p110δ [1]
(Cell-free assay)
ATR [8]
(3T3TopBP1-ER cells)
4 nM 5 nM 6 nM 7 nM 21 nM
In vitro

BEZ235 significantly reduces the phosphorylation levels of the mTOR activated kinase p70S6K. BEZ235 results in a reduction of S235/S236P-RPS6 levels with IC50 of 6.5 nM. The activity of BEZ235 against mTOR is determined using a biochemical mTOR K-LISA assay with IC50 of 20.7 nM. BEZ235 shows slightly lower activity against its β paralogue with IC50 of 75 nM. The PI3K/Akt/mTOR pathway is often constitutively activated in human tumor cells. BEZ235 blocks PI3K and mTOR kinase activity by binding to the ATP-binding cleft of these enzymes. Both PTEN-null cell lines PC3M and U87MG show a dose-dependent reduction in cell proliferation when treated with increasing concentrations of BEZ235 with an average GI50 of 10-12 nM. [1] BEZ235 is an mTORC1/2 catalytic inhibitor. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Trypanosoma brucei brucei MljWRY51cW2rY4LvZolidCCDc4PhfS=> MXWxPEBp NX;POIlNTE2VTx?= NWXYWZRISW62aYTyfZBidm:|b33hcEBi[3Srdnn0fUB4cXSqIFXDOVAhd2ZiMD6wNFI2KM7:TR?= NGWwZXUzPDhyNUm0Oi=>
MCF7 M2rhZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGrDNFYxNjBzLUGwNEDPxE1? MWm0PEBp NE\rU4lFVVOR Ml;kTWM2OD1yLkezJO69VQ>? NISxUZEzOzh5MUmwOC=>
HCT116 NVTQcnd1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVSwMlAyNTFyMDFOwG0> MVO0PEBp NXviXJRMTE2VTx?= NWf4b5pPUUN3ME2xMlE3KM7:TR?= NXm2PHk{OjN6N{G5NFQ>
U87MG NEjxe2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEPJcYIxNjBzLUGwNEDPxE1? MWW0PEBp M3vVR2ROW09? MV3JR|UxRTFwM{Kg{txO NWL3PXRmOjN6N{G5NFQ>
HBC4 M3;WWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoHLNE4xOS1zMECg{txO NUXRNmpqPDhiaB?= NVT6[XRrVG:pIFfJOVA:NThwNkGgUS=> Ml7XNlI{OzZ{NE[=
BSY1 NG\RTHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWPnR3N5OC5yMT2xNFAh|ryP MWq0PEBp NUnUOHdVVG:pIFfJOVA:NThwNEigUS=> NID1N3IzOjN|NkK0Oi=>
HBC5 MlrLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUCwMlAyNTFyMDFOwG0> M1nDTFQ5KGh? M4LBTGxw\yCJSUWwQU04Njh5IF2= MXGyNlM{PjJ2Nh?=
MCF7 NGDmZXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWmxUG5XOC5yMT2xNFAh|ryP NEfmdmE1QCCq M{XZZ2xw\yCJSUWwQU05NjF4IF2= MXeyNlM{PjJ2Nh?=
MDA-MB-231 NYrhb4hpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkTXNE4xOS1zMECg{txO MmXXOFghcA>? MWfMc4chT0l3ME2tPE4xQSCP Ml3ENlI{OzZ{NE[=
U251 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmHXNE4xOS1zMECg{txO MXm0PEBp M2LUSGxw\yCJSUWwQU04NjZ4IF2= NH7sdYozOjN|NkK0Oi=>
SF268 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmTrNE4xOS1zMECg{txO NHu0PXk1QCCq MnK0UI9oKEeLNUC9MVcvQTJiTR?= MY[yNlM{PjJ2Nh?=
SF295 Mk\vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGPCOY4xNjBzLUGwNEDPxE1? M33qfVQ5KGh? NGLsbHdNd2diR1m1NF0uQC5|MTDN M3ry[VIzOzN4MkS2
SF539 M4TYd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYTjV|M6OC5yMT2xNFAh|ryP MVu0PEBp NVzrdYdTVG:pIFfJOVA:NThwNUmgUS=> MUGyNlM{PjJ2Nh?=
SNB75 MkP0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXiwMlAyNTFyMDFOwG0> MmPLOFghcA>? MnHqUI9oKEeLNUC9MVgvPThiTR?= NXPmOW5[OjJ|M{[yOFY>
SNB78 NVzocWo4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnrVNE4xOS1zMECg{txO NH\rSoY1QCCq MV3Mc4chT0l3ME2tPE43PSCP NWjReGNtOjJ|M{[yOFY>
HCC2998 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVnGc|cxOC5yMT2xNFAh|ryP M4nBRVQ5KGh? M3G0b2xw\yCJSUWwQU05NjB3IF2= MWSyNlM{PjJ2Nh?=
KM12 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWfudXlEOC5yMT2xNFAh|ryP M1;yeVQ5KGh? M2jGPGxw\yCJSUWwQU04NjV2IF2= NVjJeVJsOjJ|M{[yOFY>
HT-29 MojXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmH6NE4xOS1zMECg{txO MmDBOFghcA>? NUOxcWI4VG:pIFfJOVA:NTdwN{WgUS=> MljPNlI{OzZ{NE[=
HCT15 NUfjTpBXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{f1fVAvODFvMUCwJO69VQ>? MX[0PEBp MlPZUI9oKEeLNUC9MVgvODNiTR?= NWG2epVJOjJ|M{[yOFY>
HCT116 NF62OGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVuwMlAyNTFyMDFOwG0> NVKwRVh2PDhiaB?= NX65b3NkVG:pIFfJOVA:NTdwNkGgUS=> NV\PT2VNOjJ|M{[yOFY>
NCI-H23 M3eyTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHLsbXUxNjBzLUGwNEDPxE1? MkLhOFghcA>? MYjMc4chT0l3ME2tO{43PCCP M4Dl[|IzOzN4MkS2
NCI-H226 NYrmRWdpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWHpZoZIOC5yMT2xNFAh|ryP MmXxOFghcA>? NYD3ZXNkVG:pIFfJOVA:NThwNESgUS=> M13WcVIzOzN4MkS2
NCI-H522 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYSwMlAyNTFyMDFOwG0> MYm0PEBp NFv5NmVNd2diR1m1NF0uQC52NTDN NFuxbFQzOjN|NkK0Oi=>
NCI-H438 MlXLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXSwMlAyNTFyMDFOwG0> MX:0PEBp MX;Mc4chT0l3ME2tPE4yOSCP NEP6OW0zOjN|NkK0Oi=>
A549 Mor1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M37se|AvODFvMUCwJO69VQ>? NFP4OXk1QCCq NYGyUWRiVG:pIFfJOVA:NThwMEegUS=> M2m2WFIzOzN4MkS2
DMS273 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFnnR5gxNjBzLUGwNEDPxE1? NVvncnpGPDhiaB?= NULFdYtqVG:pIFfJOVA:NTdwOECgUS=> MXKyNlM{PjJ2Nh?=
DMS114 NHG0fW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2LtV|AvODFvMUCwJO69VQ>? NIHMV3I1QCCq MWjMc4chT0l3ME2tPE4{QSCP MUKyNlM{PjJ2Nh?=
LOXIMVI M2HZWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH;KU3cxNjBzLUGwNEDPxE1? MmfmOFghcA>? MnTXUI9oKEeLNUC9MVgvPjZiTR?= NH3FZXMzOjN|NkK0Oi=>
OVCAR3 M1jCT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3THTVAvODFvMUCwJO69VQ>? MnvaOFghcA>? NVK0dpEzVG:pIFfJOVA:NThwMUegUS=> MkXqNlI{OzZ{NE[=
OVCAR4 NXnS[JN4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3LuVlAvODFvMUCwJO69VQ>? M4fkZ|Q5KGh? MXTMc4chT0l3ME2tPE42QCCP NHvYdnkzOjN|NkK0Oi=>
OVCAR5 MlvwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{OzWFAvODFvMUCwJO69VQ>? NXn4SGNsPDhiaB?= M{Hpb2xw\yCJSUWwQU04NjV5IF2= NGL5cIczOjN|NkK0Oi=>
OVCAR8 NWXNbXJKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3PITFAvODFvMUCwJO69VQ>? MXq0PEBp NYrGWmVmVG:pIFfJOVA:NTdwOESgUS=> M1S3W|IzOzN4MkS2
SKOV3 NFHNe3NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUP3bZRxOC5yMT2xNFAh|ryP NHnRU|A1QCCq MljMUI9oKEeLNUC9MVgvPDFiTR?= NH;JOGszOjN|NkK0Oi=>
RXF631L MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmTiNE4xOS1zMECg{txO Mm[4OFghcA>? NHX5SpJNd2diR1m1NF0uQC5{MTDN M3vHblIzOzN4MkS2
ACHN MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2rUNVAvODFvMUCwJO69VQ>? Mo[0OFghcA>? NWC0fnFWVG:pIFfJOVA:NTdwOUWgUS=> NWXZSFFkOjJ|M{[yOFY>
St-4 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlOyNE4xOS1zMECg{txO MkPFOFghcA>? NGDGUYlNd2diR1m1NF0uPy52NzDN MX:yNlM{PjJ2Nh?=
MKN1 M4m0Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXT2bnlYOC5yMT2xNFAh|ryP NVXibnM1PDhiaB?= NWX1TZRpVG:pIFfJOVA:NThwNEGgUS=> Mnf6NlI{OzZ{NE[=
MKN7 M172PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoW4NE4xOS1zMECg{txO MY[0PEBp Mnu1UI9oKEeLNUC9MVcvPjhiTR?= NUHRSGlrOjJ|M{[yOFY>
MKN28 M3\FRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVuwdHdOOC5yMT2xNFAh|ryP MoG1OFghcA>? NF:2XWVNd2diR1m1NF0uPy5yNzDN MV6yNlM{PjJ2Nh?=
MKN45 NFHuRlBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4DLTVAvODFvMUCwJO69VQ>? M1\ndlQ5KGh? MYXMc4chT0l3ME2tPE4{PCCP M1e3UlIzOzN4MkS2
MKN74 MkfOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWfK[o06OC5yMT2xNFAh|ryP Mo\EOFghcA>? NIDQTXhNd2diR1m1NF0uPy52MjDN MkXSNlI{OzZ{NE[=
DU145 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX[wMlAyNTFyMDFOwG0> NUL6UphGPDhiaB?= MkLGUI9oKEeLNUC9MVgvOTZiTR?= M{jH[|IzOzN4MkS2
PC3 MmnoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1L1[lAvODFvMUCwJO69VQ>? MWi0PEBp M{PETWxw\yCJSUWwQU05NjZ4IF2= NXzrNJpmOjJ|M{[yOFY>
Trypanosoma brucei brucei M2PwRWZ2dmO2aX;uJGF{e2G7 NH22bJkzODBibl2= NVnyVXl5OTJiaB?= NVLwOpl3TE2VTx?= NX\4d|hnTGWlcnXhd4UhcW5icHjvd5Bpd3SrZInsJIlvd3OrdH;sJJBpd3OyaHH0[UBt\X[nbB?= M2X3[FI1QDB3OUS2
Trypanosoma brucei brucei NH\zbm5HfW6ldHnvckBCe3OjeR?= Mn3aNVghcA>? M3zGNmROW09? MWfJcohq[mm2aX;uJI9nKHKnY3XweI9zNW2nZHnheIVlKGWwZH;jfZRwe2m|IHHzd4V{e2WmIHHzJIRm[3KnYYPlJIlvKHS{YX7z[oVzemmwIIXweIFs\Q>? M372PFI1QDB3OUS2
Trypanosoma brucei brucei MlXZSpVv[3Srb36gRZN{[Xl? NF[2V3ozODBibl2= MWKxNkBp M{nIN2ROW09? M1TLTWVn\mWldDDvckB{eGirbnfvcZlt\WmwIHzleoVt MX2yOFgxPTl2Nh?=
Trypanosoma brucei brucei NF3yRotHfW6ldHnvckBCe3OjeR?= MWiyNFAhdk1? NVPUSVRFOTJiaB?= NF;HOpdFVVOR NFO4bWFG\m[nY4Sgc44heGixc4DoZZRq\HmuY3jvcIlv\SCuZY\lcC=> MUWyOFgxPTl2Nh?=
UM-UC-3 NWHqPIpzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2\WdWlEPTB;M{G1JJBO MoLTV2FPT0WU
SBC-1 NE[xR|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHzCdm1KSzVyPUe0NkBxVQ>? NF31[5FUSU6JRWK=
MKN1 M{Dq[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1;LXWlEPTB;Mj64JI5O M1zpW3NCVkeHUh?=
NCI-H720 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3\0WGlEPTB;Mz61O{BvVQ>? M1PjNHNCVkeHUh?=
BFTC-909 NE\3OYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV3JR|UxRTNwN{Ggcm0> MV\TRW5ITVJ?
BPH-1 M2PlS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXXJR|UxRTRwN{[gcm0> NFrsPIVUSU6JRWK=
PC-3 MmPSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHPPRYFKSzVyPUWuNFkhdk1? M4rVNXNCVkeHUh?=
AN3-CA M3jqZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkKxTWM2OD13LkW2JI5O MlL6V2FPT0WU
HN MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MknFTWM2OD13Lkm2JI5O NHTacXJUSU6JRWK=
HCC2218 M4LEcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIL1d2FKSzVyPU[uOlEhdk1? MoLNV2FPT0WU
KP-4 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2i5dmlEPTB;NzDuUS=> MYPTRW5ITVJ?
LU-139 MnGwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1fOPWlEPTB;Nz63O{BvVQ>? MlH0V2FPT0WU
ETK-1 M4DqbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWHJR|UxRTdwOEigcm0> NVjqSW9OW0GQR1XS
Ramos-2G6-4C10 M{X5Xmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmD5TWM2OD16LkS5JI5O MYHTRW5ITVJ?
MHH-PREB-1 NG\KPXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXLJR|UxRTlwMUKgcm0> MljjV2FPT0WU
DU-4475 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1XqcGlEPTB;OT60OEBvVQ>? MXrTRW5ITVJ?
NCI-H1666 M4C1N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWXJR|UxRTlwN{Ggcm0> MlSwV2FPT0WU
CAMA-1 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnzTTWM2OD17Lkigcm0> Mlz5V2FPT0WU
TYK-nu MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4D0[GlEPTB;OT65OEBvVQ>? M4XHfXNCVkeHUh?=
MFE-280 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGHqcGJKSzVyPUmuPVkhdk1? NW\0UHVMW0GQR1XS
A549 M4WzOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3O5T2lEPTB;MUCuNVQhdk1? MoTXV2FPT0WU
769-P MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2PPbGlEPTB;MUCuOFQhdk1? MY\TRW5ITVJ?
L-363 NWfKc2lXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4\JbGlEPTB;MUCuOlkhdk1? MlXxV2FPT0WU
ES8 NU\nd3RqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYLqcWx{UUN3ME2xNE46KG6P NULjZ5pxW0GQR1XS
PA-1 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGDRPZpKSzVyPUGxMlgzKG6P NF7Yd|lUSU6JRWK=
Mewo MlXzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2PGVGlEPTB;MUGuPVkhdk1? MkDNV2FPT0WU
HSC-3 MnnUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkXoTWM2OD1zMj6yNUBvVQ>? MVfTRW5ITVJ?
H4 M1nlVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M36wU2lEPTB;MUKuOlchdk1? MXXTRW5ITVJ?
BB65-RCC MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHPRXVZKSzVyPUGyMlczKG6P NV;tbGhPW0GQR1XS
NCI-H1793 NEj1UpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M36yUWlEPTB;MUKuPFIhdk1? M4LRcnNCVkeHUh?=
KARPAS-45 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXLJR|UxRTF|LkWxJI5O MY\TRW5ITVJ?
GCT MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWrDUotPUUN3ME2xN{43QCCwTR?= MkHrV2FPT0WU
EoL-1 NYnRSGlRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH7MWoZKSzVyPUGzMlk{KG6P MXzTRW5ITVJ?
LB2241-RCC M13kOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MknCTWM2OD1zND6wNUBvVQ>? MXHTRW5ITVJ?
ES5 MoTmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoG2TWM2OD1zND63OEBvVQ>? MWnTRW5ITVJ?
LOXIMVI MmniS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV;NbYpQUUN3ME2xOE46QSCwTR?= MnjHV2FPT0WU
COR-L105 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2noWWlEPTB;MUWuNFQhdk1? M4jNXHNCVkeHUh?=
P12-ICHIKAWA NED0UotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIHjSlhKSzVyPUG1MlEhdk1? MXnTRW5ITVJ?
CHL-1 NI\QWnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUXlcWdtUUN3ME2xOU41PSCwTR?= NI\oSo5USU6JRWK=
VMRC-RCZ MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIjUflhKSzVyPUG1MlY{KG6P MX3TRW5ITVJ?
HH NVLob49qT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4TUVmlEPTB;MUWuO{BvVQ>? NX62W5E{W0GQR1XS
NUGC-3 M3nlVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGG3PJFKSzVyPUG2MlM1KG6P MXTTRW5ITVJ?
EGI-1 MoPqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH;rdJhKSzVyPUG2MlQ{KG6P MnLpV2FPT0WU
OS-RC-2 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVzoZXl1UUN3ME2xOk41PyCwTR?= NH\pNFBUSU6JRWK=
MOLT-16 NGfucYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2Cx[WlEPTB;MUeuNVUhdk1? M16zRXNCVkeHUh?=
NCI-H209 M{Pu[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEHidVhKSzVyPUG3MlI6KG6P NIS0fXBUSU6JRWK=
697 MnrTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFnzd4JKSzVyPUG3MlQ{KG6P NXvvbFJoW0GQR1XS
D-56MG MkjzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3y5RmlEPTB;MUeuOlkhdk1? MX;TRW5ITVJ?
VA-ES-BJ MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHPNO2JKSzVyPUG3Mlg{KG6P MlziV2FPT0WU
EW-16 M1nNWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYnJR|UxRTF6LkC0JI5O M3;P[HNCVkeHUh?=
HGC-27 M2fsRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVjLco5nUUN3ME2xPE4xPiCwTR?= NYXWO3p6W0GQR1XS
ES7 M{fscmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF[4RpRKSzVyPUG4MlA6KG6P MUnTRW5ITVJ?
HuH-7 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnvWTWM2OD1zOD60JI5O NHXPOFhUSU6JRWK=
BCPAP MkfQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXnjZXBXUUN3ME2xPE43PSCwTR?= MVTTRW5ITVJ?
SW1710 M1T1Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX71XpJqUUN3ME2xPE44OiCwTR?= M4fLcnNCVkeHUh?=
IST-MEL1 M13v[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnPuTWM2OD1zOD63O{BvVQ>? NFPN[ppUSU6JRWK=
SF295 Ml;CS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3rQPGlEPTB;MUiuPVMhdk1? M3XmVXNCVkeHUh?=
RPMI-7951 M3GzUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV;JR|UxRTF7LkK4JI5O NVG2Z2t4W0GQR1XS
SF126 M{\DZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUDJR|UxRTF7LkSxJI5O Mn2xV2FPT0WU
GAMG M3fXZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmXETWM2OD1zOT60PEBvVQ>? MmG4V2FPT0WU
KNS-81-FD MofKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWXJR|UxRTF7LkW0JI5O NGPWOVlUSU6JRWK=
RT-112 MnzLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoK0TWM2OD1zOT62OkBvVQ>? MXLTRW5ITVJ?
DEL M3HYS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEjlPIJKSzVyPUKwMlQ6KG6P M1PhPHNCVkeHUh?=
CGTH-W-1 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2DiOWlEPTB;MkCuOlMhdk1? MkOyV2FPT0WU
HOS MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnHyTWM2OD1{MT6wOkBvVQ>? M4rEcXNCVkeHUh?=
ES4 MmPyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NETvWW5KSzVyPUKxMlA5KG6P NW[1eXo{W0GQR1XS
RXF393 MkPjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVvuSZZOUUN3ME2yNU41PSCwTR?= MXPTRW5ITVJ?
NCI-H2030 NX3CPWtHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV[2UGx3UUN3ME2yNU42OiCwTR?= NH6yS3NUSU6JRWK=
YH-13 Mn\4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MULJR|UxRTJzLki4JI5O Mm\FV2FPT0WU
HT-1080 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1XlbGlEPTB;MkGuPVMhdk1? MYLTRW5ITVJ?
NCI-SNU-1 M3HhUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NG\LXXdKSzVyPUKxMlk2KG6P MorOV2FPT0WU
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ME-180 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkfXTWM2OD1{Mj60N{BvVQ>? M3jCNHNCVkeHUh?=
NB69 M2nHVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWLJR|UxRTJ{LkWzJI5O MnuwV2FPT0WU
J-RT3-T3-5 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn:yTWM2OD1{Mj65OkBvVQ>? Mk\RV2FPT0WU
TGBC1TKB MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH\X[GlKSzVyPUKzMlA2KG6P NIfrUo1USU6JRWK=
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MG-63 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXLJR|UxRTJ|LkS1JI5O NH;LO2RUSU6JRWK=
BV-173 NFrwN|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFfER5FKSzVyPUKzMlg4KG6P NYfOPYo5W0GQR1XS
CAL-51 NGjy[GhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkLmTWM2OD1{Mz64PUBvVQ>? NXG3WHpPW0GQR1XS
A375 MmSxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUjpenp6UUN3ME2yN{46OyCwTR?= MonpV2FPT0WU
MEL-HO M4rzeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2LBdmlEPTB;MkSuNFQhdk1? NVSyRWZ2W0GQR1XS
EFO-27 NGjuVWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{LZWmlEPTB;MkSuN|Mhdk1? MXPTRW5ITVJ?
Hs-578-T MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV;OWWxvUUN3ME2yOE42QCCwTR?= MWjTRW5ITVJ?
NBsusSR M1vNWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3H0W2lEPTB;MkSuOkBvVQ>? MVrTRW5ITVJ?
CTB-1 M3XVdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoHLTWM2OD1{ND62O{BvVQ>? NFH2NlFUSU6JRWK=
FTC-133 MnPuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2rPXGlEPTB;MkWuNUBvVQ>? NXfufYd7W0GQR1XS
MOLT-4 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX;De3R5UUN3ME2yOU4yOiCwTR?= M3ewR3NCVkeHUh?=
HO-1-N-1 MnLyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEnZ[3hKSzVyPUK1MlE2KG6P M3vMZ3NCVkeHUh?=
ES3 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEnNZ5pKSzVyPUK1MlIzKG6P M3HjT3NCVkeHUh?=
TI-73 NXHZTGx2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX7oVGRTUUN3ME2yOU4zQCCwTR?= M3jYT3NCVkeHUh?=
MPP-89 MoPWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXfJR|UxRTJ3LkOyJI5O NHThb4VUSU6JRWK=
KYSE-150 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUHVe5dSUUN3ME2yOU45QSCwTR?= M3jOWXNCVkeHUh?=
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SK-LU-1 M{L3c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWfJR|UxRTJ4LkG3JI5O NELDUY9USU6JRWK=
HOP-92 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3Lu[mlEPTB;Mk[uOFghdk1? MknpV2FPT0WU
HuO9 NHv3eIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXHUTolIUUN3ME2yOk44PiCwTR?= NHnodYRUSU6JRWK=
SW962 Ml3HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3[2cGlEPTB;Mk[uO|Yhdk1? MYHTRW5ITVJ?
RS4-11 M{\Y[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2fMfmlEPTB;Mk[uPVEhdk1? MoTsV2FPT0WU
NCI-H292 M4DEc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHHoRZJKSzVyPUK3JI5O NUnEVo9{W0GQR1XS
DB NU\jb3d2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFTafoVKSzVyPUK3MlM3KG6P MorqV2FPT0WU
SW1088 MmTpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MljvTWM2OD1{OD6yPUBvVQ>? MmHxV2FPT0WU
A204 NEHUNZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHWxWllKSzVyPUK4MlQ4KG6P MmfNV2FPT0WU
A3-KAW NELYZ2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHjVW2dKSzVyPUK4MlY1KG6P MULTRW5ITVJ?
MV-4-11 NUXSb3hQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX3EPZBmUUN3ME2yPE44KG6P Ml;MV2FPT0WU
ES1 MlTpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVrvSnIyUUN3ME2yPE45PCCwTR?= MW\TRW5ITVJ?
ONS-76 NGjPXWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXHJR|UxRTJ7LkC1JI5O NXfoUoJ3W0GQR1XS
D-263MG NGm4UYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmPOTWM2OD1{OT6zOUBvVQ>? M3zuTnNCVkeHUh?=
U-2-OS MkTqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFvh[FJKSzVyPUK5MlUhdk1? NF64SnpUSU6JRWK=
T98G M3zuZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkXnTWM2OD1{OT64PEBvVQ>? M3XneHNCVkeHUh?=
GI-ME-N MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYrmOXB{UUN3ME2yPU46OSCwTR?= NELxR4tUSU6JRWK=
BHT-101 Mk\yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MU\JR|UxRTNyLkC1JI5O NV3rS21HW0GQR1XS
NOS-1 MnrJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVPJR|UxRTNyLkGyJI5O MkDUV2FPT0WU
AsPC-1 NGHWWI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXLJR|UxRTNyLkKgcm0> MkLvV2FPT0WU
QIMR-WIL MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVLJR|UxRTNyLk[gcm0> NFKwUIpUSU6JRWK=
JVM-3 M1PmW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYj1e2FsUUN3ME2zNE45OyCwTR?= NXn3dW9oW0GQR1XS
KU-19-19 NUjPZY57T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEPpN5JKSzVyPUOxMlE{KG6P NXPtcYxYW0GQR1XS
OVCAR-8 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXnmVFVMUUN3ME2zNU4zPiCwTR?= NX;UUIV2W0GQR1XS
BEN MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MojQTWM2OD1|MT62N{BvVQ>? NWjrWZZwW0GQR1XS
BE-13 M{f0UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1P3b2lEPTB;M{GuPFIhdk1? MXTTRW5ITVJ?
EW-18 NUm2XI1uT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWPJR|UxRTNzLki2JI5O MXzTRW5ITVJ?
ECC10 NYXyeVROT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoruTWM2OD1|MT65OUBvVQ>? MWrTRW5ITVJ?
CTV-1 NEOwd5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVSxU3N5UUN3ME2zNk45OiCwTR?= MWLTRW5ITVJ?
COLO-800 NV7pVJdQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH3SeG1KSzVyPUOyMlkzKG6P MV\TRW5ITVJ?
A2058 M1H4b2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUXW[5FwUUN3ME2zN{4zPSCwTR?= M1\5XnNCVkeHUh?=
VM-CUB-1 NUPIc45WT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWXJR|UxRTN|LkSzJI5O MmLrV2FPT0WU
Ca9-22 Mn3sS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mm[zTWM2OD1|Mz61OUBvVQ>? MnLpV2FPT0WU
COLO-684 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkCxTWM2OD1|Mz61PEBvVQ>? NFrVR|dUSU6JRWK=
RPMI-8226 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYDJR|UxRTN|LkiyJI5O NGnVNYVUSU6JRWK=
SK-NEP-1 NUXZZ2RyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXmzboJRUUN3ME2zOE4yPSCwTR?= MX\TRW5ITVJ?
Becker NGG3TnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFGwNG9KSzVyPUO0MlIyKG6P MXzTRW5ITVJ?
NCI-H28 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEfBN5lKSzVyPUO0MlQ1KG6P NETU[ZpUSU6JRWK=
CAL-120 MknlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUTJR|UxRTN2LkeyJI5O M{PuVXNCVkeHUh?=
MDA-MB-157 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoX0TWM2OD1|NT60NUBvVQ>? M3vDdHNCVkeHUh?=
OVCAR-5 NIm2N4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2Kyd2lEPTB;M{WuOFchdk1? MUnTRW5ITVJ?
LAMA-84 M2\6dWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEf6fJJKSzVyPUO1Mlg4KG6P NHLnS|hUSU6JRWK=
CAKI-1 NFvCT3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{nEcmlEPTB;M{[uOFMhdk1? MnzHV2FPT0WU
Daoy NFntVolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFj5OYlKSzVyPUO2Mlchdk1? MkLTV2FPT0WU
CAL-62 NHvtSpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUXJenhWUUN3ME2zOk45PiCwTR?= NIrPXYFUSU6JRWK=
8-MG-BA MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVfxZWVXUUN3ME2zO{4zPSCwTR?= NIXXOodUSU6JRWK=
8505C M2jzS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXTjfYZHUUN3ME2zO{42OSCwTR?= NVSxZ2NJW0GQR1XS
LNCaP-Clone-FGC NVXCbHZRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUDJR|UxRTN5LkW5JI5O M3PZOHNCVkeHUh?=
CAL-39 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXfycZdzUUN3ME2zO{46KG6P NXLVe3loW0GQR1XS
MN-60 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MU\JR|UxRTN5Lkm2JI5O NHvSbHRUSU6JRWK=
RKO MkLsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXP5dY9LUUN3ME2zPE4{OyCwTR?= NWTVNFRFW0GQR1XS
U251 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NITYS4xKSzVyPUO4MlQ{KG6P M{G5XXNCVkeHUh?=
SJSA-1 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUS0bIllUUN3ME2zPE42PCCwTR?= Mnm5V2FPT0WU
CAL-12T MlXtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3\5NmlEPTB;M{iuOkBvVQ>? M4Hhe3NCVkeHUh?=
HCC1419 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUKxUpc5UUN3ME2zPE44OSCwTR?= NFj0NIJUSU6JRWK=
CO-314 NXPBN5d4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXvJR|UxRTN6Lke0JI5O NXHMWnZ5W0GQR1XS
LB1047-RCC NYXVWmR2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHjKb2tKSzVyPUO4MlgyKG6P NFvNWlZUSU6JRWK=
A101D Ml;GS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlrlTWM2OD1|OD65O{BvVQ>? MlrGV2FPT0WU
MDA-MB-175-VII Mn3NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mof1TWM2OD1|OT61NUBvVQ>? M1fySHNCVkeHUh?=
MZ2-MEL M2CwNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MonKTWM2OD1|OT62OkBvVQ>? MYrTRW5ITVJ?
NB5 M{nxPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoLXTWM2OD12MD62OEBvVQ>? MXLTRW5ITVJ?
G-401 NGOwfJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmHuTWM2OD12MD64NkBvVQ>? NF\nS21USU6JRWK=
HT Mn[5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2mxVWlEPTB;NEGuNFIhdk1? MknmV2FPT0WU
8305C M4Ltdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVSx[5hGUUN3ME20NU45PyCwTR?= M3PtSXNCVkeHUh?=
BHY M4LqZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXjETlhVUUN3ME20Nk44OiCwTR?= M2XxZ3NCVkeHUh?=
NTERA-S-cl-D1 NXfpbW9[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkfLTWM2OD12MzDuUS=> NHjQepVUSU6JRWK=
T-24 NF3jd4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUfJR|UxRTR|LkizJI5O NFH0bIxUSU6JRWK=
EPLC-272H NFizTJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3\6XmlEPTB;NESuN|khdk1? Mn;CV2FPT0WU
PSN1 NYnjUWxST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX63dphpUUN3ME20OE41KG6P M3nlfHNCVkeHUh?=
NCI-H2452 NGCzeZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTR2LkW4JI5O NHnHRldUSU6JRWK=
KS-1 M3T5W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUCyVGNZUUN3ME20OE43PiCwTR?= NI[xW3JUSU6JRWK=
HD-MY-Z MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn61TWM2OD12ND65NkBvVQ>? M4j0ZXNCVkeHUh?=
KNS-62 M3jSeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlK5TWM2OD12NT6zPEBvVQ>? NVz1U2lCW0GQR1XS
NOMO-1 NIfoXHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXHZZ4NjUUN3ME20OU45PyCwTR?= MWfTRW5ITVJ?
SK-HEP-1 NGXW[WVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnqwTWM2OD12Nj6wOEBvVQ>? NYjSfWI2W0GQR1XS
IGR-1 MlHmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGfXSWNKSzVyPUS2MlE{KG6P NFvWbYNUSU6JRWK=
KYSE-180 M4fiOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGHpNXdKSzVyPUS2MlE4KG6P NXva[llWW0GQR1XS
EW-22 NHy1WotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NE\yW5RKSzVyPUS2MlIhdk1? MYTTRW5ITVJ?
NCI-H1355 M3uyZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWPJR|UxRTR4LkO0JI5O MmruV2FPT0WU
DOHH-2 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NW\TZZN3UUN3ME20Ok4{PyCwTR?= NIDmN5VUSU6JRWK=
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PC-14 MlHXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2X5OGlEPTB;NE[uOVchdk1? NUHETZViW0GQR1XS
TE-5 NHPPbG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV3JR|UxRTR4Lki0JI5O MmfDV2FPT0WU
LB996-RCC MnTHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{Pzb2lEPTB;NEeuNVkhdk1? MoXrV2FPT0WU
NCI-H1623 M2P4V2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1n0U2lEPTB;NEeuO|Yhdk1? NV\xUnFzW0GQR1XS
NCI-H1155 NVL4S5g{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3XtWGlEPTB;NEiuN|Ihdk1? MWjTRW5ITVJ?
LoVo MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYnJR|UxRTR6LkSgcm0> MXjTRW5ITVJ?
MCF7 NH7TTGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEfTbWtKSzVyPUS4MlU5KG6P NWq1TmxZW0GQR1XS
AGS MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{f2RWlEPTB;NEiuO|chdk1? Mnj5V2FPT0WU
PFSK-1 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV;JR|UxRTR7LkC2JI5O NVjibXN2W0GQR1XS
22RV1 NVrsb2d3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1PJTWlEPTB;NEmuNFkhdk1? MWPTRW5ITVJ?
COR-L23 M3zWdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTR7LkG2JI5O MXvTRW5ITVJ?
D-283MED NXTkR4NvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWnTRodyUUN3ME20PU43OSCwTR?= NHf3W|BUSU6JRWK=
SW982 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGn0OWRKSzVyPUS5MlkyKG6P NIfiUGRUSU6JRWK=
SW620 MmfvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmnBTWM2OD13MD6zOkBvVQ>? MoH2V2FPT0WU
