Cyclic Pifithrin-α hydrobromide

Catalog No.S5791

Cyclic Pifithrin-α hydrobromide  Chemical Structure

Molecular Weight(MW): 349.29

Cyclic Pifithrin-α hydrobromide is the hydrobromide salt form of Cyclic Pifithrin-α, which is a transcriptional inhibitor of p53.

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Biological Activity

Description Cyclic Pifithrin-α hydrobromide is the hydrobromide salt form of Cyclic Pifithrin-α, which is a transcriptional inhibitor of p53.
Targets
p53 [1]
()

Protocol

Cell Research:

[1]

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  • Cell lines: H460 and IGROV-1 cell lines
  • Concentrations: 10 μM and 20 μM
  • Incubation Time: 24 h
  • Method:

    H460 and IGROV-1 cell lines were treated with either PFT or paclitaxel alone or with their combination for 24 hours. After washing with PBS, the cells were fixed in 2% paraformaldehyde for 30 minutes and permeabilized with ice-cold methanol for 20 minutes at −20°C. After blocking with PBA (PBS containing 1% bovine serum albumin), anti-p53 antibody was incubated for 1 hour at room temperature followed by incubation with Alexa Fluor 488 goat antimouse IgG secondary antibody for 1 hour. Images were observed and analyzed by confocal microscopy.


    (Only for Reference)

Solubility (25°C)

In vitro DMSO 27 mg/mL (77.29 mM)
Ethanol 3 mg/mL (8.58 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 349.29
Formula

C16H17BrN2S

CAS No. 511296-88-1
Storage powder
in solvent
Synonyms N/A

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID