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Other Ubiquitin Related Inhibitors

E1 Activating E2 conjugating E3 Ligase p97 SUMO

Isoform-selective Products

Cat.No. Product Name Information Product Use Citations Product Validations
S3692 N-Ethylmaleimide (NEM) NEM (N-Ethylmaleimide) is an organic compound that is derived from maleic acid. It is an irreversible inhibitor of all cysteine peptidases, with alkylation occurring at the active site thiol group. N-Ethylmaleimide (NEM) inactivates endogenous deubiquitinating enzymes (DUBs). N-Ethylmaleimide (NEM) specifically inhibits phosphate transport in mitochondria.
Nat Commun, 2025, 16(1):7812
Inflammation, 2025, 10.1007/s10753-025-02273-w
Toxicol Lett, 2025, 406:31-37
S7130 PR-619 PR-619 is a non-selective, reversible inhibitor of the deubiquitinylating enzymes (DUBs) with EC50 of 1-20 μM in a cell-free assay. This compound activates autophagy.
Cancer Immunol Res, 2025, 10.1158/2326-6066.CIR-24-1194
J Orthop Surg Res, 2025, 20(1):220
Sci Adv, 2025, 11(38):eadw2539
Verified customer review of PR-619
S7132 P5091 P5091 is a selective and potent inhibitor of ubiquitin-specific protease 7 (USP7) with EC50 of 4.2 μM and the closely related USP47.
Mol Metab, 2025, 94:102111
Neoplasia, 2025, 66:101192
J Exp Clin Cancer Res, 2024, 43(1):28
Verified customer review of P5091
S7133 P22077 P22077 is an inhibitor of ubiquitin-specific protease USP7 with EC50 of 8.6 μM, and this compound also inhibits the closely related USP47.
Int J Mol Sci, 2024, 25(5)2768
Hepatol Commun, 2024, 8(4)e0405
Queen's University Belfast, 2023,
S7134 IU1 IU1 is a cell-permeable, reversible and selective proteasome inhibitor of human USP14 with IC50 of 4.7 μ M, 25-fold selective to IsoT. This compound induces autophagy.
Cells, 2025, 14(11)816
Mol Med, 2025, 31(1):163
Redox Biol, 2024, 76:103318
Verified customer review of IU1
S4920 b-AP15 b-AP15 (NSC687852) is a deubiquitinases inhibitor for 19S proteasomes activity of Ub-AMC cleavage with IC50 of 2.1 μM.
Nat Cell Biol, 2025, 27(9):1448-1464
J Control Release, 2025, 380:417-432
Int J Biol Sci, 2025, 21(5):2258-2274
Verified customer review of b-AP15
S7529 ML323 ML323 displays reversible, nanomolar inhibitory activity and excellent selectivity toward USP1/UAF1 with IC50 of 76 nM.
Cancers (Basel), 2025, 17(17)2864
Oncol Res, 2025, 33(1):213-224
Nucleic Acids Res, 2024, gkae785
S7135 LDN-57444 LDN-57444 is a reversible, competitive proteasome inhibitor for Uch-L1 with IC50 of 0.88 μM, 28-fold selectivity over isoform Uch-L3.
Stem Cell Res Ther, 2025, 16(1):271
J Transl Med, 2024, 22(1):478
Cells, 2024, 13(9)737
Verified customer review of LDN-57444
S8288 VLX1570 VLX1570 is a competitive inhibitor of proteasome DUB activity, with an IC50 of ~10 μM in vitro.
Commun Biol, 2024, 7(1):25
PLoS One, 2022, 17(7):e0271245
Cancer Sci, 2021, 112(8):3302-3313
S6877 EOAI3402143 EOAI3402143 is a dose-dependent inhibitor of Usp9x, Usp24 and Usp5 that increases tumor cell apoptosis, and fully blocks or regresses myeloma tumors in mice.
Cell Rep Med, 2023, 4(4):101007
Int J Biol Sci, 2021, 17(10):2417-2429
Int J Biol Sci, 2021, 17(10):2417-2429

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