KYSE-140 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXzmRWRGUUN3ME21NE42PSCwTR?= MnjjV2FPT0WU
GCIY MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnjHTWM2OD13MD62O{BvVQ>? M2\oNnNCVkeHUh?=
MHH-ESS-1 NGDQW29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NITYWYdKSzVyPUWxMlk2KG6P NF\oUoNUSU6JRWK=
D-423MG NWjsW3RQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3rPWGlEPTB;NUKuNFghdk1? NGq1ZXRUSU6JRWK=
SF539 M2DTWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXHJR|UxRTV{LkO1JI5O MoPoV2FPT0WU
RPMI-2650 M1TJSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M16zdmlEPTB;NUKuOlkhdk1? MVvTRW5ITVJ?
GR-ST MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1zQWWlEPTB;NUKuPFchdk1? M3HBNXNCVkeHUh?=
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SK-MES-1 M1i1TWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXHJR|UxRTV|LkK2JI5O NULpV4d3W0GQR1XS
HLE NHHRUVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFXIXZNKSzVyPUWzMlQ4KG6P NWf6bmxDW0GQR1XS
RVH-421 MlrUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1nnd2lEPTB;NUOuOlchdk1? MWnTRW5ITVJ?
C32 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{\LSmlEPTB;NUOuPFMhdk1? NIjvV|hUSU6JRWK=
GB-1 NEm5NHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGjZPIlKSzVyPUW0MlIhdk1? MXHTRW5ITVJ?
SNB75 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2fJfmlEPTB;NUSuNlYhdk1? NX;0NHZwW0GQR1XS
EM-2 NVjzclFrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NET5ZXJKSzVyPUW0MlQhdk1? NU\jSpU4W0GQR1XS
RH-1 NXu5blcxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{ewdmlEPTB;NUSuO{BvVQ>? MW\TRW5ITVJ?
NKM-1 M2r1OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml3iTWM2OD13ND64NUBvVQ>? NWjTNI1nW0GQR1XS
NCI-H2405 M1vMb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4HuZmlEPTB;NUSuPFghdk1? Ml;CV2FPT0WU
KYSE-450 NGHId5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYfJR|UxRTV3LkG2JI5O MV\TRW5ITVJ?
A704 M2fIcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGnCcGpKSzVyPUW1MlU6KG6P NGPmPHNUSU6JRWK=
HAL-01 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWXJR|UxRTV3LkizJI5O NIDWSWVUSU6JRWK=
TE-11 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX;EWGVIUUN3ME21OU46QSCwTR?= M4rM[HNCVkeHUh?=
DOK MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWSw[4hMUUN3ME21Ok4xOiCwTR?= M1;3U3NCVkeHUh?=
KY821 Mn\lS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3TwR2lEPTB;NU[uNkBvVQ>? MmP4V2FPT0WU
KGN M4\CU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFXaXVhKSzVyPUW2MlMzKG6P MXLTRW5ITVJ?
MC116 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M17he2lEPTB;NUeuPEBvVQ>? MYfTRW5ITVJ?
PANC-08-13 NILCcYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYPT[3hnUUN3ME21PE4xOSCwTR?= M3LOfXNCVkeHUh?=
KE-37 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGC1SItKSzVyPUW4Mlc4KG6P NX3EUJlpW0GQR1XS
KYSE-410 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGq3VFBKSzVyPUW5MlQ4KG6P NXn1SJNMW0GQR1XS
RO82-W-1 Mo[zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnT3TWM2OD13OT65JI5O MmjpV2FPT0WU
M14 Mk\mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXLM[ZFHUUN3ME22NE4xPCCwTR?= NX\uS2s{W0GQR1XS
GI-1 NVnFPFRDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFfJTYJKSzVyPU[wMlMhdk1? NE[wO5BUSU6JRWK=
ML-2 NWP3bXhoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUTJR|UxRTZyLk[yJI5O NFT1TJpUSU6JRWK=
BFTC-905 NFPSVJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEDwSZNKSzVyPU[wMlY2KG6P MYHTRW5ITVJ?
DMS-273 M372Wmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn[5TWM2OD14MD64O{BvVQ>? M4nzTXNCVkeHUh?=
MDA-MB-361 NHO3fG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2XUWmlEPTB;NkGgcm0> M4GwT3NCVkeHUh?=
MSTO-211H NI[zbG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVzHU5FMUUN3ME22N{42OSCwTR?= Mn;mV2FPT0WU
MEG-01 Mn7pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mo\6TWM2OD14Mz61NkBvVQ>? NGLLVnFUSU6JRWK=
M059J MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnPjTWM2OD14Mz61PEBvVQ>? NXvCTVkxW0GQR1XS
LN-405 M4nLOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4[2TWlEPTB;NkOuPFUhdk1? MkHTV2FPT0WU
NCI-H1581 M4DOXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml7kTWM2OD14ND6wN{BvVQ>? NWK5[oNyW0GQR1XS
TCCSUP NEf1[HJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUXJR|UxRTZ2LkWzJI5O M4TnVHNCVkeHUh?=
SW872 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnzETWM2OD14ND61O{BvVQ>? NE\ZRZFUSU6JRWK=
KYSE-510 NHW0VHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{HrfmlEPTB;NkWuO|Uhdk1? Mki5V2FPT0WU
NCI-H1792 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUjlS3Z2UUN3ME22Ok4yPSCwTR?= MlHkV2FPT0WU
SW13 M1LMRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV;TcZRVUUN3ME22Ok42KG6P NU\TUHp6W0GQR1XS
TE-8 NEfmepJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIDrcoVKSzVyPU[2MlUzKG6P NV;SfFhOW0GQR1XS
SCH NVWzOnoxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX;SUYhVUUN3ME22O{4yKG6P MorJV2FPT0WU
NEC8 MlTtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUfJR|UxRTZ5LkK0JI5O M{\sZnNCVkeHUh?=
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EFM-19 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUjnPGhDUUN3ME22O{42KG6P NFfUd5pUSU6JRWK=
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T47D MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWLCNJlRUUN3ME22O{45PyCwTR?= NVXlUnNCW0GQR1XS
SNU-423 NHHZNoZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2\KUGlEPTB;NkeuPVghdk1? MlPCV2FPT0WU
WM-115 NWf5UFNET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4rj[WlEPTB;NkiuNVQhdk1? Mlq3V2FPT0WU
CaR-1 NE\GNW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYTJR|UxRTZ6LkK1JI5O NXTJeFZPW0GQR1XS
KU812 NXPsOoo5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3\CcWlEPTB;NkiuOlkhdk1? MoXHV2FPT0WU
AM-38 M{jGemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVPJR|UxRTZ7LkOxJI5O NXnDNZJoW0GQR1XS
KOSC-2 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkT5TWM2OD14OT65O{BvVQ>? NXfNWW8yW0GQR1XS
MC-IXC MlrFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFPVclFKSzVyPUewMlA5KG6P MYfTRW5ITVJ?
SCC-4 Mo\YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWfJR|UxRTdzLkO4JI5O MljGV2FPT0WU
Calu-3 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV;3c|lMUUN3ME23NU46QCCwTR?= MkT1V2FPT0WU
RPMI-8866 NIn4clhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHXrfHdKSzVyPUeyMlgzKG6P NGnFbHhUSU6JRWK=
OVCAR-4 NGnjfYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{DRNmlEPTB;N{OuN|Yhdk1? NGq4d49USU6JRWK=
OAW-42 MkXpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWPLbWVMUUN3ME23N{4{QSCwTR?= M32yTHNCVkeHUh?=
ATN-1 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYjJR|UxRTd|Lki3JI5O MYHTRW5ITVJ?
CHP-212 M3;ycGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXzJR|UxRTd2Lkm1JI5O M{GySXNCVkeHUh?=
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SNU-449 NFXlRWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXPJR|UxRTd3Lke5JI5O NH\kN3lUSU6JRWK=
RD NIC1TZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWrJR|UxRTd3Lki2JI5O NV;Be4x4W0GQR1XS
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S-117 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlTxTWM2OD15Nj6yO{BvVQ>? NUDKfZRzW0GQR1XS
SK-MEL-2 NYfWfGtvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MorvTWM2OD15Nj63OUBvVQ>? MXXTRW5ITVJ?
LK-2 Mnm0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2nqW2lEPTB;N{euNFUhdk1? MkXGV2FPT0WU
CP50-MEL-B M{fXcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1r3VWlEPTB;N{euOEBvVQ>? M2TOWHNCVkeHUh?=
647-V NG\aOG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXLJR|UxRTd6LkC3JI5O MYTTRW5ITVJ?
LU-134-A NID3OHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{H1e2lEPTB;N{muNFMhdk1? NXXFR2NOW0GQR1XS
5637 NITpR|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MojMTWM2OD15OT6yN{BvVQ>? MoDBV2FPT0WU
NCI-H1437 NFLseHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXTJR|UxRThyLkWgcm0> NHfKTolUSU6JRWK=
NCI-H460 NF3GN41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1jQUWlEPTB;OEGuNlMhdk1? MYjTRW5ITVJ?
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SK-N-DZ MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFLG[WtKSzVyPUKuPFY{QDFizszN M2fJWnNCVkeHUh?=
NCI-H82 M4W1UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGrYVW9KSzVyPUKuPVA{PjlizszN NYHZXZdtW0GQR1XS
JVM-2 M4r6R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1TWdGlEPTB;Mz6wN|E5QCEQvF2= MYHTRW5ITVJ?
SW1116 NW\VRpd6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUHJR|UxRTNwMEW0NVEh|ryP M3nZWnNCVkeHUh?=
MDA-MB-453 MmXGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFTrR3BKSzVyPUOuNVA1OzlizszN NHnXfXdUSU6JRWK=
Calu-6 MnfwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{DRfWlEPTB;Mz6xPVk4KM7:TR?= MnThV2FPT0WU
SHP-77 M1TxTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX:zZ4M2UUN3ME2zMlUzQCEQvF2= NUDCOIlCW0GQR1XS
Capan-2 MnHDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX;0eINzUUN3ME20MlMzPThzIN88US=> M3XY[XNCVkeHUh?=
SW948 NV7mbm5VT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoKxTWM2OD12Lke0O|c6KM7:TR?= NFf0ZVJUSU6JRWK=
HDLM-2 MknjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M17SNmlEPTB;NT6wO|czPSEQvF2= MlHlV2FPT0WU
LAN-6 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYT0NYV1UUN3ME22MlIyPDl3IN88US=> NF;2[mlUSU6JRWK=
LU-135 NVPq[W1rT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF7rVVlKSzVyPU[uOFMxPzdizszN M17zTHNCVkeHUh?=
T84 NXHPWWJ[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoC1TWM2OD14Lkm4OlQh|ryP NWPUR|FpW0GQR1XS
CAPAN-1 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWTJR|UxRTdwNkKyN|Mh|ryP NUjSPJBGW0GQR1XS
SW1417 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWHJR|UxRTdwOUG3N|Eh|ryP MXvTRW5ITVJ?
BALL-1 MlLQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX3NSZQ5UUN3ME24MlUxPDB7IN88US=> MXnTRW5ITVJ?
HT-29 NV\C[G5iT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEXyOFNKSzVyPUmuNFc2QTlizszN M4e5OnNCVkeHUh?=
C3A MkTQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHTCNW5KSzVyPUmuPFg{QTRizszN NUnn[mtrW0GQR1XS
NCI-H1993 Mn[yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlLHTWM2OD1zMD61NFgyKM7:TR?= MXHTRW5ITVJ?
SK-MEL-1 MnLrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NI[zWW5KSzVyPUGxMlYzQDlizszN MkjCV2FPT0WU
DU-145 MnPzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2\iPWlEPTB;MUSuOVA2OiEQvF2= MYDTRW5ITVJ?
KP-N-YN M3PWemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NInJUnVKSzVyPUG0MlUyODNizszN M4rkN3NCVkeHUh?=
CCRF-CEM NUexbVV6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnrhTWM2OD1zND63PFA6KM7:TR?= MWTTRW5ITVJ?
ZR-75-30 NYLtR246T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M32xNGlEPTB;MU[uN|MxOyEQvF2= MV;TRW5ITVJ?
A673 NGnt[ZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn3hTWM2OD1{MD61OVA4KM7:TR?= NULaT3c3W0GQR1XS
K-562 NWG3bIVLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVHDbFdvUUN3ME2yPE41OTh|IN88US=> NFS5[2lUSU6JRWK=

... Click to View More Cell Line Experimental Data

In vivo BEZ235 induces regression of the tumors (69%) without statistically significant effect on body weight gain. Altogether, these preliminary in vivo efficacy results show that BEZ235 causes disease stasis when administered orally as a single agent and can enhance the efficacy of other anticancer agents when used in combination studies. [1]

Protocol

Kinase Assay:

[1]

+ Expand

In vitro Protein Kinase, PI3K, and mTOR Assays:

PI3Kα, β, and δ proteins are composed of the iSH2 domain of p85 NH2-terminally fused to the full-length protein p110 protein, with the exception of α that also does not contain the last 20 amino acids. PI3Kγ is produced as full-length protein deleted for its first 144 amino acids. All constructs are fused to a COOH-terminal His tag for convenient purification and then cloned into the pBlue-Bac4.5 (for α, β, and δ isoforms) or pVL1393 (for γ isoform) plasmids. The different vectors are then cotransfected with BaculoGold WT genomic DNA using methods recommended by the vendor for production of the respective recombinant baculoviruses and proteins. BEZ235 are tested for their activity against PI3K using a Kinase-Glo assay. The kinase reaction is done in 384-well black plate. Each well is loaded with 50 μL of test items (in 90% DMSO) and 5 μL reaction buffer containing 10 μg/mL PI substrate (l-α-phosphatidylinositol; Avanti Polar Lipids; prepared in 3% octyl-glucoside) and the PI3K proteins (10, 25, 10, and 150 nM of p110α, p110β, p110δ, and p110γ, respectively) are then added to it. The reaction is started by the addition of 5 μL of 1 μM ATP prepared in the reaction buffer and is incubated for either 60 (for p110α, p110β, and p110δ) or 120 min (for p110γ). It is terminated by the addition of 10 μL Kinase-Glo buffer. The plates are then read in a Synergy 2 reader for luminescence detection.
Cell Research:

[2]

+ Expand
  • Cell lines: HCT116, DLD-1 and SW480 cells
  • Concentrations: 0-1 μM
  • Incubation Time: 48 hours
  • Method:

    The human CRC cell lines, HCT116 (PIK3CA mutant; kinase domain at H1047R), DLD-1 (PIK3CA mutant; helical domain at E545K), and SW480 (PIK3CA wild-type) and isogenic DLD-1 PIK3CA mutant as well as wild-type cells are maintained in DMEM with 10% FBS and 1 × Penicillin/Streptomycin. Cells are plated at different initial densities (HCT116: 3 × 103 cells/well, DLD-1: 5.5 × 103 cells/well, SW480: 4.5 × 103 cells/well, DLD-1 PIK3CA mutant: 7 × 103 cells/well, and DLD-1 PIK3CA wild-type: 9 × 103 cells/well) to account for differential growth kinetics. After 16 hours, cells are incubated with increasing concentrations of BEZ235, and the drug-containing growth medium is changed every 24 hours. Cell viability is assessed 16 hours after the initial plating and 48 hours after initiation of drug treatment using the colorimetric MTS assay CellTiter 96® AQueous One Solution Cell Proliferation Assay, as per the manufacturer's instructions. Cell viability after drug treatment is normalized to that of untreated cells also grown for 48 hours. For western blot analysis, cells are plated with zero or maximum inhibitory dose (500 nM) BEZ235 for 2, 6, 24, or 48 hours.


    (Only for Reference)
Animal Research:

[1]

+ Expand
  • Animal Models: Female Harlan athymic nude mice
  • Formulation: NMP/polyethylene glycol 300 (10/90, v/v)
  • Dosages: 45 mg/kg
  • Administration: p.o.
    (Only for Reference)

Solubility (25°C)

In vitro DMF 18 mg/mL warmed (38.33 mM)
DMSO 0.01 mg/mL (0.02 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
NMP+polyethylene glycol 300 (10+90, v+v)
For best results, use promptly after mixing.
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 469.55
Formula

C30H23N5O

CAS No. 915019-65-7
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

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  • Computed Result

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Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

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Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00620594 Completed Breast Cancer|Advanced Solid Tumors|Cowden Syndrome Novartis Pharmaceuticals|Novartis December 21, 2006 Phase 1
NCT01856101 Terminated Carcinoma Transitional Cell Cliniques universitaires Saint-Luc- Université Catholique de Louvain|Novartis February 2013 Phase 2
NCT01717898 Terminated Castrate-resistant Prostate Cancer Patients. Charles Ryan|Novartis Pharmaceuticals|University of California, San Francisco January 2013 Phase 1|Phase 2
NCT01658436 Completed Pancreatic Neuroendocrine Tumors (pNET) Novartis Pharmaceuticals|Novartis November 2012 Phase 2
NCT01628913 Terminated Pancreatic Neuroendocrine Tumors (pNET) Novartis Pharmaceuticals|Novartis October 2012 Phase 2
NCT01690871 Withdrawn Malignant PEComa (Perivascular Epithelioid Cell Tumors) Novartis Pharmaceuticals|Novartis September 2012 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    With difficulties in dissolving BEZ235, How can I improve its solubility?

  • Answer:

    For in vivo study, we suggest the vehicle solution NMP/polyethylene glycol 300 (10/90, v/v). Please dissolve BEZ235 in NMP as more as possible. You can sonicate and warm it in water bath for a while. Then dilute with PEG 300.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID