Pargyline hydrochloride

Catalog No.S3690 Synonyms: Pargylamine hydrochloride

Pargyline hydrochloride Chemical Structure

Molecular Weight(MW): 195.69

Pargyline is an irreversible inhibitor of monoamine oxidase (MAO)-B with Ki values of 13 and 0.5 μM for time-dependent inhibition of the activity of MAO-A and -B, respectivey.

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Biological Activity

Description Pargyline is an irreversible inhibitor of monoamine oxidase (MAO)-B with Ki values of 13 and 0.5 μM for time-dependent inhibition of the activity of MAO-A and -B, respectivey.
Targets
MAO-B [1]
(Cell-free assay)
MAO-A [1]
(Cell-free assay)
0.5 μM(Ki) 13 μM(Ki)
In vitro

Pargyline, an MAO inhibitor, prevents the activity of lysine-specific demethylase 1 (LSD1) and is excessively expressed in breast cancer. The proliferation of cells exposed to pargyline decreases in a dose- and time-dependent manner. The treatment of 2 mM pargyline exhibits an increase of the cell proportion at the G1 phase, while the major decrease of the cell proportion is at the S phase. pargyline induces an increase in the cleaved PARP expression[2].

In vivo Chronic treatment (14 days) with pargyline (10 mg/kg) markedly down-regulate the density of NAIBS (non-adrenoceptor idazoxan binding sites) in the rat brain[3].

Protocol

Cell Research:[2]
+ Expand
  • Cell lines: T47D cells
  • Concentrations: 0.5, 1, 1.5 and 2 mM
  • Incubation Time: 24, 48, 72, 96 and 120 h
  • Method: --
    (Only for Reference)
Animal Research:[3]
+ Expand
  • Animal Models: Sprague-Dawley rats
  • Formulation: normal saline
  • Dosages: 10 mg/kg
  • Administration: i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 39 mg/mL (199.29 mM)
Water 39 mg/mL (199.29 mM)
Ethanol 39 mg/mL (199.29 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 195.69
Formula

C11H13N.HCl

CAS No. 306-07-0
Storage powder
in solvent
Synonyms Pargylamine hydrochloride

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID