BV-6
Catalog No.S7597
Molecular Weight(MW): 1205.57
BV-6 is a SMAC mimetic, dual cIAP and XIAP inhibitor.
2 Customer Reviews
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IEC-1 cells were transfected with Per1/2 specific siRNAs or a control siRNA. Afterward, the cells were stimulated with TNFa (0.1 ng/ml under basal conditions) in the presence or absence of BV-6 or were left untreated. Activation of caspase-8 (I) and caspases 3/7 (J ) was assayed. Data are presented as the means±SEM of at least 3 independent experiments. *P≤0.05, **P≤0.01.
FASEB J, 2017, 31(11):4707-4719. BV-6 purchased from Selleck.
Treatment of primary CLL cells with the SMAC mimetic BV-6 for 2 hours in presence or absence of 200 ng/mL rhBAFF. Immunoblotting was performed in (H) cytoplasmic and (I) nuclear fractions.
Clin Cancer Res, 2018, doi:10.1158/1078-0432.CCR-18-1548. BV-6 purchased from Selleck.
Purity & Quality Control
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Biological Activity
| Description | BV-6 is a SMAC mimetic, dual cIAP and XIAP inhibitor. | ||
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| In vitro |
BV6 inhibits the cell viability of HCC193 NSCLC cells with IC50 of 7.2 μM, induces apoptosis in both HCC193 and H460 cell lines, and also significantly enhances the radiosensitivity of these cell lines through activation of cleaved caspase-8 and cleaved caspase-9, respectively. [1] In immature dendritic cells, BV-6 treatment results in moderate activation of the classical NF-kB pathway. [2] Furthermore, BV-6 increases CIK cell-mediated lysis of hematological (H9, THP-1, and Tanoue) and solid malignancies (RH1, RH30, and TE671). BV-6 also enhances apoptosis of peripheral blood mononuclear cells and most notably has an inhibitory effect on immune cells limiting their cytotoxic potential. [3] |
Protocol
| Cell Research:[1] |
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Solubility (25°C)
| In vitro | DMSO | 100 mg/mL (82.94 mM) |
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| Ethanol | 100 mg/mL warmed (82.94 mM) | |
| Water | 25 mg/mL (20.73 mM) |
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Information
| Molecular Weight | 1205.57 |
|---|---|
| Formula | C70H96N10O8.xCF3COOH |
| CAS No. | 1001600-56-1(free base) |
| Storage | powder |
| in solvent | |
| Synonyms | N/A |
Bio Calculators
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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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