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DUB Signaling Pathway Map

Isoform-selective Inhibitors

DUB Products

All (29)
DUB Inhibitors (29)
New DUB Products

Catalog No.	Product Name	Information	Product Use Citations
E0389^New	DUBs-IN-2	DUBs-IN-2 is a potent inhibitor of USP7 and USP8 deubiquitinating enzymes.
E1098^New	MF-094	MF-094, a potent and selective USP30 inhibitor (IC50=0.12 μM), accelerates diabetic wound healing by inhibiting the NLRP3 inflammasome.
E1118^New	SJB3-019A	SJB3-019A, a potent USP1 inhibitor, is 5 times more potent than SJB2-043 in promoting inhibitor of DNA-binding-1 (ID1) degradation and cytoxicity with IC50 of 0.0781 μM in K562 cells.
S0399	SJB2-043	SJB2-043 is a potent USP1 inhibitor that inhibits the activity of native USP1/UAF1 with IC50 of 544 nM.	Front Pharmacol, 2021, 12:695009
S0515	PLpro inhibitor	PLpro inhibitor (compound 6) is a potent papain-like protease (PLpro)/deubiquitinase (DUBs) inhibitor with IC50 of 2.6 μM and EC50 of 13.1 μM that blocks SARS virus replication.
S0884	RA-9	RA-9 is a cell-permeable, potent and selective inhibitor of proteasome-associated deubiquitinating enzymes (DUBs) with favorable toxicity profile and anticancer activity. RA-9 selectively induces apoptosis in ovarian cancer cell lines.
S2243	Degrasyn (WP1130)	Degrasyn (WP1130) is a selective deubiquitinase (DUB: USP5, UCH-L1, USP9x, USP14, and UCH37) inhibitor and also suppresses Bcr/Abl, also a JAK2 transducer (without affecting 20S proteasome) and activator of transcription (STAT). Degrasyn (WP1130) induces apoptosis and blocks autophagy.	Br J Cancer, 2021, 10.1038/s41416-021-01421-x Cell Chem Biol, 2021, S2451-9456(21)00213-0 Transl Lung Cancer Res, 2021, 10(10):3995-4011
S2913	BAY 11-7082	BAY 11-7082 (BAY 11-7821) is a NF-κB inhibitor, inhibits TNFα-induced IκBα phosphorylation with IC50 of 10 μM in tumor cells. BAY 11-7082 inhibits ubiquitin-specific protease USP7 and USP21 with IC50 of 0.19 μM and 0.96 μM, respectively. BAY 11-7082 induces apoptosis and S phase arrest in gastric cancer cells.	Nat Med, 2022, 28(4):752-765 Gastroenterology, 2022, 162(6):1716-1731.e17 Adv Sci (Weinh), 2022, 10.1002/advs.202104055
S3692	N-Ethylmaleimide (NEM)	N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It is an irreversible inhibitor of all cysteine peptidases, with alkylation occurring at the active site thiol group. N-Ethylmaleimide (NEM) inactivates endogenous deubiquitinating enzymes (DUBs). N-Ethylmaleimide (NEM) specifically inhibits phosphate transport in mitochondria.	Cell Rep, 2022, 38(12):110538 Invest Ophthalmol Vis Sci, 2022, 63(4):11 EMBO J, 2021, 40(10):e106632
S4920	b-AP15	b-AP15 (NSC687852) is a deubiquitinases inhibitor for 19S proteasomes activity of Ub-AMC cleavage with IC50 of 2.1 μM.	Sci Adv, 2022, 8(3):eabj8357 Proc Natl Acad Sci U S A, 2021, 118(29)e2024562118 Cell Death Discov, 2021, 7(1):211
S4922	NSC 632839	NSC 632839 is not only a DUB inhibitor, but also a deSUMOylase inhibitor, it inhibits USP2, USP7, and SENP2 with EC50 of 45 μM, 37 μM, and 9.8 μM, respectively.
S6748	ML364	ML364 is a small molecule inhibitor of the deubiquitinase USP2 with an IC50 of 1.1 μM in a biochemical assay using an internally quenched fluorescent di-ubiquitin substrate.	J Virol, 2020, JVI.01857-20
S6845	GRL0617	GRL0617 is a potent, selective and competitive noncovalent inhibitor of severe acute respiratory syndrome (SARS-CoV) papain-like protease (PLPro)/deubiquitinase with IC50 of 0.6 μM and Ki of 0.49 μM. GRL0617 inhibits SARS-CoV viral replication in Vero E6 cells with EC50 of 15 microM and has no associated cytotoxicity.
S6877	EOAI3402143	EOAI3402143 is a dose-dependent inhibitor of Usp9x, Usp24 and Usp5 that increases tumor cell apoptosis, and fully blocks or regresses myeloma tumors in mice.	Int J Biol Sci, 2021, 17(10):2417-2429 Transl Lung Cancer Res, 2021, 10(10):3995-4011
S6878	GSK2643943A	GSK2643943A is an inhibitor of deubiquitylating enzyme (DUB) with IC50 of 160 nM for USP20/Ub-Rho.	Nature, 2020, 10.1038/s41586-020-2928-y
S6883^New	HBX 19818	HBX19818 is a specific inhibitor of USP7 with an IC 50 of 28.1 μM.
S6933	GEN-6776	GNE-6776 is a potent, non-covalent, selective and orally bioavailable inhibitor of USP7 with IC50 of 1.34 μM and 0.61 μM for full length USP7 and USP7 catalytic domain, respectively.
S6943^New	IU1-47	IU1-47 is a potent and specific inhibitor of USP14 with an IC50 of 0.6 μM. IU1-47 shows ∼33-fold selectivity for USP14 over USP5 (IsoT).
S7130	PR-619	PR-619 is a non-selective, reversible inhibitor of the deubiquitinylating enzymes (DUBs) with EC50 of 1-20 μM in a cell-free assay. PR-619 activates autophagy.	Cell Death Differ, 2022, 10.1038/s41418-022-00983-4 Cells, 2022, 11(6)1006 Apoptosis, 2022, 10.1007/s10495-021-01706-9
S7132	P5091 (P005091)	P5091(P005091) is a selective and potent inhibitor of ubiquitin-specific protease 7 (USP7) with EC50 of 4.2 μM and the closely related USP47.	Sci Adv, 2022, 8(3):eabj8357 Nat Commun, 2021, 12(1):5010 J Clin Invest, 2021, 146893
S7133	P22077	P22077 is an inhibitor of ubiquitin-specific protease USP7 with EC50 of 8.6 μM, also inhibits the closely related USP47.	Cell Biochem Funct, 2022, 10.1002/cbf.3702 Nat Commun, 2021, 12(1):51 J Cell Sci, 2021, jcs.258922
S7134	IU1	IU1 is a cell-permeable, reversible and selective proteasome inhibitor of human USP14 with IC50 of 4.7 μ M, 25-fold selective to IsoT. IU1 induces autophagy.	Cell Death Dis, 2021, 12(9):803 FASEB J, 2021, 35(9):e21870 Cell Chem Biol, 2021, S2451-9456(21)00213-0
S7135	LDN-57444	LDN-57444 is a reversible, competitive proteasome inhibitor for Uch-L1 with IC50 of 0.88 μM, 28-fold selectivity over isoform Uch-L3.	Cell Biol Int, 2021, 10.1002/cbin.11662 J Int Med Res, 2021, 49(6):3000605211020641 Theranostics, 2020, 15;10(13):6048-6060
S7140	TCID	TCID is a DUB inhibitor for ubiquitin C-terminal hydrolase L3 with IC50 of 0.6 μM, 125-fold selective to L1.	Nat Commun, 2022, 13(1):1700 Cell Chem Biol, 2021, S2451-9456(21)00213-0
S7529	ML323	ML323 displays reversible, nanomolar inhibitory activity and excellent selectivity toward USP1/UAF1 with IC50 of 76 nM.	Oncogene, 2021, 40(25):4291-4306 J Exp Clin Cancer Res, 2021, 40(1):201 Front Pharmacol, 2021, 12:695009
S7888	Spautin-1	Spautin-1 is a potent and specific autophagy inhibitor, and inhibits the deubiquitinating activity of USP10 and USP13 with IC50 of ∼0.6-0.7 μM. Spautin-1 enhances apoptosis.	Autophagy, 2022, 1-20 Atherosclerosis, 2022, 343:10-19 J Clin Invest, 2021, 146893
S8288	VLX1570	VLX1570 is a competitive inhibitor of proteasome DUB activity, with an IC50 of ~10 μM in vitro.	Front Pharmacol, 2021, 12:778216 Cancer Sci, 2021, 112(8):3302-3313 Research Square, 2021, 10.21203/rs.3.rs-265240/v1
S8904	USP25/28 inhibitor AZ1	AZ1 is a potent and noncompetitive dual Inhibitors of the ubiquitin-specific protease (USP) 25/28 with IC50s of 0.62 μM and 0.7 μM in Ub-RH110 assay,respectively.
S8967	XL177A	XL177A is a potent, selective and irreversible inhibitor of Ubiquitin specific peptidase 7 (USP7) with IC50 of 0.34 nM.
E0389^New	DUBs-IN-2	DUBs-IN-2 is a potent inhibitor of USP7 and USP8 deubiquitinating enzymes.
E1098^New	MF-094	MF-094, a potent and selective USP30 inhibitor (IC50=0.12 μM), accelerates diabetic wound healing by inhibiting the NLRP3 inflammasome.
E1118^New	SJB3-019A	SJB3-019A, a potent USP1 inhibitor, is 5 times more potent than SJB2-043 in promoting inhibitor of DNA-binding-1 (ID1) degradation and cytoxicity with IC50 of 0.0781 μM in K562 cells.
S0399	SJB2-043	SJB2-043 is a potent USP1 inhibitor that inhibits the activity of native USP1/UAF1 with IC50 of 544 nM.	Front Pharmacol, 2021, 12:695009
S0515	PLpro inhibitor	PLpro inhibitor (compound 6) is a potent papain-like protease (PLpro)/deubiquitinase (DUBs) inhibitor with IC50 of 2.6 μM and EC50 of 13.1 μM that blocks SARS virus replication.
S0884	RA-9	RA-9 is a cell-permeable, potent and selective inhibitor of proteasome-associated deubiquitinating enzymes (DUBs) with favorable toxicity profile and anticancer activity. RA-9 selectively induces apoptosis in ovarian cancer cell lines.
S2243	Degrasyn (WP1130)	Degrasyn (WP1130) is a selective deubiquitinase (DUB: USP5, UCH-L1, USP9x, USP14, and UCH37) inhibitor and also suppresses Bcr/Abl, also a JAK2 transducer (without affecting 20S proteasome) and activator of transcription (STAT). Degrasyn (WP1130) induces apoptosis and blocks autophagy.	Br J Cancer, 2021, 10.1038/s41416-021-01421-x Cell Chem Biol, 2021, S2451-9456(21)00213-0 Transl Lung Cancer Res, 2021, 10(10):3995-4011
S2913	BAY 11-7082	BAY 11-7082 (BAY 11-7821) is a NF-κB inhibitor, inhibits TNFα-induced IκBα phosphorylation with IC50 of 10 μM in tumor cells. BAY 11-7082 inhibits ubiquitin-specific protease USP7 and USP21 with IC50 of 0.19 μM and 0.96 μM, respectively. BAY 11-7082 induces apoptosis and S phase arrest in gastric cancer cells.	Nat Med, 2022, 28(4):752-765 Gastroenterology, 2022, 162(6):1716-1731.e17 Adv Sci (Weinh), 2022, 10.1002/advs.202104055
S3692	N-Ethylmaleimide (NEM)	N-Ethylmaleimide (NEM) is an organic compound that is derived from maleic acid. It is an irreversible inhibitor of all cysteine peptidases, with alkylation occurring at the active site thiol group. N-Ethylmaleimide (NEM) inactivates endogenous deubiquitinating enzymes (DUBs). N-Ethylmaleimide (NEM) specifically inhibits phosphate transport in mitochondria.	Cell Rep, 2022, 38(12):110538 Invest Ophthalmol Vis Sci, 2022, 63(4):11 EMBO J, 2021, 40(10):e106632
S4920	b-AP15	b-AP15 (NSC687852) is a deubiquitinases inhibitor for 19S proteasomes activity of Ub-AMC cleavage with IC50 of 2.1 μM.	Sci Adv, 2022, 8(3):eabj8357 Proc Natl Acad Sci U S A, 2021, 118(29)e2024562118 Cell Death Discov, 2021, 7(1):211
S4922	NSC 632839	NSC 632839 is not only a DUB inhibitor, but also a deSUMOylase inhibitor, it inhibits USP2, USP7, and SENP2 with EC50 of 45 μM, 37 μM, and 9.8 μM, respectively.
S6748	ML364	ML364 is a small molecule inhibitor of the deubiquitinase USP2 with an IC50 of 1.1 μM in a biochemical assay using an internally quenched fluorescent di-ubiquitin substrate.	J Virol, 2020, JVI.01857-20
S6845	GRL0617	GRL0617 is a potent, selective and competitive noncovalent inhibitor of severe acute respiratory syndrome (SARS-CoV) papain-like protease (PLPro)/deubiquitinase with IC50 of 0.6 μM and Ki of 0.49 μM. GRL0617 inhibits SARS-CoV viral replication in Vero E6 cells with EC50 of 15 microM and has no associated cytotoxicity.
S6877	EOAI3402143	EOAI3402143 is a dose-dependent inhibitor of Usp9x, Usp24 and Usp5 that increases tumor cell apoptosis, and fully blocks or regresses myeloma tumors in mice.	Int J Biol Sci, 2021, 17(10):2417-2429 Transl Lung Cancer Res, 2021, 10(10):3995-4011
S6878	GSK2643943A	GSK2643943A is an inhibitor of deubiquitylating enzyme (DUB) with IC50 of 160 nM for USP20/Ub-Rho.	Nature, 2020, 10.1038/s41586-020-2928-y
S6883^New	HBX 19818	HBX19818 is a specific inhibitor of USP7 with an IC 50 of 28.1 μM.
S6933	GEN-6776	GNE-6776 is a potent, non-covalent, selective and orally bioavailable inhibitor of USP7 with IC50 of 1.34 μM and 0.61 μM for full length USP7 and USP7 catalytic domain, respectively.
S6943^New	IU1-47	IU1-47 is a potent and specific inhibitor of USP14 with an IC50 of 0.6 μM. IU1-47 shows ∼33-fold selectivity for USP14 over USP5 (IsoT).
S7130	PR-619	PR-619 is a non-selective, reversible inhibitor of the deubiquitinylating enzymes (DUBs) with EC50 of 1-20 μM in a cell-free assay. PR-619 activates autophagy.	Cell Death Differ, 2022, 10.1038/s41418-022-00983-4 Cells, 2022, 11(6)1006 Apoptosis, 2022, 10.1007/s10495-021-01706-9
S7132	P5091 (P005091)	P5091(P005091) is a selective and potent inhibitor of ubiquitin-specific protease 7 (USP7) with EC50 of 4.2 μM and the closely related USP47.	Sci Adv, 2022, 8(3):eabj8357 Nat Commun, 2021, 12(1):5010 J Clin Invest, 2021, 146893
S7133	P22077	P22077 is an inhibitor of ubiquitin-specific protease USP7 with EC50 of 8.6 μM, also inhibits the closely related USP47.	Cell Biochem Funct, 2022, 10.1002/cbf.3702 Nat Commun, 2021, 12(1):51 J Cell Sci, 2021, jcs.258922
S7134	IU1	IU1 is a cell-permeable, reversible and selective proteasome inhibitor of human USP14 with IC50 of 4.7 μ M, 25-fold selective to IsoT. IU1 induces autophagy.	Cell Death Dis, 2021, 12(9):803 FASEB J, 2021, 35(9):e21870 Cell Chem Biol, 2021, S2451-9456(21)00213-0
S7135	LDN-57444	LDN-57444 is a reversible, competitive proteasome inhibitor for Uch-L1 with IC50 of 0.88 μM, 28-fold selectivity over isoform Uch-L3.	Cell Biol Int, 2021, 10.1002/cbin.11662 J Int Med Res, 2021, 49(6):3000605211020641 Theranostics, 2020, 15;10(13):6048-6060
S7140	TCID	TCID is a DUB inhibitor for ubiquitin C-terminal hydrolase L3 with IC50 of 0.6 μM, 125-fold selective to L1.	Nat Commun, 2022, 13(1):1700 Cell Chem Biol, 2021, S2451-9456(21)00213-0
S7529	ML323	ML323 displays reversible, nanomolar inhibitory activity and excellent selectivity toward USP1/UAF1 with IC50 of 76 nM.	Oncogene, 2021, 40(25):4291-4306 J Exp Clin Cancer Res, 2021, 40(1):201 Front Pharmacol, 2021, 12:695009
S7888	Spautin-1	Spautin-1 is a potent and specific autophagy inhibitor, and inhibits the deubiquitinating activity of USP10 and USP13 with IC50 of ∼0.6-0.7 μM. Spautin-1 enhances apoptosis.	Autophagy, 2022, 1-20 Atherosclerosis, 2022, 343:10-19 J Clin Invest, 2021, 146893
S8288	VLX1570	VLX1570 is a competitive inhibitor of proteasome DUB activity, with an IC50 of ~10 μM in vitro.	Front Pharmacol, 2021, 12:778216 Cancer Sci, 2021, 112(8):3302-3313 Research Square, 2021, 10.21203/rs.3.rs-265240/v1
S8904	USP25/28 inhibitor AZ1	AZ1 is a potent and noncompetitive dual Inhibitors of the ubiquitin-specific protease (USP) 25/28 with IC50s of 0.62 μM and 0.7 μM in Ub-RH110 assay,respectively.
S8967	XL177A	XL177A is a potent, selective and irreversible inhibitor of Ubiquitin specific peptidase 7 (USP7) with IC50 of 0.34 nM.
E0389^New	DUBs-IN-2	DUBs-IN-2 is a potent inhibitor of USP7 and USP8 deubiquitinating enzymes.
E1098^New	MF-094	MF-094, a potent and selective USP30 inhibitor (IC50=0.12 μM), accelerates diabetic wound healing by inhibiting the NLRP3 inflammasome.
E1118^New	SJB3-019A	SJB3-019A, a potent USP1 inhibitor, is 5 times more potent than SJB2-043 in promoting inhibitor of DNA-binding-1 (ID1) degradation and cytoxicity with IC50 of 0.0781 μM in K562 cells.
S6883^New	HBX 19818	HBX19818 is a specific inhibitor of USP7 with an IC 50 of 28.1 μM.
S6943^New	IU1-47	IU1-47 is a potent and specific inhibitor of USP14 with an IC50 of 0.6 μM. IU1-47 shows ∼33-fold selectivity for USP14 over USP5 (IsoT).