Dactolisib (BEZ235, NVP-BEZ235)

Catalog No.S1009

Dactolisib (BEZ235, NVP-BEZ235) Chemical Structure

Molecular Weight(MW): 469.55

Dactolisib (BEZ235, NVP-BEZ235) is a dual ATP-competitive PI3K and mTOR inhibitor for p110α/γ/δ/β and mTOR(p70S6K) with IC50 of 4 nM /5 nM /7 nM /75 nM /6 nM in cell-free assays, respectively. Inhibits ATR with IC50 of 21 nM in 3T3TopBP1-ER cell.

Size Price Stock Quantity  
USD 110 In stock
USD 170 In stock
Bulk Discount

Free Overnight Delivery on orders over $ 500
Next day delivery by 10:00 a.m. Order now.

Cited by 82 Publications

11 Customer Reviews

  • Level of phospho-proteins in RTK and PI3K–Akt–mTOR pathways in treated tumours, detected with western blot.

    Nature, 2017, 728-732. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

    Relative kinase activities of p110α mutants and the inhibitory effect of PI3K inhibitors against hotspot mutants of p110α. A, recombinant FLAG-tagged PI3K p110α/p85α protein complex produced in 293T cells was immunoprecipitated , and the immunoprecipitates were used for the quantitative PI3K-HTRF assay (32).

    B, effect of three PI3K inhibitors (ZSTK474, LY294002, and NVP-BEZ235) on the enzymatic activity of two hotspot mutants (E545K and H1047R) p110α compared with the wild-type. No striking difference was observed in the IC50 concentrations of these inhibitors between wild-type and mutant p110α.
     

     

    Cancer Res 2010 70, 4982-4994. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

  • A, ANOVA of IC50 values of the dual PI3K/mTOR inhibitor NVP-BEZ235 in 23 melanoma cell lines showing no significant difference in sensitivity to this compound in B-Raf mutant and Braf wild-type cells. B, decreases in pAkt and pP70S6K in a dose and time-dependent fashion in 2 melanoma cell lines treated with NVP-BEZ235. pP70S6K levels are undetectable at all concentrations and time points studied, whereas levels of pAkt start rising again after 4 hours of drug exposure in a dose-dependent fashion. C, clonogenic assays in 2 melanoma cell lines (YUVON and YUSIK) treated with NVP-BEZ235 at different concentrations. NVPBEZ235 was effective in inhibiting colony formation at low nanomolar concentrations.

    Clin Cancer Res 2010 16, 6029-6039. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

    Three-dimensional responses of MCF7/IGF-1R cells to TAM (1 μM), E2 and IGF-1. Compared to parental MCF7 cells (a), MCF7/IGF-1R cells (b) in three-dimensional (3D) culture formed bigger acini in response to IGF-1 stimulation and displayed significant TAM resistance when treated with TAM (1 μM) + E2 + IGF-1, which was removable by kinase inhibitors BMS-536924, U0126 and BEZ235 (c). Cells (10,000/well) were seeded in 96-well plates. Acini were formed on 100% Matrigel and cultured for 14 days in starving medium containing 2% Matrigel and 5% charcoal/dextran-stripped fetal bovine serum with the treatments as indicated. Concentrations used: TAM (1 μM), E2 (1 nM) and IGF-1 (100 ng/mL). Confocal image original magnification, × 20. Red, rhodamine phalloidin (actin). Blue, Hoechst blue stain. Results are representative of two individual experiments.

    Breast Cancer Res 2011 13, R52. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

  • TAM (10 nM) agonistic behavior in MCF7/IGF-1R cells is not inhibited by phosphatidylinositol 3-kinase/Akt inhibitor BEZ235. (a) Inhibitory effects of kinase inhibitors BMS-536924, U0126 and BEZ235 on agonistic effect of TAM (10 nM) in the presence of IGF-1 (100 ng/mL). **P < 0.01. (b) Inhibitory effects of phosphatidylinositol 3-kinase (PI3K)/Akt inhibitor BEZ235 at various dose ranges on IGF-1R signaling. (c) Agonistic behavior of TAM (10 nM) in response to BEZ235 kinase inhibitor. (-), no BEZ235. Results are representative of three independent experiments. Data are expressed as means ± SD.

    Breast Cancer Res 2011 13:R52. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

    ZSTK474 and GDC-0941 selectively inhibit class I PI3K over mTOR. (A) Inhibition profiles of the selected five PI3K inhibitors for mTOR. Data shown are mean±SD (n = 3), representative of 2 or 3 independent experiments. (B) IC50 values of the PI3K inhibitors for mTOR. (C) Selectivity of each PI3K inhibitor for PI3Ka over mTOR. The selectivity index is expressed as the ratio of the IC50 value for mTOR over that for PI3Ka. The IC50 values of ZSTK474, NVP-BEZ235 and LY294002 for PI3Ka are 0.016, 0.007 and 0.6 μM, respectively, as reported previously by us.

     

     

    Eur J Cancer 2010 46, 1111-1121. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

  • (B) The effects of AZD2014, BEZ235, lapatinib, LEE011, pazopanib on PI3K/AKT signaling in sarcoma PDC line were determined by immunoblotting analysis. Cells were treated with 1 μM of the indicated drugs for 72 h.

    Transl Oncol, 2016, 9(3):197-202. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

    The effects of LY294002, rapamycin and NVP-BEZ235 on activation of PI3K-Akt-mTOR pathway in hepatocytes. (a) The mRNA expression (PI3K, Akt, mTOR, raptor) by Real-Time PCR, (b) protein expression (PI3K, Akt, mTOR, S6K) by ELISA kits; (c) protein expression of S6K and P-S6K by western blotting. The different letters indicated significant differences (P <0.05). LY = LY294002; rapa = rapamycin; NVP = NVP-BEZ235.

    Animal, 2016, 10(8):1319-27. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

  •  After starved in serum-free medium for 24h,breast cancer cells incubated with the indicated concentrations of BEZ235 for 3h,followed by 20-minute  stimulation of 100ng/ml EGF.

     

     

     

    Dr. Zhang of Tianjin Medical University. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

    After starved in serum-free medium for 24h,breast cancer cells incubated with the indicated concentrations of BEZ235 for 3h,followed by 20-minute  stimulation of 100ng/ml EGF.

     

     

    Dr. Zhang of Tianjin Medical University. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

  •  

    FIG. 4. Phospholipase A2 group 4A (PLA2G4A) expression was increased after BEZ235 treatment in basal-like xenografts. The bar graph shows the quantification of the immunoblots (mean±SD). PLA2G4A, Ethanolamine kinase 1 and 2 (ETNK1/2), Choline kinase alpha/beta (ChoKA/B), and β-actin protein expression were examined by immunoblotting of tissue samples after MRS experiments [control group (n= 5) and BEZ235-treated group (n=7)]. This demonstrated a higher expression of PLA2G4A protein ( P=0.005), but no changes in ETNK1 and ChoKA/B in samples from basal-like xenografts treated with BEZ235.

    Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

Purity & Quality Control

Choose Selective PI3K Inhibitors

Biological Activity

Description Dactolisib (BEZ235, NVP-BEZ235) is a dual ATP-competitive PI3K and mTOR inhibitor for p110α/γ/δ/β and mTOR(p70S6K) with IC50 of 4 nM /5 nM /7 nM /75 nM /6 nM in cell-free assays, respectively. Inhibits ATR with IC50 of 21 nM in 3T3TopBP1-ER cell.
Targets
p110α [1]
(Cell-free assay)
p110γ [1]
(Cell-free assay)
mTOR (p70S6K) [1]
(Cell-free assay)
p110δ [1]
(Cell-free assay)
ATR [8]
(3T3TopBP1-ER cells)
4 nM 5 nM 6 nM 7 nM 21 nM
In vitro

BEZ235 significantly reduces the phosphorylation levels of the mTOR activated kinase p70S6K. BEZ235 results in a reduction of S235/S236P-RPS6 levels with IC50 of 6.5 nM. The activity of BEZ235 against mTOR is determined using a biochemical mTOR K-LISA assay with IC50 of 20.7 nM. BEZ235 shows slightly lower activity against its β paralogue with IC50 of 75 nM. The PI3K/Akt/mTOR pathway is often constitutively activated in human tumor cells. BEZ235 blocks PI3K and mTOR kinase activity by binding to the ATP-binding cleft of these enzymes. Both PTEN-null cell lines PC3M and U87MG show a dose-dependent reduction in cell proliferation when treated with increasing concentrations of BEZ235 with an average GI50 of 10-12 nM. [1] BEZ235 is an mTORC1/2 catalytic inhibitor. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Trypanosoma brucei brucei NInYNZRCdnSrbXnjdo9jcWGuIFHzd4F6 NW\zfYxrOThiaB?= MnT3SG1UVw>? NWjr[HBwSW62aYTyfZBidm:|b33hcEBi[3Srdnn0fUB4cXSqIFXDOVAhd2ZiMD6wNFI2KM7:TR?= MoW1NlQ5ODV7NE[=
MCF7 M1X6VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4HuSFAvODFvMUCwJO69VQ>? M2OydVQ5KGh? NF;vWmhFVVOR MXXJR|UxRTBwN{Og{txO MWGyN|g4OTlyNB?=
HCT116 M{Hyc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYGwMlAyNTFyMDFOwG0> NUXaPXl6PDhiaB?= NYfKSWtvTE2VTx?= MWLJR|UxRTFwMU[g{txO MlzRNlM5PzF7MES=
U87MG MkXES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH;CeZoxNjBzLUGwNEDPxE1? NGf1NFM1QCCq M33i[mROW09? NYHtbJB4UUN3ME2xMlMzKM7:TR?= NFq2[4kzOzh5MUmwOC=>
HBC4 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlzFNE4xOS1zMECg{txO NUfaN3pKPDhiaB?= NV\NNFc3VG:pIFfJOVA:NThwNkGgUS=> MoDUNlI{OzZ{NE[=
BSY1 NHPu[INIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1fLWlAvODFvMUCwJO69VQ>? M2rKcFQ5KGh? MVnMc4chT0l3ME2tPE41QCCP NWDNflR4OjJ|M{[yOFY>
HBC5 Mk\qS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmjFNE4xOS1zMECg{txO NELXO281QCCq NU\aZoExVG:pIFfJOVA:NTdwOEegUS=> M1HGd|IzOzN4MkS2
MCF7 M{jBSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV6wMlAyNTFyMDFOwG0> NFrjW3E1QCCq M4\uV2xw\yCJSUWwQU05NjF4IF2= NFXpfFAzOjN|NkK0Oi=>
MDA-MB-231 NGPFeZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1XaUVAvODFvMUCwJO69VQ>? NWXwTJZsPDhiaB?= NUfybXUxVG:pIFfJOVA:NThwMEmgUS=> MUiyNlM{PjJ2Nh?=
U251 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHvLfHIxNjBzLUGwNEDPxE1? NHXneZA1QCCq NXXJe4ZiVG:pIFfJOVA:NTdwNk[gUS=> MX[yNlM{PjJ2Nh?=
SF268 MlvQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWniOY8xOC5yMT2xNFAh|ryP NXXUR3VGPDhiaB?= MoCwUI9oKEeLNUC9MVcvQTJiTR?= NU\aT25nOjJ|M{[yOFY>
SF295 NFLqNIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn\VNE4xOS1zMECg{txO NXf1O4dvPDhiaB?= MVrMc4chT0l3ME2tPE4{OSCP MljoNlI{OzZ{NE[=
SF539 NV\ic5NXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUmwMlAyNTFyMDFOwG0> M{\RbFQ5KGh? NXrM[G13VG:pIFfJOVA:NThwNUmgUS=> MUeyNlM{PjJ2Nh?=
SNB75 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{ftRlAvODFvMUCwJO69VQ>? NHf4dWU1QCCq M3n4b2xw\yCJSUWwQU05NjV6IF2= MYOyNlM{PjJ2Nh?=
SNB78 MoDNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4j0WlAvODFvMUCwJO69VQ>? MoL6OFghcA>? M3PJT2xw\yCJSUWwQU05NjZ3IF2= NW[1R5FCOjJ|M{[yOFY>
HCC2998 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3j5N|AvODFvMUCwJO69VQ>? NUHK[JpMPDhiaB?= NYXnZZRVVG:pIFfJOVA:NThwMEWgUS=> Mn30NlI{OzZ{NE[=
KM12 MmHDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn65NE4xOS1zMECg{txO M{jk[VQ5KGh? NWfyepFsVG:pIFfJOVA:NTdwNUSgUS=> NF3WNWIzOjN|NkK0Oi=>
HT-29 NG\5RotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4[yXFAvODFvMUCwJO69VQ>? NV;zc4pEPDhiaB?= MkK4UI9oKEeLNUC9MVcvPzViTR?= NIHkZ2IzOjN|NkK0Oi=>
HCT15 MmjMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYGwMlAyNTFyMDFOwG0> NV\6O2dPPDhiaB?= M3PSR2xw\yCJSUWwQU05NjB|IF2= NVf0PZVIOjJ|M{[yOFY>
HCT116 M3K4[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVfhfVF2OC5yMT2xNFAh|ryP NFrQXVM1QCCq MW\Mc4chT0l3ME2tO{43OSCP MV6yNlM{PjJ2Nh?=
NCI-H23 M{i4N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEDEN5MxNjBzLUGwNEDPxE1? NY\qRYVEPDhiaB?= M4jFSGxw\yCJSUWwQU04NjZ2IF2= MVqyNlM{PjJ2Nh?=
NCI-H226 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2fJfFAvODFvMUCwJO69VQ>? M{DmcFQ5KGh? NGDISVlNd2diR1m1NF0uQC52NDDN MWiyNlM{PjJ2Nh?=
NCI-H522 MkPSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVXYZWlOOC5yMT2xNFAh|ryP NXjKNIRDPDhiaB?= MYLMc4chT0l3ME2tPE41PSCP Mon1NlI{OzZ{NE[=
NCI-H438 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2n4cFAvODFvMUCwJO69VQ>? NWPv[IhOPDhiaB?= MnX3UI9oKEeLNUC9MVgvOTFiTR?= M{fNfFIzOzN4MkS2
A549 NITNS3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHXwXpQxNjBzLUGwNEDPxE1? NYSwUVZMPDhiaB?= NV7hV|B[VG:pIFfJOVA:NThwMEegUS=> NIPP[lEzOjN|NkK0Oi=>
DMS273 M17Wcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoDiNE4xOS1zMECg{txO MnnOOFghcA>? NEixSG5Nd2diR1m1NF0uPy56MDDN NYK5b3lxOjJ|M{[yOFY>
DMS114 MmjMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkTONE4xOS1zMECg{txO NFLzRoU1QCCq Mlm5UI9oKEeLNUC9MVgvOzliTR?= NWPjdVBxOjJ|M{[yOFY>
LOXIMVI MkG1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoW1NE4xOS1zMECg{txO NHzBU4Q1QCCq NIDxbHRNd2diR1m1NF0uQC54NjDN MnnuNlI{OzZ{NE[=
OVCAR3 NFfab5FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlTSNE4xOS1zMECg{txO MmDOOFghcA>? M3:xd2xw\yCJSUWwQU05NjF5IF2= MmPONlI{OzZ{NE[=
OVCAR4 NYnrdGVGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHGwUmExNjBzLUGwNEDPxE1? MoPOOFghcA>? NYexV|lIVG:pIFfJOVA:NThwNUigUS=> NEnZSmozOjN|NkK0Oi=>
OVCAR5 NEjzTmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVjKcXl5OC5yMT2xNFAh|ryP MXq0PEBp MkTiUI9oKEeLNUC9MVcvPTdiTR?= M17NT|IzOzN4MkS2
OVCAR8 M3PHRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml\PNE4xOS1zMECg{txO NW\5XJV4PDhiaB?= MY\Mc4chT0l3ME2tO{45PCCP NFXsXVkzOjN|NkK0Oi=>
SKOV3 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWGwMlAyNTFyMDFOwG0> Mn7YOFghcA>? MX;Mc4chT0l3ME2tPE41OSCP NHLTVWEzOjN|NkK0Oi=>
RXF631L MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHLYPZMxNjBzLUGwNEDPxE1? NIrDN441QCCq M{\r[Wxw\yCJSUWwQU05NjJzIF2= MVeyNlM{PjJ2Nh?=
ACHN NUn4ZmZOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVzIb2JlOC5yMT2xNFAh|ryP MVG0PEBp MlnaUI9oKEeLNUC9MVcvQTViTR?= NYT1eZdzOjJ|M{[yOFY>
St-4 NH7DU3dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{PjV|AvODFvMUCwJO69VQ>? MWm0PEBp MmH0UI9oKEeLNUC9MVcvPDdiTR?= M1[zdlIzOzN4MkS2
MKN1 NV;4S3dPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUC2ZWhEOC5yMT2xNFAh|ryP NH;EWYo1QCCq NVvsUJRVVG:pIFfJOVA:NThwNEGgUS=> M2e3V|IzOzN4MkS2
MKN7 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoXmNE4xOS1zMECg{txO NXuzbIt[PDhiaB?= M2DzWGxw\yCJSUWwQU04NjZ6IF2= M3fmW|IzOzN4MkS2
MKN28 NITYXFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYWwMlAyNTFyMDFOwG0> M{G5TVQ5KGh? NF7kOWZNd2diR1m1NF0uPy5yNzDN Mo\INlI{OzZ{NE[=
MKN45 NGTCVm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYTRcYFWOC5yMT2xNFAh|ryP MoLlOFghcA>? NFjqZodNd2diR1m1NF0uQC5|NDDN NVP3[3J6OjJ|M{[yOFY>
MKN74 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnzlNE4xOS1zMECg{txO NEHUXnc1QCCq M{O2bmxw\yCJSUWwQU04NjR{IF2= NF;yT28zOjN|NkK0Oi=>
DU145 MmLHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYOwMlAyNTFyMDFOwG0> M1;ZNlQ5KGh? M3:1PWxw\yCJSUWwQU05NjF4IF2= MnTCNlI{OzZ{NE[=
PC3 M1rKN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml74NE4xOS1zMECg{txO MmXvOFghcA>? MmHiUI9oKEeLNUC9MVgvPjZiTR?= NH;xRoEzOjN|NkK0Oi=>
Trypanosoma brucei brucei MX3GeY5kfGmxbjDBd5NigQ>? MVyyNFAhdk1? NXTXSnU4OTJiaB?= MYLEUXNQ MnHDSIVkemWjc3WgbY4heGixc4Doc5Rq\HmuIHnuc5NqfG:uIIDoc5NxcGG2ZTDs[ZZmdA>? M1XUdVI1QDB3OUS2
Trypanosoma brucei brucei MnXHSpVv[3Srb36gRZN{[Xl? MYmxPEBp NGixWJRFVVOR MVHJcohq[mm2aX;uJI9nKHKnY3XweI9zNW2nZHnheIVlKGWwZH;jfZRwe2m|IHHzd4V{e2WmIHHzJIRm[3KnYYPlJIlvKHS{YX7z[oVzemmwIIXweIFs\Q>? M4PvOVI1QDB3OUS2
Trypanosoma brucei brucei MUXGeY5kfGmxbjDBd5NigQ>? NULKSYo2OjByIH7N NXrWOI1rOTJiaB?= MUTEUXNQ MUnF[oZm[3Rib36gd5BpcW6pb335cIVqdiCuZY\lcC=> M1rETlI1QDB3OUS2
Trypanosoma brucei brucei NEPzPIFHfW6ldHnvckBCe3OjeR?= MW[yNFAhdk1? MX2xNkBp MnPRSG1UVw>? M4m1[2Vn\mWldDDvckBxcG:|cHjheIllgWylaH;sbY5mKGyndnXs MWKyOFgxPTl2Nh?=
UM-UC-3 NH[4SG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoDKTWM2OD1|MUWgdG0> MUTTRW5ITVJ?
SBC-1 MoTmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWrJNJlSUUN3ME23OFIheE1? M4LwR3NCVkeHUh?=
MKN1 M1jlPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV\JR|UxRTJwODDuUS=> M2iwWHNCVkeHUh?=
NCI-H720 MlvKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2C3TGlEPTB;Mz61O{BvVQ>? MX3TRW5ITVJ?
BFTC-909 NXjnWot[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX7s[4poUUN3ME2zMlcyKG6P NVzUWW57W0GQR1XS
BPH-1 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlLZTWM2OD12Lke2JI5O MlKwV2FPT0WU
PC-3 NWW1dGV1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFfZWG9KSzVyPUWuNFkhdk1? NYXrbYpkW0GQR1XS
AN3-CA MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF\2[phKSzVyPUWuOVYhdk1? MlzaV2FPT0WU
HN NFjtZ5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYHJR|UxRTVwOU[gcm0> MofrV2FPT0WU
HCC2218 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3m2d2lEPTB;Nj62NUBvVQ>? NHf5fm1USU6JRWK=
KP-4 NEjFdlhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIDE[ZZKSzVyPUegcm0> NHzZXlVUSU6JRWK=
LU-139 NE\wVllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVnJNHNKUUN3ME23Mlc4KG6P NI\TNpVUSU6JRWK=
ETK-1 NF74XFlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmO5TWM2OD15Lki4JI5O M3HDOXNCVkeHUh?=
Ramos-2G6-4C10 NGLD[mpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml3CTWM2OD16LkS5JI5O M2LnVXNCVkeHUh?=
MHH-PREB-1 NVX4WYhyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYPJR|UxRTlwMUKgcm0> NE\SepJUSU6JRWK=
DU-4475 NIfIbnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX;HOoNJUUN3ME25MlQ1KG6P NFXPTohUSU6JRWK=
NCI-H1666 NWD1eIxIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVnJR|UxRTlwN{Ggcm0> NVvSSpBCW0GQR1XS
CAMA-1 M3LEVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHTqcm5KSzVyPUmuPEBvVQ>? NXfXUIJEW0GQR1XS
TYK-nu Mkn3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn64TWM2OD17Lkm0JI5O MkjxV2FPT0WU
MFE-280 NVq5fnc3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmrOTWM2OD17Lkm5JI5O MYDTRW5ITVJ?
A549 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWHJR|UxRTFyLkG0JI5O NWraXGVYW0GQR1XS
769-P M1S3c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml\VTWM2OD1zMD60OEBvVQ>? NFHoVFVUSU6JRWK=
L-363 M3\BXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3zqXGlEPTB;MUCuOlkhdk1? NYTwO2pGW0GQR1XS
ES8 MljLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF\iOHBKSzVyPUGwMlkhdk1? MnzZV2FPT0WU
PA-1 M{jVV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWfJR|UxRTFzLkiyJI5O NXPFPYlKW0GQR1XS
Mewo M1vFOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYDJR|UxRTFzLkm5JI5O NWDuZYluW0GQR1XS
HSC-3 MljFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2nwcmlEPTB;MUKuNlEhdk1? MYHTRW5ITVJ?
H4 MofXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHzaU4hKSzVyPUGyMlY4KG6P NUfOUZRYW0GQR1XS
BB65-RCC NHPqcGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVTJR|UxRTF{LkeyJI5O MoO5V2FPT0WU
NCI-H1793 NEXobGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUTJR|UxRTF{LkiyJI5O M2nJXHNCVkeHUh?=
KARPAS-45 M{TjR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mlu3TWM2OD1zMz61NUBvVQ>? MXPTRW5ITVJ?
GCT Ml\oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3vQT2lEPTB;MUOuOlghdk1? MmLvV2FPT0WU
EoL-1 Mlv2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{LvUWlEPTB;MUOuPVMhdk1? M3;PeXNCVkeHUh?=
LB2241-RCC MmjFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXjUOIs{UUN3ME2xOE4xOSCwTR?= MkP5V2FPT0WU
ES5 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2L3b2lEPTB;MUSuO|Qhdk1? NUC0U2U5W0GQR1XS
LOXIMVI M3K0emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NY\MXpl3UUN3ME2xOE46QSCwTR?= Mm[zV2FPT0WU
COR-L105 NHLNVXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmXxTWM2OD1zNT6wOEBvVQ>? NWDOVpZYW0GQR1XS
P12-ICHIKAWA M2\HUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmfHTWM2OD1zNT6xJI5O NIfSRoZUSU6JRWK=
CHL-1 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{C1UWlEPTB;MUWuOFUhdk1? NFrRV4hUSU6JRWK=
VMRC-RCZ NFLUR|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEe0S3pKSzVyPUG1MlY{KG6P Mny3V2FPT0WU
HH NFPXXZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFLhS2NKSzVyPUG1Mlchdk1? M3nOU3NCVkeHUh?=
NUGC-3 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoLUTWM2OD1zNj6zOEBvVQ>? NYXsc5RqW0GQR1XS
EGI-1 NEnkNZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHzZbW9KSzVyPUG2MlQ{KG6P Mkf1V2FPT0WU
OS-RC-2 NIi0emdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4TmemlEPTB;MU[uOFchdk1? M3rhVnNCVkeHUh?=
MOLT-16 MofSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWX6VGJLUUN3ME2xO{4yPSCwTR?= M4LicnNCVkeHUh?=
NCI-H209 NVTDT496T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NELpbIJKSzVyPUG3MlI6KG6P M{H5TnNCVkeHUh?=
697 MnjRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MU\JR|UxRTF5LkSzJI5O NYXhVnlZW0GQR1XS
D-56MG MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGrWUJNKSzVyPUG3MlY6KG6P MnzlV2FPT0WU
VA-ES-BJ M2\RV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFW5W4dKSzVyPUG3Mlg{KG6P MWPTRW5ITVJ?
EW-16 NXXhcWpLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXn5NodIUUN3ME2xPE4xPCCwTR?= MVPTRW5ITVJ?
HGC-27 M{[w[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn7lTWM2OD1zOD6wOkBvVQ>? MVjTRW5ITVJ?
ES7 M4HxdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWfJcYFjUUN3ME2xPE4xQSCwTR?= MX7TRW5ITVJ?
HuH-7 MnL3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXHJR|UxRTF6LkSgcm0> NXOz[IpwW0GQR1XS
BCPAP MlXuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3fi[2lEPTB;MUiuOlUhdk1? M{\ZPHNCVkeHUh?=
SW1710 NV7Y[lVrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF3Yd3dKSzVyPUG4MlczKG6P NXvKdI5tW0GQR1XS
IST-MEL1 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mkn5TWM2OD1zOD63O{BvVQ>? MmL2V2FPT0WU
SF295 NWLpWmU3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2flR2lEPTB;MUiuPVMhdk1? NGjUfmlUSU6JRWK=
RPMI-7951 M2\TXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGXKbHFKSzVyPUG5MlI5KG6P M4jBXHNCVkeHUh?=
SF126 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVzJR|UxRTF7LkSxJI5O NVHZZ|ZNW0GQR1XS
GAMG MnzkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVv4W3VqUUN3ME2xPU41QCCwTR?= MoSxV2FPT0WU
KNS-81-FD M2H2cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUPJR|UxRTF7LkW0JI5O NUjGToRbW0GQR1XS
RT-112 Mn3nS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2LvR2lEPTB;MUmuOlYhdk1? MXHTRW5ITVJ?
DEL MkTwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXr2V2dCUUN3ME2yNE41QSCwTR?= MXvTRW5ITVJ?
CGTH-W-1 M1e3dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYDJR|UxRTJyLk[zJI5O NFPuV4dUSU6JRWK=
HOS NVu5UIZPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHnEPVJKSzVyPUKxMlA3KG6P NIfBcZVUSU6JRWK=
ES4 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWfrZnBpUUN3ME2yNU4xQCCwTR?= MU\TRW5ITVJ?
RXF393 NH\LT5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXnJR|UxRTJzLkS1JI5O NUmwb2ZJW0GQR1XS
NCI-H2030 MoDQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFnMRWlKSzVyPUKxMlUzKG6P NIXtdWxUSU6JRWK=
YH-13 M1fiUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2jBRWlEPTB;MkGuPFghdk1? MmfQV2FPT0WU
HT-1080 M17BRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3TwSmlEPTB;MkGuPVMhdk1? MWDTRW5ITVJ?
NCI-SNU-1 NUDMe3pJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF3RR3BKSzVyPUKxMlk2KG6P M2fESHNCVkeHUh?=
G-402 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHj6ZVhKSzVyPUKyMlE3KG6P NWH1[mhJW0GQR1XS
786-0 NEjh[VdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVnJR|UxRTJ{LkK5JI5O NETxfmZUSU6JRWK=
ME-180 Mlu1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnLPTWM2OD1{Mj60N{BvVQ>? M{f6cXNCVkeHUh?=
NB69 Mn3DS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWXJR|UxRTJ{LkWzJI5O MXHTRW5ITVJ?
J-RT3-T3-5 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVTuTY05UUN3ME2yNk46PiCwTR?= M1vBb3NCVkeHUh?=
TGBC1TKB M{LhWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmHyTWM2OD1{Mz6wOUBvVQ>? MVHTRW5ITVJ?
SW780 NWXrd|ViT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVrJR|UxRTJ|LkGzJI5O MV\TRW5ITVJ?
MG-63 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYHJR|UxRTJ|LkS1JI5O MV;TRW5ITVJ?
BV-173 NY\oUlJzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHHQSmpKSzVyPUKzMlg4KG6P MUDTRW5ITVJ?
CAL-51 MlzNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1Gze2lEPTB;MkOuPFkhdk1? MWTTRW5ITVJ?
A375 MlTuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGe4NHpKSzVyPUKzMlk{KG6P MUDTRW5ITVJ?
MEL-HO NXL5R295T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX[2W4hmUUN3ME2yOE4xPCCwTR?= NY\EeJp7W0GQR1XS
EFO-27 M1LVXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnTFTWM2OD1{ND6zN{BvVQ>? M2jJSHNCVkeHUh?=
Hs-578-T MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXjsc|d2UUN3ME2yOE42QCCwTR?= M3nER3NCVkeHUh?=
NBsusSR NEe5b|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYLJR|UxRTJ2Lk[gcm0> MWnTRW5ITVJ?
CTB-1 NXvzdYpsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYC0cWg1UUN3ME2yOE43PyCwTR?= M4PMZ3NCVkeHUh?=
FTC-133 NWjKO4ZsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmDSTWM2OD1{NT6xJI5O MVnTRW5ITVJ?
MOLT-4 Ml7ZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1zP[2lEPTB;MkWuNVIhdk1? MlHIV2FPT0WU
HO-1-N-1 NHHxfoRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFf2R|VKSzVyPUK1MlE2KG6P MkHwV2FPT0WU
ES3 MnW5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnLuTWM2OD1{NT6yNkBvVQ>? M3PxZXNCVkeHUh?=
TI-73 M4jN[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2\FRWlEPTB;MkWuNlghdk1? NVXreJhNW0GQR1XS
MPP-89 NUDQVYhWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlHiTWM2OD1{NT6zNkBvVQ>? NGnJTGdUSU6JRWK=
KYSE-150 NW\ySVJ4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV\WZ41vUUN3ME2yOU45QSCwTR?= NFzpSHBUSU6JRWK=
LXF-289 M{LvUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXnJR|UxRTJ4LkC0JI5O MV;TRW5ITVJ?
SK-LU-1 M{mzc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUP5UnlYUUN3ME2yOk4yPyCwTR?= NFu2dItUSU6JRWK=
HOP-92 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2\mNWlEPTB;Mk[uOFghdk1? MnHDV2FPT0WU
HuO9 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUnJR|UxRTJ4Lke2JI5O MnOwV2FPT0WU
SW962 NE\jdHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXLWN|RDUUN3ME2yOk44PiCwTR?= MluyV2FPT0WU
RS4-11 M{nzWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1vHXGlEPTB;Mk[uPVEhdk1? MXTTRW5ITVJ?
NCI-H292 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFG2SWtKSzVyPUK3JI5O NV;pTnlJW0GQR1XS
DB NF[zUWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF7FbFlKSzVyPUK3MlM3KG6P NGrPcHhUSU6JRWK=
SW1088 NYGze3h3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVT3bIZRUUN3ME2yPE4zQSCwTR?= NEHlXpVUSU6JRWK=
A204 NFnHd|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVi2[oJkUUN3ME2yPE41PyCwTR?= M2TId3NCVkeHUh?=
A3-KAW NUWwbGlWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIPOWGRKSzVyPUK4MlY1KG6P M17Nb3NCVkeHUh?=
MV-4-11 M170Smdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVXuRmNuUUN3ME2yPE44KG6P MU\TRW5ITVJ?
ES1 MljNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV7JR|UxRTJ6Lki0JI5O NWi5VlNUW0GQR1XS
ONS-76 NVS3dVdLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1PVVWlEPTB;MkmuNFUhdk1? Ml6wV2FPT0WU
D-263MG MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NInyTZpKSzVyPUK5MlM2KG6P MUfTRW5ITVJ?
U-2-OS NIewe21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkLJTWM2OD1{OT61JI5O NWTSUnFCW0GQR1XS
T98G MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUH5WXVoUUN3ME2yPU45QCCwTR?= MmrlV2FPT0WU
GI-ME-N NUDiOFFsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmDRTWM2OD1{OT65NUBvVQ>? NWOw[WtMW0GQR1XS
BHT-101 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXjJR|UxRTNyLkC1JI5O NF\ZS29USU6JRWK=
NOS-1 NYrMb2c6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYHJR|UxRTNyLkGyJI5O M1jSW3NCVkeHUh?=
AsPC-1 MnTyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MULJR|UxRTNyLkKgcm0> MYPTRW5ITVJ?
QIMR-WIL NEfnTVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mm\CTWM2OD1|MD62JI5O MWHTRW5ITVJ?
JVM-3 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVrJR|UxRTNyLkizJI5O M1XCV3NCVkeHUh?=
KU-19-19 Mm[1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHO2O|RKSzVyPUOxMlE{KG6P MkjGV2FPT0WU
OVCAR-8 M16wRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NE[1eWZKSzVyPUOxMlI3KG6P M4XFXnNCVkeHUh?=
BEN MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXfJR|UxRTNzLk[zJI5O NIT0TG1USU6JRWK=
BE-13 MlLIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIDO[GZKSzVyPUOxMlgzKG6P NIPqNZpUSU6JRWK=
EW-18 Mk[zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYXJR|UxRTNzLki2JI5O MlvrV2FPT0WU
ECC10 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXj4fJhPUUN3ME2zNU46PSCwTR?= NFLTRphUSU6JRWK=
CTV-1 M3zycmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXHJR|UxRTN{LkiyJI5O MnjvV2FPT0WU
COLO-800 M{j2bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF\PPZNKSzVyPUOyMlkzKG6P M1\rTXNCVkeHUh?=
A2058 NWDYT283T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2nxZWlEPTB;M{OuNlUhdk1? MVHTRW5ITVJ?
VM-CUB-1 Mn7YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWfNcJo2UUN3ME2zN{41OyCwTR?= NVjYNFhxW0GQR1XS
Ca9-22 M{fOSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3nQ[mlEPTB;M{OuOVUhdk1? NFS2d5JUSU6JRWK=
COLO-684 M1nLT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoS1TWM2OD1|Mz61PEBvVQ>? M4fTXnNCVkeHUh?=
RPMI-8226 NVrkc4NzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVLJR|UxRTN|LkiyJI5O NX3TT4IyW0GQR1XS
SK-NEP-1 NHvhPItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUfBOFFJUUN3ME2zOE4yPSCwTR?= NFj5RZpUSU6JRWK=
Becker M17lXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYTJR|UxRTN2LkKxJI5O NGTTU|lUSU6JRWK=
NCI-H28 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlnRTWM2OD1|ND60OEBvVQ>? M1jNWXNCVkeHUh?=
CAL-120 M2OyN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWDUNY5mUUN3ME2zOE44OiCwTR?= M1zaUXNCVkeHUh?=
MDA-MB-157 MlzxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2rC[GlEPTB;M{WuOFEhdk1? NEHVUlNUSU6JRWK=
OVCAR-5 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVzJR|UxRTN3LkS3JI5O M3vJU3NCVkeHUh?=
LAMA-84 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4DqdWlEPTB;M{WuPFchdk1? MUfTRW5ITVJ?
CAKI-1 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmHOTWM2OD1|Nj60N{BvVQ>? MlexV2FPT0WU
Daoy MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUHNdJprUUN3ME2zOk44KG6P M3zFOXNCVkeHUh?=
CAL-62 M2T2O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlnlTWM2OD1|Nj64OkBvVQ>? Mnq2V2FPT0WU
8-MG-BA NIfMcodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUXJR|UxRTN5LkK1JI5O MYHTRW5ITVJ?
8505C M{jUWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXfJR|UxRTN5LkWxJI5O NV3yZ4RpW0GQR1XS
LNCaP-Clone-FGC NFLGXGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWXJR|UxRTN5LkW5JI5O NGHmWopUSU6JRWK=
CAL-39 NXruR3Q4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1vneWlEPTB;M{euPUBvVQ>? M3WxVHNCVkeHUh?=
MN-60 Mo\3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUjERXI3UUN3ME2zO{46PiCwTR?= MmX2V2FPT0WU
RKO MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUfJR|UxRTN6LkOzJI5O NXXtVHVkW0GQR1XS
U251 M2K4cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlH1TWM2OD1|OD60N{BvVQ>? NYDiVmxmW0GQR1XS
SJSA-1 M1no[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVTKR5B{UUN3ME2zPE42PCCwTR?= NYH1fYNQW0GQR1XS
CAL-12T NVfhSXEyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlHETWM2OD1|OD62JI5O M3zL[HNCVkeHUh?=
HCC1419 NH35XYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnzVTWM2OD1|OD63NUBvVQ>? M1rDOHNCVkeHUh?=
CO-314 Ml;HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlzUTWM2OD1|OD63OEBvVQ>? M{PsSnNCVkeHUh?=
LB1047-RCC NE[5[WtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXHSZWRpUUN3ME2zPE45OSCwTR?= MnmwV2FPT0WU
A101D NYXa[3M3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmO0TWM2OD1|OD65O{BvVQ>? NHvwd|dUSU6JRWK=
MDA-MB-175-VII NIHtc2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWHaWWdXUUN3ME2zPU42OSCwTR?= MYTTRW5ITVJ?
MZ2-MEL MnG3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFLjcGVKSzVyPUO5MlY3KG6P NWL1dYdzW0GQR1XS
NB5 MljyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUTJR|UxRTRyLk[0JI5O NIC4UnBUSU6JRWK=
G-401 NE\2[ppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2S4U2lEPTB;NECuPFIhdk1? MVHTRW5ITVJ?
HT MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWLJR|UxRTRzLkCyJI5O NWPkdmhoW0GQR1XS
8305C MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH7x[29KSzVyPUSxMlg4KG6P NF72XJlUSU6JRWK=
BHY NXzhZ|d6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFm5V2tKSzVyPUSyMlczKG6P M1:wPHNCVkeHUh?=
NTERA-S-cl-D1 NX3TTY5lT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIXMOGRKSzVyPUSzJI5O NWrsNGt3W0GQR1XS
T-24 NGrydGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWr6[GpWUUN3ME20N{45OyCwTR?= M2PHenNCVkeHUh?=
EPLC-272H NVTVUYJxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mlu2TWM2OD12ND6zPUBvVQ>? M2fsfHNCVkeHUh?=
PSN1 Mk[xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnjzTWM2OD12ND60JI5O MknaV2FPT0WU
NCI-H2452 MkDXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFS4flVKSzVyPUS0MlU5KG6P MX;TRW5ITVJ?
KS-1 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXjk[WVSUUN3ME20OE43PiCwTR?= M3nqOHNCVkeHUh?=
HD-MY-Z M{\McGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1XLdmlEPTB;NESuPVIhdk1? MWjTRW5ITVJ?
KNS-62 NHT1XXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWjJR|UxRTR3LkO4JI5O MU\TRW5ITVJ?
NOMO-1 NH\DU29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnXCTWM2OD12NT64O{BvVQ>? NHzBfpVUSU6JRWK=
SK-HEP-1 NEO5dlhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHvmSZZKSzVyPUS2MlA1KG6P MV;TRW5ITVJ?
IGR-1 NHnYfGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVfJR|UxRTR4LkGzJI5O Mm\LV2FPT0WU
KYSE-180 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXPnWpVGUUN3ME20Ok4yPyCwTR?= MULTRW5ITVJ?
EW-22 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml\OTWM2OD12Nj6yJI5O M1PON3NCVkeHUh?=
NCI-H1355 NY\wZmJRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUXJR|UxRTR4LkO0JI5O NXLXRVV1W0GQR1XS
DOHH-2 M{ftWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV;LVnc{UUN3ME20Ok4{PyCwTR?= MXzTRW5ITVJ?
A4-Fuk M13uT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlXZTWM2OD12Nj61NkBvVQ>? M4LJOXNCVkeHUh?=
PC-14 MnW2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXv2fnRMUUN3ME20Ok42PyCwTR?= MoLUV2FPT0WU
TE-5 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWq1cXBrUUN3ME20Ok45PCCwTR?= M4TT[HNCVkeHUh?=
LB996-RCC NXXzXXlbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUDKZVFNUUN3ME20O{4yQSCwTR?= NWjyWHp6W0GQR1XS
NCI-H1623 M17LO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXLaNJdWUUN3ME20O{44PiCwTR?= MWLTRW5ITVJ?
NCI-H1155 NX7lb4IzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX3aNox[UUN3ME20PE4{OiCwTR?= MkLVV2FPT0WU
LoVo NX;MXINKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV;YToExUUN3ME20PE41KG6P NG\vd5ZUSU6JRWK=
MCF7 NF3JSIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYfleo9NUUN3ME20PE42QCCwTR?= NHXXVFdUSU6JRWK=
AGS NGXTVJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3mwbGlEPTB;NEiuO|chdk1? M2jNWXNCVkeHUh?=
PFSK-1 M2juWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUnJR|UxRTR7LkC2JI5O NWXqUWxpW0GQR1XS
22RV1 NWqzSGI6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3XYfGlEPTB;NEmuNFkhdk1? NUD2VmpXW0GQR1XS
COR-L23 NXXYO|JWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFX0WmZKSzVyPUS5MlE3KG6P MUfTRW5ITVJ?
D-283MED Mmn1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGOyfI9KSzVyPUS5MlYyKG6P MoX2V2FPT0WU
SW982 NULRXllPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYnJR|UxRTR7LkmxJI5O MXTTRW5ITVJ?
SW620 NIK3PHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnS5TWM2OD13MD6zOkBvVQ>? MnHqV2FPT0WU
KYSE-140 NXPqR2s5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2TwemlEPTB;NUCuOVUhdk1? MUTTRW5ITVJ?
GCIY M2ewXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{nlZmlEPTB;NUCuOlchdk1? MVXTRW5ITVJ?
MHH-ESS-1 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUTiWHdKUUN3ME21NU46PSCwTR?= NVvZfXFxW0GQR1XS
D-423MG NF6yOFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoOxTWM2OD13Mj6wPEBvVQ>? MYDTRW5ITVJ?
SF539 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVzMPFNiUUN3ME21Nk4{PSCwTR?= MnTvV2FPT0WU
RPMI-2650 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVXJR|UxRTV{Lk[5JI5O NHPrS4xUSU6JRWK=
GR-ST NVX6UVliT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWrJR|UxRTV{Lki3JI5O M37FV3NCVkeHUh?=
YKG-1 NHL5eHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2LteGlEPTB;NUOgcm0> M17SZXNCVkeHUh?=
SK-MES-1 MlXrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYDMO2syUUN3ME21N{4zPiCwTR?= MljpV2FPT0WU
HLE M3;yd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGfBU4hKSzVyPUWzMlQ4KG6P NFr5OmxUSU6JRWK=
RVH-421 MnOzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHLPc2dKSzVyPUWzMlY4KG6P NIjVcpNUSU6JRWK=
C32 NGLJ[IpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUDJR|UxRTV|LkizJI5O NFft[4JUSU6JRWK=
GB-1 NV;0PG1KT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXnNTo5XUUN3ME21OE4zKG6P M4\oeXNCVkeHUh?=
SNB75 NX;pcGtPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGnhWYpKSzVyPUW0MlI3KG6P MWLTRW5ITVJ?
EM-2 NX3TWY44T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX\DZ3NVUUN3ME21OE41KG6P NGe0dYRUSU6JRWK=
RH-1 M1jiR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mnu5TWM2OD13ND63JI5O MoDIV2FPT0WU
NKM-1 NWS3[4pKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVT3TodNUUN3ME21OE45OSCwTR?= NV;aOXQ2W0GQR1XS
NCI-H2405 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV7PdmZsUUN3ME21OE45QCCwTR?= MUfTRW5ITVJ?
KYSE-450 NWL4OGRNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWfnWZZvUUN3ME21OU4yPiCwTR?= MnzrV2FPT0WU
A704 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{LEU2lEPTB;NUWuOVkhdk1? NIHlTHdUSU6JRWK=
HAL-01 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVHjTFN2UUN3ME21OU45OyCwTR?= NWPQW|BvW0GQR1XS
TE-11 NETTUWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH:5WpBKSzVyPUW1Mlk6KG6P M{DnOHNCVkeHUh?=
DOK MkH5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUW2WGRCUUN3ME21Ok4xOiCwTR?= MYrTRW5ITVJ?
KY821 NF75fIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFzET5hKSzVyPUW2MlIhdk1? MkXwV2FPT0WU
KGN MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF;MU3VKSzVyPUW2MlMzKG6P MmDSV2FPT0WU
MC116 NUDYSXp1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4rlO2lEPTB;NUeuPEBvVQ>? NWHxO5VTW0GQR1XS
PANC-08-13 M3rrSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGPQcGFKSzVyPUW4MlAyKG6P MnThV2FPT0WU
KE-37 M3;SOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV\y[ZFLUUN3ME21PE44PyCwTR?= M17CRXNCVkeHUh?=
KYSE-410 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmfVTWM2OD13OT60O{BvVQ>? MXjTRW5ITVJ?
RO82-W-1 NFT3OZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3TnfWlEPTB;NUmuPUBvVQ>? NWX5Tm5VW0GQR1XS
M14 NVjwc5BZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml7ITWM2OD14MD6wOEBvVQ>? NUPKNZZ4W0GQR1XS
GI-1 NVfJZld[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4[xV2lEPTB;NkCuN{BvVQ>? M4X5XHNCVkeHUh?=
ML-2 NUHlW4xHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{myNWlEPTB;NkCuOlIhdk1? MoG5V2FPT0WU
BFTC-905 NGmxVJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXfVOFRoUUN3ME22NE43PSCwTR?= MUTTRW5ITVJ?
DMS-273 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2fPcmlEPTB;NkCuPFchdk1? NYT5RZBUW0GQR1XS
MDA-MB-361 MmO5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFHCOlNKSzVyPU[xJI5O MoXYV2FPT0WU
MSTO-211H NF\VW29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWLJR|UxRTZ|LkWxJI5O MX\TRW5ITVJ?
MEG-01 NUjwW4F5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYLJdHNDUUN3ME22N{42OiCwTR?= MVTTRW5ITVJ?
M059J NGrpcXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3PjOmlEPTB;NkOuOVghdk1? NXv6PWFRW0GQR1XS
LN-405 MlTHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVTsWIVIUUN3ME22N{45PSCwTR?= NWjPRlN5W0GQR1XS
NCI-H1581 NELlSmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnLpTWM2OD14ND6wN{BvVQ>? M{XadHNCVkeHUh?=
TCCSUP NH3wTXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEfacnJKSzVyPU[0MlU{KG6P Mlq4V2FPT0WU
SW872 MkXTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWDJR|UxRTZ2LkW3JI5O M1jQNXNCVkeHUh?=
KYSE-510 NIf0RoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWDEO2lVUUN3ME22OU44PSCwTR?= MknNV2FPT0WU
NCI-H1792 NFnYeJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3PiOWlEPTB;Nk[uNVUhdk1? NGXtcXhUSU6JRWK=
SW13 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVvJR|UxRTZ4LkWgcm0> M37ifnNCVkeHUh?=
TE-8 MnjQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlLZTWM2OD14Nj61NkBvVQ>? MX3TRW5ITVJ?
SCH NI\VdlVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MY\JR|UxRTZ5LkGgcm0> M37zVXNCVkeHUh?=
NEC8 NIrHWo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGPRbpRKSzVyPU[3MlI1KG6P MYTTRW5ITVJ?
HuO-3N1 Ml;HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NITSZZNKSzVyPU[3MlMyKG6P MYTTRW5ITVJ?
EFM-19 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYLscpVLUUN3ME22O{42KG6P MXTTRW5ITVJ?
HEC-1 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUjJR|UxRTZ5LkWyJI5O M3TsenNCVkeHUh?=
T47D MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEewOXZKSzVyPU[3Mlg4KG6P M1LBNXNCVkeHUh?=
SNU-423 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFn3XItKSzVyPU[3Mlk5KG6P MkXuV2FPT0WU
WM-115 NH;3eGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1XZc2lEPTB;NkiuNVQhdk1? NHrwcpdUSU6JRWK=
CaR-1 NXP2S5JCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWTJR|UxRTZ6LkK1JI5O M3rTcHNCVkeHUh?=
KU812 NGjLfnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUPneXh4UUN3ME22PE43QSCwTR?= NHT5S4RUSU6JRWK=
AM-38 M3i1d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWPJR|UxRTZ7LkOxJI5O NVHjRodjW0GQR1XS
KOSC-2 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWPQOWIxUUN3ME22PU46PyCwTR?= MVHTRW5ITVJ?
MC-IXC NUi2PYhyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGD0bmxKSzVyPUewMlA5KG6P MULTRW5ITVJ?
SCC-4 NV7CfIZ{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX3JR|UxRTdzLkO4JI5O NFH5PGxUSU6JRWK=
Calu-3 NYCwenNsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVrJR|UxRTdzLkm4JI5O Mn:zV2FPT0WU
RPMI-8866 M2nIR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn;MTWM2OD15Mj64NkBvVQ>? MYrTRW5ITVJ?
OVCAR-4 NGP6bWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlXmTWM2OD15Mz6zOkBvVQ>? MXnTRW5ITVJ?
OAW-42 M3jkW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlLDTWM2OD15Mz6zPUBvVQ>? MXPTRW5ITVJ?
ATN-1 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGT4SppKSzVyPUezMlg4KG6P M3u5Z3NCVkeHUh?=
CHP-212 MnXnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUnJR|UxRTd2Lkm1JI5O M4rzcHNCVkeHUh?=
C2BBe1 M{S0RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWTDTJE{UUN3ME23OU4xOyCwTR?= NXX0[GlvW0GQR1XS
A498 M3LLdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVPJR|UxRTd3LkG1JI5O MofPV2FPT0WU
SH-4 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlH6TWM2OD15NT6yNUBvVQ>? M1W2VHNCVkeHUh?=
SNU-449 M4\ucWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NI\tTFFKSzVyPUe1Mlc6KG6P MoC1V2FPT0WU
RD M{DkPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUfJR|UxRTd3Lki2JI5O MV3TRW5ITVJ?
PANC-03-27 NYnRXmJWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEjqWZFKSzVyPUe2MlI2KG6P NFrseoJUSU6JRWK=
S-117 NGDZPJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUHJR|UxRTd4LkK3JI5O M3Pkb3NCVkeHUh?=
SK-MEL-2 NH;BZmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1TtTmlEPTB;N{[uO|Uhdk1? MYTTRW5ITVJ?
LK-2 NHzNS|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVn6T3hPUUN3ME23O{4xPSCwTR?= MmTjV2FPT0WU
CP50-MEL-B MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF;OPIVKSzVyPUe3MlQhdk1? MYfTRW5ITVJ?
647-V M17IXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml64TWM2OD15OD6wO{BvVQ>? M4fjO3NCVkeHUh?=
LU-134-A MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGPp[WhKSzVyPUe5MlA{KG6P NV3obIVsW0GQR1XS
5637 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3\JPWlEPTB;N{muNlMhdk1? M3HDUHNCVkeHUh?=
NCI-H1437 M3vrXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHH0bpNKSzVyPUiwMlUhdk1? M37idXNCVkeHUh?=
NCI-H460 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NELHZ2hKSzVyPUixMlI{KG6P M1TuUnNCVkeHUh?=
BxPC-3 NW\JZm1PT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXjJR|UxRThzLkS2JI5O M3\v[nNCVkeHUh?=
CAN MmXVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXT5XYNQUUN3ME24NU45PCCwTR?= M1fWS3NCVkeHUh?=
KINGS-1 NWfJT211T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH;QO5RKSzVyPUiyMlMzKG6P MknYV2FPT0WU
OCUB-M NX\EcXNLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV30dJBKUUN3ME24Nk41OSCwTR?= MXzTRW5ITVJ?
KALS-1 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYPJR|UxRTh{LkW0JI5O MlPzV2FPT0WU
OCI-AML2 M3O2RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mlz0TWM2OD16Mj62NUBvVQ>? M3\6SnNCVkeHUh?=
A253 Mm\RS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mnz3TWM2OD16Mj62OUBvVQ>? M2L3OXNCVkeHUh?=
LCLC-97TM1 NVHoc4RFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVrJR|UxRTh{Lki2JI5O MmHCV2FPT0WU
NCI-H520 NX\3W3pYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NInhNXNKSzVyPUizMlA3KG6P M3LlfHNCVkeHUh?=
P30-OHK Ml;6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2X0OGlEPTB;OEOuOUBvVQ>? NHHweoxUSU6JRWK=
SBC-5 NHrqO3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2nTOGlEPTB;OEOuOVIhdk1? Ml7jV2FPT0WU
HCE-T NGnhN5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4riSmlEPTB;OEOuO|Qhdk1? NUfnVVF[W0GQR1XS
JEG-3 NWfBOIg3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUDJR|UxRTh2LkGgcm0> M4TLbXNCVkeHUh?=
KG-1 NYrmW2duT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWnJR|UxRTh2LkK0JI5O M4rOUnNCVkeHUh?=
MIA-PaCa-2 NGHwUHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHLMfZlKSzVyPUi0MlU1KG6P M13TUnNCVkeHUh?=
CAL-33 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3vnWmlEPTB;OEWuNFghdk1? M4jOcnNCVkeHUh?=
639-V NUHXfHpTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWnJR|UxRTh3LkSyJI5O NEjh[3BUSU6JRWK=
NCI-H1048 Mkn0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV3JR|UxRTh4LkOxJI5O NYjEXpJwW0GQR1XS
NCI-H1573 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{DWUWlEPTB;OEeuOFghdk1? NFvmbHFUSU6JRWK=
NCI-H2228 MknTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX3JR|UxRTh6LkK2JI5O NGrLUYZUSU6JRWK=
NB14 M37v[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXTJR|UxRTh6LkOgcm0> MoT6V2FPT0WU
SCC-25 MkDzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4rHZmlEPTB;OEmuPFIhdk1? M3XVfnNCVkeHUh?=
A431 M33aRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUjJR|UxRTh7Lkm3JI5O M1q5dnNCVkeHUh?=
SN12C NUnsSINlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NET1b5JKSzVyPUmwMlYzKG6P NIfTVo5USU6JRWK=
HuCCT1 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoHYTWM2OD17MD63OkBvVQ>? MoWwV2FPT0WU
LS-123 NEPidJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX\JR|UxRTl{LkG4JI5O MlK4V2FPT0WU
CAL-85-1 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUTJR|UxRTl{LkS4JI5O NV;PRYNWW0GQR1XS
ES6 NUDmXWhWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mln4TWM2OD17Mj64N{BvVQ>? NYnmVFFJW0GQR1XS
NCI-H650 M2Wzb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHHPOmxKSzVyPUm0MlA6KG6P NGLWWG5USU6JRWK=
NCI-H446 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlLkTWM2OD17NT6xNkBvVQ>? NVTMXVByW0GQR1XS
EW-13 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVHJR|UxRTl3Lke1JI5O MkHIV2FPT0WU
HSC-2 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml31TWM2OD17NT64PUBvVQ>? M1[1S3NCVkeHUh?=
U031 M4Oy[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXrtclkzUUN3ME25Ok44OyCwTR?= NF;SXotUSU6JRWK=
EW-11 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEf2UFdKSzVyPUm2Mlg5KG6P NE[4S3VUSU6JRWK=
GAK NYrHeY5wT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmLJTWM2OD17OD65N{BvVQ>? MlG0V2FPT0WU
SK-OV-3 Mmf4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWrJR|UxRTFyMD6wO{BvVQ>? NH7sdIRUSU6JRWK=
OMC-1 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoLBTWM2OD1zMECuNVghdk1? M1LZRnNCVkeHUh?=
TK10 NE\uRY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWL5cHg2UUN3ME2xNFAvOjFibl2= NIHVOplUSU6JRWK=
EKVX NH2zUldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MU\JR|UxRTFyMD62JI5O NF33SopUSU6JRWK=
Detroit562 NH;1TXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlH5TWM2OD1zMEKuNVchdk1? MlvpV2FPT0WU
SF268 NXrmSGRUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1jDTmlEPTB;MUCyMlM1KG6P M2HzSXNCVkeHUh?=
SNU-387 MlntS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFG5c3pKSzVyPUGwOE4yPyCwTR?= MlXyV2FPT0WU
MDA-MB-231 NHfyXldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWHJR|UxRTFyNT6wOkBvVQ>? NHn5eYNUSU6JRWK=
NCI-H1563 NWnIU5VQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXLDTVBTUUN3ME2xNFUvOThibl2= NHrUTXlUSU6JRWK=
D-502MG M2TPbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEX6NVFKSzVyPUGwOU44KG6P NX6w[G51W0GQR1XS
A2780 M4rHcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWL3dollUUN3ME2xNFYvPDdibl2= NX\pVGpXW0GQR1XS
IA-LM MmmwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoS4TWM2OD1zMEeuOVEhdk1? M2jTR3NCVkeHUh?=
D-392MG NVmyVHppT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlTwTWM2OD1zMEeuOVQhdk1? NX2wO3VYW0GQR1XS
MS-1 M2Kxdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlH4TWM2OD1zMEeuO|Ehdk1? M{n6b3NCVkeHUh?=
SW1990 MknHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3L5[WlEPTB;MUC4MlU1KG6P NVXOWlloW0GQR1XS
HEL M1nOdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXPZS41xUUN3ME2xNFkvOjlibl2= Ml32V2FPT0WU
SW1573 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXXlTXJKUUN3ME2xNFkvOzFibl2= NF;1bnNUSU6JRWK=
SW1783 NX7ZS2N6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M37q[2lEPTB;MUGwMlIzKG6P MV\TRW5ITVJ?
COLO-680N M2DlbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVzJR|UxRTFzMD63OkBvVQ>? M4e1c3NCVkeHUh?=
NCI-N87 NULhO5ZWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWi2THJqUUN3ME2xNVEvODRibl2= NXnPVY9lW0GQR1XS
SK-MEL-28 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MU\JR|UxRTFzMT61OUBvVQ>? NHLkWXFUSU6JRWK=
BT-20 MmixS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1P2fGlEPTB;MUGyMlAyKG6P MmrlV2FPT0WU
NCI-H1648 MoLhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlPJTWM2OD1zMUOgcm0> Mo\FV2FPT0WU
no-11 MnTDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1S0UWlEPTB;MUGzMlI5KG6P NUj1ZYFpW0GQR1XS
MOLT-13 NHPjUJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVLyXGx4UUN3ME2xNVMvPDRibl2= MVrTRW5ITVJ?
NCI-H2170 Ml[2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoTTTWM2OD1zMUSuOVEhdk1? NW\rTINyW0GQR1XS
HTC-C3 NGXHd5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUPnVo1QUUN3ME2xNVYvQDVibl2= NUjGe2tDW0GQR1XS
LU-99A MnzVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVLJR|UxRTFzNz6yNUBvVQ>? M2f1XXNCVkeHUh?=
HCC2998 M4LM[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3fmbWlEPTB;MUG3MlkzKG6P NUG1doRTW0GQR1XS
NB13 NWf1eZo3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkDSTWM2OD1zMUeuPVkhdk1? MX\TRW5ITVJ?
GT3TKB MmfxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHrjSGlKSzVyPUGxPE4xQCCwTR?= MWPTRW5ITVJ?
BT-549 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVnJR|UxRTFzOD65OUBvVQ>? NFi0SGtUSU6JRWK=
NCI-H747 NVXTWotyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3\rbmlEPTB;MUG5MlM1KG6P MUHTRW5ITVJ?
EW-1 NXzkNG5PT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGnY[HpKSzVyPUGyNE4zKG6P NV3Rb4JxW0GQR1XS
LB831-BLC NHXI[ZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFPrU4JKSzVyPUGyNE43OyCwTR?= NU\F[3Y4W0GQR1XS
NMC-G1 Mm[wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mlq0TWM2OD1zMkGuNVEhdk1? MlHEV2FPT0WU
COLO-679 NVrrfphZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWLJR|UxRTF{Mj6xOUBvVQ>? M2flbHNCVkeHUh?=
HL-60 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmfnTWM2OD1zMkOuNUBvVQ>? NEHXd3ZUSU6JRWK=
MKN7 NVPtZ2pjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWfHO|hrUUN3ME2xNlMvQDNibl2= NF3qeolUSU6JRWK=
RERF-LC-MS MlXIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYfSNYU{UUN3ME2xNlQvOzFibl2= NHewUnRUSU6JRWK=
DMS-114 M4nqOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4LLXmlEPTB;MUK1MlA6KG6P Mn3wV2FPT0WU
HuP-T4 NEKzRlhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWDJR|UxRTF{Nj65O{BvVQ>? MWrTRW5ITVJ?
HCC2157 MnT0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mo\aTWM2OD1zMkeuOUBvVQ>? MWLTRW5ITVJ?
SKG-IIIa MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXnJR|UxRTF{OD64JI5O M3PleXNCVkeHUh?=
HCT-116 NUXUfZRwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmfMTWM2OD1zM{CuOlQhdk1? MkPaV2FPT0WU
BB30-HNC NYjVWpJMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mk\QTWM2OD1zM{CuO|ghdk1? M4\ifHNCVkeHUh?=
KYSE-270 NELs[XZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXnJR|UxRTF|MD64PEBvVQ>? MYXTRW5ITVJ?
MFM-223 NVGwSppUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYO5bVFYUUN3ME2xN|EvPTFibl2= MUXTRW5ITVJ?
NH-12 M4Pjc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIG1TVRKSzVyPUGzNk46QSCwTR?= NFS4N2ZUSU6JRWK=
U-118-MG MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXf2WXdKUUN3ME2xN|MvPjJibl2= NGfBPHBUSU6JRWK=
ESS-1 MkixS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnznTWM2OD1zM{WuNVghdk1? NWG2cZJUW0GQR1XS
D-247MG NUDoO4hET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF;pUotKSzVyPUGzOU4zOSCwTR?= NUXEflBiW0GQR1XS
IGROV-1 NInvTY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M17lRmlEPTB;MUO1Mlc3KG6P NFnGU|dUSU6JRWK=
C-33-A MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF24WVhKSzVyPUGzOU46PyCwTR?= MWfTRW5ITVJ?
NCI-H1693 Mn:5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4DuOWlEPTB;MUO2MlEzKG6P MnvMV2FPT0WU
MLMA Mn3uS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXnVSVQxUUN3ME2xN|YvPThibl2= MVnTRW5ITVJ?
SK-N-AS NH3o[JpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWDJR|UxRTF|Nz6xO{BvVQ>? MkP6V2FPT0WU
NCI-H1755 Mmn4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml7jTWM2OD1zM{iuPFUhdk1? MUPTRW5ITVJ?
CHP-134 Ml2yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmXzTWM2OD1zM{muOVUhdk1? NED2c3NUSU6JRWK=
LS-513 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHLuOlBKSzVyPUG0NE46OSCyTR?= NGPsO5FUSU6JRWK=
TE-12 Ml;uS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkXtTWM2OD1zNECuPVMhdk1? M1LYTnNCVkeHUh?=
KNS-42 M1TmRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH6w[nNKSzVyPUG0OE4{KG6P NVnxZ5FLW0GQR1XS
SJRH30 NF\yV3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVPqR245UUN3ME2xOFQvPDRibl2= NIG3O5JUSU6JRWK=
NCI-H1092 NGToRXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFSySGVKSzVyPUG0OE42OiCwTR?= M4S1dnNCVkeHUh?=
H-EMC-SS NU\kN5lnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEjrO4FKSzVyPUG0Ok45OSCwTR?= NUH6[|JWW0GQR1XS
SK-MEL-3 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUDyclZjUUN3ME2xOFcvPTVibl2= MoPJV2FPT0WU
SK-N-FI M{n6T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXHJR|UxRTF2Nz61PUBvVQ>? MlLaV2FPT0WU
NCI-H2126 M4iyPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXvIfGp2UUN3ME2xOFgvOTVibl2= M4XlOHNCVkeHUh?=
NCI-H1299 MnjYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX3JR|UxRTF3MD6yNkBvVQ>? MnX3V2FPT0WU
CFPAC-1 NH\K[FVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXjJR|UxRTF3MD62OkBvVQ>? M3fX[XNCVkeHUh?=
NCI-H661 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFqwWHVKSzVyPUG1NU4zPiCwTR?= Ml;CV2FPT0WU
KYSE-70 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MorqTWM2OD1zNUGuO|khdk1? M2H5dnNCVkeHUh?=
SW900 NUPXb|lCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{SxVWlEPTB;MUW0MlY2KG6P M3;M[HNCVkeHUh?=
Ca-Ski NFX1[VVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2TFPGlEPTB;MUW2MlM6KG6P MVvTRW5ITVJ?
HPAF-II NEnVNXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV;JR|UxRTF3Nj60O{BvVQ>? MnvlV2FPT0WU
LB2518-MEL MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4DCS2lEPTB;MUW3MlEhdk1? MnrLV2FPT0WU
LC-2-ad MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWHFd5dxUUN3ME2xOVgvPjJibl2= NHuz[ItUSU6JRWK=
HCC1806 MljkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFTMcmhKSzVyPUG2O{45QCCwTR?= MknXV2FPT0WU
UACC-62 M13LWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHTpU|lKSzVyPUG2PE4xQSCwTR?= M4\ZdXNCVkeHUh?=
KM-H2 NF6yN4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH:wWXRKSzVyPUG3NE42QCCwTR?= NV\6TVBrW0GQR1XS
NCI-H2347 NFK4VJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYPJR|UxRTF5Mj63NkBvVQ>? MWHTRW5ITVJ?
SCC-15 NEHUUZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn;NTWM2OD1zN{OuOlYhdk1? MV3TRW5ITVJ?
BB49-HNC NUO5RYVqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{H5WmlEPTB;MUezMlgyKG6P M1L5NXNCVkeHUh?=
GMS-10 NIL0TWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NE\ObWdKSzVyPUG3N{46PCCwTR?= MknmV2FPT0WU
NCI-H2052 NWq1ZZNtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYfJR|UxRTF5ND65JI5O NXLaRmRsW0GQR1XS
SW626 NE\TZZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGPNNJdKSzVyPUG3Ok4xPiCwTR?= M2TibHNCVkeHUh?=
MDA-MB-415 M4rmUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGfkfGZKSzVyPUG3Ok43OSCwTR?= NGjYc|JUSU6JRWK=
Saos-2 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{HlVGlEPTB;MUe5MlM2KG6P MkK5V2FPT0WU
DK-MG M{j3emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4PaNWlEPTB;MUiwMlMhdk1? NWj0NHI1W0GQR1XS
SNU-C2B M3PVVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NInTeZFKSzVyPUG4NE44OyCwTR?= NETVRXVUSU6JRWK=
A427 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2ryVmlEPTB;MUiyMlU4KG6P NGrOUpRUSU6JRWK=
KP-N-YS NUX4PHU1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGOzNJpKSzVyPUG4OUBvVQ>? NF\zUlJUSU6JRWK=
J82 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3PFcmlEPTB;MUi1MlE5KG6P NY\L[HVjW0GQR1XS
LS-411N Ml3qS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoXsTWM2OD1zOEeuNlghdk1? NFPq[WhUSU6JRWK=
HCC1937 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlvFTWM2OD1zOEeuOFkhdk1? MkLRV2FPT0WU
OE33 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NILYcmZKSzVyPUG4PE46PyCwTR?= MVrTRW5ITVJ?
NB7 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWGwNpRNUUN3ME2xPFkvQDlibl2= MXrTRW5ITVJ?
SW684 NFT6UlZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGfacIJKSzVyPUG5Ok4yOyCwTR?= NHfKVpVUSU6JRWK=
HT-144 MojjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVT0Tm5rUUN3ME2xPVYvOTVibl2= MlLYV2FPT0WU
SK-MEL-30 MlXMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml\hTWM2OD1zOU[uNkBvVQ>? NEPBU4tUSU6JRWK=
DBTRG-05MG NV72cWJ7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFW3c4VKSzVyPUG5PE41PyCwTR?= MonWV2FPT0WU
NCI-H1395 NETUdWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYCwTIZvUUN3ME2xPVgvQDVibl2= MmjBV2FPT0WU
NCI-H2122 M4naT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXvYfotIUUN3ME2yNFAvPTlibl2= NX7ucmdXW0GQR1XS
no-10 M1WwbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUfJR|UxRTJyMT6wOEBvVQ>? NUHGN2dRW0GQR1XS
SW48 NYeyWYJ6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUnJR|UxRTJyMT6zNUBvVQ>? NHziRWxUSU6JRWK=
NCI-H1650 MnXSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEjBdpdKSzVyPUKwOE4xOSCwTR?= MUHTRW5ITVJ?
MZ1-PC M1rIbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXzENnpLUUN3ME2yNFUvPThibl2= Mn7JV2FPT0WU
U-266 M4CxZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3uz[mlEPTB;MkC1Mlc6KG6P NIH1PJBUSU6JRWK=
CAS-1 NIKwb5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVHmPHRrUUN3ME2yNFcvPDRibl2= NE\QblVUSU6JRWK=
AU565 NFuxfpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEnKNYZKSzVyPUKxNk45OiCwTR?= NH2yVoFUSU6JRWK=
UACC-257 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV7JR|UxRTJzMz65PUBvVQ>? MYLTRW5ITVJ?
CAL-27 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnLBTWM2OD1{MUeuNFUhdk1? Mo\vV2FPT0WU
NCI-H23 NX3Dc3M6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkHxTWM2OD1{MUmuN|Mhdk1? MWHTRW5ITVJ?
TE-6 NYHtWWplT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYXJVFRiUUN3ME2yNVkvPjhibl2= NUXKRY17W0GQR1XS
TGBC24TKB M1qyemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlHxTWM2OD1{MkKuNVchdk1? Mmn1V2FPT0WU
TE-1 NUjCNos6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHPCPXpKSzVyPUKyNk45QCCwTR?= NUi2W3NIW0GQR1XS
RCC10RGB Mn[4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlXxTWM2OD1{MkSuNVkhdk1? NF;6S5BUSU6JRWK=
NCI-H596 M33LTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnTZTWM2OD1{MkiuNlIhdk1? M2rDW3NCVkeHUh?=
SW954 MnvLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF7SbnNKSzVyPUKzN{45OyCwTR?= MYLTRW5ITVJ?
NCI-H2087 M3jqSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3ToO2lEPTB;MkO0MlUyKG6P M{P6dHNCVkeHUh?=
SK-PN-DW NVi4ZphHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXrMdnp[UUN3ME2yN|UvOTlibl2= NXfJSYNVW0GQR1XS
KM12 M4TuTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXi0SVA3UUN3ME2yN|UvPyCwTR?= Ml7tV2FPT0WU
BT-474 NH3rPXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3Lid2lEPTB;MkO1Mlc{KG6P MWHTRW5ITVJ?
IST-MES1 M1fkTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYDJR|UxRTJ|Nj61O{BvVQ>? MYDTRW5ITVJ?
HT-1197 NYD6ZZpDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3HBWGlEPTB;MkO4MlA6KG6P NWnoT2FTW0GQR1XS
CAL-54 NVv5NIVZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVjJR|UxRTJ|OD60PUBvVQ>? M3nFSHNCVkeHUh?=
NB10 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV3JR|UxRTJ2MD6wOkBvVQ>? NYnhcG5NW0GQR1XS
PANC-10-05 NIXMUmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX;5PIRkUUN3ME2yOFUvPTZibl2= MoLuV2FPT0WU
NCI-H522 NXHBWYdDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MofsTWM2OD1{NEiuN|Ehdk1? NWjGNHhUW0GQR1XS
A388 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXHUWlRvUUN3ME2yOFkvQDJibl2= NU\iXFE{W0GQR1XS
GOTO NYnHN28zT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIjoWnNKSzVyPUK1NE4zQSCwTR?= MoTUV2FPT0WU
KLE NES0V5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVSxfmJuUUN3ME2yOVEvQDdibl2= NFK3[4VUSU6JRWK=
KYSE-520 NHy4dotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWHJR|UxRTJ3Mj64OkBvVQ>? NHjNS3JUSU6JRWK=
HCE-4 M{LNcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1jO[GlEPTB;Mk[yMlUhdk1? M{HTW3NCVkeHUh?=
KURAMOCHI NUjKUmlDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mkn2TWM2OD1{NkWuPUBvVQ>? Mk\JV2FPT0WU
HCC38 NFi1bIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHnWNnBKSzVyPUK2Ok41QCCwTR?= MV3TRW5ITVJ?
FADU M2nIU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWPoRoZZUUN3ME2yOlYvPjNibl2= Ml;nV2FPT0WU
CW-2 NFfMdHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGHORohKSzVyPUK2PU46PiCwTR?= MYTTRW5ITVJ?
L-428 NGXXbVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{TCcWlEPTB;Mke1MlE2KG6P M4nZbnNCVkeHUh?=
HCC1569 NELoNZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF3nbGFKSzVyPUK3OU45PCCwTR?= MnLXV2FPT0WU
NCI-H810 MmfYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M13qeWlEPTB;Mke4MlMyKG6P M3LWTHNCVkeHUh?=
LB771-HNC M4Lz[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXzJR|UxRTJ6NT64OEBvVQ>? NES5VoVUSU6JRWK=
LCLC-103H MljLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWPzVmNmUUN3ME2yPFUvQTlibl2= MVrTRW5ITVJ?
EFO-21 M4[1T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVi5VGhFUUN3ME2yPFcvPjhibl2= MXHTRW5ITVJ?
CAL-72 MoryS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2jHdmlEPTB;MkmzMlE6KG6P MlzjV2FPT0WU
SCC-9 NVf1emduT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1LjemlEPTB;MkmzMlIzKG6P NV20UXE1W0GQR1XS
COLO-829 Ml;pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoXCTWM2OD1{OU[uOUBvVQ>? MVnTRW5ITVJ?
U-87-MG NGT1Z|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYj2bHZOUUN3ME2zNFAvPzNibl2= NW\iXY1MW0GQR1XS
MZ7-mel MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVvJR|UxRTN{Mz63OkBvVQ>? M3W4bXNCVkeHUh?=
NCI-H1770 MnjpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{[3TGlEPTB;M{K2Mlc1KG6P M3r1dHNCVkeHUh?=
ChaGo-K-1 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1zldGlEPTB;M{K4MlEhdk1? M2XT[XNCVkeHUh?=
SiHa NX;PcJZTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4rycWlEPTB;M{K5MlI1KG6P MnHoV2FPT0WU
NCI-SNU-5 MoDJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4jnPWlEPTB;M{O2Mlc4KG6P MYnTRW5ITVJ?
DJM-1 M4rmPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3\xOWlEPTB;M{SwMlM{KG6P NHLYWItUSU6JRWK=
OE19 NI\vXXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYDJR|UxRTN2MD61N{BvVQ>? NVXybI17W0GQR1XS
NCI-H1651 NYnNNoVIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVvCS3V2UUN3ME2zOFQvOThibl2= MmTCV2FPT0WU
COLO-792 NGTR[I1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mle5TWM2OD1|NUSuOFIhdk1? MoO4V2FPT0WU
ACHN M1H3dWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVPJR|UxRTN3Nj63NUBvVQ>? MU\TRW5ITVJ?
TH-3 MmTjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmC5TWM2OD1|N{muPVUhdk1? MoLzV2FPT0WU
HT-1376 NFvWfYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWHJR|UxRTN6ND64PEBvVQ>? NEezWGtUSU6JRWK=
RH-18 MlSwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX3JR|UxRTN7ND63OEBvVQ>? NV3QZmNtW0GQR1XS
NB6 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlO4TWM2OD1|OU[uOlYhdk1? M{fLdnNCVkeHUh?=
COLO-320-HSR NXXPTYhiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH3ieGpKSzVyPUSwN{4{PyCwTR?= NF3OS3VUSU6JRWK=
UACC-893 NVu5eplKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn36TWM2OD12ME[uOFchdk1? NXXnTnoxW0GQR1XS
DSH1 NF;Rcm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkXwTWM2OD12ME[uPVEhdk1? M{TJ[nNCVkeHUh?=
TE-10 NV7Ec3BZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVTJR|UxRTRyNz6wNUBvVQ>? M1fCVnNCVkeHUh?=
HCC70 NXXmRVJmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{THb2lEPTB;NEC5MlIyKG6P NF3rZ3hUSU6JRWK=
TGBC11TKB M3;F[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHW3WIVKSzVyPUSxNE4{OyCwTR?= M4\ub3NCVkeHUh?=
NCI-H727 NV70Z2VzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYrJR|UxRTRzMj6xNUBvVQ>? M4nCZXNCVkeHUh?=
ALL-PO MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2r6W2lEPTB;NEG1MlY6KG6P NH3CcG1USU6JRWK=
ABC-1 NFPkWWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{PYbmlEPTB;NEKwMlQ2KG6P MXzTRW5ITVJ?
NCI-H69 NH7BNVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoP4TWM2OD12Mk[uO|Yhdk1? NF65dGFUSU6JRWK=
GP5d MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWDJR|UxRTR|ND60NUBvVQ>? M3q5NHNCVkeHUh?=
UMC-11 MmH5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1PFeGlEPTB;NEW4MlM3KG6P NUfQ[WxxW0GQR1XS
RMG-I MoixS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MojsTWM2OD12NkeuOVYhdk1? MmXlV2FPT0WU
YAPC MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXjJR|UxRTR7MD62JI5O M2HHb3NCVkeHUh?=
LS-1034 NXLiR2g2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYjJR|UxRTR7MT6wOkBvVQ>? MUTTRW5ITVJ?
RCM-1 NVzZdmRHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUjJR|UxRTR7Nj62PEBvVQ>? MU\TRW5ITVJ?
HCC1954 M{DJdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHLNT4JKSzVyPUWxNk42KG6P MmroV2FPT0WU
SK-MEL-24 NHXreGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVvJR|UxRTVzNj61NUBvVQ>? NHL6cIVUSU6JRWK=
NB12 NGfqZ4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmOzTWM2OD13MkiuOFIhdk1? MnnZV2FPT0WU
SW756 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUjJR|UxRTV3ND65OkBvVQ>? MlmzV2FPT0WU
HCC1187 M4CxNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWPJR|UxRTV5NT64N{BvVQ>? MlXRV2FPT0WU
NCI-H2342 M3W5[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIXOXHhKSzVyPUW5NE4{QSCwTR?= NU\oTHZKW0GQR1XS
NCI-H2291 NGHSXIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{jHbmlEPTB;NUm4MlMyKG6P MlTuV2FPT0WU
OVCAR-3 M2TiO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3jSfWlEPTB;NUm4Mlk3KG6P NUTuZoZNW0GQR1XS
MHH-NB-11 NVnyWGQ{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M13QN2lEPTB;NkK5MlAyKG6P M4HEOXNCVkeHUh?=
SAS Mly1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlTlTWM2OD14NUKuOlchdk1? NX;kUox[W0GQR1XS
COLO-824 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mo[xTWM2OD14OEmuN|chdk1? MlzPV2FPT0WU
HCC1395 NFXMT2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVfJR|UxRTZ7OD61JI5O M{OzT3NCVkeHUh?=
COLO-668 M3\LdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWHJR|UxRTdyNj6xJI5O MmToV2FPT0WU
NCI-H226 MofFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVPJR|UxRTdyNz64JI5O NFHHNoRUSU6JRWK=
NB17 M{Tiemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2HS[mlEPTB;N{KxMlc2KG6P MXvTRW5ITVJ?
SW1463 MlLwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUfJR|UxRTd|OT6xPUBvVQ>? NVrMW4ZrW0GQR1XS
TGW NWHPNVJCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlziTWM2OD15NkCuNVUhdk1? M{fSXnNCVkeHUh?=
NCI-H526 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoX3TWM2OD16MkOuOVMhdk1? NEDxZmFUSU6JRWK=
COR-L88 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWPJR|UxRTh2OD6xNkBvVQ>? NEe2bVVUSU6JRWK=
NCI-H441 M4S5cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVv2eVdrUUN3ME24PVUvOjJibl2= M1HqdHNCVkeHUh?=
NCI-H630 M4Xudmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWPJR|UxRTlzMj65OkBvVQ>? MoDyV2FPT0WU
Mo-T Mo\YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVW5WYtlUUN3ME25OFcvQDhibl2= M{LyVXNCVkeHUh?=
JAR MkXaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2TENWlEPTB;OUW2MlI1KG6P NF3SOmxUSU6JRWK=
NCI-H1838 Mnz5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mlq4TWM2OD1zLkCyN|g5KM7:TR?= NVLsW5JDW0GQR1XS
DoTc2-4510 NYW2OmdDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoOwTWM2OD1zLkC3N|c3KM7:TR?= NI\1d5pUSU6JRWK=
MKN28 NEHEUoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4TpR2lEPTB;MT6wPVAzPCEQvF2= NHi5d2lUSU6JRWK=
HuP-T3 Mkm4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFzlfoZKSzVyPUGuNVE6ODVizszN Mn\BV2FPT0WU
TE-9 NFzBc5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4PGemlEPTB;MT6xNlk4OyEQvF2= M1PMVXNCVkeHUh?=
NY M1HRVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2fHTWlEPTB;MT6xOlc6OiEQvF2= NFfy[HJUSU6JRWK=
HT55 NYfGRodiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX\JR|UxRTFwM{GzOFQh|ryP M3fONnNCVkeHUh?=
SW837 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoGyTWM2OD1zLkOyPVc5KM7:TR?= NHP6VVdUSU6JRWK=
NCI-H2029 MljzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3:yVGlEPTB;MT60NVc6OSEQvF2= NVG1UIw5W0GQR1XS
IST-SL1 MoPhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHPXWphKSzVyPUGuOFQzPCEQvF2= M1HMbHNCVkeHUh?=
COLO-741 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH;aXlBKSzVyPUGuOFk4PzFizszN NYHTbWdUW0GQR1XS
LU-65 NY[wb2xHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGnJdXJKSzVyPUGuOlIzPDlizszN NGjVSo1USU6JRWK=
NCI-H1304 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1TabWlEPTB;MT62OVQ6QCEQvF2= NGCyPYZUSU6JRWK=
KARPAS-299 MoeyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmDnTWM2OD1zLke5OFc6KM7:TR?= NFPEbXpUSU6JRWK=
NCI-H358 NX3LPG1oT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml3sTWM2OD1zLkm1OVA{KM7:TR?= MYrTRW5ITVJ?
OAW-28 NG[zRoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEHLZ4lKSzVyPUKuNFY6OTlizszN MWXTRW5ITVJ?
C8166 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{j0b2lEPTB;Mj62N|M6OiEQvF2= NXv0[2NuW0GQR1XS
COLO-678 NIfaeIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlH5TWM2OD1{LkizO|Y5KM7:TR?= NVzYdoE2W0GQR1XS
SK-N-DZ NYPMR5dtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3HqTmlEPTB;Mj64OlM5OSEQvF2= M3zzNXNCVkeHUh?=
NCI-H82 Mmf6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIflOVFKSzVyPUKuPVA{PjlizszN NEfUZmFUSU6JRWK=
JVM-2 M{TIOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVHJR|UxRTNwMEOxPFgh|ryP NWLtUFViW0GQR1XS
SW1116 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXPJR|UxRTNwMEW0NVEh|ryP M3njT3NCVkeHUh?=
MDA-MB-453 NYTLeXFyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXjJR|UxRTNwMUC0N|kh|ryP MkGwV2FPT0WU
Calu-6 M{Due2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWnJR|UxRTNwMUm5O{DPxE1? NGi2eJRUSU6JRWK=
SHP-77 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWfuVIEyUUN3ME2zMlUzQCEQvF2= MYfTRW5ITVJ?
Capan-2 Mo\HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{\WT2lEPTB;ND6zNlU5OSEQvF2= MXPTRW5ITVJ?
SW948 NIq5V25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3LFb2lEPTB;ND63OFc4QSEQvF2= MYrTRW5ITVJ?
HDLM-2 MoHZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFnmPZVKSzVyPUWuNFc4OjVizszN MU\TRW5ITVJ?
LAN-6 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHnkTnlKSzVyPU[uNlE1QTVizszN MY\TRW5ITVJ?
LU-135 NFn1OHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV3JR|UxRTZwNEOwO|ch|ryP M4\lNnNCVkeHUh?=
T84 M{PI[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXnJR|UxRTZwOUi2OEDPxE1? Mo[yV2FPT0WU
CAPAN-1 MkfXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXLJR|UxRTdwNkKyN|Mh|ryP MWXTRW5ITVJ?
SW1417 Mny3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4nUSWlEPTB;Nz65NVc{OSEQvF2= M2X3V3NCVkeHUh?=
BALL-1 M1jte2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV3JR|UxRThwNUC0NFkh|ryP NXuwbYlbW0GQR1XS
HT-29 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVHJR|UxRTlwMEe1PVkh|ryP M3TL[XNCVkeHUh?=
C3A NYXuT2RXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{P1Z2lEPTB;OT64PFM6PCEQvF2= M4LsPXNCVkeHUh?=
NCI-H1993 NWC1WJk{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NULacoVWUUN3ME2xNE42ODhzIN88US=> M4jQXXNCVkeHUh?=
SK-MEL-1 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUPQfJFvUUN3ME2xNU43Ojh7IN88US=> M1jjUHNCVkeHUh?=
DU-145 M{LxZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1vXfWlEPTB;MUSuOVA2OiEQvF2= M375cHNCVkeHUh?=
KP-N-YN NHvlbFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFLXfZRKSzVyPUG0MlUyODNizszN M1\tWnNCVkeHUh?=
CCRF-CEM MoXUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUDJR|UxRTF2Lke4NFkh|ryP NIjpXoxUSU6JRWK=
ZR-75-30 M4Hy[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUDzZ|RbUUN3ME2xOk4{OzB|IN88US=> Mlq3V2FPT0WU
A673 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3r0fWlEPTB;MkCuOVUxPyEQvF2= NIK4RWVUSU6JRWK=
K-562 MnnuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1nISGlEPTB;MkiuOFE5OyEQvF2= M2TvW3NCVkeHUh?=

... Click to View More Cell Line Experimental Data

In vivo BEZ235 induces regression of the tumors (69%) without statistically significant effect on body weight gain. Altogether, these preliminary in vivo efficacy results show that BEZ235 causes disease stasis when administered orally as a single agent and can enhance the efficacy of other anticancer agents when used in combination studies. [1]

Protocol

Kinase Assay:

[1]

+ Expand

In vitro Protein Kinase, PI3K, and mTOR Assays:

PI3Kα, β, and δ proteins are composed of the iSH2 domain of p85 NH2-terminally fused to the full-length protein p110 protein, with the exception of α that also does not contain the last 20 amino acids. PI3Kγ is produced as full-length protein deleted for its first 144 amino acids. All constructs are fused to a COOH-terminal His tag for convenient purification and then cloned into the pBlue-Bac4.5 (for α, β, and δ isoforms) or pVL1393 (for γ isoform) plasmids. The different vectors are then cotransfected with BaculoGold WT genomic DNA using methods recommended by the vendor for production of the respective recombinant baculoviruses and proteins. BEZ235 are tested for their activity against PI3K using a Kinase-Glo assay. The kinase reaction is done in 384-well black plate. Each well is loaded with 50 μL of test items (in 90% DMSO) and 5 μL reaction buffer containing 10 μg/mL PI substrate (l-α-phosphatidylinositol; Avanti Polar Lipids; prepared in 3% octyl-glucoside) and the PI3K proteins (10, 25, 10, and 150 nM of p110α, p110β, p110δ, and p110γ, respectively) are then added to it. The reaction is started by the addition of 5 μL of 1 μM ATP prepared in the reaction buffer and is incubated for either 60 (for p110α, p110β, and p110δ) or 120 min (for p110γ). It is terminated by the addition of 10 μL Kinase-Glo buffer. The plates are then read in a Synergy 2 reader for luminescence detection.
Cell Research:

[2]

+ Expand
  • Cell lines: HCT116, DLD-1 and SW480 cells
  • Concentrations: 0-1 μM
  • Incubation Time: 48 hours
  • Method:

    The human CRC cell lines, HCT116 (PIK3CA mutant; kinase domain at H1047R), DLD-1 (PIK3CA mutant; helical domain at E545K), and SW480 (PIK3CA wild-type) and isogenic DLD-1 PIK3CA mutant as well as wild-type cells are maintained in DMEM with 10% FBS and 1 × Penicillin/Streptomycin. Cells are plated at different initial densities (HCT116: 3 × 103 cells/well, DLD-1: 5.5 × 103 cells/well, SW480: 4.5 × 103 cells/well, DLD-1 PIK3CA mutant: 7 × 103 cells/well, and DLD-1 PIK3CA wild-type: 9 × 103 cells/well) to account for differential growth kinetics. After 16 hours, cells are incubated with increasing concentrations of BEZ235, and the drug-containing growth medium is changed every 24 hours. Cell viability is assessed 16 hours after the initial plating and 48 hours after initiation of drug treatment using the colorimetric MTS assay CellTiter 96® AQueous One Solution Cell Proliferation Assay, as per the manufacturer's instructions. Cell viability after drug treatment is normalized to that of untreated cells also grown for 48 hours. For western blot analysis, cells are plated with zero or maximum inhibitory dose (500 nM) BEZ235 for 2, 6, 24, or 48 hours.


    (Only for Reference)
Animal Research:

[1]

+ Expand
  • Animal Models: Female Harlan athymic nude mice
  • Formulation: NMP/polyethylene glycol 300 (10/90, v/v)
  • Dosages: 45 mg/kg
  • Administration: p.o.
    (Only for Reference)

Solubility (25°C)

In vitro DMF 18 mg/mL warmed (38.33 mM)
DMSO 0.01 mg/mL (0.02 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order:
NMP+polyethylene glycol 300 (10+90, v+v)
For best results, use promptly after mixing.
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 469.55
Formula

C30H23N5O

CAS No. 915019-65-7
Storage powder
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00620594 Completed Breast Cancer|Advanced Solid Tumors|Cowden Syndrome Novartis Pharmaceuticals|Novartis December 21, 2006 Phase 1
NCT01856101 Terminated Carcinoma Transitional Cell Cliniques universitaires Saint-Luc- Université Catholique de Louvain|Novartis February 2013 Phase 2
NCT01717898 Terminated Castrate-resistant Prostate Cancer Patients. Charles Ryan|Novartis Pharmaceuticals|University of California, San Francisco January 2013 Phase 1|Phase 2
NCT01658436 Completed Pancreatic Neuroendocrine Tumors (pNET) Novartis Pharmaceuticals|Novartis November 2012 Phase 2
NCT01628913 Terminated Pancreatic Neuroendocrine Tumors (pNET) Novartis Pharmaceuticals|Novartis October 2012 Phase 2
NCT01690871 Withdrawn Malignant PEComa (Perivascular Epithelioid Cell Tumors) Novartis Pharmaceuticals|Novartis September 2012 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    With difficulties in dissolving BEZ235, How can I improve its solubility?

  • Answer:

    For in vivo study, we suggest the vehicle solution NMP/polyethylene glycol 300 (10/90, v/v). Please dissolve BEZ235 in NMP as more as possible. You can sonicate and warm it in water bath for a while. Then dilute with PEG 300.

PI3K Signaling Pathway Map

PI3K Inhibitors with Unique Features

Related PI3K Products

Tags: buy Dactolisib (BEZ235, NVP-BEZ235) | Dactolisib (BEZ235, NVP-BEZ235) supplier | purchase Dactolisib (BEZ235, NVP-BEZ235) | Dactolisib (BEZ235, NVP-BEZ235) cost | Dactolisib (BEZ235, NVP-BEZ235) manufacturer | order Dactolisib (BEZ235, NVP-BEZ235) | Dactolisib (BEZ235, NVP-BEZ235) distributor
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID