MAO-B Selective Inhibitors

Catalog No. Product Name Information Selective / Pan IC50 / Ki
S2102 Rasagiline Mesylate

Rasagiline Mesylate (TVP-1012) is a new MAO-B inhibitor for the treatment of idiopathic Parkinson's disease.

Selective MAO-B, IC50: 4.43 nM
S5795 Rasagiline

Rasagiline (TVP-1012) is a novel selective and irreversible MAO-B propargylamine inhibitor with in vitro IC50s of 4.43 nM and 412 nM for MAO-B and MAO-A, respectively.

Selective MAO-B, IC50: 4.43 nM
S6422 Lazabemide

Lazabemide (Ro 19-6327) is a reversible and selective inhibitor of monoamine oxidase B (MAO-B) with Ki value of 7.9 nM.

Selective MAO-B, Ki: 7.9 nM
S5357 Safinamide

Safinamide (EMD-1195686, PNU-15774E) is an orally active, selective, reversible monoamine oxidase-B inhibitor with both dopaminergic and non-dopaminergic (glutamatergic) properties. The IC50 value of safinamide for MAO-B is 98 nM.

Selective MAO-B, Ki: 16.7 nM
S1472 Safinamide Mesylate

Safinamide Mesylate (PNU-151774E, FCE28073) is mesylate salt of Safinamide, selectively and reversibly inhibits MAO-B with IC50 of 98 nM, exhibits 5918-fold selectivity against MAO-A. Phase 3.

Selective MAO-B, IC50: 98 nM
S6602 TB5

TB5 is a potent and selective MAO-B inhibitor with Ki values of 110 and 1,450 nM for MAO-B and MAO-A, respectively.

Selective MAO-B, Ki: 110 nM
S3690 Pargyline hydrochloride

Pargyline is an irreversible inhibitor of monoamine oxidase (MAO)-B with Ki values of 13 and 0.5 μM for time-dependent inhibition of the activity of MAO-A and -B, respectivey.

Selective MAO-B, Ki: 0.5 μM
S4246 Tranylcypromine (2-PCPA) HCl

Tranylcypromine HCl (2-PCPA, SKF-385, Parnate) is a monoamine oxidase inhibitor, which inhibits CYP2A6 with Ki of 0.08 μM and 0.2 μM in cDNA-expressing microsomes and Human Liver Microsomes, respectively.

Pan MAO-B, IC50: 7 μM
S4717 Isatin

Isatin (2,3-Indolinedione) is an endogenous MAO inhibitor with an IC50 of 15 μM and more active against MAO-B than MAO-A.

Pan MAO-B, IC50: 14 μM
S2339 Paeonol

Paeonol (Peonol), a phenolic compound extracted from Chinese herbs Paeonia suffruticosa (moutan cortex) and Cynanchum paniculatum, inhibits MAO with an IC50 of about 50 μM.

Pan MAO-B, IC50: 42.5 μM