Dactolisib (BEZ235, NVP-BEZ235)

Catalog No.S1009

Dactolisib (BEZ235, NVP-BEZ235) Chemical Structure

Molecular Weight(MW): 469.55

Dactolisib (BEZ235, NVP-BEZ235) is a dual ATP-competitive PI3K and mTOR inhibitor for p110α/γ/δ/β and mTOR(p70S6K) with IC50 of 4 nM /5 nM /7 nM /75 nM /6 nM in cell-free assays, respectively. Inhibits ATR with IC50 of 21 nM in 3T3TopBP1-ER cell.

Size Price Stock Quantity  
USD 110 In stock
USD 170 In stock
Bulk Discount

Free Overnight Delivery on orders over $ 500
Next day delivery by 10:00 a.m. Order now.

Cited by 81 Publications

10 Customer Reviews

  • Relative kinase activities of p110α mutants and the inhibitory effect of PI3K inhibitors against hotspot mutants of p110α. A, recombinant FLAG-tagged PI3K p110α/p85α protein complex produced in 293T cells was immunoprecipitated , and the immunoprecipitates were used for the quantitative PI3K-HTRF assay (32).

    B, effect of three PI3K inhibitors (ZSTK474, LY294002, and NVP-BEZ235) on the enzymatic activity of two hotspot mutants (E545K and H1047R) p110α compared with the wild-type. No striking difference was observed in the IC50 concentrations of these inhibitors between wild-type and mutant p110α.
     

     

    Cancer Res 2010 70, 4982-4994. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

    A, ANOVA of IC50 values of the dual PI3K/mTOR inhibitor NVP-BEZ235 in 23 melanoma cell lines showing no significant difference in sensitivity to this compound in B-Raf mutant and Braf wild-type cells. B, decreases in pAkt and pP70S6K in a dose and time-dependent fashion in 2 melanoma cell lines treated with NVP-BEZ235. pP70S6K levels are undetectable at all concentrations and time points studied, whereas levels of pAkt start rising again after 4 hours of drug exposure in a dose-dependent fashion. C, clonogenic assays in 2 melanoma cell lines (YUVON and YUSIK) treated with NVP-BEZ235 at different concentrations. NVPBEZ235 was effective in inhibiting colony formation at low nanomolar concentrations.

    Clin Cancer Res 2010 16, 6029-6039. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

  • Three-dimensional responses of MCF7/IGF-1R cells to TAM (1 μM), E2 and IGF-1. Compared to parental MCF7 cells (a), MCF7/IGF-1R cells (b) in three-dimensional (3D) culture formed bigger acini in response to IGF-1 stimulation and displayed significant TAM resistance when treated with TAM (1 μM) + E2 + IGF-1, which was removable by kinase inhibitors BMS-536924, U0126 and BEZ235 (c). Cells (10,000/well) were seeded in 96-well plates. Acini were formed on 100% Matrigel and cultured for 14 days in starving medium containing 2% Matrigel and 5% charcoal/dextran-stripped fetal bovine serum with the treatments as indicated. Concentrations used: TAM (1 μM), E2 (1 nM) and IGF-1 (100 ng/mL). Confocal image original magnification, × 20. Red, rhodamine phalloidin (actin). Blue, Hoechst blue stain. Results are representative of two individual experiments.

    Breast Cancer Res 2011 13, R52. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

    TAM (10 nM) agonistic behavior in MCF7/IGF-1R cells is not inhibited by phosphatidylinositol 3-kinase/Akt inhibitor BEZ235. (a) Inhibitory effects of kinase inhibitors BMS-536924, U0126 and BEZ235 on agonistic effect of TAM (10 nM) in the presence of IGF-1 (100 ng/mL). **P < 0.01. (b) Inhibitory effects of phosphatidylinositol 3-kinase (PI3K)/Akt inhibitor BEZ235 at various dose ranges on IGF-1R signaling. (c) Agonistic behavior of TAM (10 nM) in response to BEZ235 kinase inhibitor. (-), no BEZ235. Results are representative of three independent experiments. Data are expressed as means ± SD.

    Breast Cancer Res 2011 13:R52. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

  • ZSTK474 and GDC-0941 selectively inhibit class I PI3K over mTOR. (A) Inhibition profiles of the selected five PI3K inhibitors for mTOR. Data shown are mean±SD (n = 3), representative of 2 or 3 independent experiments. (B) IC50 values of the PI3K inhibitors for mTOR. (C) Selectivity of each PI3K inhibitor for PI3Ka over mTOR. The selectivity index is expressed as the ratio of the IC50 value for mTOR over that for PI3Ka. The IC50 values of ZSTK474, NVP-BEZ235 and LY294002 for PI3Ka are 0.016, 0.007 and 0.6 μM, respectively, as reported previously by us.

     

     

    Eur J Cancer 2010 46, 1111-1121. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

    (B) The effects of AZD2014, BEZ235, lapatinib, LEE011, pazopanib on PI3K/AKT signaling in sarcoma PDC line were determined by immunoblotting analysis. Cells were treated with 1 μM of the indicated drugs for 72 h.

    Transl Oncol, 2016, 9(3):197-202. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

  • The effects of LY294002, rapamycin and NVP-BEZ235 on activation of PI3K-Akt-mTOR pathway in hepatocytes. (a) The mRNA expression (PI3K, Akt, mTOR, raptor) by Real-Time PCR, (b) protein expression (PI3K, Akt, mTOR, S6K) by ELISA kits; (c) protein expression of S6K and P-S6K by western blotting. The different letters indicated significant differences (P <0.05). LY = LY294002; rapa = rapamycin; NVP = NVP-BEZ235.

    Animal, 2016, 10(8):1319-27. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

     After starved in serum-free medium for 24h,breast cancer cells incubated with the indicated concentrations of BEZ235 for 3h,followed by 20-minute  stimulation of 100ng/ml EGF.

     

     

     

    Dr. Zhang of Tianjin Medical University. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

  • After starved in serum-free medium for 24h,breast cancer cells incubated with the indicated concentrations of BEZ235 for 3h,followed by 20-minute  stimulation of 100ng/ml EGF.

     

     

    Dr. Zhang of Tianjin Medical University. Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

     

    FIG. 4. Phospholipase A2 group 4A (PLA2G4A) expression was increased after BEZ235 treatment in basal-like xenografts. The bar graph shows the quantification of the immunoblots (mean±SD). PLA2G4A, Ethanolamine kinase 1 and 2 (ETNK1/2), Choline kinase alpha/beta (ChoKA/B), and β-actin protein expression were examined by immunoblotting of tissue samples after MRS experiments [control group (n= 5) and BEZ235-treated group (n=7)]. This demonstrated a higher expression of PLA2G4A protein ( P=0.005), but no changes in ETNK1 and ChoKA/B in samples from basal-like xenografts treated with BEZ235.

    Dactolisib (BEZ235, NVP-BEZ235) purchased from Selleck.

Purity & Quality Control

Choose Selective PI3K Inhibitors

Biological Activity

Description Dactolisib (BEZ235, NVP-BEZ235) is a dual ATP-competitive PI3K and mTOR inhibitor for p110α/γ/δ/β and mTOR(p70S6K) with IC50 of 4 nM /5 nM /7 nM /75 nM /6 nM in cell-free assays, respectively. Inhibits ATR with IC50 of 21 nM in 3T3TopBP1-ER cell.
Targets
p110α [1]
(Cell-free assay)
p110γ [1]
(Cell-free assay)
mTOR (p70S6K) [1]
(Cell-free assay)
p110δ [1]
(Cell-free assay)
ATR [8]
(3T3TopBP1-ER cells)
4 nM 5 nM 6 nM 7 nM 21 nM
In vitro

BEZ235 significantly reduces the phosphorylation levels of the mTOR activated kinase p70S6K. BEZ235 results in a reduction of S235/S236P-RPS6 levels with IC50 of 6.5 nM. The activity of BEZ235 against mTOR is determined using a biochemical mTOR K-LISA assay with IC50 of 20.7 nM. BEZ235 shows slightly lower activity against its β paralogue with IC50 of 75 nM. The PI3K/Akt/mTOR pathway is often constitutively activated in human tumor cells. BEZ235 blocks PI3K and mTOR kinase activity by binding to the ATP-binding cleft of these enzymes. Both PTEN-null cell lines PC3M and U87MG show a dose-dependent reduction in cell proliferation when treated with increasing concentrations of BEZ235 with an average GI50 of 10-12 nM. [1] BEZ235 is an mTORC1/2 catalytic inhibitor. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
Trypanosoma brucei brucei MWjBcpRqdWmlcn;ibYFtKEG|c3H5 Mo\qNVghcA>? NH;meWZFVVOR NVrBeVBDSW62aYTyfZBidm:|b33hcEBi[3Srdnn0fUB4cXSqIFXDOVAhd2ZiMD6wNFI2KM7:TR?= NEPNNpYzPDhyNUm0Oi=>
MCF7 M17PN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mo\KNE4xOS1zMECg{txO MlXKOFghcA>? NWDaPHVwTE2VTx?= NHPWbGlKSzVyPUCuO|Mh|ryP MVmyN|g4OTlyNB?=
HCT116 M33aXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXHuNWJVOC5yMT2xNFAh|ryP NGXzN5U1QCCq MWjEUXNQ M3LZTGlEPTB;MT6xOkDPxE1? M1PCW|I{QDdzOUC0
U87MG MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVXaRXBbOC5yMT2xNFAh|ryP MkXyOFghcA>? M1HsUWROW09? NVm0XWtJUUN3ME2xMlMzKM7:TR?= MYWyN|g4OTlyNB?=
HBC4 MlvMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1KwfVAvODFvMUCwJO69VQ>? MoruOFghcA>? MlTuUI9oKEeLNUC9MVgvPjFiTR?= MWOyNlM{PjJ2Nh?=
BSY1 NYnSTI9mT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkDjNE4xOS1zMECg{txO NFy1Tm01QCCq MoPMUI9oKEeLNUC9MVgvPDhiTR?= NHXUcYgzOjN|NkK0Oi=>
HBC5 NGnXcGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYnEO5F1OC5yMT2xNFAh|ryP NVnBPI9MPDhiaB?= MnfTUI9oKEeLNUC9MVcvQDdiTR?= MWeyNlM{PjJ2Nh?=
MCF7 NXPxe3BvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlHLNE4xOS1zMECg{txO M3jaT|Q5KGh? MkfPUI9oKEeLNUC9MVgvOTZiTR?= MUSyNlM{PjJ2Nh?=
MDA-MB-231 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2Hwb|AvODFvMUCwJO69VQ>? NHizSmE1QCCq NGWwToNNd2diR1m1NF0uQC5yOTDN NXLDO5FUOjJ|M{[yOFY>
U251 NHf3dJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{e2e|AvODFvMUCwJO69VQ>? NFPmWlk1QCCq MmLoUI9oKEeLNUC9MVcvPjZiTR?= Mo[1NlI{OzZ{NE[=
SF268 NV72eZZzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVmwMlAyNTFyMDFOwG0> MX60PEBp NEjlRWlNd2diR1m1NF0uPy57MjDN NGHjSVgzOjN|NkK0Oi=>
SF295 NHH1OXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXLYNIp2OC5yMT2xNFAh|ryP NH7pR241QCCq NYHleHJ[VG:pIFfJOVA:NThwM{GgUS=> MVKyNlM{PjJ2Nh?=
SF539 Mn;5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGDqeZUxNjBzLUGwNEDPxE1? MWq0PEBp Mn70UI9oKEeLNUC9MVgvPTliTR?= NWnOZlFUOjJ|M{[yOFY>
SNB75 MmjRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGWw[poxNjBzLUGwNEDPxE1? NGTJdlY1QCCq NXzFUVM4VG:pIFfJOVA:NThwNUigUS=> MXqyNlM{PjJ2Nh?=
SNB78 M1TLW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXqwMlAyNTFyMDFOwG0> MmX6OFghcA>? NWTsR2tPVG:pIFfJOVA:NThwNkWgUS=> NHGxN4UzOjN|NkK0Oi=>
HCC2998 NGr2UJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUDDVZN[OC5yMT2xNFAh|ryP Mn3FOFghcA>? M3PpeWxw\yCJSUWwQU05NjB3IF2= NHXNWmozOjN|NkK0Oi=>
KM12 MojaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF3nPHYxNjBzLUGwNEDPxE1? MVO0PEBp NEjXNVRNd2diR1m1NF0uPy53NDDN NEDoOokzOjN|NkK0Oi=>
HT-29 M3LR[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX2wMlAyNTFyMDFOwG0> MVK0PEBp NVfZTGxiVG:pIFfJOVA:NTdwN{WgUS=> MViyNlM{PjJ2Nh?=
HCT15 NUfsW|ZnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlSxNE4xOS1zMECg{txO MojMOFghcA>? MmP4UI9oKEeLNUC9MVgvODNiTR?= NX;DeoIzOjJ|M{[yOFY>
HCT116 NXX1dVlsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkflNE4xOS1zMECg{txO M1XkZlQ5KGh? M1jHTWxw\yCJSUWwQU04NjZzIF2= NU\HTVRlOjJ|M{[yOFY>
NCI-H23 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFXrN3MxNjBzLUGwNEDPxE1? NGnieJA1QCCq M4XEcGxw\yCJSUWwQU04NjZ2IF2= NXHM[Jk2OjJ|M{[yOFY>
NCI-H226 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXGwMlAyNTFyMDFOwG0> NWP1RXlSPDhiaB?= NHL3bnRNd2diR1m1NF0uQC52NDDN NIH5TJIzOjN|NkK0Oi=>
NCI-H522 NYHwRoFwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXnLcZVsOC5yMT2xNFAh|ryP NYrvN4VJPDhiaB?= MVfMc4chT0l3ME2tPE41PSCP MmLSNlI{OzZ{NE[=
NCI-H438 MlO2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUPndW5SOC5yMT2xNFAh|ryP NUTZ[5hsPDhiaB?= NIH1cVdNd2diR1m1NF0uQC5zMTDN MVSyNlM{PjJ2Nh?=
A549 NGLEZYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4nJT|AvODFvMUCwJO69VQ>? Mnf1OFghcA>? NI[wVJhNd2diR1m1NF0uQC5yNzDN M3n6V|IzOzN4MkS2
DMS273 NH;a[phIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnX6NE4xOS1zMECg{txO MkXrOFghcA>? NWPZSGI4VG:pIFfJOVA:NTdwOECgUS=> MoT4NlI{OzZ{NE[=
DMS114 M{XOfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVWwMlAyNTFyMDFOwG0> NILWeo41QCCq M{TaN2xw\yCJSUWwQU05NjN7IF2= NU\ZVWdWOjJ|M{[yOFY>
LOXIMVI MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoW1NE4xOS1zMECg{txO NEjvWmw1QCCq MlPOUI9oKEeLNUC9MVgvPjZiTR?= NYnkNYNMOjJ|M{[yOFY>
OVCAR3 M1LJWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHG3c|YxNjBzLUGwNEDPxE1? NX64PYV5PDhiaB?= MlLuUI9oKEeLNUC9MVgvOTdiTR?= M1fqd|IzOzN4MkS2
OVCAR4 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGfqfnMxNjBzLUGwNEDPxE1? NF7ZO3U1QCCq NXjncopKVG:pIFfJOVA:NThwNUigUS=> MXSyNlM{PjJ2Nh?=
OVCAR5 NY\NS|RHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXjudHFqOC5yMT2xNFAh|ryP MVS0PEBp NGnubVdNd2diR1m1NF0uPy53NzDN NYfMUppnOjJ|M{[yOFY>
OVCAR8 MnTES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVzoOHd{OC5yMT2xNFAh|ryP MXG0PEBp M3Po[2xw\yCJSUWwQU04Njh2IF2= NIf1SJozOjN|NkK0Oi=>
SKOV3 M134dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUSwMlAyNTFyMDFOwG0> Mke4OFghcA>? NFzzUmdNd2diR1m1NF0uQC52MTDN MnPmNlI{OzZ{NE[=
RXF631L M1rD[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVuwMlAyNTFyMDFOwG0> MUe0PEBp MoDKUI9oKEeLNUC9MVgvOjFiTR?= Mn[0NlI{OzZ{NE[=
ACHN MlXES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NI[ycXkxNjBzLUGwNEDPxE1? MnrCOFghcA>? NGW1[oVNd2diR1m1NF0uPy57NTDN NIH5e5UzOjN|NkK0Oi=>
St-4 MnzjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2n4eVAvODFvMUCwJO69VQ>? M1LFOFQ5KGh? MYTMc4chT0l3ME2tO{41PyCP MXSyNlM{PjJ2Nh?=
MKN1 NXLsZmhsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnPaNE4xOS1zMECg{txO M3KxUFQ5KGh? M{C0Umxw\yCJSUWwQU05NjRzIF2= NHrmZ|czOjN|NkK0Oi=>
MKN7 NEGwUJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXywMlAyNTFyMDFOwG0> MWO0PEBp MXXMc4chT0l3ME2tO{43QCCP NGP3c2IzOjN|NkK0Oi=>
MKN28 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3;Uc|AvODFvMUCwJO69VQ>? NUPFOFJvPDhiaB?= M2T2XWxw\yCJSUWwQU04NjB5IF2= NGnEOG0zOjN|NkK0Oi=>
MKN45 NEiycpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2DwXVAvODFvMUCwJO69VQ>? M2q4XFQ5KGh? M2n4Zmxw\yCJSUWwQU05NjN2IF2= M2P0b|IzOzN4MkS2
MKN74 M2rZd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{DFdVAvODFvMUCwJO69VQ>? NX;QTY9mPDhiaB?= MUDMc4chT0l3ME2tO{41OiCP NV;vTmJkOjJ|M{[yOFY>
DU145 MmG5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUWwMlAyNTFyMDFOwG0> MX[0PEBp NXfXUIgxVG:pIFfJOVA:NThwMU[gUS=> NIi4PHEzOjN|NkK0Oi=>
PC3 MlPTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH3mNlQxNjBzLUGwNEDPxE1? MUi0PEBp MVrMc4chT0l3ME2tPE43PiCP NULUOIJxOjJ|M{[yOFY>
Trypanosoma brucei brucei MV;GeY5kfGmxbjDBd5NigQ>? NIjvfFczODBibl2= NFvCWIYyOiCq NH7kNlRFVVOR MVPE[YNz\WG|ZTDpckBxcG:|cHjveIllgWxiaX7vd4l1d2xicHjvd5Bp[XSnIHzleoVt NFPwcJQzPDhyNUm0Oi=>
Trypanosoma brucei brucei NHX2[oFHfW6ldHnvckBCe3OjeR?= M3G3RlE5KGh? NUPUe29[TE2VTx?= MkSzTY5pcWKrdHnvckBw\iC{ZXPldJRwei2vZXTpZZRm\CCnbnTvZ5l1d3OrczDhd5Nme3OnZDDhd{Bl\WO{ZXHz[UBqdiC2cnHud4ZmenKrbjD1dJRic2V? M3nQclI1QDB3OUS2
Trypanosoma brucei brucei MkT2SpVv[3Srb36gRZN{[Xl? MmXGNlAxKG6P NXPDbJBrOTJiaB?= Ml32SG1UVw>? M2DtZ2Vn\mWldDDvckB{eGirbnfvcZlt\WmwIHzleoVt MUeyOFgxPTl2Nh?=
Trypanosoma brucei brucei MYfGeY5kfGmxbjDBd5NigQ>? MW[yNFAhdk1? MXGxNkBp MY\EUXNQ MlO2SYZn\WO2IH;uJJBpd3OyaHH0bYR6dGOqb3zpcoUhdGW4ZXy= M1vBe|I1QDB3OUS2
UM-UC-3 NGnXW4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3Gw[WlEPTB;M{G1JJBO MUXTRW5ITVJ?
SBC-1 M{nrc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXP4TIF1UUN3ME23OFIheE1? NXm4VlN6W0GQR1XS
MKN1 MlvVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnnpTWM2OD1{Lkigcm0> M3noe3NCVkeHUh?=
NCI-H720 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXv0UXNWUUN3ME2zMlU4KG6P MXTTRW5ITVJ?
BFTC-909 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVruOHpbUUN3ME2zMlcyKG6P Mn3RV2FPT0WU
BPH-1 Mn:3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFv6[3ZKSzVyPUSuO|Yhdk1? MoLiV2FPT0WU
PC-3 NVfXTGQ2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX\JR|UxRTVwMEmgcm0> M4DXNXNCVkeHUh?=
AN3-CA NILoUnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV7JR|UxRTVwNU[gcm0> MmK2V2FPT0WU
HN M1Lk[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWPJR|UxRTVwOU[gcm0> MULTRW5ITVJ?
HCC2218 M{DYSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYrvbWpuUUN3ME22MlYyKG6P NHz4cVFUSU6JRWK=
KP-4 NWT6bWVpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MljhTWM2OD15IH7N NXL4OpdtW0GQR1XS
LU-139 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHfQOWVKSzVyPUeuO|chdk1? NYXtdmlmW0GQR1XS
ETK-1 M2m5XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml;kTWM2OD15Lki4JI5O NV3idm46W0GQR1XS
Ramos-2G6-4C10 NULQVVNNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFXWd2RKSzVyPUiuOFkhdk1? Mo\DV2FPT0WU
MHH-PREB-1 Moj5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWnJR|UxRTlwMUKgcm0> M2PGT3NCVkeHUh?=
DU-4475 NIXwZnZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGrvVnhKSzVyPUmuOFQhdk1? M4fm[3NCVkeHUh?=
NCI-H1666 NH7IT3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn:zTWM2OD17LkexJI5O NYPyXJFMW0GQR1XS
CAMA-1 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXLwdG9wUUN3ME25Mlghdk1? M1LpSXNCVkeHUh?=
TYK-nu MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV\JR|UxRTlwOUSgcm0> MU\TRW5ITVJ?
MFE-280 MonTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHTBfndKSzVyPUmuPVkhdk1? MnrkV2FPT0WU
A549 NIrzW5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFXR[ZRKSzVyPUGwMlE1KG6P NGPGPYhUSU6JRWK=
769-P MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV;GWG1OUUN3ME2xNE41PCCwTR?= M3TST3NCVkeHUh?=
L-363 MnLwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlzqTWM2OD1zMD62PUBvVQ>? M3jxSnNCVkeHUh?=
ES8 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWPuNnVHUUN3ME2xNE46KG6P Ml;UV2FPT0WU
PA-1 M1TsUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWTY[41XUUN3ME2xNU45OiCwTR?= M373cXNCVkeHUh?=
Mewo NW\jWmpYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlfjTWM2OD1zMT65PUBvVQ>? NFXQTmxUSU6JRWK=
HSC-3 NWXyfY9PT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEi5V|NKSzVyPUGyMlIyKG6P MY\TRW5ITVJ?
H4 NYHTNVhIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlzqTWM2OD1zMj62O{BvVQ>? MoDIV2FPT0WU
BB65-RCC MorES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVrHR5I5UUN3ME2xNk44OiCwTR?= M4\vSXNCVkeHUh?=
NCI-H1793 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFjyVFhKSzVyPUGyMlgzKG6P MV\TRW5ITVJ?
KARPAS-45 M3\JXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVLJR|UxRTF|LkWxJI5O M2HZbXNCVkeHUh?=
GCT M3:yTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV\jToR7UUN3ME2xN{43QCCwTR?= NVW1WpFEW0GQR1XS
EoL-1 MmnMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmLoTWM2OD1zMz65N{BvVQ>? NYLoOpd4W0GQR1XS
LB2241-RCC M37UbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHjuPVVKSzVyPUG0MlAyKG6P NGn3VIpUSU6JRWK=
ES5 NUHS[YZLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVjNWHJnUUN3ME2xOE44PCCwTR?= NF6wUFFUSU6JRWK=
LOXIMVI NYT4fYhFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlnKTWM2OD1zND65PUBvVQ>? MmizV2FPT0WU
COR-L105 M3jI[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn\YTWM2OD1zNT6wOEBvVQ>? MX\TRW5ITVJ?
P12-ICHIKAWA NX3OUG5{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1rNc2lEPTB;MUWuNUBvVQ>? NG\PeFVUSU6JRWK=
CHL-1 MofjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV7JR|UxRTF3LkS1JI5O NVvkNnJXW0GQR1XS
VMRC-RCZ MlzTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV;JR|UxRTF3Lk[zJI5O MnLZV2FPT0WU
HH NES5SJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYPJR|UxRTF3Lkegcm0> MljBV2FPT0WU
NUGC-3 M4TnRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVLJR|UxRTF4LkO0JI5O MVfTRW5ITVJ?
EGI-1 NUHIbJBTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1\zPGlEPTB;MU[uOFMhdk1? MX;TRW5ITVJ?
OS-RC-2 MkC4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mm\KTWM2OD1zNj60O{BvVQ>? NVHUV2RUW0GQR1XS
MOLT-16 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NU\xbpFpUUN3ME2xO{4yPSCwTR?= MofnV2FPT0WU
NCI-H209 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWDJR|UxRTF5LkK5JI5O NVPXZWhwW0GQR1XS
697 NEnj[I9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlvJTWM2OD1zNz60N{BvVQ>? MXzTRW5ITVJ?
D-56MG MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4ftbGlEPTB;MUeuOlkhdk1? MkP0V2FPT0WU
VA-ES-BJ MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHjHWopKSzVyPUG3Mlg{KG6P MWLTRW5ITVJ?
EW-16 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mki0TWM2OD1zOD6wOEBvVQ>? MknsV2FPT0WU
HGC-27 NIHVPYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn64TWM2OD1zOD6wOkBvVQ>? MnfoV2FPT0WU
ES7 NWPBWnROT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXuxUG91UUN3ME2xPE4xQSCwTR?= MW\TRW5ITVJ?
HuH-7 M3\TR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEfuTGZKSzVyPUG4MlQhdk1? M3fFeXNCVkeHUh?=
BCPAP MlG5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml7KTWM2OD1zOD62OUBvVQ>? MYLTRW5ITVJ?
SW1710 M3X3Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4jpbWlEPTB;MUiuO|Ihdk1? MnXaV2FPT0WU
IST-MEL1 MljTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlrGTWM2OD1zOD63O{BvVQ>? MX3TRW5ITVJ?
SF295 NGnNW4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1zNcWlEPTB;MUiuPVMhdk1? NG\RcllUSU6JRWK=
RPMI-7951 NV70N3l5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUXhS2k{UUN3ME2xPU4zQCCwTR?= NGDUbpJUSU6JRWK=
SF126 NUfHPGZiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYDLbY9jUUN3ME2xPU41OSCwTR?= MVfTRW5ITVJ?
GAMG MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXrjS3pbUUN3ME2xPU41QCCwTR?= NF7FflVUSU6JRWK=
KNS-81-FD MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3jBPGlEPTB;MUmuOVQhdk1? M336eXNCVkeHUh?=
RT-112 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUnpSJg5UUN3ME2xPU43PiCwTR?= MkO4V2FPT0WU
DEL NVrGcFRRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWrxV3NYUUN3ME2yNE41QSCwTR?= MnrVV2FPT0WU
CGTH-W-1 M1Lzdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHvsenNKSzVyPUKwMlY{KG6P NVK5e2Z5W0GQR1XS
HOS MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWrMTmFiUUN3ME2yNU4xPiCwTR?= Mo\SV2FPT0WU
ES4 NWPDdpdxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVPJR|UxRTJzLkC4JI5O NIrNVJJUSU6JRWK=
RXF393 NIfMbZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnHqTWM2OD1{MT60OUBvVQ>? MXnTRW5ITVJ?
NCI-H2030 M{HG[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3vKdWlEPTB;MkGuOVIhdk1? M2[1UXNCVkeHUh?=
YH-13 NVTQWmtqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXfJR|UxRTJzLki4JI5O M1TwfnNCVkeHUh?=
HT-1080 M4DYbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NImz[FdKSzVyPUKxMlk{KG6P Mk[3V2FPT0WU
NCI-SNU-1 NUPuelM1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlmwTWM2OD1{MT65OUBvVQ>? NHnqXG5USU6JRWK=
G-402 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoPvTWM2OD1{Mj6xOkBvVQ>? MWjTRW5ITVJ?
786-0 NY\wdoF7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2fVTmlEPTB;MkKuNlkhdk1? M{jSWnNCVkeHUh?=
ME-180 NUniUlNCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXv3UYs4UUN3ME2yNk41OyCwTR?= M3fFZnNCVkeHUh?=
NB69 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mk\UTWM2OD1{Mj61N{BvVQ>? MXXTRW5ITVJ?
J-RT3-T3-5 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFLFNJZKSzVyPUKyMlk3KG6P Mkj6V2FPT0WU
TGBC1TKB Moi5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnzOTWM2OD1{Mz6wOUBvVQ>? MlnsV2FPT0WU
SW780 Mmq4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2XmPWlEPTB;MkOuNVMhdk1? NIWydJhUSU6JRWK=
MG-63 NWj0N3hXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{niUGlEPTB;MkOuOFUhdk1? MYHTRW5ITVJ?
BV-173 NEfaOGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXrEV5Z{UUN3ME2yN{45PyCwTR?= NITYVYJUSU6JRWK=
CAL-51 MnTYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{PVVmlEPTB;MkOuPFkhdk1? MmHpV2FPT0WU
A375 NXHJXZRvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2rUeWlEPTB;MkOuPVMhdk1? NWPJWWh{W0GQR1XS
MEL-HO MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFPVboNKSzVyPUK0MlA1KG6P M2TNVHNCVkeHUh?=
EFO-27 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3jCcmlEPTB;MkSuN|Mhdk1? NXLYNJZUW0GQR1XS
Hs-578-T NI\hNJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFrIR3dKSzVyPUK0MlU5KG6P NFjNe|lUSU6JRWK=
NBsusSR Mn\HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmHoTWM2OD1{ND62JI5O M12zWHNCVkeHUh?=
CTB-1 MoPaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWTJR|UxRTJ2Lk[3JI5O MVLTRW5ITVJ?
FTC-133 Mm\kS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1q2R2lEPTB;MkWuNUBvVQ>? M{H4bHNCVkeHUh?=
MOLT-4 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{\zVWlEPTB;MkWuNVIhdk1? NGrW[mlUSU6JRWK=
HO-1-N-1 Mm\kS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXjSR3lYUUN3ME2yOU4yPSCwTR?= NIC5NWZUSU6JRWK=
ES3 NELNc|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVTJR|UxRTJ3LkKyJI5O M3u2[XNCVkeHUh?=
TI-73 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1yxTWlEPTB;MkWuNlghdk1? NI\0eIhUSU6JRWK=
MPP-89 NIrDTZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX7tdWRUUUN3ME2yOU4{OiCwTR?= MY\TRW5ITVJ?
KYSE-150 MmDuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFnMU5BKSzVyPUK1Mlg6KG6P NVPxe2RUW0GQR1XS
LXF-289 NH7PfnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3zVe2lEPTB;Mk[uNFQhdk1? NHLmOmhUSU6JRWK=
SK-LU-1 MlSxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH7OUJBKSzVyPUK2MlE4KG6P MVHTRW5ITVJ?
HOP-92 MmLpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWPJR|UxRTJ4LkS4JI5O MU\TRW5ITVJ?
HuO9 MkL1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1r1UWlEPTB;Mk[uO|Yhdk1? NEC1OYhUSU6JRWK=
SW962 Ml\jS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVHJR|UxRTJ4Lke2JI5O Mo\1V2FPT0WU
RS4-11 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYDZcVU6UUN3ME2yOk46OSCwTR?= M2PoU3NCVkeHUh?=
NCI-H292 M1zsNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{n6VGlEPTB;Mkegcm0> NHvt[oRUSU6JRWK=
DB NYjkeFBbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVzaOJJFUUN3ME2yO{4{PiCwTR?= NEjz[49USU6JRWK=
SW1088 NX7Hd5JKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXHhcnhQUUN3ME2yPE4zQSCwTR?= MXTTRW5ITVJ?
A204 MkDHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{fnTWlEPTB;MkiuOFchdk1? MXPTRW5ITVJ?
A3-KAW NHjQOVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NE\vNG1KSzVyPUK4MlY1KG6P MlTZV2FPT0WU
MV-4-11 NF;CT3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFXYNItKSzVyPUK4Mlchdk1? MoDCV2FPT0WU
ES1 NHn1eZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUn4XnJXUUN3ME2yPE45PCCwTR?= M17TXnNCVkeHUh?=
ONS-76 Mlm4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmTuTWM2OD1{OT6wOUBvVQ>? MXjTRW5ITVJ?
D-263MG NITvNGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGfJWmtKSzVyPUK5MlM2KG6P NWjLSpoyW0GQR1XS
U-2-OS MlPFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{H3Z2lEPTB;MkmuOUBvVQ>? MonRV2FPT0WU
T98G NXjORWJLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWLJR|UxRTJ7Lki4JI5O MUHTRW5ITVJ?
GI-ME-N NX;WTIRjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF3zVGxKSzVyPUK5MlkyKG6P NIniPHhUSU6JRWK=
BHT-101 NEPk[29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{PQW2lEPTB;M{CuNFUhdk1? MWfTRW5ITVJ?
NOS-1 NGX6SFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NU\0[Fg2UUN3ME2zNE4yOiCwTR?= NHXvOmRUSU6JRWK=
AsPC-1 M1\SWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV;JR|UxRTNyLkKgcm0> NETsfm5USU6JRWK=
QIMR-WIL NILkS2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYjJR|UxRTNyLk[gcm0> MkPUV2FPT0WU
JVM-3 NX7YO5ZPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIf2UI5KSzVyPUOwMlg{KG6P NUHwV|ZjW0GQR1XS
KU-19-19 M3HyZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoLWTWM2OD1|MT6xN{BvVQ>? MX3TRW5ITVJ?
OVCAR-8 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1nZ[WlEPTB;M{GuNlYhdk1? MojGV2FPT0WU
BEN MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MknSTWM2OD1|MT62N{BvVQ>? NF3JRlBUSU6JRWK=
BE-13 MkHZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV3WbIJXUUN3ME2zNU45OiCwTR?= NUS1UoFxW0GQR1XS
EW-18 NUm4e5pXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV3JR|UxRTNzLki2JI5O M{HudXNCVkeHUh?=
ECC10 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M362[mlEPTB;M{GuPVUhdk1? NUfpVFN4W0GQR1XS
CTV-1 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVzzZpZIUUN3ME2zNk45OiCwTR?= MXrTRW5ITVJ?
COLO-800 NF:zTFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mo\zTWM2OD1|Mj65NkBvVQ>? NFXCVFJUSU6JRWK=
A2058 NFXreVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4OwfmlEPTB;M{OuNlUhdk1? MnT2V2FPT0WU
VM-CUB-1 M3zqOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXPJR|UxRTN|LkSzJI5O MnizV2FPT0WU
Ca9-22 NWnxO4N4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mm\4TWM2OD1|Mz61OUBvVQ>? NH3ocnJUSU6JRWK=
COLO-684 M{TZfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmXETWM2OD1|Mz61PEBvVQ>? Mnv3V2FPT0WU
RPMI-8226 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkHTTWM2OD1|Mz64NkBvVQ>? NVvGW3loW0GQR1XS
SK-NEP-1 NUH4T3I5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1SwT2lEPTB;M{SuNVUhdk1? MWfTRW5ITVJ?
Becker NVjzXG9NT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXPJR|UxRTN2LkKxJI5O M{m4XHNCVkeHUh?=
NCI-H28 MlrJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlLHTWM2OD1|ND60OEBvVQ>? MknKV2FPT0WU
CAL-120 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFuyPFhKSzVyPUO0MlczKG6P Ml7YV2FPT0WU
MDA-MB-157 NVnKXIlNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVPiXWhbUUN3ME2zOU41OSCwTR?= NICzNohUSU6JRWK=
OVCAR-5 NH3XbpdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVvJR|UxRTN3LkS3JI5O MmLDV2FPT0WU
LAMA-84 M2rCW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVvQd|JPUUN3ME2zOU45PyCwTR?= M{TCWHNCVkeHUh?=
CAKI-1 NXS0SYVKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWGwcmM2UUN3ME2zOk41OyCwTR?= MYfTRW5ITVJ?
Daoy M4\lOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkGyTWM2OD1|Nj63JI5O MluyV2FPT0WU
CAL-62 Mlz4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUXJR|UxRTN4Lki2JI5O MYnTRW5ITVJ?
8-MG-BA M2XsVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NImxU2pKSzVyPUO3MlI2KG6P M1XERnNCVkeHUh?=
8505C MnHYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYfJR|UxRTN5LkWxJI5O Mm\hV2FPT0WU
LNCaP-Clone-FGC MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mm\yTWM2OD1|Nz61PUBvVQ>? MnP6V2FPT0WU
CAL-39 NHv3d2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn7TTWM2OD1|Nz65JI5O M3T5THNCVkeHUh?=
MN-60 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3G3emlEPTB;M{euPVYhdk1? NHnEbnVUSU6JRWK=
RKO NV\DO4tYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUnJR|UxRTN6LkOzJI5O NI\1dWxUSU6JRWK=
U251 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{WxVGlEPTB;M{iuOFMhdk1? NWfX[YR5W0GQR1XS
SJSA-1 NH7nVWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHjE[WNKSzVyPUO4MlU1KG6P NEThcGJUSU6JRWK=
CAL-12T M375OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXzJR|UxRTN6Lk[gcm0> MUPTRW5ITVJ?
HCC1419 MkXSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGfienhKSzVyPUO4MlcyKG6P MUDTRW5ITVJ?
CO-314 M{TqRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn7qTWM2OD1|OD63OEBvVQ>? M{HZTXNCVkeHUh?=
LB1047-RCC M2H6Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX[0PZlqUUN3ME2zPE45OSCwTR?= NH\DcGJUSU6JRWK=
A101D NUXPWWVFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEGxN|JKSzVyPUO4Mlk4KG6P NIGzWlFUSU6JRWK=
MDA-MB-175-VII M3XFR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXzJR|UxRTN7LkWxJI5O NIfY[3RUSU6JRWK=
MZ2-MEL NH7z[5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUjibXF6UUN3ME2zPU43PiCwTR?= NFTRT|FUSU6JRWK=
NB5 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXLJR|UxRTRyLk[0JI5O NWH3b4hKW0GQR1XS
G-401 NYC4cpRMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWfJR|UxRTRyLkiyJI5O M{O4fXNCVkeHUh?=
HT MknHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn7iTWM2OD12MT6wNkBvVQ>? NHO2[YRUSU6JRWK=
8305C M3PPPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4\KZWlEPTB;NEGuPFchdk1? MXPTRW5ITVJ?
BHY M4L0O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M37WeGlEPTB;NEKuO|Ihdk1? M2LoXHNCVkeHUh?=
NTERA-S-cl-D1 M3zEcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2LlXGlEPTB;NEOgcm0> Mm\yV2FPT0WU
T-24 MlftS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn76TWM2OD12Mz64N{BvVQ>? NUHObnpOW0GQR1XS
EPLC-272H NWX0fFN{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV7EfIxTUUN3ME20OE4{QSCwTR?= NEPzSGdUSU6JRWK=
PSN1 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mly5TWM2OD12ND60JI5O NVqzUFBXW0GQR1XS
NCI-H2452 NWnxdpFST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGrvPHpKSzVyPUS0MlU5KG6P NVjKWGJWW0GQR1XS
KS-1 M{PY[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnywTWM2OD12ND62OkBvVQ>? MoDCV2FPT0WU
HD-MY-Z NWDHfllzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4PiVWlEPTB;NESuPVIhdk1? MkHpV2FPT0WU
KNS-62 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml;GTWM2OD12NT6zPEBvVQ>? Mlm0V2FPT0WU
NOMO-1 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUTJR|UxRTR3Lki3JI5O M2rZNHNCVkeHUh?=
SK-HEP-1 M2\PWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2Ww[WlEPTB;NE[uNFQhdk1? NXy0UZZPW0GQR1XS
IGR-1 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2rwSWlEPTB;NE[uNVMhdk1? NEHYbmRUSU6JRWK=
KYSE-180 M37WOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXnJ[3NYUUN3ME20Ok4yPyCwTR?= MVHTRW5ITVJ?
EW-22 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkjwTWM2OD12Nj6yJI5O NGrGVFJUSU6JRWK=
NCI-H1355 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWHFcZQ3UUN3ME20Ok4{PCCwTR?= MmXqV2FPT0WU
DOHH-2 M1LE[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmK1TWM2OD12Nj6zO{BvVQ>? M4CzTHNCVkeHUh?=
A4-Fuk NUPrfY5LT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUDWOpFIUUN3ME20Ok42OiCwTR?= NVTDWGF[W0GQR1XS
PC-14 NEXKU3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{T1SWlEPTB;NE[uOVchdk1? MlHkV2FPT0WU
TE-5 NFjvWVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnqzTWM2OD12Nj64OEBvVQ>? NHTyXJBUSU6JRWK=
LB996-RCC MkXoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF\z[lhKSzVyPUS3MlE6KG6P MmPKV2FPT0WU
NCI-H1623 Ml\yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkPnTWM2OD12Nz63OkBvVQ>? NIrxW|VUSU6JRWK=
NCI-H1155 MoLDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWnJR|UxRTR6LkOyJI5O MkDRV2FPT0WU
LoVo NHPXUHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2PPZmlEPTB;NEiuOEBvVQ>? M2TrR3NCVkeHUh?=
MCF7 NXO2UHVCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHjqV45KSzVyPUS4MlU5KG6P MWrTRW5ITVJ?
AGS NYXGVldUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXPuSYZpUUN3ME20PE44PyCwTR?= M1vrVXNCVkeHUh?=
PFSK-1 MmLYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml31TWM2OD12OT6wOkBvVQ>? MWfTRW5ITVJ?
22RV1 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFfRRoZKSzVyPUS5MlA6KG6P MmjmV2FPT0WU
COR-L23 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXTJc3dOUUN3ME20PU4yPiCwTR?= MnrZV2FPT0WU
D-283MED M1T2XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXPqXXN2UUN3ME20PU43OSCwTR?= M3HHb3NCVkeHUh?=
SW982 NITXPXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYPJR|UxRTR7LkmxJI5O MUPTRW5ITVJ?
SW620 M125d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFzxWm5KSzVyPUWwMlM3KG6P NVi5eohyW0GQR1XS
KYSE-140 NE\ac2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mni4TWM2OD13MD61OUBvVQ>? M2G0dXNCVkeHUh?=
GCIY MoO2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MonzTWM2OD13MD62O{BvVQ>? M1TNdnNCVkeHUh?=
MHH-ESS-1 NIDmO3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXPJR|UxRTVzLkm1JI5O MnHEV2FPT0WU
D-423MG NX20TYF1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4frT2lEPTB;NUKuNFghdk1? M1vENXNCVkeHUh?=
SF539 M4jTWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NY\Dco9rUUN3ME21Nk4{PSCwTR?= NIXpPXFUSU6JRWK=
RPMI-2650 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWDJR|UxRTV{Lk[5JI5O MkTZV2FPT0WU
GR-ST MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1foO2lEPTB;NUKuPFchdk1? M2PqUHNCVkeHUh?=
YKG-1 NWKxfoFuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWjJR|UxRTV|IH7N MYfTRW5ITVJ?
SK-MES-1 M{DaSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1:4UmlEPTB;NUOuNlYhdk1? MVHTRW5ITVJ?
HLE MkL3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1n1eGlEPTB;NUOuOFchdk1? NUTWUlBwW0GQR1XS
RVH-421 NV3LfnFnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXnkPHAyUUN3ME21N{43PyCwTR?= MnP3V2FPT0WU
C32 MoTDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUXtPXFuUUN3ME21N{45OyCwTR?= NGPQNVlUSU6JRWK=
GB-1 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUHJR|UxRTV2LkKgcm0> M1fOb3NCVkeHUh?=
SNB75 NEjaeYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXXJR|UxRTV2LkK2JI5O MVHTRW5ITVJ?
EM-2 NVOxXpFMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1TFWWlEPTB;NUSuOEBvVQ>? NEjqbIJUSU6JRWK=
RH-1 NF;5SIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlTuTWM2OD13ND63JI5O MYDTRW5ITVJ?
NKM-1 NF\VdGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mo\iTWM2OD13ND64NUBvVQ>? NYXkNWdEW0GQR1XS
NCI-H2405 MlTOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoDhTWM2OD13ND64PEBvVQ>? MWXTRW5ITVJ?
KYSE-450 MlfiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYfJR|UxRTV3LkG2JI5O MYTTRW5ITVJ?
A704 MmDNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIPUNIhKSzVyPUW1MlU6KG6P NGjkOIlUSU6JRWK=
HAL-01 M4TXXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlrtTWM2OD13NT64N{BvVQ>? MkiyV2FPT0WU
TE-11 NFe3R|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVLJR|UxRTV3Lkm5JI5O M4ezSXNCVkeHUh?=
DOK MlLzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{L3WGlEPTB;NU[uNFIhdk1? MYnTRW5ITVJ?
KY821 M4fnT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHjrWXFKSzVyPUW2MlIhdk1? NUTob4lmW0GQR1XS
KGN M33acWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX;2W45YUUN3ME21Ok4{OiCwTR?= M2e5XXNCVkeHUh?=
MC116 NVTvTm9oT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXOyUGJHUUN3ME21O{45KG6P MVrTRW5ITVJ?
PANC-08-13 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoL4TWM2OD13OD6wNUBvVQ>? MWrTRW5ITVJ?
KE-37 MmS5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NG\qNmRKSzVyPUW4Mlc4KG6P NHjhSHpUSU6JRWK=
KYSE-410 NWrOWlZsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVPVT|J7UUN3ME21PU41PyCwTR?= MmftV2FPT0WU
RO82-W-1 M4r3RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUHJR|UxRTV7Lkmgcm0> NVzlfGtNW0GQR1XS
M14 NF3PeoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnH3TWM2OD14MD6wOEBvVQ>? NE\vR21USU6JRWK=
GI-1 NWm3cIxmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV;JR|UxRTZyLkOgcm0> MULTRW5ITVJ?
ML-2 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmrVTWM2OD14MD62NkBvVQ>? NXrzN21PW0GQR1XS
BFTC-905 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnnVTWM2OD14MD62OUBvVQ>? NI\lTmpUSU6JRWK=
DMS-273 NV7OOWRWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVLycVBmUUN3ME22NE45PyCwTR?= MYLTRW5ITVJ?
MDA-MB-361 NY\mWVlOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{j1bGlEPTB;NkGgcm0> MYPTRW5ITVJ?
MSTO-211H MmDRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{X6PWlEPTB;NkOuOVEhdk1? MWLTRW5ITVJ?
MEG-01 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH\0ToNKSzVyPU[zMlUzKG6P MUPTRW5ITVJ?
M059J NHjRXVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUPJR|UxRTZ|LkW4JI5O M3\NcHNCVkeHUh?=
LN-405 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXTscYljUUN3ME22N{45PSCwTR?= M1nqenNCVkeHUh?=
NCI-H1581 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYfJR|UxRTZ2LkCzJI5O MWLTRW5ITVJ?
TCCSUP NHTidmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHTKd5JKSzVyPU[0MlU{KG6P NFHuZ|hUSU6JRWK=
SW872 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmXzTWM2OD14ND61O{BvVQ>? M4PCb3NCVkeHUh?=
KYSE-510 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVjJR|UxRTZ3Lke1JI5O MXHTRW5ITVJ?
NCI-H1792 MnHlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmP6TWM2OD14Nj6xOUBvVQ>? MV;TRW5ITVJ?
SW13 M4P2Tmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmT2TWM2OD14Nj61JI5O MWDTRW5ITVJ?
TE-8 MoXVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX3JR|UxRTZ4LkWyJI5O MYjTRW5ITVJ?
SCH Mk\ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml3jTWM2OD14Nz6xJI5O Mm[5V2FPT0WU
NEC8 M4\NOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVnWe5VyUUN3ME22O{4zPCCwTR?= M{PWe3NCVkeHUh?=
HuO-3N1 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFX5UJhKSzVyPU[3MlMyKG6P M1rxZXNCVkeHUh?=
EFM-19 NVfvWJZUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mon5TWM2OD14Nz61JI5O MnnoV2FPT0WU
HEC-1 M4PxNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn\oTWM2OD14Nz61NkBvVQ>? NVrOWVRXW0GQR1XS
T47D MkO2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHLpR|RKSzVyPU[3Mlg4KG6P MULTRW5ITVJ?
SNU-423 M3TRR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGD6PZVKSzVyPU[3Mlk5KG6P NVfBZmNuW0GQR1XS
WM-115 NX\zfXVHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHXTTZJKSzVyPU[4MlE1KG6P M3zrfXNCVkeHUh?=
CaR-1 M1zFTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2LUPGlEPTB;NkiuNlUhdk1? NY\ofJBmW0GQR1XS
KU812 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXi0eFRZUUN3ME22PE43QSCwTR?= MlznV2FPT0WU
AM-38 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEfhN|lKSzVyPU[5MlMyKG6P MVzTRW5ITVJ?
KOSC-2 M37kWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2D4PWlEPTB;NkmuPVchdk1? Ml3vV2FPT0WU
MC-IXC M2frcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnHKTWM2OD15MD6wPEBvVQ>? Ml7hV2FPT0WU
SCC-4 NXrLT5ZCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF72TI9KSzVyPUexMlM5KG6P MV\TRW5ITVJ?
Calu-3 M3PCd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYDjV2VLUUN3ME23NU46QCCwTR?= NFO5dppUSU6JRWK=
RPMI-8866 M1Hl[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVTkVmZlUUN3ME23Nk45OiCwTR?= MonDV2FPT0WU
OVCAR-4 NF\ZVpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NW[zfGRqUUN3ME23N{4{PiCwTR?= MmPGV2FPT0WU
OAW-42 MlTPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVzRZ|VqUUN3ME23N{4{QSCwTR?= NVnMRpcyW0GQR1XS
ATN-1 MmLwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUjJR|UxRTd|Lki3JI5O Mn\aV2FPT0WU
CHP-212 NGjsc49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3S2W2lEPTB;N{SuPVUhdk1? NXT0XWs2W0GQR1XS
C2BBe1 NUHTU4loT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYjJR|UxRTd3LkCzJI5O Ml;DV2FPT0WU
A498 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXvDSXdqUUN3ME23OU4yPSCwTR?= NILSSGdUSU6JRWK=
SH-4 M3vD[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX;JR|UxRTd3LkKxJI5O NFK1OIdUSU6JRWK=
SNU-449 NGXRXndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWi2OYhnUUN3ME23OU44QSCwTR?= NGrUd|lUSU6JRWK=
RD M4f5VGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHT1SoZKSzVyPUe1Mlg3KG6P MVXTRW5ITVJ?
PANC-03-27 NULSSJVHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVjJR|UxRTd4LkK1JI5O M376THNCVkeHUh?=
S-117 M1KzWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUTJR|UxRTd4LkK3JI5O MYHTRW5ITVJ?
SK-MEL-2 Mnq2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGmxfnVKSzVyPUe2Mlc2KG6P MY\TRW5ITVJ?
LK-2 M1fkS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnzITWM2OD15Nz6wOUBvVQ>? M2XlZXNCVkeHUh?=
CP50-MEL-B MnTHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{XEUmlEPTB;N{euOEBvVQ>? NVjJToU5W0GQR1XS
647-V MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1T6TmlEPTB;N{iuNFchdk1? NIrnT2xUSU6JRWK=
LU-134-A NIHMfm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWXJR|UxRTd7LkCzJI5O MkmzV2FPT0WU
5637 NVPWVVltT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVHJR|UxRTd7LkKzJI5O M1vLVXNCVkeHUh?=
NCI-H1437 NFfWTYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NITz[o1KSzVyPUiwMlUhdk1? NWrzWo5MW0GQR1XS
NCI-H460 NVzjfoRjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV7JR|UxRThzLkKzJI5O MkXOV2FPT0WU
BxPC-3 MornS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml22TWM2OD16MT60OkBvVQ>? NEH3bpJUSU6JRWK=
CAN MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFr5ZlBKSzVyPUixMlg1KG6P NFPhV3pUSU6JRWK=
KINGS-1 NUi2W3o2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVXJR|UxRTh{LkOyJI5O M1nDbnNCVkeHUh?=
OCUB-M NGHzNZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGnkOVRKSzVyPUiyMlQyKG6P NILpfFBUSU6JRWK=
KALS-1 NYPBXVBHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVH4VWpVUUN3ME24Nk42PCCwTR?= NVrQ[nNkW0GQR1XS
OCI-AML2 Mn\zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF;lcmdKSzVyPUiyMlYyKG6P NEXa[mZUSU6JRWK=
A253 M1rzdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MliyTWM2OD16Mj62OUBvVQ>? M4H2N3NCVkeHUh?=
LCLC-97TM1 NYj0bYhQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV\JR|UxRTh{Lki2JI5O MVHTRW5ITVJ?
NCI-H520 Mo\pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4LJe2lEPTB;OEOuNFYhdk1? NWrSfok5W0GQR1XS
P30-OHK M3jVeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYnJR|UxRTh|LkWgcm0> MlLlV2FPT0WU
SBC-5 MlHQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWLJR|UxRTh|LkWyJI5O M4DwXXNCVkeHUh?=
HCE-T NIS5XGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4LrSWlEPTB;OEOuO|Qhdk1? M4DON3NCVkeHUh?=
JEG-3 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlvuTWM2OD16ND6xJI5O Mo\pV2FPT0WU
KG-1 M{PUZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVXJR|UxRTh2LkK0JI5O M3\Eb3NCVkeHUh?=
MIA-PaCa-2 MnH6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHLye49KSzVyPUi0MlU1KG6P M{XtVnNCVkeHUh?=
CAL-33 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWPofYFSUUN3ME24OU4xQCCwTR?= MkTMV2FPT0WU
639-V M1Tmemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWHre5FSUUN3ME24OU41OiCwTR?= NGHBSGtUSU6JRWK=
NCI-H1048 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYPiO|ZIUUN3ME24Ok4{OSCwTR?= MYDTRW5ITVJ?
NCI-H1573 MlnkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MULJR|UxRTh5LkS4JI5O M1fIRnNCVkeHUh?=
NCI-H2228 M3HBWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEHUUW5KSzVyPUi4MlI3KG6P M1rIVXNCVkeHUh?=
NB14 M4nWWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M331NWlEPTB;OEiuN{BvVQ>? NIS4VXlUSU6JRWK=
SCC-25 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXfJR|UxRTh7LkiyJI5O NVrKWmZnW0GQR1XS
A431 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUCx[JVNUUN3ME24PU46PyCwTR?= MUjTRW5ITVJ?
SN12C NHni[ZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUTJR|UxRTlyLk[yJI5O NWDmW2VqW0GQR1XS
HuCCT1 M2i0TWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NETyOWRKSzVyPUmwMlc3KG6P M2e5OnNCVkeHUh?=
LS-123 M{TvVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4POcmlEPTB;OUKuNVghdk1? M1LvUXNCVkeHUh?=
CAL-85-1 MmTlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWLJR|UxRTl{LkS4JI5O M1fHO3NCVkeHUh?=
ES6 NVX3c3ZNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkmwTWM2OD17Mj64N{BvVQ>? Ml6xV2FPT0WU
NCI-H650 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFu3XJFKSzVyPUm0MlA6KG6P NWDzO3ZsW0GQR1XS
NCI-H446 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{\ZUWlEPTB;OUWuNVIhdk1? NEDQcmxUSU6JRWK=
EW-13 M{XiTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlvDTWM2OD17NT63OUBvVQ>? NF\iNm9USU6JRWK=
HSC-2 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHfwb3hKSzVyPUm1Mlg6KG6P M1:3THNCVkeHUh?=
U031 NVfhcYlwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX7vepp5UUN3ME25Ok44OyCwTR?= M{f1OXNCVkeHUh?=
EW-11 NIS2Ro1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXjJR|UxRTl4Lki4JI5O NU\hbIdRW0GQR1XS
GAK NXzVZY0{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn:yTWM2OD17OD65N{BvVQ>? NF75PYpUSU6JRWK=
SK-OV-3 NV\tZldpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVvJR|UxRTFyMD6wO{BvVQ>? NV;KSWFNW0GQR1XS
OMC-1 NXv6[HViT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUjpdXZqUUN3ME2xNFAvOThibl2= M17jN3NCVkeHUh?=
TK10 M2TxdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXyyNWlkUUN3ME2xNFAvOjFibl2= M4npeXNCVkeHUh?=
EKVX M{T5[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1;kWGlEPTB;MUCwMlYhdk1? MmrpV2FPT0WU
Detroit562 NW\Nc|hKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUTJR|UxRTFyMj6xO{BvVQ>? MWTTRW5ITVJ?
SF268 MoK4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4\PcWlEPTB;MUCyMlM1KG6P MljvV2FPT0WU
SNU-387 M3TIOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkP2TWM2OD1zMESuNVchdk1? NH;zXnRUSU6JRWK=
MDA-MB-231 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYnJR|UxRTFyNT6wOkBvVQ>? M3vrTnNCVkeHUh?=
NCI-H1563 Mkm2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn:yTWM2OD1zMEWuNVghdk1? MmD0V2FPT0WU
D-502MG NU\Mcnd[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIKwUoZKSzVyPUGwOU44KG6P NV2yOZpsW0GQR1XS
A2780 NVjx[nJ[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NELsSHRKSzVyPUGwOk41PyCwTR?= NUT2NHFCW0GQR1XS
IA-LM M2jrUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3PLTGlEPTB;MUC3MlUyKG6P NHf6UnZUSU6JRWK=
D-392MG MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MY\JR|UxRTFyNz61OEBvVQ>? NGXy[ppUSU6JRWK=
MS-1 NWrUPWx3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWTJR|UxRTFyNz63NUBvVQ>? M{SzPHNCVkeHUh?=
SW1990 MmrhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFn6cFFKSzVyPUGwPE42PCCwTR?= M4nYSHNCVkeHUh?=
HEL MknSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml;nTWM2OD1zMEmuNlkhdk1? MkXsV2FPT0WU
SW1573 MonwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYXJR|UxRTFyOT6zNUBvVQ>? M2PlOHNCVkeHUh?=
SW1783 MmnrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoTWTWM2OD1zMUCuNlIhdk1? MVfTRW5ITVJ?
COLO-680N M4LX[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXHONFNyUUN3ME2xNVAvPzZibl2= NUPEbXVTW0GQR1XS
NCI-N87 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX7JR|UxRTFzMT6wOEBvVQ>? NVfxWYhlW0GQR1XS
SK-MEL-28 M2nxXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M33OTGlEPTB;MUGxMlU2KG6P NXzIe3pwW0GQR1XS
BT-20 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2OyNGlEPTB;MUGyMlAyKG6P M37jcXNCVkeHUh?=
NCI-H1648 MkKzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NI\RbnRKSzVyPUGxN{BvVQ>? NHHPcWRUSU6JRWK=
no-11 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{PWU2lEPTB;MUGzMlI5KG6P NXvucoM4W0GQR1XS
MOLT-13 M3SxbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3TWNmlEPTB;MUGzMlQ1KG6P M4\4VXNCVkeHUh?=
NCI-H2170 NIrzb2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVvJR|UxRTFzND61NUBvVQ>? NWHtXmRMW0GQR1XS
HTC-C3 NXS3PI9YT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkXmTWM2OD1zMU[uPFUhdk1? MkDFV2FPT0WU
LU-99A NVS1bYk5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlvWTWM2OD1zMUeuNlEhdk1? NYG3TXVuW0GQR1XS
HCC2998 NWS1c3F1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2j6fmlEPTB;MUG3MlkzKG6P NYnNOZRpW0GQR1XS
NB13 M1XUemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXjJR|UxRTFzNz65PUBvVQ>? M37QfnNCVkeHUh?=
GT3TKB MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MULJR|UxRTFzOD6wPEBvVQ>? M3LLS3NCVkeHUh?=
BT-549 M1jvcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2jV[mlEPTB;MUG4Mlk2KG6P NIPvXHFUSU6JRWK=
NCI-H747 NHK4SFlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUTYW4Z3UUN3ME2xNVkvOzRibl2= NV\GOXhbW0GQR1XS
EW-1 MmTlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2D1dWlEPTB;MUKwMlIhdk1? NVO1cox{W0GQR1XS
LB831-BLC NXyxUmZST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1HNTmlEPTB;MUKwMlY{KG6P M4XHR3NCVkeHUh?=
NMC-G1 MnHrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkDDTWM2OD1zMkGuNVEhdk1? MoGwV2FPT0WU
COLO-679 NH3jRVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NG\RZ|hKSzVyPUGyNk4yPSCwTR?= MkLlV2FPT0WU
HL-60 NHfJV2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFjKPJpKSzVyPUGyN{4yKG6P MVrTRW5ITVJ?
MKN7 Mk[2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGKyb2hKSzVyPUGyN{45OyCwTR?= M{jOeHNCVkeHUh?=
RERF-LC-MS MoX1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MojOTWM2OD1zMkSuN|Ehdk1? NWLuSFgxW0GQR1XS
DMS-114 M1LUNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXzDPHBPUUN3ME2xNlUvODlibl2= MXjTRW5ITVJ?
HuP-T4 M1rrdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4\HcmlEPTB;MUK2Mlk4KG6P MVfTRW5ITVJ?
HCC2157 M3\qXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoXHTWM2OD1zMkeuOUBvVQ>? M1LhT3NCVkeHUh?=
SKG-IIIa NHTXPYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEHNSo5KSzVyPUGyPE45KG6P MlPRV2FPT0WU
HCT-116 M1vBTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVvJR|UxRTF|MD62OEBvVQ>? MkSxV2FPT0WU
BB30-HNC MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4\Q[WlEPTB;MUOwMlc5KG6P M2Lvd3NCVkeHUh?=
KYSE-270 NEe1V25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnuwTWM2OD1zM{CuPFghdk1? M1jX[nNCVkeHUh?=
MFM-223 NX\ZcXVtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVrjeoR{UUN3ME2xN|EvPTFibl2= MUjTRW5ITVJ?
NH-12 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkDmTWM2OD1zM{KuPVkhdk1? NIfUVppUSU6JRWK=
U-118-MG NH;xOINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV7JR|UxRTF|Mz62NkBvVQ>? MUDTRW5ITVJ?
ESS-1 NITTW3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mmf3TWM2OD1zM{WuNVghdk1? M4SwTXNCVkeHUh?=
D-247MG MnS3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEi2[nZKSzVyPUGzOU4zOSCwTR?= MonpV2FPT0WU
IGROV-1 M1nhUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1fHcmlEPTB;MUO1Mlc3KG6P MnzMV2FPT0WU
C-33-A NFH0NGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2TzV2lEPTB;MUO1Mlk4KG6P MYnTRW5ITVJ?
NCI-H1693 NI\5bZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnnGTWM2OD1zM{[uNVIhdk1? NH7Gd3hUSU6JRWK=
MLMA MoH4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX:1dlY5UUN3ME2xN|YvPThibl2= Ml3RV2FPT0WU
SK-N-AS MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{DFZ2lEPTB;MUO3MlE4KG6P NWXIZ4szW0GQR1XS
NCI-H1755 NYfKdIo6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHfWOWRKSzVyPUGzPE45PSCwTR?= NWLOPHVIW0GQR1XS
CHP-134 NV7CTpBqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWTHb|lCUUN3ME2xN|kvPTVibl2= NHr6[XRUSU6JRWK=
LS-513 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4nmTGlEPTB;MUSwMlkyKHCP MXjTRW5ITVJ?
TE-12 MnPvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWWwTGp1UUN3ME2xOFAvQTNibl2= NVzhXWY4W0GQR1XS
KNS-42 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mo\lTWM2OD1zNESuN{BvVQ>? NXv4XHE1W0GQR1XS
SJRH30 M2HkXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUPJR|UxRTF2ND60OEBvVQ>? M{PXd3NCVkeHUh?=
NCI-H1092 NYLmXoNIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmG0TWM2OD1zNESuOVIhdk1? MY\TRW5ITVJ?
H-EMC-SS NWjFeppDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFPHeo9KSzVyPUG0Ok45OSCwTR?= MVjTRW5ITVJ?
SK-MEL-3 MoK3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWnJR|UxRTF2Nz61OUBvVQ>? MVnTRW5ITVJ?
SK-N-FI MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFGwUIVKSzVyPUG0O{42QSCwTR?= M1\MSHNCVkeHUh?=
NCI-H2126 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIjkOnJKSzVyPUG0PE4yPSCwTR?= MWXTRW5ITVJ?
NCI-H1299 M4nFemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{TGSWlEPTB;MUWwMlIzKG6P MWXTRW5ITVJ?
CFPAC-1 NFr2UJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlTDTWM2OD1zNUCuOlYhdk1? M2q2[3NCVkeHUh?=
NCI-H661 NGDkSY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVfJR|UxRTF3MT6yOkBvVQ>? M{\Fd3NCVkeHUh?=
KYSE-70 MlfxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NInaWohKSzVyPUG1NU44QSCwTR?= MUnTRW5ITVJ?
SW900 MkHOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYPJR|UxRTF3ND62OUBvVQ>? MX3TRW5ITVJ?
Ca-Ski MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXryO2JGUUN3ME2xOVYvOzlibl2= NGTyeXBUSU6JRWK=
HPAF-II M1rjOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlG3TWM2OD1zNU[uOFchdk1? M{DYVXNCVkeHUh?=
LB2518-MEL NHjU[4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWTJR|UxRTF3Nz6xJI5O M1H1T3NCVkeHUh?=
LC-2-ad MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2PKR2lEPTB;MUW4MlYzKG6P NF\FRoVUSU6JRWK=
HCC1806 NH[zZW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M33qRWlEPTB;MU[3Mlg5KG6P MVLTRW5ITVJ?
UACC-62 MoHTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{XuemlEPTB;MU[4MlA6KG6P MUHTRW5ITVJ?
KM-H2 Mn7XS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnHwTWM2OD1zN{CuOVghdk1? MXLTRW5ITVJ?
NCI-H2347 M2jEXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWPJR|UxRTF5Mj63NkBvVQ>? M1vheHNCVkeHUh?=
SCC-15 NF7vTZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEPHc2dKSzVyPUG3N{43PiCwTR?= M1f2cXNCVkeHUh?=
BB49-HNC MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYLQTINnUUN3ME2xO|MvQDFibl2= MnjoV2FPT0WU
GMS-10 NXvpSlV5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn60TWM2OD1zN{OuPVQhdk1? MYnTRW5ITVJ?
NCI-H2052 NUXJc3Q6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUHJR|UxRTF5ND65JI5O M3zz[nNCVkeHUh?=
SW626 M4jUdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHjuWVFKSzVyPUG3Ok4xPiCwTR?= Ml7yV2FPT0WU
MDA-MB-415 NGnac2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXO2[o9tUUN3ME2xO|YvPjFibl2= M1zRSHNCVkeHUh?=
Saos-2 Ml\US5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUmzfHRwUUN3ME2xO|kvOzVibl2= M4CxSXNCVkeHUh?=
DK-MG NYXP[XgyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NILSeHlKSzVyPUG4NE4{KG6P M2TqfnNCVkeHUh?=
SNU-C2B NV6xSYJuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{PHT2lEPTB;MUiwMlc{KG6P MlLzV2FPT0WU
A427 NGnR[25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV3Z[nBzUUN3ME2xPFIvPTdibl2= NFzBd3BUSU6JRWK=
KP-N-YS NHPtPFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXLJR|UxRTF6NTDuUS=> M2\RWnNCVkeHUh?=
J82 NVvFfpZET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHfIPFRKSzVyPUG4OU4yQCCwTR?= M3z5[nNCVkeHUh?=
LS-411N NH3VbmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NILhO5RKSzVyPUG4O{4zQCCwTR?= NYrZN4txW0GQR1XS
HCC1937 NYm0RWRQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn3vTWM2OD1zOEeuOFkhdk1? M2n0SnNCVkeHUh?=
OE33 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV3JR|UxRTF6OD65O{BvVQ>? M3jXNnNCVkeHUh?=
NB7 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV7tPYxWUUN3ME2xPFkvQDlibl2= M3riUHNCVkeHUh?=
SW684 NVfBUZhpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlXoTWM2OD1zOU[uNVMhdk1? NVz2enpIW0GQR1XS
HT-144 M{[x[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml72TWM2OD1zOU[uNVUhdk1? M2LFVHNCVkeHUh?=
SK-MEL-30 M4HGSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVHJR|UxRTF7Nj6yJI5O NWPtPWdTW0GQR1XS
DBTRG-05MG NX;zOGhCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mm[zTWM2OD1zOUiuOFchdk1? NF6ydmNUSU6JRWK=
NCI-H1395 NUmw[GFrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M373dWlEPTB;MUm4Mlg2KG6P NXz6WoZVW0GQR1XS
NCI-H2122 NF7zS3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFfhXYNKSzVyPUKwNE42QSCwTR?= MYjTRW5ITVJ?
no-10 MkDtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M13IfWlEPTB;MkCxMlA1KG6P NIDXZVZUSU6JRWK=
SW48 NYHvWIRVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2XXNmlEPTB;MkCxMlMyKG6P MWPTRW5ITVJ?
NCI-H1650 NFLk[Y1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1[xRmlEPTB;MkC0MlAyKG6P MlPMV2FPT0WU
MZ1-PC NYLFWIxlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWToZYxmUUN3ME2yNFUvPThibl2= NFX0Z3FUSU6JRWK=
U-266 NFLC[pVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVLJR|UxRTJyNT63PUBvVQ>? NXPBcXlqW0GQR1XS
CAS-1 NEXvXZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1PYRmlEPTB;MkC3MlQ1KG6P NXTCNJJYW0GQR1XS
AU565 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVXyTXE3UUN3ME2yNVIvQDJibl2= MXHTRW5ITVJ?
UACC-257 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGXmNXBKSzVyPUKxN{46QSCwTR?= MWHTRW5ITVJ?
CAL-27 NVP6bIxyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1Xuc2lEPTB;MkG3MlA2KG6P MYrTRW5ITVJ?
NCI-H23 NVO2VFlHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NI\zcI5KSzVyPUKxPU4{OyCwTR?= MUPTRW5ITVJ?
TE-6 NHvDbldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYrQZmV4UUN3ME2yNVkvPjhibl2= NY\tSHN[W0GQR1XS
TGBC24TKB M2DlbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4DXZmlEPTB;MkKyMlE4KG6P NHzFWpRUSU6JRWK=
TE-1 NWTQU|J5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVLJR|UxRTJ{Mj64PEBvVQ>? NV\EVnc3W0GQR1XS
RCC10RGB NH\RS5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYPJR|UxRTJ{ND6xPUBvVQ>? NWXnZnN7W0GQR1XS
NCI-H596 NGLQWlhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVG1ZpEzUUN3ME2yNlgvOjJibl2= M3\uU3NCVkeHUh?=
SW954 NUe5[XFnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml7aTWM2OD1{M{OuPFMhdk1? NFW5bYhUSU6JRWK=
NCI-H2087 NIK0U25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2ThOGlEPTB;MkO0MlUyKG6P NVzaRZVuW0GQR1XS
SK-PN-DW NXvHPJZUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWfJR|UxRTJ|NT6xPUBvVQ>? NH7STFdUSU6JRWK=
KM12 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{\FW2lEPTB;MkO1Mlchdk1? MlnqV2FPT0WU
BT-474 NHHZVWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWnJR|UxRTJ|NT63N{BvVQ>? NIHxUIJUSU6JRWK=
IST-MES1 NYLvV2hMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1[yd2lEPTB;MkO2MlU4KG6P M2\BR3NCVkeHUh?=
HT-1197 MlW0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV3XPINEUUN3ME2yN|gvODlibl2= MYLTRW5ITVJ?
CAL-54 Ml3zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NITqO45KSzVyPUKzPE41QSCwTR?= M{Kxe3NCVkeHUh?=
NB10 M3;ZU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1zDc2lEPTB;MkSwMlA3KG6P MlTZV2FPT0WU
PANC-10-05 MmPsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFmzNoRKSzVyPUK0OU42PiCwTR?= M2XOfHNCVkeHUh?=
NCI-H522 M4DDXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHLk[YRKSzVyPUK0PE4{OSCwTR?= MmXpV2FPT0WU
A388 Mm\PS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH7MelBKSzVyPUK0PU45OiCwTR?= MmTKV2FPT0WU
GOTO NELqb5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEe5dGtKSzVyPUK1NE4zQSCwTR?= MXHTRW5ITVJ?
KLE MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV;hXGhiUUN3ME2yOVEvQDdibl2= M1\ER3NCVkeHUh?=
KYSE-520 Mn7VS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFzYUnFKSzVyPUK1Nk45PiCwTR?= NU\Kb|NvW0GQR1XS
HCE-4 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NG\3bGlKSzVyPUK2Nk42KG6P MoXnV2FPT0WU
KURAMOCHI NGXCeo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXrJR|UxRTJ4NT65JI5O MXfTRW5ITVJ?
HCC38 NFnYfWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIPtTpFKSzVyPUK2Ok41QCCwTR?= NFrrbVRUSU6JRWK=
FADU M1LVTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4q2UGlEPTB;Mk[2MlY{KG6P MWnTRW5ITVJ?
CW-2 MmT2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXW2bphSUUN3ME2yOlkvQTZibl2= NX[3eZlvW0GQR1XS
L-428 NUKyTWp{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX7JR|UxRTJ5NT6xOUBvVQ>? MorqV2FPT0WU
HCC1569 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIn5W25KSzVyPUK3OU45PCCwTR?= NFnibo9USU6JRWK=
NCI-H810 NEL4OXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{XIdGlEPTB;Mke4MlMyKG6P NWXmdnlNW0GQR1XS
LB771-HNC M3;2UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYfJR|UxRTJ6NT64OEBvVQ>? M1rGRnNCVkeHUh?=
LCLC-103H M2C4VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlHvTWM2OD1{OEWuPVkhdk1? NG\VS4RUSU6JRWK=
EFO-21 MmPYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4T2eGlEPTB;Mki3MlY5KG6P NWntOmpxW0GQR1XS
CAL-72 MoLkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmrsTWM2OD1{OUOuNVkhdk1? NGG5XG1USU6JRWK=
SCC-9 NWG0eW55T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX\vT2tFUUN3ME2yPVMvOjJibl2= M2DyT3NCVkeHUh?=
COLO-829 M{m0d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3jzTmlEPTB;Mkm2MlUhdk1? NELxV|JUSU6JRWK=
U-87-MG M{\aNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFvxbVJKSzVyPUOwNE44OyCwTR?= NHWyfVVUSU6JRWK=
MZ7-mel MnrlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWDt[JpiUUN3ME2zNlMvPzZibl2= Ml3LV2FPT0WU
NCI-H1770 MnPqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1rPd2lEPTB;M{K2Mlc1KG6P NH;qc4ZUSU6JRWK=
ChaGo-K-1 MnS5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX7jZXc{UUN3ME2zNlgvOSCwTR?= NIPJbXZUSU6JRWK=
SiHa Mmr0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2L3[mlEPTB;M{K5MlI1KG6P NYKzVGhlW0GQR1XS
NCI-SNU-5 M33LeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIfnVJJKSzVyPUOzOk44PyCwTR?= NFi0XGJUSU6JRWK=
DJM-1 M4DhWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXHJR|UxRTN2MD6zN{BvVQ>? Ml7hV2FPT0WU
OE19 Mm\yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3jHRWlEPTB;M{SwMlU{KG6P NWToV4xIW0GQR1XS
NCI-H1651 NIjINlNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEXyc2FKSzVyPUO0OE4yQCCwTR?= MV7TRW5ITVJ?
COLO-792 M2i5[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFTQT|hKSzVyPUO1OE41OiCwTR?= M3nXV3NCVkeHUh?=
ACHN M1j0Wmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUjJR|UxRTN3Nj63NUBvVQ>? NWizZW9{W0GQR1XS
TH-3 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWr4cGdyUUN3ME2zO|kvQTVibl2= MnrFV2FPT0WU
HT-1376 NEHm[JJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWXJR|UxRTN6ND64PEBvVQ>? MoPzV2FPT0WU
RH-18 MoPhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NW\S[otlUUN3ME2zPVQvPzRibl2= MoD5V2FPT0WU
NB6 Mn62S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkXqTWM2OD1|OU[uOlYhdk1? M3LKWnNCVkeHUh?=
COLO-320-HSR M4HOeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYfJR|UxRTRyMz6zO{BvVQ>? MUDTRW5ITVJ?
UACC-893 NXnle2tmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MljTTWM2OD12ME[uOFchdk1? M1m5WXNCVkeHUh?=
DSH1 M3vnSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1vJ[GlEPTB;NEC2MlkyKG6P Ml3oV2FPT0WU
TE-10 NHqzbFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFnoRZdKSzVyPUSwO{4xOSCwTR?= MlrYV2FPT0WU
HCC70 NXP1OXVRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWPJR|UxRTRyOT6yNUBvVQ>? M1rRW3NCVkeHUh?=
TGBC11TKB NEPTPWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEDlTYZKSzVyPUSxNE4{OyCwTR?= NVrBN3k6W0GQR1XS
NCI-H727 NGfIe|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGrz[YNKSzVyPUSxNk4yOSCwTR?= MULTRW5ITVJ?
ALL-PO M3rpWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{fHV2lEPTB;NEG1MlY6KG6P M13BcHNCVkeHUh?=
ABC-1 MoTOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mnz6TWM2OD12MkCuOFUhdk1? M3vQWXNCVkeHUh?=
NCI-H69 NECxZm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVfJR|UxRTR{Nj63OkBvVQ>? MljmV2FPT0WU
GP5d MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NU\TTpd4UUN3ME20N|QvPDFibl2= MYfTRW5ITVJ?
UMC-11 NE\UfVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1KxZ2lEPTB;NEW4MlM3KG6P M{T6c3NCVkeHUh?=
RMG-I MnrmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHL5dZlKSzVyPUS2O{42PiCwTR?= NEfn[VZUSU6JRWK=
YAPC NGnt[W5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYK4OY1kUUN3ME20PVAvPiCwTR?= MV\TRW5ITVJ?
LS-1034 NU\oVWdMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnHhTWM2OD12OUGuNFYhdk1? NIGySHFUSU6JRWK=
RCM-1 MmWxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWrJR|UxRTR7Nj62PEBvVQ>? Ml;EV2FPT0WU
HCC1954 M4nudGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1;RPGlEPTB;NUGyMlUhdk1? MYfTRW5ITVJ?
SK-MEL-24 NE\NVG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVzJR|UxRTVzNj61NUBvVQ>? MX;TRW5ITVJ?
NB12 NGDhb4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWnRZndZUUN3ME21NlgvPDJibl2= MYrTRW5ITVJ?
SW756 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NET3R5NKSzVyPUW1OE46PiCwTR?= MUTTRW5ITVJ?
HCC1187 NGf6PVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVXJR|UxRTV5NT64N{BvVQ>? NFjUO4dUSU6JRWK=
NCI-H2342 NVTMXplFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3[xZmlEPTB;NUmwMlM6KG6P M13RUHNCVkeHUh?=
NCI-H2291 NUnFNGJWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYHLd416UUN3ME21PVgvOzFibl2= MkK0V2FPT0WU
OVCAR-3 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2nId2lEPTB;NUm4Mlk3KG6P MorGV2FPT0WU
MHH-NB-11 NF3tTmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWTubIdGUUN3ME22NlkvODFibl2= MkLSV2FPT0WU
SAS NX;5[ZJ4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYjYcVZXUUN3ME22OVIvPjdibl2= MXrTRW5ITVJ?
COLO-824 M4nNTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3fMOWlEPTB;Nki5MlM4KG6P M1XHfHNCVkeHUh?=
HCC1395 Mnr6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX3JR|UxRTZ7OD61JI5O MYPTRW5ITVJ?
COLO-668 MkTZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmP2TWM2OD15ME[uNUBvVQ>? MmfFV2FPT0WU
NCI-H226 NYCwVIdyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{LMfWlEPTB;N{C3Mlghdk1? NXjXVlRKW0GQR1XS
NB17 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnP3TWM2OD15MkGuO|Uhdk1? NEX5WlBUSU6JRWK=
SW1463 MlrjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2mzT2lEPTB;N{O5MlE6KG6P NF3kRZZUSU6JRWK=
TGW NX7zeGw3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHTjOJZKSzVyPUe2NE4yPSCwTR?= M1;BNHNCVkeHUh?=
NCI-H526 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M13tTGlEPTB;OEKzMlU{KG6P Ml;YV2FPT0WU
COR-L88 M{DoNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{XY[mlEPTB;OES4MlEzKG6P NVO3c4tKW0GQR1XS
NCI-H441 NGSyPIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXrX[5VYUUN3ME24PVUvOjJibl2= NUTZT41iW0GQR1XS
NCI-H630 NITueo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlvRTWM2OD17MUKuPVYhdk1? NHrkVWFUSU6JRWK=
Mo-T Mor1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{P4fGlEPTB;OUS3Mlg5KG6P MXvTRW5ITVJ?
JAR M2fKVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUftZ2NmUUN3ME25OVYvOjRibl2= NGiyb5NUSU6JRWK=
NCI-H1838 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkXVTWM2OD1zLkCyN|g5KM7:TR?= M2PSdnNCVkeHUh?=
DoTc2-4510 NGHhNVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHLmdHFKSzVyPUGuNFc{PzZizszN NGDzc|NUSU6JRWK=
MKN28 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoC0TWM2OD1zLkC5NFI1KM7:TR?= MnT4V2FPT0WU
HuP-T3 NFXoUWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4m0N2lEPTB;MT6xNVkxPSEQvF2= MVnTRW5ITVJ?
TE-9 NUTiNFBjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWPJR|UxRTFwMUK5O|Mh|ryP MnHBV2FPT0WU
NY MmKzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFHYUXFKSzVyPUGuNVY4QTJizszN M2rHOHNCVkeHUh?=
HT55 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVPVOY9yUUN3ME2xMlMyOzR2IN88US=> MUfTRW5ITVJ?
SW837 M1nqZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUP4XoZUUUN3ME2xMlMzQTd6IN88US=> MXrTRW5ITVJ?
NCI-H2029 MnjBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3rldGlEPTB;MT60NVc6OSEQvF2= MUnTRW5ITVJ?
IST-SL1 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEHxfnBKSzVyPUGuOFQzPCEQvF2= M2i2SHNCVkeHUh?=
COLO-741 NHG1VJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkHITWM2OD1zLkS5O|cyKM7:TR?= MVjTRW5ITVJ?
LU-65 NG\ucFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXnJR|UxRTFwNkKyOFkh|ryP MWTTRW5ITVJ?
NCI-H1304 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mmm2TWM2OD1zLk[1OFk5KM7:TR?= NF3iWYtUSU6JRWK=
KARPAS-299 M3H4cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkTBTWM2OD1zLke5OFc6KM7:TR?= M17O[XNCVkeHUh?=
NCI-H358 MofyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXvJR|UxRTFwOUW1NFMh|ryP MWfTRW5ITVJ?
OAW-28 NYf2Z4cxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEX6W4RKSzVyPUKuNFY6OTlizszN M4Xv[nNCVkeHUh?=
C8166 M2TrZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlPJTWM2OD1{Lk[zN|kzKM7:TR?= NXrWW5M{W0GQR1XS
COLO-678 Ml3GS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mmq0TWM2OD1{LkizO|Y5KM7:TR?= MVTTRW5ITVJ?
SK-N-DZ MofyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH3Vbm5KSzVyPUKuPFY{QDFizszN NXu0bpQ1W0GQR1XS
NCI-H82 NVjmcnloT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUm5Wo9PUUN3ME2yMlkxOzZ7IN88US=> NX3TUZpCW0GQR1XS
JVM-2 NUO2UnZkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NU\yT4VWUUN3ME2zMlA{OTh6IN88US=> MkizV2FPT0WU
SW1116 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYLJR|UxRTNwMEW0NVEh|ryP M{PLS3NCVkeHUh?=
MDA-MB-453 M2jvPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVvpbIFxUUN3ME2zMlExPDN7IN88US=> MnztV2FPT0WU
Calu-6 M1XVZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWfrdVgyUUN3ME2zMlE6QTdizszN MkfvV2FPT0WU
SHP-77 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NY\OdlhtUUN3ME2zMlUzQCEQvF2= NVOyPZdXW0GQR1XS
Capan-2 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUjJR|UxRTRwM{K1PFEh|ryP NH\3UY1USU6JRWK=
SW948 NGW2W4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIXDd2NKSzVyPUSuO|Q4PzlizszN NV:3UVRnW0GQR1XS
HDLM-2 M{PHPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1zneGlEPTB;NT6wO|czPSEQvF2= NWfHdHdVW0GQR1XS
LAN-6 M{LNWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkfpTWM2OD14LkKxOFk2KM7:TR?= M4O0NHNCVkeHUh?=
LU-135 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXnYc4xsUUN3ME22MlQ{ODd5IN88US=> M{Ht[nNCVkeHUh?=
T84 M4nlcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlfBTWM2OD14Lkm4OlQh|ryP MUnTRW5ITVJ?
CAPAN-1 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2rU[2lEPTB;Nz62NlI{OyEQvF2= M3nXVHNCVkeHUh?=
SW1417 MnnjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml\2TWM2OD15LkmxO|MyKM7:TR?= NEHMXJNUSU6JRWK=
BALL-1 NWTiVHNbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVfJR|UxRThwNUC0NFkh|ryP MWLTRW5ITVJ?
HT-29 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1X6Z2lEPTB;OT6wO|U6QSEQvF2= MkO4V2FPT0WU
C3A NWHT[lBxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1nEbWlEPTB;OT64PFM6PCEQvF2= NV75TI9yW0GQR1XS
NCI-H1993 M{jWcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4DIbWlEPTB;MUCuOVA5OSEQvF2= Ml\5V2FPT0WU
SK-MEL-1 MmX3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXnJR|UxRTFzLk[yPFkh|ryP NFjqTm1USU6JRWK=
DU-145 NUDDRZl{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkjZTWM2OD1zND61NFUzKM7:TR?= NX3sfmk1W0GQR1XS
KP-N-YN MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3\YOGlEPTB;MUSuOVExOyEQvF2= NXe0OWtpW0GQR1XS
CCRF-CEM NGDLVWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHmzXnJKSzVyPUG0Mlc5ODlizszN MmPHV2FPT0WU
ZR-75-30 NVXCc21tT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXTJR|UxRTF4LkOzNFMh|ryP NUXaXHBjW0GQR1XS
A673 NYH5NJpVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH6xfnhKSzVyPUKwMlU2ODdizszN NYjqcm9XW0GQR1XS
K-562 MlPVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYT0VoRSUUN3ME2yPE41OTh|IN88US=> NEnOTohUSU6JRWK=

... Click to View More Cell Line Experimental Data

In vivo BEZ235 induces regression of the tumors (69%) without statistically significant effect on body weight gain. Altogether, these preliminary in vivo efficacy results show that BEZ235 causes disease stasis when administered orally as a single agent and can enhance the efficacy of other anticancer agents when used in combination studies. [1]

Protocol

Kinase Assay:

[1]

+ Expand

In vitro Protein Kinase, PI3K, and mTOR Assays:

PI3Kα, β, and δ proteins are composed of the iSH2 domain of p85 NH2-terminally fused to the full-length protein p110 protein, with the exception of α that also does not contain the last 20 amino acids. PI3Kγ is produced as full-length protein deleted for its first 144 amino acids. All constructs are fused to a COOH-terminal His tag for convenient purification and then cloned into the pBlue-Bac4.5 (for α, β, and δ isoforms) or pVL1393 (for γ isoform) plasmids. The different vectors are then cotransfected with BaculoGold WT genomic DNA using methods recommended by the vendor for production of the respective recombinant baculoviruses and proteins. BEZ235 are tested for their activity against PI3K using a Kinase-Glo assay. The kinase reaction is done in 384-well black plate. Each well is loaded with 50 μL of test items (in 90% DMSO) and 5 μL reaction buffer containing 10 μg/mL PI substrate (l-α-phosphatidylinositol; Avanti Polar Lipids; prepared in 3% octyl-glucoside) and the PI3K proteins (10, 25, 10, and 150 nM of p110α, p110β, p110δ, and p110γ, respectively) are then added to it. The reaction is started by the addition of 5 μL of 1 μM ATP prepared in the reaction buffer and is incubated for either 60 (for p110α, p110β, and p110δ) or 120 min (for p110γ). It is terminated by the addition of 10 μL Kinase-Glo buffer. The plates are then read in a Synergy 2 reader for luminescence detection.
Cell Research:

[2]

+ Expand
  • Cell lines: HCT116, DLD-1 and SW480 cells
  • Concentrations: 0-1 μM
  • Incubation Time: 48 hours
  • Method:

    The human CRC cell lines, HCT116 (PIK3CA mutant; kinase domain at H1047R), DLD-1 (PIK3CA mutant; helical domain at E545K), and SW480 (PIK3CA wild-type) and isogenic DLD-1 PIK3CA mutant as well as wild-type cells are maintained in DMEM with 10% FBS and 1 × Penicillin/Streptomycin. Cells are plated at different initial densities (HCT116: 3 × 103 cells/well, DLD-1: 5.5 × 103 cells/well, SW480: 4.5 × 103 cells/well, DLD-1 PIK3CA mutant: 7 × 103 cells/well, and DLD-1 PIK3CA wild-type: 9 × 103 cells/well) to account for differential growth kinetics. After 16 hours, cells are incubated with increasing concentrations of BEZ235, and the drug-containing growth medium is changed every 24 hours. Cell viability is assessed 16 hours after the initial plating and 48 hours after initiation of drug treatment using the colorimetric MTS assay CellTiter 96® AQueous One Solution Cell Proliferation Assay, as per the manufacturer's instructions. Cell viability after drug treatment is normalized to that of untreated cells also grown for 48 hours. For western blot analysis, cells are plated with zero or maximum inhibitory dose (500 nM) BEZ235 for 2, 6, 24, or 48 hours.


    (Only for Reference)
Animal Research:

[1]

+ Expand
  • Animal Models: Female Harlan athymic nude mice
  • Formulation: NMP/polyethylene glycol 300 (10/90, v/v)
  • Dosages: 45 mg/kg
  • Administration: p.o.
    (Only for Reference)

Solubility (25°C)

In vitro DMF 18 mg/mL warmed (38.33 mM)
DMSO 0.01 mg/mL (0.02 mM)
Water <1 mg/mL
In vivo NMP+polyethylene glycol 300 (10+90, v+v) 30 mg/mL

* 1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 469.55
Formula

C30H23N5O

CAS No. 915019-65-7
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00620594 Completed Breast Cancer|Advanced Solid Tumors|Cowden Syndrome Novartis Pharmaceuticals|Novartis December 21, 2006 Phase 1
NCT01856101 Terminated Carcinoma Transitional Cell Cliniques universitaires Saint-Luc- Université Catholique de Louvain|Novartis February 2013 Phase 2
NCT01717898 Terminated Castrate-resistant Prostate Cancer Patients. Charles Ryan|Novartis Pharmaceuticals|University of California, San Francisco January 2013 Phase 1|Phase 2
NCT01658436 Completed Pancreatic Neuroendocrine Tumors (pNET) Novartis Pharmaceuticals|Novartis November 2012 Phase 2
NCT01628913 Terminated Pancreatic Neuroendocrine Tumors (pNET) Novartis Pharmaceuticals|Novartis October 2012 Phase 2
NCT01690871 Withdrawn Malignant PEComa (Perivascular Epithelioid Cell Tumors) Novartis Pharmaceuticals|Novartis September 2012 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

PI3K Signaling Pathway Map

PI3K Inhibitors with Unique Features

Related PI3K Products

Tags: buy Dactolisib (BEZ235, NVP-BEZ235) | Dactolisib (BEZ235, NVP-BEZ235) supplier | purchase Dactolisib (BEZ235, NVP-BEZ235) | Dactolisib (BEZ235, NVP-BEZ235) cost | Dactolisib (BEZ235, NVP-BEZ235) manufacturer | order Dactolisib (BEZ235, NVP-BEZ235) | Dactolisib (BEZ235, NVP-BEZ235) distributor
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID