Clindamycin HCl

For research use only.

Licensed by Pfizer Catalog No.S2457

1 publication

Clindamycin HCl  Chemical Structure

CAS No. 21462-39-5

Clindamycin HCl inhibits protein synthesis by acting on the 50S ribosomal, used for the treatment of bacterial infections.

Selleck's Clindamycin HCl has been cited by 1 publication

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Biological Activity

Description Clindamycin HCl inhibits protein synthesis by acting on the 50S ribosomal, used for the treatment of bacterial infections.
50S ribosomal [1]
In vitro

Clindamycin is a classical inhibitor of bacterial protein synthesis, by binding to the 23S ribosomal RNA of the 50S ribosomal subunit. [1]

In vivo Clindamycin hydrochloride results in fast absorption after oral administration in dogs, with a mean absorption time (MAT) of 0.87 hour, and bioavailability is 72.55%. Clindamycin hydrochloride results in total clearance (CL) of Clindamycin after both IV and oral administration (0.503 vs. 0.458 L/h/kg) in dogs. Clindamycin hydrochloride results in volume of distribution at steady-state (IV) at 2.48 L/kg, indicating a wide distribution of clindamycin in body fluids and tissues. Clindamycin serum concentrations after IV and oral administration remain above 0.5 μg/mL approximately for 10 hours. [1] Clindamycin hydrochloride significantly reduces oral malodor from the dogs' baseline levels through 42 days. Clindamycin hydrochloride also results in significant reductions in dental plaque, dental calculus, and gingival bleeding in dogs. [2] Clindamycin hydrochloride (2.5 mg/lb), after ultrasonic scaling, root planing, and polishing (USRP) , has a significant effect on plaque and pocket depth measures of periodontal disease but not on gingivitis in canine. [3] Clindamycin hydrochloride results in complete remission ratio of 71.4% (15/21) in dogs with canine superficial bacterial pyoderma after treat within 14 to 28 days. [4]


Solubility (25°C)

In vitro DMSO 92 mg/mL (199.37 mM)
Water 92 mg/mL (199.37 mM)
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 461.44


CAS No. 21462-39-5
Storage powder
in solvent
Synonyms N/A
Smiles CCCC1CC(N(C1)C)C(=O)NC(C2C(C(C(C(O2)SC)O)O)O)C(C)Cl.Cl

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04946500 Active not recruiting -- Prosthetic Joint Infection|Staphylococcus University Hospital Brest May 15 2021 --
NCT04220918 Recruiting -- Medication Adherence|Medication Reaction Children''s Hospital of Philadelphia|National Institute on Deafness and Other Communication Disorders (NIDCD)|Monell Chemical Senses Center February 14 2020 --
NCT03845790 Recruiting Other: Blood and microdialysis samples Surgical Site Infection Poitiers University Hospital May 26 2019 Phase 1
NCT02782078 Completed Biological: Clindamycin and rifampicin dosages Staphylococcal Infections Assistance Publique - Hôpitaux de Paris March 6 2017 Not Applicable

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