MAO-A Selective Inhibitors

Catalog No. Product Name Information Selective / Pan IC50 / Ki
S3868 Harmine

Harmine (Telepathine) is an alkaloid of the β-carboline family that regulates PPARγ expression through inhibition of the Wnt signaling pathway. It also selectively binds to MAO-A and reversibly inhibits monoamine oxidase A (MAO-A) but not the variant MAO-B.

Selective MAO-A, Ki: 0.048 μM
S0160 Toloxatone (MD69276)

Toloxatone (MD69276, Humoryl, Perenum, Umoril) is a reversible inhibitor of monoamine oxidase A (MAO-A) with IC50 of  0.93 µM. Toloxatone is an antidepressant agent.

Selective MAO-A, IC50: 0.93 μM
S3212 Moclobemide (Ro 111163)

Moclobemide is a MAO-A (5-HT) inhibitor with IC50 of 6.1 μM.

Selective MAO-A (5-HT), IC50: 6.1 μM
S2419 Eprobemide

Eprobemide is a reversible monoamine oxidase A (MAO-A) inhibitor. Eprobemide acts as an antidepressant in Russia.

Selective
S2102 Rasagiline Mesylate

Rasagiline Mesylate (TVP-1012) is a new MAO-B inhibitor for the treatment of idiopathic Parkinson's disease.

Pan MAO-A, IC50: 412 nM
S5795 Rasagiline

Rasagiline (TVP-1012) is a novel selective and irreversible MAO-B propargylamine inhibitor with in vitro IC50s of 4.43 nM and 412 nM for MAO-B and MAO-A, respectively.

Pan MAO-A, IC50: 412 nM
S4246 Tranylcypromine (2-PCPA) HCl

Tranylcypromine HCl (2-PCPA, SKF-385, Parnate) is a monoamine oxidase inhibitor, which inhibits CYP2A6 with Ki of 0.08 μM and 0.2 μM in cDNA-expressing microsomes and Human Liver Microsomes, respectively.

Pan MAO-A, IC50: 11.5 μM
S3690 Pargyline hydrochloride

Pargyline is an irreversible inhibitor of monoamine oxidase (MAO)-B with Ki values of 13 and 0.5 μM for time-dependent inhibition of the activity of MAO-A and -B, respectivey.

Pan MAO-A, Ki: 13 μM
S2339 Paeonol

Paeonol (Peonol), a phenolic compound extracted from Chinese herbs Paeonia suffruticosa (moutan cortex) and Cynanchum paniculatum, inhibits MAO with an IC50 of about 50 μM.

Pan MAO-A, IC50: 54.6 μM
S4717 Isatin

Isatin (2,3-Indolinedione) is an endogenous MAO inhibitor with an IC50 of 15 μM and more active against MAO-B than MAO-A.

Pan MAO-A, IC50: 58 μM